Published in Nat New Biol on June 23, 1971
A chemotactic role for prostaglandins released from polymorphonuclear leucocytes during phagocytosis. Br J Pharmacol (1975) 2.79
The release of prostaglandins and rabbit aorta contracting substance (RCS) from rabbit spleen and its antagonism by anti-inflammatory drugs. Br J Pharmacol (1972) 2.52
Prostaglandins, oxygen tension and smooth muscle tone. Br J Pharmacol (1972) 2.51
Release of rabbit aorta contracting substance (RCS) and prostaglandins induced by chemical or mechanical stimulation of guinea-pig lungs. Br J Pharmacol (1973) 2.42
Eleventh Gaddum memorial lecture. Lipocortin and the mechanism of action of the glucocorticoids. Br J Pharmacol (1988) 2.38
The contribution of prostaglandin production to contractions of the isolated uterus of the rat. Br J Pharmacol (1973) 2.33
Radioimmunoassay measurement of prostaglandins E, A, and F in human plasma. J Clin Invest (1973) 2.09
Prostaglandins and the mechanism of analgesia produced by aspirin-like drugs. Br J Pharmacol (1973) 2.07
Acute inflammation. A review. Am J Pathol (1977) 2.06
Effects of prostaglandins and cholera enterotoxin on intestinal mucosal cyclic AMP accumulation. Evidence against an essential role for prostaglandins in the action of toxin. J Clin Invest (1974) 1.89
Proceedings: Prostaglandin generation maintains the smooth muscle tone of the rabbit isolated jejunum. Br J Pharmacol (1972) 1.80
Pharmacokinetics of aspirin and salicylate in relation to inhibition of arachidonate cyclooxygenase and antiinflammatory activity. Proc Natl Acad Sci U S A (1987) 1.80
Inhibition of soluble epoxide hydrolase reduces LPS-induced thermal hyperalgesia and mechanical allodynia in a rat model of inflammatory pain. Life Sci (2006) 1.71
Antigen stimulation of prostaglandin synthesis and control of immune responses. Proc Natl Acad Sci U S A (1976) 1.67
Regulation of B-lymphocyte clonal proliferation by stimulatory and inhibitory macrophage-derived factors. J Exp Med (1977) 1.67
The effect of indomethacin on the cardiovascular and metabolic responses to E. coli endotoxin in the cat. Br J Pharmacol (1974) 1.63
Role of prostaglandin E in the biphasic fever response to endotoxin. J Exp Med (1981) 1.58
Initiation of cell proliferation in cultured mouse fibroblasts by prostaglandin F2alpha. Proc Natl Acad Sci U S A (1975) 1.52
The role of cyclooxygenase-2 in cell proliferation and cell death in human malignancies. Int J Cell Biol (2010) 1.51
Some effects of inhibiting endogenous prostaglandin formation on the responses of the cat spleen. Br J Pharmacol (1973) 1.47
Aspirin-like drugs interfere with arachidonate metabolism by inhibition of the 12-hydroperoxy-5,8,10,14-eicosatetraenoic acid peroxidase activity of the lipoxygenase pathway. Proc Natl Acad Sci U S A (1979) 1.43
Prostaglandin production by macrophages and the effect of anti-inflammatory drugs. Br J Pharmacol (1978) 1.40
Endothelium-independent relaxation of rabbit coronary artery by 17 beta-oestradiol in vitro. Br J Pharmacol (1991) 1.35
Inhibition by glucocorticoids of prostaglandin release from adipose tissue in vitro. Br J Pharmacol (1977) 1.35
Regulated formation of eicosanoids. J Clin Invest (2001) 1.33
Pharmacological analysis of the acute inflammatory process induced in the rat's paw by local injection of carrageenin and by heating. Br J Pharmacol (1973) 1.32
Prostaglandins, bioassay and inflammation. Br J Pharmacol (2006) 1.24
Modification, by aspirin and indomethacin, of the haemodynamic and prostaglandin releasing effects of E. coli endotoxin in the dog. Br J Pharmacol (1977) 1.23
Sensitivity of fatty acid cyclooxygenase from human aorta to acetylation by aspirin. Proc Natl Acad Sci U S A (1978) 1.17
Further experiments to establish that the analgesic action of aspirin-like drugs depends on the inhibition of prostaglandin biosynthesis. Br J Pharmacol (1973) 1.16
