Published in Am J Hum Genet on January 01, 1988
Linkage disequilibrium, cystic fibrosis, and genetic counseling. Am J Hum Genet (1989) 2.19
Cloning human telomeric DNA fragments into Saccharomyces cerevisiae using a yeast-artificial-chromosome vector. Proc Natl Acad Sci U S A (1989) 2.10
Analysis of DNA polymorphism haplotypes linked to the cystic fibrosis locus in North American black and Caucasian families supports the existence of multiple mutations of the cystic fibrosis gene. Am J Hum Genet (1989) 1.81
DNA marker haplotype association with pancreatic sufficiency in cystic fibrosis. Am J Hum Genet (1989) 1.66
Recombinations between IRP and cystic fibrosis. Am J Hum Genet (1988) 1.44
Genealogical analysis of cystic fibrosis families and chromosome 7q RFLP haplotypes in the Hutterite Brethren. Am J Hum Genet (1989) 1.40
Familial bone marrow monosomy 7. Evidence that the predisposing locus is not on the long arm of chromosome 7. J Clin Invest (1989) 1.03
A 12 megabase restriction map at the cystic fibrosis locus. Nucleic Acids Res (1989) 1.01
Approaches to localizing disease genes as applied to cystic fibrosis. Nucleic Acids Res (1990) 0.98
Cystic fibrosis mutations in the Hutterite Brethren. Am J Hum Genet (1990) 0.94
Joint estimation of recombination fractions and interference coefficients in multilocus linkage analysis. Am J Hum Genet (1990) 0.90
The human serum paraoxonase/arylesterase polymorphism. Am J Hum Genet (1988) 0.82
Comparative map for mice and humans. Mamm Genome (1991) 0.81
The genotype of a new linked DNA marker, MP6d-9, is related to the clinical course of cystic fibrosis. J Med Genet (1990) 0.79
The gene CYP3 encoding P450pcn1 (nifedipine oxidase) is tightly linked to the gene COL1A2 encoding collagen type 1 alpha on 7q21-q22.1. Am J Hum Genet (1988) 0.79
Prenatal diagnosis of cystic fibrosis using closely linked DNA probes. J Inherit Metab Dis (1989) 0.75
Recent advances in cystic fibrosis. J Inherit Metab Dis (1988) 0.75
Strategies for multilocus linkage analysis in humans. Proc Natl Acad Sci U S A (1984) 48.41
Easy calculations of lod scores and genetic risks on small computers. Am J Hum Genet (1984) 28.51
A closely linked genetic marker for cystic fibrosis. Nature (1985) 7.85
Localization of cystic fibrosis locus to human chromosome 7cen-q22. Nature (1985) 7.77
Cystic fibrosis locus defined by a genetically linked polymorphic DNA marker. Science (1985) 5.81
A polymorphic DNA marker linked to cystic fibrosis is located on chromosome 7. Nature (1985) 5.07
Linkage of cystic fibrosis to two tightly linked DNA markers: joint report from a collaborative study. Am J Hum Genet (1986) 3.83
The human met oncogene is related to the tyrosine kinase oncogenes. Nature (1985) 3.46
Linkage relationships of paraoxonase (PON) with other markers: indication of PON-cystic fibrosis synteny. Clin Genet (1985) 2.96
Isolation of a further anonymous informative DNA sequence from chromosome seven closely linked to cystic fibrosis. Nucleic Acids Res (1986) 2.34
Linkage of COL1A2 collagen gene to cystic fibrosis, and its clinical implications. Lancet (1985) 2.14
Further linkage data on cystic fibrosis: the Utah Study. Am J Hum Genet (1986) 1.63
Genetic analysis of cystic fibrosis using linked DNA markers. Am J Hum Genet (1986) 1.32
Linkage of cystic fibrosis to the pro alpha 2(I) collagen gene, COL1A2, on chromosome 7. Cytogenet Cell Genet (1986) 1.29
Highly polymorphic RFLP probes as diagnostic tools. Cold Spring Harb Symp Quant Biol (1986) 1.09
Linkage of DNA probe B79a (D7S13) to cystic fibrosis. Am J Hum Genet (1987) 0.88
Investigation of genetic linkage in human families. Adv Hum Genet (1987) 0.86
Genetic alterations during colorectal-tumor development. N Engl J Med (1988) 26.82
Variable number of tandem repeat (VNTR) markers for human gene mapping. Science (1987) 25.71
Identification of the cystic fibrosis gene: chromosome walking and jumping. Science (1989) 21.46
Chromosome 17 deletions and p53 gene mutations in colorectal carcinomas. Science (1989) 11.53
