Published in Cell on July 25, 2008
Mammalian sirtuins: biological insights and disease relevance. Annu Rev Pathol (2010) 8.55
Recent progress in the biology and physiology of sirtuins. Nature (2009) 7.73
The genetics of mammalian circadian order and disorder: implications for physiology and disease. Nat Rev Genet (2008) 7.65
Circadian integration of metabolism and energetics. Science (2010) 6.86
The meter of metabolism. Cell (2008) 5.71
Circadian clock feedback cycle through NAMPT-mediated NAD+ biosynthesis. Science (2009) 5.30
Hepatocyte-specific deletion of SIRT1 alters fatty acid metabolism and results in hepatic steatosis and inflammation. Cell Metab (2009) 5.02
Central and peripheral circadian clocks in mammals. Annu Rev Neurosci (2012) 4.73
A novel pathway regulates memory and plasticity via SIRT1 and miR-134. Nature (2010) 4.39
The secret life of NAD+: an old metabolite controlling new metabolic signaling pathways. Endocr Rev (2009) 3.23
Decoding the epigenetic language of neuronal plasticity. Neuron (2008) 3.23
Retinoid-related orphan receptors (RORs): critical roles in development, immunity, circadian rhythm, and cellular metabolism. Nucl Recept Signal (2009) 3.19
Ten years of NAD-dependent SIR2 family deacetylases: implications for metabolic diseases. Trends Pharmacol Sci (2010) 3.05
Clocks not winding down: unravelling circadian networks. Nat Rev Mol Cell Biol (2010) 2.95
Metabolism and cancer: the circadian clock connection. Nat Rev Cancer (2009) 2.91
Genetics of circadian rhythms in Mammalian model organisms. Adv Genet (2011) 2.80
Circadian topology of metabolism. Nature (2012) 2.63
Circadian rhythms, sleep, and metabolism. J Clin Invest (2011) 2.60
Metabolic regulation of epigenetics. Cell Metab (2012) 2.55
Circadian rhythms and metabolic syndrome: from experimental genetics to human disease. Circ Res (2010) 2.49
The cAMP/PKA pathway rapidly activates SIRT1 to promote fatty acid oxidation independently of changes in NAD(+). Mol Cell (2011) 2.36
Molecular architecture of the mammalian circadian clock. Trends Cell Biol (2013) 2.26
Coordination of the transcriptome and metabolome by the circadian clock. Proc Natl Acad Sci U S A (2012) 2.22
Are sirtuins viable targets for improving healthspan and lifespan? Nat Rev Drug Discov (2012) 2.22
Hormonal regulation of hepatic glucose production in health and disease. Cell Metab (2011) 2.12
Sirtuins mediate mammalian metabolic responses to nutrient availability. Nat Rev Endocrinol (2012) 2.12
Energetics, epigenetics, mitochondrial genetics. Mitochondrion (2009) 2.08
NAD+ and sirtuins in aging and disease. Trends Cell Biol (2014) 2.07
The histone methyltransferase MLL1 permits the oscillation of circadian gene expression. Nat Struct Mol Biol (2010) 2.00
Sirtuin 1 and sirtuin 3: physiological modulators of metabolism. Physiol Rev (2012) 1.99
Metabolism control by the circadian clock and vice versa. Nat Struct Mol Biol (2009) 1.99
Deleted in breast cancer-1 regulates SIRT1 activity and contributes to high-fat diet-induced liver steatosis in mice. J Clin Invest (2010) 1.97
AKT and TOR signaling set the pace of the circadian pacemaker. Curr Biol (2010) 1.97
Healthy clocks, healthy body, healthy mind. Trends Cell Biol (2009) 1.95
How might circadian rhythms control mood? Let me count the ways... Biol Psychiatry (2013) 1.95
Regulation of SIRT1 in cellular functions: role of polyphenols. Arch Biochem Biophys (2010) 1.91
SIRT1 and other sirtuins in metabolism. Trends Endocrinol Metab (2013) 1.90
Genomic and epigenetic insights into the molecular bases of heterosis. Nat Rev Genet (2013) 1.87
The nexus of chromatin regulation and intermediary metabolism. Nature (2013) 1.87
Targeting sirtuin 1 to improve metabolism: all you need is NAD(+)? Pharmacol Rev (2011) 1.85
Clocks, metabolism, and the epigenome. Mol Cell (2012) 1.84
