Published in J Nat Prod on October 31, 2017
Structure and activity of largazole, a potent antiproliferative agent from the Floridian marine cyanobacterium Symploca sp. J Am Chem Soc (2008) 2.34
Total synthesis and molecular target of largazole, a histone deacetylase inhibitor. J Am Chem Soc (2008) 1.76
A small-molecule inducer of the antioxidant response element. Chem Biol (2010) 1.65
Marine natural products: a new wave of drugs? Future Med Chem (2011) 1.57
Telomere-independent Rap1 is an IKK adaptor and regulates NF-kappaB-dependent gene expression. Nat Cell Biol (2010) 1.47
A genomic screen for activators of the antioxidant response element. Proc Natl Acad Sci U S A (2007) 1.44
Lyngbyastatins 5-7, potent elastase inhibitors from Floridian marine cyanobacteria, Lyngbya spp. J Nat Prod (2007) 1.42
Lyngbyastatin 4, a dolastatin 13 analogue with elastase and chymotrypsin inhibitory activity from the marine cyanobacterium Lyngbya confervoides. J Nat Prod (2007) 1.32
Apratoxin a reversibly inhibits the secretory pathway by preventing cotranslational translocation. Mol Pharmacol (2009) 1.28
Apratoxin E, a cytotoxic peptolide from a guamanian collection of the marine cyanobacterium Lyngbya bouillonii. J Nat Prod (2008) 1.28
Isolation and biological evaluation of 8-epi-malyngamide C from the Floridian marine cyanobacterium Lyngbya majuscula. J Nat Prod (2010) 1.27
Phylogenetic and chemical diversity of three chemotypes of bloom-forming lyngbya species (Cyanobacteria: Oscillatoriales) from reefs of southeastern Florida. Appl Environ Microbiol (2009) 1.17
Combinatorial strategies by marine cyanobacteria: symplostatin 4, an antimitotic natural dolastatin 10/15 hybrid that synergizes with the coproduced HDAC inhibitor largazole. Chembiochem (2009) 1.14
Anticolon cancer activity of largazole, a marine-derived tunable histone deacetylase inhibitor. J Pharmacol Exp Ther (2010) 1.13
Cytotoxic halogenated macrolides and modified peptides from the apratoxin-producing marine cyanobacterium Lyngbya bouillonii from Guam. J Nat Prod (2010) 1.13
Grassystatins A-C from marine cyanobacteria, potent cathepsin E inhibitors that reduce antigen presentation. J Med Chem (2009) 1.09
Synthesis and activity of largazole analogues with linker and macrocycle modification. Org Lett (2008) 1.07
Molassamide, a depsipeptide serine protease inhibitor from the marine cyanobacterium Dichothrix utahensis. J Nat Prod (2010) 1.06
Total structure determination of grassypeptolide, a new marine cyanobacterial cytotoxin. Org Lett (2008) 1.06
Largazole: from discovery to broad-spectrum therapy. Nat Prod Rep (2012) 1.03
Multidimensional Screening Platform for Simultaneously Targeting Oncogenic KRAS and Hypoxia-Inducible Factors Pathways in Colorectal Cancer. ACS Chem Biol (2016) 1.03
Systematic Chemical Mutagenesis Identifies a Potent Novel Apratoxin A/E Hybrid with Improved in Vivo Antitumor Activity. ACS Med Chem Lett (2011) 1.02
Lyngbyastatins 8-10, elastase inhibitors with cyclic depsipeptide scaffolds isolated from the marine cyanobacterium Lyngbya semiplena. Mar Drugs (2009) 1.01
Lyngbyoic acid, a "tagged" fatty acid from a marine cyanobacterium, disrupts quorum sensing in Pseudomonas aeruginosa. Mol Biosyst (2011) 0.97
Total synthesis and biological evaluation of grassypeptolide A. Chemistry (2013) 0.95
Kempopeptins A and B, serine protease inhibitors with different selectivity profiles from a marine cyanobacterium, Lyngbya sp. J Nat Prod (2008) 0.94
Grassypeptolides A-C, cytotoxic bis-thiazoline containing marine cyclodepsipeptides. J Org Chem (2010) 0.93
Largamides A-C, tiglic acid-containing cyclodepsipeptides with elastase-inhibitory activity from the marine cyanobacterium Lyngbya confervoides. Planta Med (2009) 0.93
The molecular pharmacology of symplostatin 1: a new antimitotic dolastatin 10 analog. Int J Cancer (2003) 0.93
Caylobolide B, a macrolactone from symplostatin 1-producing marine cyanobacteria Phormidium spp. from Florida. J Nat Prod (2010) 0.92
Pitiprolamide, a proline-rich dolastatin 16 analogue from the marine cyanobacterium Lyngbya majuscula from Guam. J Nat Prod (2010) 0.92
Cyanobacterial peptides as a prototype for the design of potent β-secretase inhibitors and the development of selective chemical probes for other aspartic proteases. J Med Chem (2012) 0.92
Seaweed extracts and unsaturated fatty acid constituents from the green alga Ulva lactuca as activators of the cytoprotective Nrf2-ARE pathway. Free Radic Biol Med (2013) 0.91