A photoreceptor cell-specific ATP-binding transporter gene (ABCR) is mutated in recessive Stargardt macular dystrophy. Nat Genet (1997) 10.93
Mutations of chromosome 5q21 genes in FAP and colorectal cancer patients. Science (1991) 9.89
A major segment of the neurofibromatosis type 1 gene: cDNA sequence, genomic structure, and point mutations. Cell (1990) 8.10
A candidate for the cystic fibrosis locus isolated by selection for methylation-free islands. Nature (1987) 7.88
Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome. Cell (1996) 7.86
A closely linked genetic marker for cystic fibrosis. Nature (1985) 7.85
Localization of cystic fibrosis locus to human chromosome 7cen-q22. Nature (1985) 7.77
Germline and somatic mutations in the tyrosine kinase domain of the MET proto-oncogene in papillary renal carcinomas. Nat Genet (1997) 6.83
Quantum computers. Nature (2010) 6.79
Cell-cycle control of c-myc but not c-ras expression is lost following chemical transformation. Cell (1984) 6.53
Construction of linkage maps with DNA markers for human chromosomes. Nature (1985) 6.38
A ribonucleotide reductase gene involved in a p53-dependent cell-cycle checkpoint for DNA damage. Nature (2000) 6.01
Mutation of the Stargardt disease gene (ABCR) in age-related macular degeneration. Science (1997) 6.00
When is cancer pain mild, moderate or severe? Grading pain severity by its interference with function. Pain (1995) 5.97
Molecular cloning of a new transforming gene from a chemically transformed human cell line. Nature (1984) 5.85
p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53. Cell (2000) 5.64
Allelotype of colorectal carcinomas. Science (1989) 5.54
The action of tetrodotoxin on electrogenic components of squid giant axons. J Gen Physiol (1965) 5.42
AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1. Nat Genet (2000) 5.26
Dating the origin of the CCR5-Delta32 AIDS-resistance allele by the coalescence of haplotypes. Am J Hum Genet (1998) 5.24
The neurofibromatosis type 1 gene encodes a protein related to GAP. Cell (1990) 5.24
Interleukin-2 receptor gamma chain: a functional component of the interleukin-7 receptor. Science (1993) 5.22
Somatic mutations of the APC gene in colorectal tumors: mutation cluster region in the APC gene. Hum Mol Genet (1992) 5.14
Hemizygosity at the elastin locus in a developmental disorder, Williams syndrome. Nat Genet (1993) 5.09
Complete genome structure of the nitrogen-fixing symbiotic bacterium Mesorhizobium loti. DNA Res (2000) 4.94
A novel potassium channel gene, KCNQ2, is mutated in an inherited epilepsy of newborns. Nat Genet (1998) 4.89
The GAP-related domain of the neurofibromatosis type 1 gene product interacts with ras p21. Cell (1990) 4.84
Progress towards construction of a total restriction fragment map of a human chromosome. Nucleic Acids Res (1987) 4.68
Interleukin-2 receptor gamma chain: a functional component of the interleukin-4 receptor. Science (1993) 4.63
Rapid colorectal adenoma formation initiated by conditional targeting of the Apc gene. Science (1997) 4.62
The gene for familial polyposis coli maps to the long arm of chromosome 5. Science (1987) 4.48
Associations between cigarette smoking, lifestyle factors, and microsatellite instability in colon tumors. J Natl Cancer Inst (2000) 4.39
Transient regulation of protein synthesis in Escherichia coli upon shift-up of growth temperature. J Bacteriol (1978) 4.38
The role of the human homologue of Drosophila patched in sporadic basal cell carcinomas. Nat Genet (1996) 4.36
Complete genomic sequence of the filamentous nitrogen-fixing cyanobacterium Anabaena sp. strain PCC 7120. DNA Res (2001) 4.27
A pore mutation in a novel KQT-like potassium channel gene in an idiopathic epilepsy family. Nat Genet (1998) 4.25
A primary genetic map of markers of human chromosome 10. Genomics (1988) 4.23
Disruption of the APC gene by a retrotransposal insertion of L1 sequence in a colon cancer. Cancer Res (1992) 4.21
Mechanism of met oncogene activation. Cell (1986) 4.20
Complete genome sequence of the alkaliphilic bacterium Bacillus halodurans and genomic sequence comparison with Bacillus subtilis. Nucleic Acids Res (2000) 4.11