Post-translational modifications in circadian rhythms. Trends Biochem Sci (2009) 1.80
Calorie restriction and sirtuins revisited. Genes Dev (2013) 1.79
SIRT1 mediates central circadian control in the SCN by a mechanism that decays with aging. Cell (2013) 1.71
Sirtuin 1 in lipid metabolism and obesity. Ann Med (2011) 1.65
Deficient of a clock gene, brain and muscle Arnt-like protein-1 (BMAL1), induces dyslipidemia and ectopic fat formation. PLoS One (2011) 1.65
A molecular mechanism for circadian clock negative feedback. Science (2011) 1.64
CLOCK and BMAL1 regulate MyoD and are necessary for maintenance of skeletal muscle phenotype and function. Proc Natl Acad Sci U S A (2010) 1.63
The implications of multiple circadian clock origins. PLoS Biol (2009) 1.61
Crystal structures of human SIRT3 displaying substrate-induced conformational changes. J Biol Chem (2009) 1.60
The NAD World: a new systemic regulatory network for metabolism and aging--Sirt1, systemic NAD biosynthesis, and their importance. Cell Biochem Biophys (2009) 1.58
The emerging and diverse roles of sirtuins in cancer: a clinical perspective. Onco Targets Ther (2013) 1.57
NAD(+)-SIRT1 control of H3K4 trimethylation through circadian deacetylation of MLL1. Nat Struct Mol Biol (2015) 1.55
Mammalian circadian clock and metabolism - the epigenetic link. J Cell Sci (2010) 1.55
Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways. Mol Cell Proteomics (2012) 1.54
miRNA-132 orchestrates chromatin remodeling and translational control of the circadian clock. Hum Mol Genet (2010) 1.53
A novel protein, CHRONO, functions as a core component of the mammalian circadian clock. PLoS Biol (2014) 1.52
SIRT1 promotes the central adaptive response to diet restriction through activation of the dorsomedial and lateral nuclei of the hypothalamus. J Neurosci (2010) 1.51
Intestine-specific deletion of SIRT1 in mice impairs DCoH2-HNF-1α-FXR signaling and alters systemic bile acid homeostasis. Gastroenterology (2013) 1.50
Molecular components of the Mammalian circadian clock. Handb Exp Pharmacol (2013) 1.47
Metabolism and the circadian clock converge. Physiol Rev (2013) 1.47
SIRT1 genetic variation is related to BMI and risk of obesity. Diabetes (2009) 1.44
Calorie restriction and the exercise of chromatin. Genes Dev (2009) 1.44
CRY Drives Cyclic CK2-Mediated BMAL1 Phosphorylation to Control the Mammalian Circadian Clock. PLoS Biol (2015) 1.42
Plasticity and specificity of the circadian epigenome. Nat Neurosci (2010) 1.41
SIRT1-dependent regulation of chromatin and transcription: linking NAD(+) metabolism and signaling to the control of cellular functions. Biochim Biophys Acta (2009) 1.41
Nutrient-dependent regulation of PGC-1alpha's acetylation state and metabolic function through the enzymatic activities of Sirt1/GCN5. Biochim Biophys Acta (2009) 1.39
NAD(+) Metabolism and the Control of Energy Homeostasis: A Balancing Act between Mitochondria and the Nucleus. Cell Metab (2015) 1.38
Minireview: the PGC-1 coactivator networks: chromatin-remodeling and mitochondrial energy metabolism. Mol Endocrinol (2008) 1.37
Human blood metabolite timetable indicates internal body time. Proc Natl Acad Sci U S A (2012) 1.37
Rev-erb-alpha: an integrator of circadian rhythms and metabolism. J Appl Physiol (1985) (2009) 1.34
KAT(ching) metabolism by the tail: insight into the links between lysine acetyltransferases and metabolism. Chembiochem (2010) 1.32
Regulation of metabolism: the circadian clock dictates the time. Trends Endocrinol Metab (2011) 1.32
The circadian oscillator gene GIGANTEA mediates a long-term response of the Arabidopsis thaliana circadian clock to sucrose. Proc Natl Acad Sci U S A (2011) 1.31
Circadian rhythm disruption in cancer biology. Mol Med (2012) 1.31
T cell replicative senescence in human aging. Curr Pharm Des (2013) 1.31
HDAC3 is negatively regulated by the nuclear protein DBC1. J Biol Chem (2010) 1.30