Protection of human cultured cells against oxidative stress by Rhodiola rosea without activation of antioxidant defenses. Free Radic Biol Med (2009) 0.90
Biological targets and mechanisms of action of natural products from marine cyanobacteria. Nat Prod Rep (2015) 0.90
Potent elastase inhibitors from cyanobacteria: structural basis and mechanisms mediating cytoprotective and anti-inflammatory effects in bronchial epithelial cells. J Med Chem (2013) 0.89
Dragonamides C and D, linear lipopeptides from the marine cyanobacterium brown Lyngbya polychroa. J Nat Prod (2008) 0.88
Tiglicamides A-C, cyclodepsipeptides from the marine cyanobacterium Lyngbya confervoides. Phytochemistry (2009) 0.88
Caldora penicillata gen. nov., comb. nov. (cyanobacteria), a pantropical marine species with biomedical relevance. J Phycol (2015) 0.88
Discovery and mechanism of natural products as modulators of histone acetylation. Curr Drug Targets (2012) 0.87
Combination therapy for renal cell cancer: what are possible options? Oncology (2011) 0.86
Malyngamide 3 and cocosamides A and B from the marine cyanobacterium Lyngbya majuscula from Cocos Lagoon, Guam. J Nat Prod (2011) 0.85
Veraguamides A-G, cyclic hexadepsipeptides from a dolastatin 16-producing cyanobacterium Symploca cf. hydnoides from Guam. J Nat Prod (2011) 0.85
Pitipeptolides C-F, antimycobacterial cyclodepsipeptides from the marine cyanobacterium Lyngbya majuscula from Guam. Phytochemistry (2011) 0.84
Total synthesis of grassystatin A, a probe for cathepsin E function. Bioorg Med Chem (2012) 0.84
Continuing studies on the cyanobacterium Lyngbya sp.: isolation and structure determination of 15-norlyngbyapeptin A and lyngbyabellin D. J Nat Prod (2003) 0.83
Can we develop effective combination antiangiogenic therapy for patients with hepatocellular carcinoma? Oncol Rev (2011) 0.83
Amantelides A and B, Polyhydroxylated Macrolides with Differential Broad-Spectrum Cytotoxicity from a Guamanian Marine Cyanobacterium. J Nat Prod (2015) 0.82
In Vitro and In Vivo Osteogenic Activity of Largazole. ACS Med Chem Lett (2011) 0.82
Activation of the antioxidant response element by specific oxidized metabolites of linoleic acid. Prostaglandins Leukot Essent Fatty Acids (2009) 0.81
Improved total synthesis and biological evaluation of potent apratoxin S4 based anticancer agents with differential stability and further enhanced activity. J Med Chem (2014) 0.80
Weapons in disguise--activating mechanisms and protecting group chemistry in nature. Chemistry (2010) 0.80
Intramolecular modulation of serine protease inhibitor activity in a marine cyanobacterium with antifeedant properties. Mar Drugs (2010) 0.80
Marine cyanobacterial fatty acid amides acting on cannabinoid receptors. Chembiochem (2012) 0.79
Bioassay-guided isolation and identification of desacetylmicrocolin B from Lyngbya cf. polychroa. Planta Med (2009) 0.79
Cultivated sea lettuce is a multiorgan protector from oxidative and inflammatory stress by enhancing the endogenous antioxidant defense system. Cancer Prev Res (Phila) (2013) 0.78
In vitro and in vivo characterization of a tunable dual-reactivity probe of the Nrf2-ARE pathway. ACS Chem Biol (2013) 0.78
Grassypeptolides as natural inhibitors of dipeptidyl peptidase 8 and T-cell activation. Chembiochem (2014) 0.78
Biological effects of Byrsocarpus coccineus in vitro. Pharm Biol (2010) 0.77
Combination therapy targeting cancer metabolism. Med Hypotheses (2010) 0.77
Modular strategies for structure and function employed by marine cyanobacteria: characterization and synthesis of pitinoic acids. Org Lett (2013) 0.77
Porpoisamides A and B, two novel epimeric cyclic depsipeptides from a Florida Keys collection of Lyngbya sp. Bioorg Med Chem (2011) 0.75
Caldoramide, a Modified Pentapeptide from the Marine Cyanobacterium Caldora penicillata. J Nat Prod (2016) 0.75
Construction and characterization of melanocortin-2 and -4 receptor chimeras. Adv Exp Med Biol (2009) 0.75
Correction to Caylobolide B, a Macrolactone from Symplostatin 1-Producing Marine Cyanobacteria Phormidium spp. from Florida. J Nat Prod (2016) 0.75
Apratyramide, a Marine-Derived Peptidic Stimulator of VEGF-A and Other Growth Factors with Potential Application in Wound Healing. ACS Chem Biol (2017) 0.75
Discovery, Synthesis, and Biological Evaluation of Anaenamides C and D from a New Marine Cyanobacterium, sp. J Nat Prod (2022) 0.75