Kinetics of prostaglandin production in various inflammatory lesions, measured in draining lymph. Am J Pathol (1979) 1.15
The synovial prostaglandin system in chronic inflammatory arthritis: differential effects of steroidal and nonsteroidal anti-inflammatory drugs. Br J Pharmacol (1981) 1.15
The mechanisms of action of NSAIDs in analgesia. Drugs (1996) 1.14
Future innovations in anti-platelet therapies. Br J Pharmacol (2008) 1.13
Proceedings: Potentiation by prostaglandins of the nociceptive activity of bradykinin in the dog knee joint. Br J Pharmacol (1974) 1.12
Output of prostaglandins from the rabbit kidney, its increase on renal nerve stimulation and its inhibition by indomethacin. Br J Pharmacol (1972) 1.11
Adventures in vascular biology: a tale of two mediators. Philos Trans R Soc Lond B Biol Sci (2006) 1.10
Bradykinin and functional vasodilatation in the salivary gland. Br J Pharmacol (1976) 1.10
Prostaglandins, nonsteroidal anti-inflammatory agents and eye disease. Trans Am Ophthalmol Soc (1976) 1.09
Historical perspective and future directions in platelet research. J Thromb Haemost (2011) 1.06
Inhibition of the prostaglandin synthetase systems in ocular tissues by indomethacin. Br J Pharmacol (1974) 1.06
Effect of inhibitors of nitric oxide release and action on vascular tone in isolated lungs of pig, sheep, dog and man. J Physiol (1994) 1.05
Prostaglandin production in arthritis. Ann Rheum Dis (1978) 1.04
Effect of prostaglandin 15(R) 15 methyl-E2 methyl ester on aspirin and taurocholic acid-induced gastric mucosal haemorrhage in rats. Gut (1976) 1.04
Dysfunctions of pokeweed mitogen-stimulated T and B lymphocyte responses induced by gammaglobulin therapy. J Clin Invest (1981) 1.04
Prostaglandin antagonism by sodium p-benzyl-4-[1-oxo-2-(4-chlorobenzyl)-3-phenylpropyl]pheenyl phosphonate (N-0164). Br J Pharmacol (1976) 1.02
Arachidonate metabolism via lipoxygenase and 12L-hydroperoxy-5,8,10,14-icosatetraenoic acid peroxidase sensitive to anti-inflammatory drugs. Proc Natl Acad Sci U S A (1980) 1.02
Antiplatelet drugs. Br J Pharmacol (2006) 0.98
Peripheral analgesia: mechanism of the analgesic action of aspirin-like drugs and opiate-antagonists. Br J Clin Pharmacol (1980) 0.98
Endogenous prostaglandins, adenosine 3':5'-monophosphate and sodium transport across isolated frog skin. J Physiol (1976) 0.98
Comparison between lidocaine and bupivacaine as local anesthetics with diflunisal for postoperative pain control after lower third molar surgery. Anesth Prog (1988) 0.98
Profile of circulating vasoactive substances in hemorrhagic shock and their pharmacologic manipulation. J Clin Invest (1974) 0.98
Inhibition of peristalsis in guinea-pig isolated ileum and colon by drugs that block prostaglandin synthesis. Br J Pharmacol (1976) 0.97
From plant extract to molecular panacea: a commentary on Stone (1763) 'An account of the success of the bark of the willow in the cure of the agues'. Philos Trans R Soc Lond B Biol Sci (2015) 0.94
Aspirin and other anti-inflammatory drugs. Thorax (2000) 0.93
Opposite nociceptive effects of the arginine/NO/cGMP pathway stimulation in dermal and subcutaneous tissues. Br J Pharmacol (2003) 0.93
Proceedings: the concomitant release of bradykinin and prostaglandin in the inflammatory response to carrageenin. Br J Pharmacol (1974) 0.93
Actions of putative transmitters in the chicken vagus nerve/oesophagus and Remak nerve/rectum preparations. Br J Pharmacol (1974) 0.92
Long-acting analgesic or long-acting local anesthetic in controlling immediate postoperative pain after lower third molar surgery. Anesth Prog (1987) 0.92
Response of the human cardia sphincter to circulating prostaglandins F2ALPHA and E2 and to antiinflammatory drugs. Gut (1975) 0.92
Proceedings: Reduction of shortening heat during a series of tetanic contractions in frog sartorius muscle. J Physiol (1974) 0.91