"Clocks" in the NAD World: NAD as a metabolic oscillator for the regulation of metabolism and aging. Biochim Biophys Acta (2009) 1.29
The circadian clock in cancer development and therapy. Prog Mol Biol Transl Sci (2013) 1.28
Biochemical analysis of the canonical model for the mammalian circadian clock. J Biol Chem (2011) 1.27
Protein deacetylation by SIRT1: an emerging key post-translational modification in metabolic regulation. Pharmacol Res (2009) 1.27
The sirtuin pathway in ageing and Alzheimer disease: mechanistic and therapeutic considerations. Lancet Neurol (2011) 1.27
SIRT1 and energy metabolism. Acta Biochim Biophys Sin (Shanghai) (2013) 1.25
Epigenetic regulation of ageing: linking environmental inputs to genomic stability. Nat Rev Mol Cell Biol (2015) 1.24
Sirtuins and renal diseases: relationship with aging and diabetic nephropathy. Clin Sci (Lond) (2013) 1.23
bHLH-PAS proteins in cancer. Nat Rev Cancer (2013) 1.23
SIRT1 in neurodevelopment and brain senescence. Neuron (2014) 1.22
The chronobiology, etiology and pathophysiology of obesity. Int J Obes (Lond) (2010) 1.22
High-throughput screening and chemical biology: new approaches for understanding circadian clock mechanisms. Chem Biol (2009) 1.21
Clock genes, intestinal transport and plasma lipid homeostasis. Trends Endocrinol Metab (2009) 1.21
Circadian regulation of molecular, dietary, and metabolic signaling mechanisms of human breast cancer growth by the nocturnal melatonin signal and the consequences of its disruption by light at night. J Pineal Res (2011) 1.20
Role of deleted in breast cancer 1 (DBC1) protein in SIRT1 deacetylase activation induced by protein kinase A and AMP-activated protein kinase. J Biol Chem (2012) 1.19
Regulation of nucleotide excision repair activity by transcriptional and post-transcriptional control of the XPA protein. Nucleic Acids Res (2010) 1.19
Three novel acetylation sites in the Foxp3 transcription factor regulate the suppressive activity of regulatory T cells. J Immunol (2012) 1.18
Mammalian sirtuins and energy metabolism. Int J Biol Sci (2011) 1.17
Mutation of Arabidopsis spliceosomal timekeeper locus1 causes circadian clock defects. Plant Cell (2012) 1.17
Redox regulation of SIRT1 in inflammation and cellular senescence. Free Radic Biol Med (2013) 1.17
Dissecting systemic control of metabolism and aging in the NAD World: the importance of SIRT1 and NAMPT-mediated NAD biosynthesis. FEBS Lett (2011) 1.17
Biochemical effects of SIRT1 activators. Biochim Biophys Acta (2009) 1.16
CHD1 remodels chromatin and influences transient DNA methylation at the clock gene frequency. PLoS Genet (2011) 1.16
Chromatin modifications and their function. Cell (2007) 55.98
The language of covalent histone modifications. Nature (2000) 44.92
The role of chromatin during transcription. Cell (2007) 26.48
Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase. Nature (2000) 20.54
Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha. Cell (2006) 19.16
Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1. Nature (2005) 18.41
Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. Science (2004) 17.38
hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase. Cell (2001) 15.97
Negative control of p53 by Sir2alpha promotes cell survival under stress. Cell (2001) 15.05
Histone acetylation in chromatin structure and transcription. Nature (1997) 14.64
Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans. Nature (2001) 14.44
Coordinated transcription of key pathways in the mouse by the circadian clock. Cell (2002) 14.07
A rapid micropreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells. Nucleic Acids Res (1991) 13.54
Obesity and metabolic syndrome in circadian Clock mutant mice. Science (2005) 12.66
Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma. Nature (2004) 10.32
