Published in PLoS One on September 20, 2017
Identification and characterization of genes for a second anthranilate synthase in Pseudomonas aeruginosa: interchangeability of the two anthranilate synthases and evolutionary implications. J Bacteriol (1990) 5.01
The biochemistry and medical significance of the flavonoids. Pharmacol Ther (2002) 4.77
Motile cilia of human airway epithelia are chemosensory. Science (2009) 4.40
Production of beta-defensins by human airway epithelia. Proc Natl Acad Sci U S A (1998) 3.85
Human beta-defensin 2 is a salt-sensitive peptide antibiotic expressed in human lung. J Clin Invest (1998) 3.51
Resistance to antibiotics: are we in the post-antibiotic era? Arch Med Res (2005) 2.98
Microtiter dish biofilm formation assay. J Vis Exp (2011) 2.84
T2R38 taste receptor polymorphisms underlie susceptibility to upper respiratory infection. J Clin Invest (2012) 2.66
Calu-3: a human airway epithelial cell line that shows cAMP-dependent Cl- secretion. Am J Physiol (1994) 2.33
National Ambulatory Medical Care Survey: 2000 summary. Adv Data (2002) 2.32
Lactic acid permeabilizes gram-negative bacteria by disrupting the outer membrane. Appl Environ Microbiol (2000) 2.25
Tissue distribution of lysozyme in man. J Histochem Cytochem (1975) 2.16
Recent advances in understanding the antibacterial properties of flavonoids. Int J Antimicrob Agents (2011) 2.13
Innate immunity in the respiratory epithelium. Am J Respir Cell Mol Biol (2011) 2.04
Healthcare expenditures for sinusitis in 1996: contributions of asthma, rhinitis, and other airway disorders. J Allergy Clin Immunol (1999) 1.91
LYSOZYME LYSIS OF GRAM-NEGATIVE BACTERIA WITHOUT PRODUCTION OF SPHEROPLASTS. J Gen Microbiol (1964) 1.66
Flavones and flavone synthases. Phytochemistry (2005) 1.54
Fluorometric assessment of gram-negative bacterial permeabilization. J Appl Microbiol (2000) 1.53
Flavonoids apigenin and quercetin inhibit melanoma growth and metastatic potential. Int J Cancer (2000) 1.50
Lysozyme secretion by submucosal glands protects the airway from bacterial infection. Am J Respir Cell Mol Biol (2005) 1.49
Mechanisms of action of Pseudomonas aeruginosa pyocyanin on human ciliary beat in vitro. Infect Immun (1993) 1.42
Bitter and sweet taste receptors regulate human upper respiratory innate immunity. J Clin Invest (2014) 1.42
Antibacterial, antifungal, and antiviral activities of some flavonoids. Microbiol Res (2009) 1.32
National Hospital Ambulatory Medical Care Survey: 2000 outpatient department summary. Adv Data (2002) 1.32
Effect of ciliostatic factors from Pseudomonas aeruginosa on rabbit respiratory cilia. Infect Immun (1986) 1.30
Regulation of the depth and composition of airway surface liquid. J Anat (2002) 1.29
Pathophysiology of rhinitis. Lactoferrin and lysozyme in nasal secretions. J Clin Invest (1989) 1.24
Ultrastructural immunocytochemical localisation of lysozyme in human bronchial glands. Thorax (1977) 1.23
Regulation of antiprotease and antimicrobial protein secretion by airway submucosal gland serous cells. J Biol Chem (2004) 1.19
Microbial DNA induces a host defense reaction of human respiratory epithelial cells. J Immunol (2004) 1.18
Inflammation-mediated upregulation of centrosomal protein 110, a negative modulator of ciliogenesis, in patients with chronic rhinosinusitis. J Allergy Clin Immunol (2011) 1.17
Protein kinase C inhibition by plant flavonoids. Kinetic mechanisms and structure-activity relationships. Biochem Pharmacol (1989) 1.15
Respiratory carcinoma cell lines. MUC genes and glycoconjugates. Am J Respir Cell Mol Biol (1999) 1.13
Flavonoids and the inhibition of PKC and PI 3-kinase. Gen Pharmacol (1999) 1.12
Secretion of lactoferrin and lysozyme by cultures of human airway epithelium. Am J Physiol Lung Cell Mol Physiol (2004) 1.10
Flavones with antibacterial activity against cariogenic bacteria. J Ethnopharmacol (1996) 1.07
Pseudomonas aeruginosa pyocyanin directly oxidizes glutathione and decreases its levels in airway epithelial cells. Am J Physiol Lung Cell Mol Physiol (2004) 1.07
