Published in Cancer Metastasis Rev on January 01, 1986
Breast cancer classification and prognosis based on gene expression profiles from a population-based study. Proc Natl Acad Sci U S A (2003) 13.00
Murine models to evaluate novel and conventional therapeutic strategies for cancer. Am J Pathol (2007) 3.03
A metastatic nude-mouse model of human pancreatic cancer constructed orthotopically with histologically intact patient specimens. Proc Natl Acad Sci U S A (1992) 2.76
In vivo selection and characterization of metastatic variants from human pancreatic adenocarcinoma by using orthotopic implantation in nude mice. Neoplasia (1999) 2.71
A critical analysis of current in vitro and in vivo angiogenesis assays. Int J Exp Pathol (2009) 2.24
Models of human metastatic colon cancer in nude mice orthotopically constructed by using histologically intact patient specimens. Proc Natl Acad Sci U S A (1991) 2.17
Tissue factor promotes melanoma metastasis by a pathway independent of blood coagulation. Proc Natl Acad Sci U S A (1995) 1.98
Technical considerations for studying cancer metastasis in vivo. Clin Exp Metastasis (1997) 1.62
Activation of estrogen receptor transfected into a receptor-negative breast cancer cell line decreases the metastatic and invasive potential of the cells. Proc Natl Acad Sci U S A (1992) 1.48
Growth and invasion of human melanomas in human skin grafted to immunodeficient mice. Am J Pathol (1993) 1.39
Coordinate role for cell surface chondroitin sulfate proteoglycan and alpha 4 beta 1 integrin in mediating melanoma cell adhesion to fibronectin. J Cell Biol (1992) 1.25
Separable growth and migration factors for large-cell lymphoma cells secreted by microvascular endothelial cells derived from target organs for metastasis. Br J Cancer (1992) 1.21
Metastatic potential of human melanoma cells in nude mice--characterisation of phenotype, cytokine secretion and tumour-associated antigens. Br J Cancer (1996) 1.09
Overexpression of normal and mutated forms of HRAS induces orthotopic bladder invasion in a human transitional cell carcinoma. Proc Natl Acad Sci U S A (1990) 1.09
Can cancer cells transform normal host cells into malignant cells? Br J Cancer (1997) 1.06
Prevention of metastasis in a 4T1 murine breast cancer model by doxorubicin carried by folate conjugated pH sensitive polymeric micelles. J Control Release (2011) 1.04
Effects of inoculation site and Matrigel on growth and metastasis of human breast cancer cells. Br J Cancer (1994) 1.01
Immunobead filtration: a novel approach for the isolation and propagation of tumor cells. Am J Pathol (1997) 1.01
The role of microenvironment in tumor angiogenesis. Genes Nutr (2008) 0.98
Animal models of cancer in the head and neck region. Clin Exp Otorhinolaryngol (2009) 0.95
Establishment of human osteosarcoma cell lines with high metastatic potential to lungs and their utilities for therapeutic studies on metastatic osteosarcoma. Clin Exp Metastasis (2002) 0.94
Urinary-type plasminogen activator receptor/alpha 3 beta 1 integrin signaling, altered gene expression, and oral tumor progression. Mol Cancer Res (2010) 0.91
High collagenolytic activity in spontaneously highly metastatic variants derived from a human pancreatic cancer cell line (SUIT-2) in nude mice. Clin Exp Metastasis (2000) 0.91
NG2 proteoglycan and the actin-binding protein fascin define separate populations of actin-containing filopodia and lamellipodia during cell spreading and migration. Mol Biol Cell (1996) 0.91
A novel spontaneous metastasis model of human osteosarcoma developed using orthotopic transplantation of intact tumor tissue into tibia of nude mice. Clin Exp Metastasis (1997) 0.90
In vivo and in vitro invasion in relation to phenotypic characteristics of human colorectal carcinoma cells. Br J Cancer (1995) 0.89
Nude mice model of human hepatocellular carcinoma via orthotopic implantation of histologically intact tissue. World J Gastroenterol (2004) 0.89
