Use of primary cultures of human hepatocytes in toxicology studies.

PubWeight™: 0.90‹?›

🔗 View Article (PMID 2917345)

Published in Cancer Res on March 01, 1989

Authors

B E Butterworth1, T Smith-Oliver, L Earle, D J Loury, R D White, D J Doolittle, P K Working, R C Cattley, R Jirtle, G Michalopoulos

Author Affiliations

1: Chemical Industry Institute of Toxicology, Research Triangle Park, North Carolina 27709.

Articles by these authors

(truncated to the top 100)

A dust-obscured massive maximum-starburst galaxy at a redshift of 6.34. Nature (2013) 4.43

Primary culture of parenchymal liver cells on collagen membranes. Morphological and biochemical observations. Exp Cell Res (1975) 3.87

"Black blood" T2-weighted inversion-recovery MR imaging of the heart. Radiology (1996) 3.34

Disruption of androgen-regulated male reproductive development by di(n-butyl) phthalate during late gestation in rats is different from flutamide. Toxicol Appl Pharmacol (1999) 3.23

Physical and biological predictors of changes in whole-lung function following thoracic irradiation. Int J Radiat Oncol Biol Phys (1997) 3.17

Protegrin-1: a broad-spectrum, rapidly microbicidal peptide with in vivo activity. Antimicrob Agents Chemother (1997) 3.12

An international literature survey of "IARC Group I carcinogens" reported in mainstream cigarette smoke. Food Chem Toxicol (1998) 2.77

Purification and biological characterization of human hepatopoietin A, a polypeptide growth factor for hepatocytes. Cancer Res (1989) 2.59

Male reproductive tract malformations in rats following gestational and lactational exposure to Di(n-butyl) phthalate: an antiandrogenic mechanism? Toxicol Sci (1998) 2.53

Role of PPAR alpha in the mechanism of action of the nongenotoxic carcinogen and peroxisome proliferator Wy-14,643. Carcinogenesis (1997) 2.46

Differences in the quality of semen in outdoor workers during summer and winter. N Engl J Med (1990) 2.43

Control of hepatocyte replication by two serum factors. Cancer Res (1984) 2.20

Dose-dependent alterations in androgen-regulated male reproductive development in rats exposed to Di(n-butyl) phthalate during late gestation. Toxicol Sci (2000) 2.19

MCM7 amplification and overexpression are associated with prostate cancer progression. Oncogene (2006) 2.07

Hepatocyte growth factor/hepatopoietin A stimulates the growth of rat kidney proximal tubule epithelial cells (RPTE), rat nonparenchymal liver cells, human melanoma cells, mouse keratinocytes and stimulates anchorage-independent growth of SV-40 transformed RPTE. Biochem Biophys Res Commun (1991) 1.95

Liver regeneration studies with rat hepatocytes in primary culture. Cancer Res (1982) 1.81

Relationship of hepatic peroxisome proliferation and replicative DNA synthesis to the hepatocarcinogenicity of the peroxisome proliferators di(2-ethylhexyl)phthalate and [4-chloro-6-(2,3-xylidino)-2-pyrimidinylthio]acetic acid (Wy-14,643) in rats. Cancer Res (1988) 1.70

Long-term cognitive outcomes following out-of-hospital cardiac arrest: a population-based study. Neurology (2011) 1.51

Human biliary epithelial cells secrete and respond to cytokines and hepatocyte growth factors in vitro: interleukin-6, hepatocyte growth factor and epidermal growth factor promote DNA synthesis in vitro. Hepatology (1994) 1.49

Intramural hematoma of the thoracic aorta: MR image findings and their prognostic implications. Radiology (1997) 1.49

Cine MR imaging: potential for the evaluation of cardiovascular function. AJR Am J Roentgenol (1987) 1.49

Does intraoperative hetastarch administration increase blood loss and transfusion requirements after cardiac surgery? Anesth Analg (2000) 1.48

Defibrillator failures. Causes of problems and recommendations for improvement. Defibrillator Working Group. JAMA (1990) 1.48

meso-Tetra(hydroxyphenyl)porphyrins, a new class of potent tumour photosensitisers with favourable selectivity. Br J Cancer (1986) 1.47

The Maze procedure: surgical therapy for refractory atrial fibrillation. Cleve Clin J Med (1993) 1.45

Induction of severe tumor hypoxia by modifiers of the oxygen affinity of hemoglobin. Int J Radiat Oncol Biol Phys (1989) 1.45

Animal protection and medical science. Lancet (1994) 1.45

Muscarinic receptors in rat sympathetic ganglia. Br J Pharmacol (1980) 1.44

Development of protegrins for the treatment and prevention of oral mucositis: structure-activity relationships of synthetic protegrin analogues. Biopolymers (2000) 1.44

New digital measurement methods for left ventricular volume using real-time three-dimensional echocardiography: comparison with electromagnetic flow method and magnetic resonance imaging. Eur J Echocardiogr (2000) 1.43

