Endogenous nitric oxide inhibits human platelet adhesion to vascular endothelium.

PubWeight™: 4.55‹?› | Rank: Top 1%

🔗 View Article (PMID 2889967)

Published in Lancet on November 07, 1987

Authors

M W Radomski1, R M Palmer, S Moncada

Author Affiliations

1: Wellcome Research Laboratories, Langley Court, Beckenham, Kent.

Articles citing this

(truncated to the top 100)

Nitric oxide: an endogenous modulator of leukocyte adhesion. Proc Natl Acad Sci U S A (1991) 8.04

Stimulation of the nitric oxide synthase pathway in human hepatocytes by cytokines and endotoxin. J Exp Med (1992) 3.42

Inducible isoforms of cyclooxygenase and nitric-oxide synthase in inflammation. Proc Natl Acad Sci U S A (1994) 3.20

Release of endothelin from the porcine aorta. Inhibition by endothelium-derived nitric oxide. J Clin Invest (1990) 2.61

Pathogenesis of myocardial ischemia-reperfusion injury and rationale for therapy. Am J Cardiol (2010) 2.52

Inhibition and stimulation of nitric oxide synthesis in the human forearm arterial bed of patients with insulin-dependent diabetes. J Clin Invest (1992) 2.26

Human neutrophils and mononuclear cells inhibit platelet aggregation by releasing a nitric oxide-like factor. Proc Natl Acad Sci U S A (1989) 2.08

Role of nitric oxide in maintaining vascular integrity in endotoxin-induced acute intestinal damage in the rat. Br J Pharmacol (1990) 1.94

Antiplatelet effects of dietary nitrate in healthy volunteers: involvement of cGMP and influence of sex. Free Radic Biol Med (2013) 1.78

Platelet receptors and signaling in the dynamics of thrombus formation. Haematologica (2009) 1.65

Resuscitating the microcirculation in sepsis: the central role of nitric oxide, emerging concepts for novel therapies, and challenges for clinical trials. Acad Emerg Med (2008) 1.61

Immediate release of a nitric oxide-like factor from bovine aortic endothelial cells by Escherichia coli lipopolysaccharide. Proc Natl Acad Sci U S A (1990) 1.54

Nitric oxide in inflammatory bowel disease: a universal messenger in an unsolved puzzle. Immunology (2004) 1.54

In vivo transfer of nitric oxide between a plasma protein-bound reservoir and low molecular weight thiols. J Clin Invest (1994) 1.53

Regulation of platelet granule exocytosis by S-nitrosylation. Proc Natl Acad Sci U S A (2005) 1.52

Endothelium-derived relaxing factor reduces platelet adhesion to bovine endothelial cells. Proc Natl Acad Sci U S A (1988) 1.51

Nitric oxide and nanotechnology: a novel approach to inhibit neointimal hyperplasia. J Vasc Surg (2008) 1.47

Endothelial cytosolic proteins bind to the 3' untranslated region of endothelial nitric oxide synthase mRNA: regulation by tumor necrosis factor alpha. Mol Cell Biol (1997) 1.44

Basal release of nitric oxide from aortic rings is greater in female rabbits than in male rabbits: implications for atherosclerosis. Proc Natl Acad Sci U S A (1992) 1.39

Mechanisms of vein graft adaptation to the arterial circulation: insights into the neointimal algorithm and management strategies. Circ J (2010) 1.39

Cardiopulmonary complications of sickle cell disease: role of nitric oxide and hemolytic anemia. Hematology Am Soc Hematol Educ Program (2005) 1.36

Endothelium-dependent vascular responses. Mediators and mechanisms. J Clin Invest (1989) 1.36

Hypercoagulability and thrombotic complications in hemolytic anemias. Haematologica (2009) 1.36

Effect of nitric oxide on circular muscle of the canine small intestine. J Physiol (1991) 1.34

Beneficial effect of a short-acting NO donor for the prevention of neointimal hyperplasia. Free Radic Biol Med (2007) 1.30

Beyond lipid-lowering: effects of statins on endothelial nitric oxide. Eur J Clin Pharmacol (2003) 1.30