Species-specific metastasis of human tumor cells in the severe combined immunodeficiency mouse engrafted with human tissue. Proc Natl Acad Sci U S A (1995) 0.88
Horizontal transmission of malignancy: in-vivo fusion of human lymphomas with hamster stroma produces tumors retaining human genes and lymphoid pathology. PLoS One (2013) 0.87
Characterization of a highly metastatic, orthotopic lung cancer model in the nude rat. Clin Exp Metastasis (1999) 0.87
Renoprotective effect of human umbilical cord-derived mesenchymal stem cells in immunodeficient mice suffering from acute kidney injury. PLoS One (2012) 0.85
Different patterns of macrophage infiltration into allogeneic-murine and xenogeneic-human neoplasms growing in nude mice. Am J Pathol (1992) 0.83
Challenges and advances in mouse modeling for human pancreatic tumorigenesis and metastasis. Cancer Metastasis Rev (2013) 0.82
Protein kinase activity is associated with CD63 in melanoma cells. J Transl Med (2005) 0.81
Establishment of fluorescent lung carcinoma metastasis model and its real-time microscopic detection in SCID mice. Clin Exp Metastasis (2002) 0.81
Antitumor immune activity by chemokine CX3CL1 in an orthotopic implantation of lung cancer model in vivo. Mol Clin Oncol (2012) 0.81
Establishment of a new human extrahepatic bile duct carcinoma cell line (OCUCh-LM1) and experimental liver metastatic model. Br J Cancer (1995) 0.80
Reliable establishment of human sarcoma xenografts in the nude rat. Sarcoma (1999) 0.79
In-vivo fusion of human cancer and hamster stromal cells permanently transduces and transcribes human DNA. PLoS One (2014) 0.79
The laboratory opossum (Monodelphis domestica) as a natural mammalian model for human cancer research. Int J Clin Exp Pathol (2008) 0.78
UM-SCC-103: a unique tongue cancer cell line that recapitulates the tumorigenic stem cell population of the primary tumor. Ann Otol Rhinol Laryngol (2014) 0.78
Dissection of tumour and host cells from target organs of metastasis for testing gene expression directly ex vivo. Br J Cancer (1996) 0.75
Evaluation of a reductively activated duocarmycin prodrug against murine and human solid cancers. Cancer Biol Ther (2013) 0.75
Establishment of a triple-negative type human breast cancer cell line that selectively metastasizes to the lung after orthotropic implantation. Exp Ther Med (2010) 0.75
Tumor Presence Induces Global Immune Changes and Enhances Nanoparticle Clearance. ACS Nano (2015) 0.75
Characterization of the role of the photosensitizer, deuteporfin, in the detection of lymphatic metastases in a pancreatic cancer xenograft model. Oncol Lett (2015) 0.75
Intracranial Tumor Cell Migration and the Development of Multiple Brain Metastases in Malignant Melanoma. Transl Oncol (2016) 0.75
Timeline metastatic progression: in the wake of the « seed and soil » theory. Med Oncol (2017) 0.75
A unique allogenic model of metastatic pheochromocytoma: PC12 rat pheochromocytoma xenografts to nude mice and establishment of metastases-derived PC12 variants. Clin Exp Metastasis (1998) 0.75
Metastasis results from preexisting variant cells within a malignant tumor. Science (1977) 6.47
The pathogenesis of cancer metastasis. Nature (1980) 5.74
Selection of successive tumour lines for metastasis. Nat New Biol (1973) 5.03
Metastasis: quantitative analysis of distribution and fate of tumor emboli labeled with 125 I-5-iodo-2'-deoxyuridine. J Natl Cancer Inst (1970) 4.88
Biological diversity in metastatic neoplasms: origins and implications. Science (1982) 3.95
Biological behavior of malignant melanoma cells correlated to their survival in vivo. Cancer Res (1975) 3.59
Tumor heterogeneity and the biology of cancer invasion and metastasis. Cancer Res (1978) 3.54
Correlation of patterns of anchorage-independent growth with in vivo behavior of cells from a murine fibrosarcoma. Proc Natl Acad Sci U S A (1980) 3.38
The biology of cancer invasion and metastasis. Adv Cancer Res (1978) 2.94
Orthotopic models are necessary to predict therapy of transplantable tumors in mice. Cancer Metastasis Rev (1999) 2.83