Histone acetylation and transcriptional regulatory mechanisms. Genes Dev (1998) 10.16
Extensive and divergent circadian gene expression in liver and heart. Nature (2002) 9.64
Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice. Proc Natl Acad Sci U S A (2003) 9.14
Mammalian SIRT1 represses forkhead transcription factors. Cell (2004) 8.89
Alteration of nucleosome structure as a mechanism of transcriptional regulation. Annu Rev Biochem (1998) 8.86
Posttranslational mechanisms regulate the mammalian circadian clock. Cell (2001) 7.93
The silencing protein SIR2 and its homologs are NAD-dependent protein deacetylases. Proc Natl Acad Sci U S A (2000) 7.92
The Rpd3/Hda1 family of lysine deacetylases: from bacteria and yeast to mice and men. Nat Rev Mol Cell Biol (2008) 6.90
A transcription factor response element for gene expression during circadian night. Nature (2002) 6.55
Calorie restriction, SIRT1 and metabolism: understanding longevity. Nat Rev Mol Cell Biol (2005) 6.34
HDAC6 regulates Hsp90 acetylation and chaperone-dependent activation of glucocorticoid receptor. Mol Cell (2005) 6.00
SIRT1 functionally interacts with the metabolic regulator and transcriptional coactivator PGC-1{alpha}. J Biol Chem (2005) 5.93
Histone acetylation and deacetylation in yeast. Nat Rev Mol Cell Biol (2003) 5.92
Synergistic coupling of histone H3 phosphorylation and acetylation in response to epidermal growth factor stimulation. Mol Cell (2000) 5.79
Histones and histone modifications. Curr Biol (2004) 5.78
DNA repair, genome stability, and aging. Cell (2005) 5.52
Functional identification of the mouse circadian Clock gene by transgenic BAC rescue. Cell (1997) 5.51
Signaling to chromatin through histone modifications. Cell (2000) 5.36
Circadian regulator CLOCK is a histone acetyltransferase. Cell (2006) 5.24
Rhythmic CLOCK-BMAL1 binding to multiple E-box motifs drives circadian Dbp transcription and chromatin transitions. Nat Genet (2006) 5.08
SIRT1 deacetylates and positively regulates the nuclear receptor LXR. Mol Cell (2007) 5.01
Early aging and age-related pathologies in mice deficient in BMAL1, the core componentof the circadian clock. Genes Dev (2006) 4.90
Rev-erbalpha, a heme sensor that coordinates metabolic and circadian pathways. Science (2007) 4.68
Transcriptional coactivator PGC-1alpha integrates the mammalian clock and energy metabolism. Nature (2007) 4.54
A web of circadian pacemakers. Cell (2002) 4.39
Sir2p and Sas2p opposingly regulate acetylation of yeast histone H4 lysine16 and spreading of heterochromatin. Nat Genet (2002) 4.36
The biochemistry of sirtuins. Annu Rev Biochem (2006) 4.32
Regulation of E2F1 activity by acetylation. EMBO J (2000) 4.18
Phosphorylation of serine 10 in histone H3 is functionally linked in vitro and in vivo to Gcn5-mediated acetylation at lysine 14. Mol Cell (2000) 4.05
Chromosomal gradient of histone acetylation established by Sas2p and Sir2p functions as a shield against gene silencing. Nat Genet (2002) 3.91
Sirtuins: critical regulators at the crossroads between cancer and aging. Oncogene (2007) 3.85
Genetic links between diet and lifespan: shared mechanisms from yeast to humans. Nat Rev Genet (2007) 3.59
Interplay of circadian clocks and metabolic rhythms. Annu Rev Genet (2006) 3.49
Metabolism and the control of circadian rhythms. Annu Rev Biochem (2001) 3.41
Two-step cross-linking method for identification of NF-kappaB gene network by chromatin immunoprecipitation. Biotechniques (2005) 3.11
Bimodal regulation of mPeriod promoters by CREB-dependent signaling and CLOCK/BMAL1 activity. Proc Natl Acad Sci U S A (2002) 3.03
SIRT1 regulates the histone methyl-transferase SUV39H1 during heterochromatin formation. Nature (2007) 2.76
The circadian gene per1 plays an important role in cell growth and DNA damage control in human cancer cells. Mol Cell (2006) 2.71