Surface-localized spermidine protects the Pseudomonas aeruginosa outer membrane from antibiotic treatment and oxidative stress. J Bacteriol (2011) 1.07
Oxidative stress caused by pyocyanin impairs CFTR Cl(-) transport in human bronchial epithelial cells. Free Radic Biol Med (2008) 1.05
Synthesis and biological evaluation of novel C (7) modified chrysin analogues as antibacterial agents. Bioorg Med Chem Lett (2005) 1.05
Host-microbial interactions in patients with chronic rhinosinusitis. J Allergy Clin Immunol (2013) 1.04
Recurrent acute rhinosinusitis: epidemiology and health care cost burden. Otolaryngol Head Neck Surg (2011) 1.03
Antimicrobial defensin peptides of the human nasal mucosa. Ann Otol Rhinol Laryngol (2002) 1.03
The microbiology and antimicrobial resistance patterns in chronic rhinosinusitis. Am J Otolaryngol (2004) 1.00
Antimicrobial properties and membrane-active mechanism of a potential α-helical antimicrobial derived from cathelicidin PMAP-36. PLoS One (2014) 0.97
Assessment of trends in antimicrobial resistance in chronic rhinosinusitis. Ann Otol Rhinol Laryngol (2008) 0.95
D-Alanine:D-alanine ligase as a new target for the flavonoids quercetin and apigenin. Int J Antimicrob Agents (2008) 0.94
Optical imaging of Ca2+-evoked fluid secretion by murine nasal submucosal gland serous acinar cells. J Physiol (2007) 0.92
Chronic rhinosinusitis pathogenesis. J Allergy Clin Immunol (2015) 0.91
Redox-independent activation of NF-kappaB by Pseudomonas aeruginosa pyocyanin in a cystic fibrosis airway epithelial cell line. J Biol Chem (2008) 0.91
Variation in synergistic activity by flavone and its related compounds on the increased susceptibility of various strains of methicillin-resistant Staphylococcus aureus to beta-lactam antibiotics. Int J Antimicrob Agents (2004) 0.91
Wogonin prevents lipopolysaccharide-induced acute lung injury and inflammation in mice via peroxisome proliferator-activated receptor gamma-mediated attenuation of the nuclear factor-kappaB pathway. Immunology (2014) 0.89
Ca²⁺ signaling and fluid secretion by secretory cells of the airway epithelium. Cell Calcium (2014) 0.88
Chronic rhinosinusitis and antibiotics: the good, the bad, and the ugly. Am J Rhinol Allergy (2013) 0.88
Mouse nasal epithelial innate immune responses to Pseudomonas aeruginosa quorum-sensing molecules require taste signaling components. Innate Immun (2013) 0.88
Bitter and sweet taste receptors in the respiratory epithelium in health and disease. J Mol Med (Berl) (2014) 0.87
Mucins suppress virulence traits of Candida albicans. MBio (2014) 0.87
Vasoactive intestinal peptide regulates sinonasal mucociliary clearance and synergizes with histamine in stimulating sinonasal fluid secretion. FASEB J (2013) 0.86
CFTR and lysozyme secretion in human airway epithelial cells. Pflugers Arch (2001) 0.86
Taste receptors in innate immunity. Cell Mol Life Sci (2014) 0.86
Proteomics of nasal mucus in chronic rhinosinusitis. Am J Rhinol (2008) 0.85
The emerging role of the bitter taste receptor T2R38 in upper respiratory infection and chronic rhinosinusitis. Am J Rhinol Allergy (2013) 0.85
Draft Genome Sequence of the Methicillin-Resistant Staphylococcus aureus Isolate MRSA-M2. Genome Announc (2013) 0.84
Interaction of Gram-negative bacteria with cationic proteins: Dependence on the surface characteristics of the bacterial cell. Int J Gen Med (2009) 0.84
Antibiotic resistance: a "dark side" of biofilm‑associated chronic infections. Pol Arch Med Wewn (2013) 0.83
Quantitative turbidimetric assay of enzymatic gram-negative bacteria lysis. Anal Chem (2010) 0.83
Antibacterial activity of apical surface fluid from the human airway cell line Calu-3: pharmacologic alteration by corticosteroids and beta(2)-agonists. Am J Respir Cell Mol Biol (2001) 0.83
Inhibition of TNF-α-induced MUC5AC mucin gene expression and production by wogonin through the inactivation of NF-κB signaling in airway epithelial cells. Phytother Res (2013) 0.83