Identification and characterization of the potential promoter regions of 1031 kinds of human genes. Genome Res (2001) 4.03
A primary genetic map of chromosome 13q. Am J Hum Genet (1986) 4.01
Sequence of MET protooncogene cDNA has features characteristic of the tyrosine kinase family of growth-factor receptors. Proc Natl Acad Sci U S A (1987) 3.99
Multiple endocrine neoplasia type 1 gene maps to chromosome 11 and is lost in insulinoma. Nature (1988) 3.96
The spectrum of symptoms and QT intervals in carriers of the gene for the long-QT syndrome. N Engl J Med (1992) 3.92
The Wnt/Ca2+ pathway: a new vertebrate Wnt signaling pathway takes shape. Trends Genet (2000) 3.91
An ancient retrotransposal insertion causes Fukuyama-type congenital muscular dystrophy. Nature (1998) 3.86
Linkage of cystic fibrosis to two tightly linked DNA markers: joint report from a collaborative study. Am J Hum Genet (1986) 3.83
Genetic acceleration of AIDS progression by a promoter variant of CCR5. Science (1998) 3.60
Localization of the genetic defect in familial adenomatous polyposis within a small region of chromosome 5. Am J Hum Genet (1988) 3.58
A mapped set of DNA markers for human chromosome 17. Genomics (1988) 3.55
Plus and minus strand leader RNAs in negative strand virus-infected cells. Cell (1979) 3.50
Genetic mapping of chronic childhood-onset spinal muscular atrophy to chromosome 5q11.2-13.3. Nature (1990) 3.48
Diverse transcriptional initiation revealed by fine, large-scale mapping of mRNA start sites. EMBO Rep (2001) 3.47
The human met oncogene is related to the tyrosine kinase oncogenes. Nature (1985) 3.46
Microsatellite instability in sporadic colon cancer is associated with an improved prognosis at the population level. Cancer Epidemiol Biomarkers Prev (2001) 3.43
Results of surgical and nonsurgical treatment for small-sized hepatocellular carcinomas: a retrospective and nationwide survey in Japan. The Liver Cancer Study Group of Japan. Hepatology (2000) 3.42
Mutational spectra of PTEN/MMAC1 gene: a tumor suppressor with lipid phosphatase activity. J Natl Cancer Inst (1999) 3.41
Efficient computations in multilocus linkage analysis. Am J Hum Genet (1988) 3.39
Linkage of a cardiac arrhythmia, the long QT syndrome, and the Harvey ras-1 gene. Science (1991) 3.38
InIB-dependent internalization of Listeria is mediated by the Met receptor tyrosine kinase. Cell (2000) 3.31
Multiple mutations in highly conserved residues are found in mildly affected cystic fibrosis patients. Cell (1990) 3.29
Altered urinary bladder function in mice lacking the vanilloid receptor TRPV1. Nat Neurosci (2002) 3.28
Precise localization of NF1 to 17q11.2 by balanced translocation. Am J Hum Genet (1989) 3.27
Protein kinase C is differentially stimulated by Wnt and Frizzled homologs in a G-protein-dependent manner. Curr Biol (1999) 3.25
Race-specific HIV-1 disease-modifying effects associated with CCR5 haplotypes. Proc Natl Acad Sci U S A (1999) 3.21
Rapid confirmation of single copy lambda prophage integration by PCR. Nucleic Acids Res (1994) 3.19
Integrating case-control and TDT studies. Ann Hum Genet (2005) 3.19
Genome-wide analysis of gene expression in human hepatocellular carcinomas using cDNA microarray: identification of genes involved in viral carcinogenesis and tumor progression. Cancer Res (2001) 3.18
A high-throughput SNP typing system for genome-wide association studies. J Hum Genet (2001) 3.18
Isolation and mapping of a polymorphic DNA sequence (pTHH22) on chromosome 9 [D9S12]. Nucleic Acids Res (1988) 3.17
IL-6 is produced by osteoblasts and induces bone resorption. J Immunol (1990) 3.14
Gene organization deduced from the complete sequence of liverwort Marchantia polymorpha mitochondrial DNA. A primitive form of plant mitochondrial genome. J Mol Biol (1992) 3.11
Further characterization of Sendai virus DI-RNAs: a model for their generation. Cell (1977) 3.10
Interaction of VSV leader RNA and nucleocapsid protein may control VSV genome replication. Cell (1981) 3.06