The role of nitric oxide as an endogenous regulator of platelet and neutrophil activation within the pulmonary circulation of the rabbit. Br J Pharmacol (1991) 1.28

Antiinflammatory activity of soluble guanylate cyclase: cGMP-dependent down-regulation of P-selectin expression and leukocyte recruitment. Proc Natl Acad Sci U S A (2004) 1.26

Vascular effects of dietary nitrate (as found in green leafy vegetables and beetroot) via the nitrate-nitrite-nitric oxide pathway. Br J Clin Pharmacol (2013) 1.26

Increased adhesion and aggregation of platelets lacking cyclic guanosine 3',5'-monophosphate kinase I. J Exp Med (1999) 1.24

Anti-adhesive effect of nitric oxide on Plasmodium falciparum cytoadherence under flow. Am J Pathol (2003) 1.23

Uric acid and insulin sensitivity and risk of incident hypertension. Arch Intern Med (2009) 1.21

Vascular aging: chronic oxidative stress and impairment of redox signaling-consequences for vascular homeostasis and disease. Ann Med (2012) 1.18

NG-methyl-L-arginine causes endothelium-dependent contraction and inhibition of cyclic GMP formation in artery and vein. Proc Natl Acad Sci U S A (1990) 1.17

Superoxide anions enhance platelet adhesion and aggregation. Br J Pharmacol (1989) 1.14

Heightened efficacy of nitric oxide-based therapies in type II diabetes mellitus and metabolic syndrome. Am J Physiol Heart Circ Physiol (2008) 1.13

Inducible nitric oxide synthase: a little bit of good in all of us. Gut (2000) 1.12

Arginase activity mediates retinal inflammation in endotoxin-induced uveitis. Am J Pathol (2009) 1.12

Glutathione peroxidase potentiates the inhibition of platelet function by S-nitrosothiols. J Clin Invest (1995) 1.11

The use of oxyhaemoglobin to explore the events underlying inhibition of platelet aggregation induced by NO or NO-donors. Br J Pharmacol (1990) 1.11

Nitric oxide-loaded echogenic liposomes for nitric oxide delivery and inhibition of intimal hyperplasia. J Am Coll Cardiol (2009) 1.10

Effect of NG-monomethyl-L-arginine on kinin-induced vasodilation in the human forearm. Br J Clin Pharmacol (1994) 1.10

Cardiac preservation is enhanced in a heterotopic rat transplant model by supplementing the nitric oxide pathway. J Clin Invest (1994) 1.10

Nitric oxide. Novel biology with clinical relevance. Ann Surg (1995) 1.09

The vasodilator action of nebivolol in forearm vasculature of subjects with essential hypertension. Br J Clin Pharmacol (1999) 1.08

Chronic nitric oxide inhibition in utero produces persistent pulmonary hypertension in newborn lambs. J Clin Invest (1994) 1.08

Historical perspective and future directions in platelet research. J Thromb Haemost (2011) 1.06

The nitric oxide-endothelin-1 connection. Heart Fail Rev (2003) 1.06

Nitric oxide regulation of protein trafficking in the cardiovascular system. Cardiovasc Res (2007) 1.04

Regulation of cell physiology and pathology by protein S-glutathionylation: lessons learned from the cardiovascular system. Antioxid Redox Signal (2012) 1.03

Peroxynitrite in myocardial ischemia-reperfusion injury. Heart Fail Rev (2002) 1.01

Effect of blood nitrite and nitrate levels on murine platelet function. PLoS One (2013) 1.00

Direct, real-time measurement of shear stress-induced nitric oxide produced from endothelial cells in vitro. Nitric Oxide (2010) 1.00

The nitric oxide/cyclic GMP pathway in organ transplantation: critical role in successful lung preservation. Proc Natl Acad Sci U S A (1994) 0.99

Increased superoxide and endothelial NO synthase uncoupling in blood vessels of Bmal1-knockout mice. Circ Res (2012) 0.99

Endothelial effects of antihypertensive treatment: focus on irbesartan. Vasc Health Risk Manag (2008) 0.99

Nitric oxide. Ann Rheum Dis (1996) 0.99

Modulation by nitric oxide of platelet-activating factor-induced albumin extravasation in the conscious rat. Br J Pharmacol (1993) 0.98