Inhibition of steroid production in Leydig cells by non-steroidal anti-inflammatory and related compounds: evidence for the involvement of lipoxygenase products in steroidogenesis. Biochem J (1984) 0.90
Release of prostaglandin-like substances by Shigella endotoxin and its inhibition by non-steroidal anti-inflammatory compounds. Br J Pharmacol (1975) 0.90
Differential effect of aspirin on thromboxane and prostaglandin biosynthesis in man. Br J Clin Pharmacol (1989) 0.89
Inhibition of functional vasodilatation and prostaglandin formation in rabbit adipose tissue by indomethacin and aspirin. Br J Pharmacol (1973) 0.88
Prostaglandin release from cat and dog spleen. Br J Pharmacol (1975) 0.87
Antigen-stimulated changes in cyclic nucleotide levels in the mouse. Proc Natl Acad Sci U S A (1975) 0.86
4-trifluoromethyl derivatives of salicylate, triflusal and its main metabolite 2-hydroxy-4-trifluoromethylbenzoic acid, are potent inhibitors of nuclear factor kappaB activation. Br J Pharmacol (1999) 0.86
Nitric oxide 9 years on. J R Soc Med (1996) 0.85
Formation of a factor increasing vascular permeability during electrical stimulation of the saphenous nerve in rats. Br J Pharmacol (1974) 0.84
In vitro prostanoid release from spinal cord following peripheral inflammation: effects of substance P, NMDA and capsaicin. Br J Pharmacol (1999) 0.84
The prostanoids in hemostasis and thrombosis: a review. Am J Pathol (1980) 0.83
Role of LKB1-CRTC1 on glycosylated COX-2 and response to COX-2 inhibition in lung cancer. J Natl Cancer Inst (2014) 0.83
Induction of differentiation of human leukemia cells by combinations of COX inhibitors and 1,25-dihydroxyvitamin D3 involves Raf1 but not Erk 1/2 signaling. Cell Cycle (2008) 0.83
Aspirin: pharmacology and clinical applications. Thrombosis (2011) 0.83
Regulation of cyclic AMP formation in brain tissue by alpha-adrenergic receptors: requisite intermediacy of prostaglandins of the E series. Proc Natl Acad Sci U S A (1980) 0.82
Synthesis and evaluation of carbaborane derivatives of indomethacin as cyclooxygenase inhibitors. Bioorg Med Chem (2011) 0.82
Action at a distance: mutations of peripheral residues transform rapid reversible inhibitors to slow, tight binders of cyclooxygenase-2. J Biol Chem (2015) 0.82
Recovery of prostacyclin synthesis by rabbit aortic endothelium and other tissues after inhibition by aspirin. Br J Pharmacol (1987) 0.82
Endothelin induces an increase in renal vascular resistance and a fall in glomerular filtration rate in the rabbit isolated perfused kidney. Br J Pharmacol (1989) 0.81
The effects of indomethacin and prostaglandins E2 and F2 alpha on canine tracheal mucus generation. Agents Actions (1982) 0.81
Ortho-carbaborane derivatives of indomethacin as cyclooxygenase (COX)-2 selective inhibitors. Bioorg Med Chem (2012) 0.81
Effects of aspirin-like drugs on canine gastric mucosal blood flow and acid secretion. Br J Pharmacol (1977) 0.81
The scientific basis for analgesic use in dentistry. Anesth Prog (1986) 0.81
A vasodilator innervation to the central artery of the rabbit ear. Br J Pharmacol (1974) 0.81
Modulation of inflammatory response by selective inhibition of cyclooxygenase-1 and cyclooxygenase-2 in acute kidney injury. Inflamm Res (2009) 0.81
Vasodilatation and inhibition of mediator release represent two distinct mechanisms for prostaglandin modulation of acute mast cell-dependent inflammation. Br J Pharmacol (1990) 0.81
The role of prostaglandins in chemically induced inflammation. Br J Exp Pathol (1976) 0.79
A comparison between the prostaglandin releasing effects of angiotensin II and angiotensin III. Agents Actions (1977) 0.79
Cyclooxygenase-1-selective inhibitors based on the (E)-2'-des-methyl-sulindac sulfide scaffold. J Med Chem (2012) 0.79
Nobel lecture. Adventures and excursions in bioassay--the stepping stones to prostacyclin. Postgrad Med J (1983) 0.79
Non-steroidal anti-inflammatory drugs and the kidney. Br Med J (Clin Res Ed) (1986) 0.78