Anti-Inflammatory Effect of Apigenin on LPS-Induced Pro-Inflammatory Mediators and AP-1 Factors in Human Lung Epithelial Cells. Inflammation (2016) 0.82
Bitter taste receptor activation by flavonoids and isoflavonoids: modeled structural requirements for activation of hTAS2R14 and hTAS2R39. J Agric Food Chem (2013) 0.82
Protective effect of wogonin on proinflammatory cytokine generation via Jak1/3-STAT1/3 pathway in lipopolysaccharide stimulated BV2 microglial cells. Toxicol Ind Health (2013) 0.82
Phorbol ester or epidermal growth-factor-induced MUC5AC mucin gene expression and production from airway epithelial cells are inhibited by apigenin and wogonin. Phytother Res (2012) 0.82
Synthesis and inhibitory activity against COX-2 catalyzed prostaglandin production of chrysin derivatives. Bioorg Med Chem Lett (2004) 0.82
Bacterial pattern in chronic sinusitis and cystic fibrosis. Otolaryngol Head Neck Surg (2011) 0.81
Soy isoflavones and other isoflavonoids activate the human bitter taste receptors hTAS2R14 and hTAS2R39. J Agric Food Chem (2011) 0.81
Role of the bitter taste receptor T2R38 in upper respiratory infection and chronic rhinosinusitis. Curr Opin Allergy Clin Immunol (2015) 0.80
Wogonin attenuates endotoxin-induced prostaglandin E2 and nitric oxide production via Src-ERK1/2-NFκB pathway in BV-2 microglial cells. Environ Toxicol (2013) 0.80
Chapter 4: Chronic rhinosinusitis. Am J Rhinol Allergy (2013) 0.80
Expression of human beta-defensin 2 in human nasal mucosa. Eur Arch Otorhinolaryngol (2003) 0.80
Protective effects of the aqueous extract of Scutellaria baicalensis against acrolein-induced oxidative stress in cultured human umbilical vein endothelial cells. Pharm Biol (2010) 0.79
Microbiology of chronic rhinosinusitis. Eur J Clin Microbiol Infect Dis (2016) 0.79
In vitro effects of anthocyanidins on sinonasal epithelial nitric oxide production and bacterial physiology. Am J Rhinol Allergy (2016) 0.78
Bacteriology and antibiotic resistance in chronic rhinosinusitis. Facial Plast Surg Clin North Am (2012) 0.78
Vancomycin resistance reversal in enterococci by flavonoids. J Pharm Pharmacol (2001) 0.77
High specific selectivity and Membrane-Active Mechanism of the synthetic centrosymmetric α-helical peptides with Gly-Gly pairs. Sci Rep (2015) 0.77
Review of flavonoids: A diverse group of natural compounds with anti-Candida albicans activity in vitro. Arch Oral Biol (2016) 0.76
Flavones: From Biosynthesis to Health Benefits. Plants (Basel) (2016) 0.76
Flavones modulate respiratory epithelial innate immunity: anti-inflammatory effects and activation of T2R14. J Biol Chem (2017) 0.76
Activation of human bitter taste receptors by polymethoxylated flavonoids. Biosci Biotechnol Biochem (2016) 0.76
Synthesis and PGE2 inhibitory activity of vinylated and allylated chrysin analogues. Arch Pharm Res (2003) 0.76
Protein composition of apical surface fluid from the human airway cell line Calu-3: effect of ion transport mediators. Clin Chim Acta (2004) 0.76
Synthesis and antibacterial activity of substituted flavones, 4-thioflavones and 4-iminoflavones. Bioorg Med Chem (2006) 0.76
Polymethoxyflavones Isolated from the Peel of Miaray Mandarin (Citrus miaray) Have Biofilm Inhibitory Activity in Vibrio harveyi. J Agric Food Chem (2015) 0.75
Activities of wogonin analogs and other flavones against Flavobacterium columnare. Chem Biodivers (2015) 0.75
Fungal Aflatoxins Reduce Respiratory Mucosal Ciliary Function. Sci Rep (2016) 0.75
New insights into upper airway innate immunity. Am J Rhinol Allergy (2016) 0.75
Apigenin Inhibits Tumor Necrosis Factor-α-Induced Production and Gene Expression of Mucin through Regulating Nuclear Factor-Kappa B Signaling Pathway in Airway Epithelial Cells. Biomol Ther (Seoul) (2014) 0.75
Bitter taste bodyguards. Sci Am (2016) 0.75
Plant Natural compounds with antibacterial activity towards common pathogens of pond-cultured channel catfish (Ictalurus punctatus). Toxins (Basel) (2010) 0.75