Decreased nitric oxide in the exhaled air of patients with systemic sclerosis with pulmonary hypertension. Thorax (1997) 0.98

Dysregulation of L-arginine metabolism and bioavailability associated to free plasma heme. Am J Physiol Cell Physiol (2010) 0.97

Verotoxin and ricin have novel effects on preproendothelin-1 expression but fail to modify nitric oxide synthase (ecNOS) expression and NO production in vascular endothelium. J Clin Invest (1998) 0.97

Plasma ADMA predicts restenosis of arteriovenous fistula. J Am Soc Nephrol (2008) 0.97

S-nitrosothiols cause prolonged, nitric oxide-mediated relaxation in human saphenous vein and internal mammary artery: therapeutic potential in bypass surgery. Br J Pharmacol (2000) 0.97

The glu298asp polymorphism in the nitric oxide synthase 3 gene is associated with the risk of ischemic stroke in two large independent case-control studies. Hum Genet (2006) 0.96

Genes and abdominal aortic aneurysm. Ann Vasc Surg (2010) 0.95

Indolent course of tubulointerstitial disease in a mouse model of subpressor, low-dose nitric oxide synthase inhibition. Am J Physiol Renal Physiol (2008) 0.95

Insulin enhances the effect of nitric oxide at inhibiting neointimal hyperplasia in a rat model of type 1 diabetes. Am J Physiol Heart Circ Physiol (2010) 0.95

Endothelin-1 inhibits platelet aggregation in vivo: a study with 111indium-labelled platelets. Br J Pharmacol (1990) 0.94

Arginase: an old enzyme with new tricks. Trends Pharmacol Sci (2015) 0.94

Nitric oxide and redox regulation in the liver: part II. Redox biology in pathologic hepatocytes and implications for intervention. J Surg Res (2009) 0.94

Endothelial nitric oxide synthase gene polymorphisms in non-arteritic anterior ischemic optic neuropathy. Graefes Arch Clin Exp Ophthalmol (2007) 0.93

Gender dimorphisms in progenitor and stem cell function in cardiovascular disease. J Cardiovasc Transl Res (2010) 0.92

Endothelial nitric oxide in humans in health and disease. Int J Exp Pathol (1999) 0.92

Liposomal modular complexes for simultaneous targeted delivery of bioactive gases and therapeutics. J Control Release (2009) 0.92

Inhibition of the release of endothelium-derived relaxing factor in vitro and in vivo by dipeptides containing NG-nitro-L-arginine. Br J Pharmacol (1991) 0.90

Interactions of constitutive nitric oxide with PAF and thromboxane on rat intestinal vascular integrity in acute endotoxaemia. Br J Pharmacol (1994) 0.90

Pharmacological characteristics of solid-phase von Willebrand factor in human platelets. Br J Pharmacol (2001) 0.90

Arginase as a mediator of diabetic retinopathy. Front Immunol (2013) 0.90

N-Substituted analogues of S-nitroso-N-acetyl-D,L-penicillamine: chemical stability and prolonged nitric oxide mediated vasodilatation in isolated rat femoral arteries. Br J Pharmacol (1999) 0.89

Inducible and endothelial nitric oxide synthase expression during development of transplant arteriosclerosis in rat aortic grafts. Am J Pathol (1996) 0.89

Histone deacetylase 3 antagonizes aspirin-stimulated endothelial nitric oxide production by reversing aspirin-induced lysine acetylation of endothelial nitric oxide synthase. Circ Res (2010) 0.89

Vascular responses to endothelin-1 following inhibition of nitric oxide synthesis in the conscious rat. Br J Pharmacol (1993) 0.88

beta-Actin regulates platelet nitric oxide synthase 3 activity through interaction with heat shock protein 90. Proc Natl Acad Sci U S A (2007) 0.88

Nitric oxide, platelet function, myocardial infarction and reperfusion therapies. Heart Fail Rev (2003) 0.88

Association between arterial stiffness and variations in oestrogen-related genes. J Hum Hypertens (2009) 0.88