Isolated left ventricular apical hypoplasia: a new congenital anomaly described with cardiac tomography. Heart (2004) 1.43

Ultrasonic absorption and relaxation spectra in aqueous bovine hemoglobin. Biopolymers (1972) 1.42

Tissue distribution of hepatopoietin-A: a heparin-binding polypeptide growth factor for hepatocytes. Proc Natl Acad Sci U S A (1990) 1.41

Lung and heart-lung transplantation: the state of the art. Cleve Clin J Med (1992) 1.40

"IARC group 2A Carcinogens" reported in cigarette mainstream smoke. Food Chem Toxicol (2000) 1.40

Substituted benzaldehydes designed to increase the oxygen affinity of human haemoglobin and inhibit the sickling of sickle erythrocytes. Br J Pharmacol (1984) 1.36

Cardiac tumors: diagnosis and management. Curr Probl Cardiol (1992) 1.34

Mechanism of action of the nongenotoxic peroxisome proliferators: role of the peroxisome proliferator-activator receptor alpha. J Natl Cancer Inst (1998) 1.32

Potential cost-effectiveness of public access defibrillation in the United States. Circulation (1998) 1.31

Comparative pharmacokinetics, tissue distribution, and therapeutic effectiveness of cisplatin encapsulated in long-circulating, pegylated liposomes (SPI-077) in tumor-bearing mice. Cancer Chemother Pharmacol (1999) 1.31

The effect of human C apolipoproteins on the in vitro hepatic metabolism of triglyceride emulsions in the rat. J Biol Chem (1982) 1.29

Collagen as a substrate for cell growth and differentiation. Methods Enzymol (1982) 1.28

Active and passive smoking and pathological indicators of lung cancer--a report of limited value? JAMA (1993) 1.26

Alpha 1-adrenergic effects and liver regeneration. Hepatology (1988) 1.25

Regional heterogeneity of function in nonischemic dilated cardiomyopathy. Cardiovasc Res (2001) 1.24

Criteria for identifying and listing substances known to cause reproductive toxicity under California's Proposition 65. Reprod Toxicol (1990) 1.22

Transplantation system for determining the clonogenic survival of parenchymal hepatocytes exposed to ionizing radiation. Cancer Res (1981) 1.22

Establishing a rural family practice research network. Fam Med (1988) 1.22

Interleukin-6, hepatocyte growth factor, and their receptors in biliary epithelial cells during a type I ductular reaction in mice: interactions between the periductal inflammatory and stromal cells and the biliary epithelium. Hepatology (1998) 1.20

Characterization of ductular hepatocytes in end-stage cirrhosis. Arch Pathol Lab Med (1990) 1.20

Role of peroxisome proliferator-activated receptor alpha in altered cell cycle regulation in mouse liver. Carcinogenesis (1998) 1.20

Hydroporphyrins of the meso-tetra(hydroxyphenyl)porphyrin series as tumour photosensitizers. Biochem J (1989) 1.19

Neutral glycolipids of migrating and nonmigrating rabbit corneal epithelium in organ and cell culture. Invest Ophthalmol Vis Sci (1990) 1.19

Immunohistochemical detection of active transforming growth factor-beta in situ using engineered tissue. Am J Pathol (1995) 1.15

Ultrastructure of adult rat hepatocytes cultured on floating collagen membranes. Cancer Res (1978) 1.14

Evaluation of a QRS scoring system for estimating myocardial infarct size. II. Correlation with quantitative anatomic findings for anterior infarcts. Am J Cardiol (1982) 1.13

Oxidative inactivation of cytochrome P-450 1A (CYP1A) stimulated by 3,3',4,4'-tetrachlorobiphenyl: production of reactive oxygen by vertebrate CYP1As. Mol Pharmacol (1999) 1.12

Isolation, culture, and transplantation of human hepatocytes. J Natl Cancer Inst (1982) 1.12

The uptake of L-glutamate by the retina. Brain Res (1976) 1.12

Arthroscopic lysis and lavage as the preferred treatment for internal derangement of the temporomandibular joint. J Oral Maxillofac Surg (2001) 1.12

Effects of di-n-butyl phthalate (DBP) on male reproductive development in the rat: implications for human risk assessment. Food Chem Toxicol (2000) 1.12

IL-18-binding protein protects against lipopolysaccharide- induced lethality and prevents the development of Fas/Fas ligand-mediated models of liver disease in mice. J Immunol (2001) 1.12

Occupational lead exposure, nephropathy, and renal cancer. Am J Ind Med (1980) 1.12

A comparison of the mainstream smoke chemistry and mutagenicity of a representative sample of the US cigarette market with two Kentucky reference cigarettes (K1R4F and K1R5F). Food Chem Toxicol (2000) 1.11

The natural history of the so-called aneurysm of the membranous ventricular septum in childhood. Circulation (1974) 1.10

Hemodynamic effects of isoflurane and halothane in patients with coronary artery disease. Anesth Analg (1976) 1.10