CLOCK-mediated acetylation of BMAL1 controls circadian function. Nature (2007) 2.65
Regulation of CLOCK and MOP4 by nuclear hormone receptors in the vasculature: a humoral mechanism to reset a peripheral clock. Cell (2001) 2.59
BMAL1-dependent circadian oscillation of nuclear CLOCK: posttranslational events induced by dimerization of transcriptional activators of the mammalian clock system. Genes Dev (2003) 2.37
Circadian clock control by SUMOylation of BMAL1. Science (2005) 2.30
Coupling of human circadian and cell cycles by the timeless protein. Mol Cell Biol (2005) 2.24
A role for histone deacetylase HDAC1 in modulating the transcriptional activity of MyoD: inhibition of the myogenic program. EMBO J (2001) 2.23
PGC-1beta controls mitochondrial metabolism to modulate circadian activity, adaptive thermogenesis, and hepatic steatosis. Proc Natl Acad Sci U S A (2007) 2.19
The role of nuclear architecture in genomic instability and ageing. Nat Rev Mol Cell Biol (2007) 2.17
Light induces chromatin modification in cells of the mammalian circadian clock. Nat Neurosci (2000) 1.98
Transcriptional oscillation of canonical clock genes in mouse peripheral tissues. BMC Mol Biol (2004) 1.94
Phenotypic rescue of a peripheral clock genetic defect via SCN hierarchical dominance. Cell (2002) 1.71
Histone acetyltransferases in control. Curr Biol (1997) 1.68
Rheostat control of gene expression by metabolites. Mol Cell (2006) 1.53
Riding tandem: circadian clocks and the cell cycle. Cell (2007) 1.49
Phase resetting of the mammalian circadian clock by DNA damage. Curr Biol (2008) 1.37
Signaling to the circadian clock: plasticity by chromatin remodeling. Curr Opin Cell Biol (2007) 1.30
Emerging links between the biological clock and the DNA damage response. Chromosoma (2007) 1.12
A conserved DNA damage response pathway responsible for coupling the cell division cycle to the circadian and metabolic cycles. Cell Cycle (2007) 1.10
Chromatin remodeling and circadian control: master regulator CLOCK is an enzyme. Cold Spring Harb Symp Quant Biol (2007) 0.96
Circadian transcription: passing the HAT to CLOCK. Cell (2006) 0.95
To SIR with Polycomb: linking silencing mechanisms. Bioessays (2005) 0.84
Mammalian sirtuins--emerging roles in physiology, aging, and calorie restriction. Genes Dev (2006) 8.48
Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation. Mol Cell Biol (2007) 7.97
Circadian control of the NAD+ salvage pathway by CLOCK-SIRT1. Science (2009) 5.35
ATF4 is a substrate of RSK2 and an essential regulator of osteoblast biology; implication for Coffin-Lowry Syndrome. Cell (2004) 5.27
Circadian regulator CLOCK is a histone acetyltransferase. Cell (2006) 5.24
Calorie restriction reduces oxidative stress by SIRT3-mediated SOD2 activation. Cell Metab (2010) 4.97
Mitotic phosphorylation of histone H3: spatio-temporal regulation by mammalian Aurora kinases. Mol Cell Biol (2002) 4.50
A fasting inducible switch modulates gluconeogenesis via activator/coactivator exchange. Nature (2008) 4.43
A web of circadian pacemakers. Cell (2002) 4.39
The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth. PLoS One (2008) 4.32
Decoding the epigenetic language of neuronal plasticity. Neuron (2008) 3.23
Bimodal regulation of mPeriod promoters by CREB-dependent signaling and CLOCK/BMAL1 activity. Proc Natl Acad Sci U S A (2002) 3.03
Metabolism and cancer: the circadian clock connection. Nat Rev Cancer (2009) 2.91
The chromatoid body of male germ cells: similarity with processing bodies and presence of Dicer and microRNA pathway components. Proc Natl Acad Sci U S A (2006) 2.75
CLOCK-mediated acetylation of BMAL1 controls circadian function. Nature (2007) 2.65
Chromatin remodelling and epigenetic features of germ cells. Nature (2005) 2.49
Circadian clock control by SUMOylation of BMAL1. Science (2005) 2.30
Coordination of the transcriptome and metabolome by the circadian clock. Proc Natl Acad Sci U S A (2012) 2.22