Platelet aggregation responses are critically regulated in vivo by endogenous nitric oxide but not by endothelial nitric oxide synthase. Br J Pharmacol (2009) 0.88

Circulating levels of dimethylarginines, chronic kidney disease and long-term clinical outcome in non-ST-elevation myocardial infarction. PLoS One (2012) 0.88

Insights into the arginine paradox: evidence against the importance of subcellular location of arginase and eNOS. Am J Physiol Heart Circ Physiol (2013) 0.88

Therapeutic Potential of the Nitrite-Generated NO Pathway in Vascular Dysfunction. Front Immunol (2013) 0.88

Pharmacology of endothelium-derived nitric oxide and nitrovasodilators. West J Med (1991) 0.88

Hemolysis-associated hypercoagulability in sickle cell disease: the plot (and blood) thickens! Haematologica (2008) 0.87

Balancing role of nitric oxide in complement-mediated activation of platelets from mCd59a and mCd59b double-knockout mice. Am J Hematol (2009) 0.87

Endothelial NO synthase gene polymorphisms and risk of ischemic stroke in Asian population: a meta-analysis. PLoS One (2013) 0.87

On the protective mechanisms of nitric oxide in acute pancreatitis. Gut (1998) 0.87

The role of platelets in the recruitment of leukocytes during vascular disease. Platelets (2015) 0.87

A potential role for extracellular nitric oxide generation in cGMP-independent inhibition of human platelet aggregation: biochemical and pharmacological considerations. Br J Pharmacol (2005) 0.87

Physiological importance of nitric oxide. BMJ (1991) 0.86

Increased superoxide generation and decreased stress protein Hsp90 expression in human umbilical cord vein endothelial cells (HUVECs) from pregnancies complicated by preeclampsia. Hypertens Pregnancy (2006) 0.86

S-nitrosoglutathione inhibits platelet activation and deposition in coronary artery saphenous vein grafts in vitro and in vivo. Heart (1998) 0.86

The anti-inflammatory and analgesic action of transdermal glyceryltrinitrate in the treatment of infusion-related thrombophlebitis. Postgrad Med J (1993) 0.86

Articles by these authors

Nitric oxide: physiology, pathophysiology, and pharmacology. Pharmacol Rev (1991) 42.38

Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. Nature (1987) 35.44

Vascular endothelial cells synthesize nitric oxide from L-arginine. Nature (1988) 18.41

An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation. Nature (1976) 13.19

Superoxide anion is involved in the breakdown of endothelium-derived vascular relaxing factor. Nature (1986) 9.93

Characterization of three inhibitors of endothelial nitric oxide synthase in vitro and in vivo. Br J Pharmacol (1990) 8.85

Role of endothelium-derived nitric oxide in the regulation of blood pressure. Proc Natl Acad Sci U S A (1989) 8.34

Formation of nitric oxide from L-arginine in the central nervous system: a transduction mechanism for stimulation of the soluble guanylate cyclase. Proc Natl Acad Sci U S A (1989) 7.79

L-arginine is the physiological precursor for the formation of nitric oxide in endothelium-dependent relaxation. Biochem Biophys Res Commun (1988) 7.77

Effects of endothelium-derived nitric oxide on peripheral arteriolar tone in man. Lancet (1989) 7.69

Biosynthesis of nitric oxide from L-arginine. A pathway for the regulation of cell function and communication. Biochem Pharmacol (1989) 6.87

Nitric oxide synthases in mammals. Biochem J (1994) 6.50

A specific inhibitor of nitric oxide formation from L-arginine attenuates endothelium-dependent relaxation. Br J Pharmacol (1989) 6.30

Altered immune responses in mice lacking inducible nitric oxide synthase. Nature (1995) 6.20

Development and validation of a prognostic index for 1-year mortality in older adults after hospitalization. JAMA (2001) 6.02

Macrophage killing of Leishmania parasite in vivo is mediated by nitric oxide from L-arginine. J Immunol (1990) 5.87

Indomethacin and aspirin abolish prostaglandin release from the spleen. Nat New Biol (1971) 5.62

Accumulation of an endogenous inhibitor of nitric oxide synthesis in chronic renal failure. Lancet (1992) 5.36