Comparison of the cytotoxic and mutagenic potential of liquid smoke food flavourings, cigarette smoke condensate and wood smoke condensate. Food Chem Toxicol (1999) 1.10

Ductular reaction after submassive necrosis in humans. Special emphasis on analysis of ductular hepatocytes. Am J Pathol (1996) 1.10

Chemical and biological studies of a cigarette that heats rather than burns tobacco. J Clin Pharmacol (1990) 1.10

Congenital abnormalities of the thoracic aorta presenting in the adult. J Thorac Imaging (1994) 1.08

Pathology of recombinant human transforming growth factor-beta 1 in rats and rabbits. Int Rev Exp Pathol (1993) 1.07

Retrospective cardiac gating: a review of technical aspects and future directions. Magn Reson Imaging (1990) 1.07

Binding of alpha 2-macroglobulin to hepatocytes: mechanism of in vivo clearance. Biochem Biophys Res Commun (1985) 1.07

Electrocardiographic evaluation of defibrillation shocks delivered to out-of-hospital sudden cardiac arrest patients. Resuscitation (1999) 1.06

Malignant tumors of the heart and great vessels: MR imaging appearance. Radiographics (1997) 1.06

Myopodin, a synaptopodin homologue, is frequently deleted in invasive prostate cancers. Am J Pathol (2001) 1.06

Effect of BW12C on oxygen affinity of haemoglobin in sickle-cell disease. Lancet (1986) 1.06

Right ventricular outflow tract ventricular tachycardia: detection of previously unrecognized anatomic abnormalities using cine magnetic resonance imaging. J Am Coll Cardiol (1994) 1.05

Custom CAD/CAM total temporomandibular joint reconstruction system: preliminary multicenter report. J Oral Maxillofac Surg (1995) 1.04

New perspectives on rural EMT defibrillation. Ann Emerg Med (1988) 1.04

Brief report: birth status, medical complications, and social environment: individual differences in development of preterm, very low birth weight infants. J Pediatr Psychol (2000) 1.04

NH2-terminal amino acid sequence of rabbit hepatopoietin A, a heparin-binding polypeptide growth factor for hepatocytes. Biochem Biophys Res Commun (1989) 1.04

Hormonal regulation and the effects of glucose on tyrosine aminotransferase activity in adult rat hepatocytes cultured on floating collagen membranes. Cancer Res (1978) 1.03

Morphologic and histochemical analysis of hepatocytes transplanted into syngeneic hosts. Am J Pathol (1980) 1.03

Automatic external defibrillators for public access defibrillation: recommendations for specifying and reporting arrhythmia analysis algorithm performance, incorporating new waveforms, and enhancing safety. A statement for health professionals from the American Heart Association Task Force on Automatic External Defibrillation, Subcommittee on AED Safety and Efficacy. Circulation (1997) 1.03

Longitudinal study of free running exercise challenge: reproducibility. Arch Dis Child (1996) 1.03

Hepatocyte growth factor is a mitogen for Schwann cells and is present in neurofibromas. J Neurosci (1994) 1.02

Cytochrome P-450 induction by phenobarbital and 3-methylcholanthrene in primary cultures of hepatocytes. Science (1976) 1.02

Evaluation of a QRS scoring system for estimating myocardial infarct size. III. Correlation with quantitative anatomic findings for inferior infarcts. Am J Cardiol (1983) 1.01

Kinetic analysis of amino acid uptake by the rat retina in vitro. Br J Pharmacol (1973) 1.00

Peroxisome proliferators alter the expression of estrogen-metabolizing enzymes. Biochimie (1997) 1.00

Are surveillance of resistant enteric bacilli and antimicrobial usage among neonates in a newborn intensive care unit useful? Pediatrics (1981) 1.00

Cell proliferation and apoptosis in normal liver and preneoplastic foci. Environ Health Perspect (1993) 0.99

Identification and partial characterization of receptor binding sites for HGF on rat hepatocytes. Biochem Biophys Res Commun (1990) 0.98

Real-time ultrasonography in the evaluation of urinary stress incontinence. Am J Obstet Gynecol (1980) 0.98

A pilot study of intermittent intravenous cyclophosphamide for the treatment of systemic sclerosis associated lung disease. J Rheumatol (1998) 0.98

Bioactivation and covalent binding of halothane in vitro: studies with [3H]- and [14C]halothane. J Pharmacol Exp Ther (1980) 0.98

Mammary carcinoma cell population growth in preirradiated and unirradiated transplant sites. Viable tumor growth, vascularity, and the tumor-bed effect. Radiology (1975) 0.98

Degeneration and regeneration of the olfactory epithelium following inhalation exposure to methyl bromide: pathology, cell kinetics, and olfactory function. Toxicol Appl Pharmacol (1988) 0.97

Evidence that the fertilization envelope blocks sperm entry in eggs of Xenopus laevis: interaction of sperm with isolated envelopes. Dev Biol (1976) 0.97