Control of AIF-mediated cell death by the functional interplay of SIRT1 and PARP-1 in response to DNA damage. Cell Cycle (2006) 2.17
The chromatoid body: a germ-cell-specific RNA-processing centre. Nat Rev Mol Cell Biol (2007) 2.15
The histone methyltransferase MLL1 permits the oscillation of circadian gene expression. Nat Struct Mol Biol (2010) 2.00
Metabolism control by the circadian clock and vice versa. Nat Struct Mol Biol (2009) 1.99
Neuronal SIRT1 regulates endocrine and behavioral responses to calorie restriction. Genes Dev (2009) 1.97
PER2 controls lipid metabolism by direct regulation of PPARγ. Cell Metab (2010) 1.91
Preparation, isolation and characterization of stage-specific spermatogenic cells for cellular and molecular analysis. Nat Methods (2004) 1.91
RNA granules in germ cells. Cold Spring Harb Perspect Biol (2011) 1.80
Impaired function of primitive hematopoietic cells in mice lacking the Mixed-Lineage-Leukemia homolog MLL5. Blood (2008) 1.80
EGFRvIII antibody-conjugated iron oxide nanoparticles for magnetic resonance imaging-guided convection-enhanced delivery and targeted therapy of glioblastoma. Cancer Res (2010) 1.79
Connecting threads: epigenetics and metabolism. Cell (2012) 1.75
Phenotypic rescue of a peripheral clock genetic defect via SCN hierarchical dominance. Cell (2002) 1.71
Chromatin remodeling and neuronal response: multiple signaling pathways induce specific histone H3 modifications and early gene expression in hippocampal neurons. J Cell Sci (2003) 1.70
SIRT3 reverses aging-associated degeneration. Cell Rep (2013) 1.65
Selective Kv1.3 channel blocker as therapeutic for obesity and insulin resistance. Proc Natl Acad Sci U S A (2013) 1.64
The LIM-only protein FHL2 is a serum-inducible transcriptional coactivator of AP-1. Proc Natl Acad Sci U S A (2003) 1.64
Polar nuclear localization of H1T2, a histone H1 variant, required for spermatid elongation and DNA condensation during spermiogenesis. Proc Natl Acad Sci U S A (2005) 1.59
Mammalian circadian clock and metabolism - the epigenetic link. J Cell Sci (2010) 1.55
Key role of Src kinase in S100B-induced activation of the receptor for advanced glycation end products in vascular smooth muscle cells. J Biol Chem (2006) 1.52
Interplay of PIWI/Argonaute protein MIWI and kinesin KIF17b in chromatoid bodies of male germ cells. J Cell Sci (2006) 1.52
Bindarit: an anti-inflammatory small molecule that modulates the NFκB pathway. Cell Cycle (2012) 1.51
Crystal structure and interactions of the PAS repeat region of the Drosophila clock protein PERIOD. Mol Cell (2005) 1.51
Riding tandem: circadian clocks and the cell cycle. Cell (2007) 1.49
Coupling cAMP signaling to transcription in the liver: pivotal role of CREB and CREM. Exp Cell Res (2002) 1.48
Metabolism and the circadian clock converge. Physiol Rev (2013) 1.47
Regulation of BMAL1 protein stability and circadian function by GSK3beta-mediated phosphorylation. PLoS One (2010) 1.44
Plasticity and specificity of the circadian epigenome. Nat Neurosci (2010) 1.41
Distinct functions of TBP and TLF/TRF2 during spermatogenesis: requirement of TLF for heterochromatic chromocenter formation in haploid round spermatids. Development (2002) 1.37
Genome-wide profiling of the core clock protein BMAL1 targets reveals a strict relationship with metabolism. Mol Cell Biol (2010) 1.35
Regulation of steroidogenesis and the steroidogenic acute regulatory protein by a member of the cAMP response-element binding protein family. Mol Endocrinol (2002) 1.34
Chromatin remodeling, metabolism and circadian clocks: the interplay of CLOCK and SIRT1. Int J Biochem Cell Biol (2008) 1.33
Signaling mediated by the dopamine D2 receptor potentiates circadian regulation by CLOCK:BMAL1. Proc Natl Acad Sci U S A (2006) 1.32