Comparative pharmacology of endothelium-derived relaxing factor, nitric oxide and prostacyclin in platelets. Br J Pharmacol (1987) 5.23

A novel citrulline-forming enzyme implicated in the formation of nitric oxide by vascular endothelial cells. Biochem Biophys Res Commun (1989) 5.14

The anti-aggregating properties of vascular endothelium: interactions between prostacyclin and nitric oxide. Br J Pharmacol (1987) 4.88

Pharmacology and endogenous roles of prostaglandin endoperoxides, thromboxane A2, and prostacyclin. Pharmacol Rev (1978) 4.66

Arterial walls generate from prostaglandin endoperoxides a substance (prostaglandin X) which relaxes strips of mesenteric and coeliac ateries and inhibits platelet aggregation. Prostaglandins (1976) 4.54

Glucocorticoids inhibit the expression of an inducible, but not the constitutive, nitric oxide synthase in vascular endothelial cells. Proc Natl Acad Sci U S A (1990) 4.49

Arterial walls are protected against deposition of platelet thrombi by a substance (prostaglandin X) which they make from prostaglandin endoperoxides. Prostaglandins (1976) 4.44

Bioassay of prostacyclin and endothelium-derived relaxing factor (EDRF) from porcine aortic endothelial cells. Br J Pharmacol (1986) 4.23

Reversible inhibition of cytochrome c oxidase, the terminal enzyme of the mitochondrial respiratory chain, by nitric oxide. Implications for neurodegenerative diseases. FEBS Lett (1994) 4.19

Endothelium-derived relaxing factor. Identification as nitric oxide and role in the control of vascular tone and platelet function. Biochem Pharmacol (1988) 4.16

Human arterial and venous tissues generate prostacyclin (prostaglandin x), a potent inhibitor of platelet aggregation. Lancet (1977) 4.11

An L-arginine/nitric oxide pathway present in human platelets regulates aggregation. Proc Natl Acad Sci U S A (1990) 3.98

A randomized trial of care in a hospital medical unit especially designed to improve the functional outcomes of acutely ill older patients. N Engl J Med (1995) 3.77

Relation between symptoms of depression and health status outcomes in acutely ill hospitalized older persons. Ann Intern Med (1997) 3.76

Effects of prostacyclin (PGX) on cyclic AMP concentrations in human platelets. Prostaglandins (1977) 3.74

Eicosapentaenoic acid and prevention of thrombosis and atherosclerosis? Lancet (1978) 3.74

Synthesis of nitric oxide from L-arginine by neutrophils. Release and interaction with superoxide anion. Biochem J (1989) 3.70

The chemical structure of prostaglandin X (prostacyclin). Prostaglandins (1976) 3.63

Widespread tissue distribution, species distribution and changes in activity of Ca(2+)-dependent and Ca(2+)-independent nitric oxide synthases. FEBS Lett (1991) 3.43

Arachidonic acid metabolites and the interactions between platelets and blood-vessel walls. N Engl J Med (1979) 3.29

Roles of nitric oxide in tumor growth. Proc Natl Acad Sci U S A (1995) 3.28

Differential formation of prostacyclin (PGX or PGI2) by layers of the arterial wall. An explanation for the anti-thrombotic properties of vascular endothelium. Thromb Res (1977) 3.28

The role of nitric oxide and cGMP in platelet adhesion to vascular endothelium. Biochem Biophys Res Commun (1987) 3.25

Development and mechanism of a specific supersensitivity to nitrovasodilators after inhibition of vascular nitric oxide synthesis in vivo. Proc Natl Acad Sci U S A (1991) 3.22

Does delirium contribute to poor hospital outcomes? A three-site epidemiologic study. J Gen Intern Med (1998) 3.21

Prostaglandins, aspirin-like drugs and the oedema of inflammation. Nature (1973) 3.20

Protective and pathological roles of nitric oxide in endotoxin shock. Cardiovasc Res (1992) 3.15

Dexamethasone prevents the induction by endotoxin of a nitric oxide synthase and the associated effects on vascular tone: an insight into endotoxin shock. Biochem Biophys Res Commun (1990) 3.14