Nobel lecture, 8th December 1982. Adventures and excursions in bioassay: the stepping stones to prostacyclin. Br J Pharmacol (1983) 0.78
Inhibition by non-steroid anti-inflammatory agents of rabbit aorta contracting activity generated in blood by slow reacting substance C. Br J Pharmacol (1974) 0.78
Effects of non-steroidal anti-inflammatory drugs on prostacyclin and thromboxane biosynthesis in patients with mild essential hypertension. Br J Clin Pharmacol (1990) 0.78
Pathogenic Mechanisms and In Vitro Diagnosis of AERD. J Allergy (Cairo) (2012) 0.78
Effect of 4-trifluoromethyl derivatives of salicylate on nuclear factor kappaB-dependent transcription in human astrocytoma cells. Br J Pharmacol (2001) 0.78
Inhibition of prostaglandin synthesis augments the effects of sympathetic nerve stimulation on the cat spleen. Br J Pharmacol (1971) 0.78
Endogenous monoamine analgesic systems: amitriptyline in painful diabetic neuropathy. Anesth Prog (1987) 0.77
Distinctive pharmacological profile of a nonadrenergic inhibitory system in bullfrog lung. Br J Pharmacol (1983) 0.77
Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. Nat New Biol (1971) 37.53
Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. Nature (1987) 35.44
Vascular endothelial cells synthesize nitric oxide from L-arginine. Nature (1988) 18.41
Release of additional factors in anaphylaxis and its antagonism by anti-inflammatory drugs. Nature (1969) 13.60
An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation. Nature (1976) 13.19
Superoxide anion is involved in the breakdown of endothelium-derived vascular relaxing factor. Nature (1986) 9.93
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Accumulation of an endogenous inhibitor of nitric oxide synthesis in chronic renal failure. Lancet (1992) 5.36
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A novel citrulline-forming enzyme implicated in the formation of nitric oxide by vascular endothelial cells. Biochem Biophys Res Commun (1989) 5.14
Prostaglandins, aspirin-like drugs and analgesia. Nat New Biol (1972) 4.91
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The pivotal role of tumour necrosis factor alpha in the development of inflammatory hyperalgesia. Br J Pharmacol (1992) 3.21
Prostaglandins, aspirin-like drugs and the oedema of inflammation. Nature (1973) 3.20
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Involvement of nitric oxide in the reflex relaxation of the stomach to accommodate food or fluid. Nature (1991) 2.82
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Increased concentrations of nitrite in synovial fluid and serum samples suggest increased nitric oxide synthesis in rheumatic diseases. Ann Rheum Dis (1992) 2.63
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The release of prostaglandins and rabbit aorta contracting substance (RCS) from rabbit spleen and its antagonism by anti-inflammatory drugs. Br J Pharmacol (1972) 2.52
Pharmacokinetic function of the pulmonary circulation. Physiol Rev (1974) 2.52
Unstable metabolites of arachidonic acid and their role in haemostasis and thrombosis. Br Med Bull (1978) 2.51
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Production of hydroxyl radicals from the simultaneous generation of superoxide and nitric oxide. Biochem J (1992) 2.51
Intrarenal prostaglandin release attenuates the renal vasoconstrictor activity of angiotensin. J Pharmacol Exp Ther (1973) 2.48
Imidazole: a selective inhibitor of thromboxane synthetase. Prostaglandins (1977) 2.48
The disappearance of bradykinin and eledoisin in the circulation and vascular beds of the cat. Br J Pharmacol Chemother (1967) 2.44
Inhibition of nitric oxide synthesis in septic shock: how much is beneficial? Lancet (1992) 2.44
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S-nitroso-glutathione inhibits platelet activation in vitro and in vivo. Br J Pharmacol (1992) 2.39