Regulation of metabolism: the circadian clock dictates the time. Trends Endocrinol Metab (2011) 1.32
Circadian regulation of cell cycle and apoptosis proteins in mouse bone marrow and tumor. FASEB J (2004) 1.30
The intracellular localisation of TAF7L, a paralogue of transcription factor TFIID subunit TAF7, is developmentally regulated during male germ-cell differentiation. J Cell Sci (2003) 1.30
Differential functions of the Aurora-B and Aurora-C kinases in mammalian spermatogenesis. Mol Endocrinol (2006) 1.30
Signaling to the circadian clock: plasticity by chromatin remodeling. Curr Opin Cell Biol (2007) 1.30
Light induction of a vertebrate clock gene involves signaling through blue-light receptors and MAP kinases. Curr Biol (2002) 1.23
CK2alpha phosphorylates BMAL1 to regulate the mammalian clock. Nat Struct Mol Biol (2009) 1.23
Protein phosphatase PHLPP1 controls the light-induced resetting of the circadian clock. Proc Natl Acad Sci U S A (2010) 1.20
CREM-dependent transcription in male germ cells controlled by a kinesin. Science (2002) 1.20
Dietary restriction: standing up for sirtuins. Science (2010) 1.17
Testis-specific transcription mechanisms promoting male germ-cell differentiation. Reproduction (2004) 1.16
Common pathways in circadian and cell cycle clocks: light-dependent activation of Fos/AP-1 in zebrafish controls CRY-1a and WEE-1. Proc Natl Acad Sci U S A (2005) 1.16
Circadian clock and breast cancer: a molecular link. Cell Cycle (2007) 1.14
DAX-1, an unusual orphan receptor at the crossroads of steroidogenic function and sexual differentiation. Mol Endocrinol (2003) 1.14
Zebrafish CRY represses transcription mediated by CLOCK-BMAL heterodimer without inhibiting its binding to DNA. Genes Cells (2002) 1.14
Role of glucocorticoids and cAMP-mediated repression in limiting corticotropin-releasing hormone transcription during stress. J Neurosci (2005) 1.14
CircadiOmics: integrating circadian genomics, transcriptomics, proteomics and metabolomics. Nat Methods (2012) 1.14
Poly(ADP-ribose) polymerase-2 contributes to the fidelity of male meiosis I and spermiogenesis. Proc Natl Acad Sci U S A (2006) 1.13
A direct role of SRY and SOX proteins in pre-mRNA splicing. Proc Natl Acad Sci U S A (2002) 1.12
No circadian rhythms in testis: Period1 expression is clock independent and developmentally regulated in the mouse. Mol Endocrinol (2003) 1.12
Cell-specific occupancy of an extended repertoire of CREM and CREB binding loci in male germ cells. BMC Genomics (2010) 1.12
Circadian control by the reduction/oxidation pathway: catalase represses light-dependent clock gene expression in the zebrafish. Proc Natl Acad Sci U S A (2007) 1.11
Structural and functional features of transcription factors controlling the circadian clock. Curr Opin Genet Dev (2005) 1.11
Mouse Period1 (mPER1) acts as a circadian adaptor to entrain the oscillator to environmental light/dark cycles by regulating mPER2 protein. J Neurosci (2005) 1.11
Circadian acetylome reveals regulation of mitochondrial metabolic pathways. Proc Natl Acad Sci U S A (2013) 1.11
The sirtuins, oxidative stress and aging: an emerging link. Aging (Albany NY) (2013) 1.08
The circadian clock: a framework linking metabolism, epigenetics and neuronal function. Nat Rev Neurosci (2012) 1.08
Proinflammatory stimuli control N-acylphosphatidylethanolamine-specific phospholipase D expression in macrophages. Mol Pharmacol (2011) 1.07
Circadian clock regulates the host response to Salmonella. Proc Natl Acad Sci U S A (2013) 1.07
A small C-terminal sequence of Aurora B is responsible for localization and function. Mol Biol Cell (2004) 1.07
Inhibition of Aurora-B kinase activity by poly(ADP-ribosyl)ation in response to DNA damage. Proc Natl Acad Sci U S A (2005) 1.05
The nuclear import of TAF10 is regulated by one of its three histone fold domain-containing interaction partners. Mol Cell Biol (2005) 1.04