Persistent inhibition of cell respiration by nitric oxide: crucial role of S-nitrosylation of mitochondrial complex I and protective action of glutathione. Proc Natl Acad Sci U S A (1998) 3.10

An improved method for washing of human platelets with prostacyclin. Thromb Res (1983) 3.07

Control of regional blood flow by endothelium-derived nitric oxide. Hypertension (1990) 2.93

Functional status before hospitalization in acutely ill older adults: validity and clinical importance of retrospective reports. J Am Geriatr Soc (2000) 2.92

Identification of an enzyme in platelet microsomes which generates thromboxane A2 from prostaglandin endoperoxides. Nature (1976) 2.83

Endogenous nitric oxide is present in the exhaled air of rabbits, guinea pigs and humans. Biochem Biophys Res Commun (1991) 2.79

Nitric oxide from L-arginine stimulates the soluble guanylate cyclase in adrenal glands. Biochem Biophys Res Commun (1989) 2.73

Nitric oxide synthase activities in human myocardium. Lancet (1993) 2.72

Induction of calcium-dependent nitric oxide synthases by sex hormones. Proc Natl Acad Sci U S A (1994) 2.70

Nitric oxide synthesized from L-arginine regulates vascular tone in the coronary circulation of the rabbit. Br J Pharmacol (1989) 2.68

Prostacyclin (PGX) is the endogenous metabolite responsible for relaxation of coronary arteries induced by arachindonic acid. Prostaglandins (1977) 2.67

Increased concentrations of nitrite in synovial fluid and serum samples suggest increased nitric oxide synthesis in rheumatic diseases. Ann Rheum Dis (1992) 2.63

Chemokinetic activity of arachidonic and lipoxygenase products on leuocyctes of different species. Prostaglandins (1980) 2.59

Rapid development of atherosclerotic lesions in the rabbit carotid artery induced by perivascular manipulation. Atherosclerosis (1989) 2.58

NMDA receptor activation induces nitric oxide synthesis from arginine in rat brain slices. Eur J Pharmacol (1989) 2.53

Arrest of preterm labour and prolongation of gestation with glyceryl trinitrate, a nitric oxide donor. Lancet (1994) 2.53

Unstable metabolites of arachidonic acid and their role in haemostasis and thrombosis. Br Med Bull (1978) 2.51

Production of hydroxyl radicals from the simultaneous generation of superoxide and nitric oxide. Biochem J (1992) 2.51

Imidazole: a selective inhibitor of thromboxane synthetase. Prostaglandins (1977) 2.48

Inhibition of nitric oxide synthesis in septic shock: how much is beneficial? Lancet (1992) 2.44

Measuring prognosis and case mix in hospitalized elders. The importance of functional status. J Gen Intern Med (1997) 2.42

S-nitroso-glutathione inhibits platelet activation in vitro and in vivo. Br J Pharmacol (1992) 2.39

The role of TH1 and TH2 cells in a rodent malaria infection. Science (1993) 2.38

Modulation of acute inflammation by endogenous nitric oxide. Eur J Pharmacol (1992) 2.32

Acetylcholine induces vasodilatation in the rabbit isolated heart through the release of nitric oxide, the endogenous nitrovasodilator. Br J Pharmacol (1988) 2.32

Glucocorticoids inhibit the induction of nitric oxide synthase in macrophages. Biochem Biophys Res Commun (1990) 2.31

Anti-inflammatory glucocorticoids inhibit the induction by endotoxin of nitric oxide synthase in the lung, liver and aorta of the rat. Biochem Biophys Res Commun (1990) 2.31

A lipid peroxide inhibits the enzyme in blood vessel microsomes that generates from prostaglandin endoperoxides the substance (prostaglandin X) which prevents platelet aggregation. Prostaglandins (1976) 2.28

Nitric oxide synthase activity in human gynecological cancer. Cancer Res (1994) 2.27

Inhibition of nitric oxide synthase as a potential therapeutic target. Annu Rev Pharmacol Toxicol (1999) 2.26

Selective inhibition of prostaglandin production in inflammatory exudates and gastric mucosa. Nature (1980) 2.24

Nitric oxide synthase activity in human breast cancer. Br J Cancer (1995) 2.22