Blockade of NF-kappaB activity in human prostate cancer cells is associated with suppression of angiogenesis, invasion, and metastasis. Oncogene (2001) 2.71
In vivo selection and characterization of metastatic variants from human pancreatic adenocarcinoma by using orthotopic implantation in nude mice. Neoplasia (1999) 2.71
Influence of organ environment on the growth, selection, and metastasis of human colon carcinoma cells in nude mice. Cancer Res (1988) 2.67
Selection of highly metastatic variants of different human prostatic carcinomas using orthotopic implantation in nude mice. Clin Cancer Res (1996) 2.59
The relationship of embolic homogeneity, number, size and viability to the incidence of experimental metastasis. Eur J Cancer (1973) 2.54
Blockade of the epidermal growth factor receptor signaling by a novel tyrosine kinase inhibitor leads to apoptosis of endothelial cells and therapy of human pancreatic carcinoma. Cancer Res (2000) 2.43
In vitro selection of murine B16 melanoma variants with enhanced tissue-invasive properties. Cancer Res (1980) 2.40
Interferon-alpha-mediated down-regulation of angiogenesis-related genes and therapy of bladder cancer are dependent on optimization of biological dose and schedule. Clin Cancer Res (1999) 2.39
Elevated expression of phosphatidylserine in the outer membrane leaflet of human tumor cells and recognition by activated human blood monocytes. Cancer Res (1991) 2.37
In vivo selection of highly metastatic cells from surgical specimens of different primary human colon carcinomas implanted into nude mice. Cancer Res (1988) 2.36
Expression of angiogenesis-related genes and progression of human ovarian carcinomas in nude mice. J Natl Cancer Inst (1998) 2.36
Growth and metastasis of tumor cells isolated from a human renal cell carcinoma implanted into different organs of nude mice. Cancer Res (1986) 2.30
Expression of interleukin 8 correlates with the metastatic potential of human melanoma cells in nude mice. Cancer Res (1994) 2.28
Metastatic heterogeneity of cells from an ultraviolet light-induced murine fibrosarcoma of recent origin. Cancer Res (1978) 2.28
Macrophage-derived metalloelastase is responsible for the generation of angiostatin in Lewis lung carcinoma. Cell (1997) 2.16
Metastatic behavior of human tumor cell lines grown in the nude mouse. Cancer Res (1984) 2.13
Organ selectivity for implantation survival and growth of B16 melanoma variant tumor lines. J Natl Cancer Inst (1976) 2.09
A human melanoma line heterogeneous with respect to metastatic capacity in athymic nude mice. J Natl Cancer Inst (1984) 2.08
Influence of organ environment on extracellular matrix degradative activity and metastasis of human colon carcinoma cells. J Natl Cancer Inst (1990) 2.00
Metastatic model for human prostate cancer using orthotopic implantation in nude mice. J Natl Cancer Inst (1992) 2.00
Specificity of arrest, survival, and growth of selected metastatic variant cell lines. Cancer Res (1978) 1.99
Blockade of nuclear factor-kappaB signaling inhibits angiogenesis and tumorigenicity of human ovarian cancer cells by suppressing expression of vascular endothelial growth factor and interleukin 8. Cancer Res (2000) 1.98
Role of organ selectivity in the determination of metastatic patterns of B16 melanoma. Cancer Res (1980) 1.97
Relative malignant potential of human breast carcinoma cell lines established from pleural effusions and a brain metastasis. Invasion Metastasis (1991) 1.95
Mekk3 is essential for early embryonic cardiovascular development. Nat Genet (2000) 1.95
A simple quantitative assay for studying the invasive potential of high and low human metastatic variants. Cancer Lett (1987) 1.94
Interferons alpha and beta down-regulate the expression of basic fibroblast growth factor in human carcinomas. Proc Natl Acad Sci U S A (1995) 1.87
Interactions among clonal subpopulations affect stability of the metastatic phenotype in polyclonal populations of B16 melanoma cells. Proc Natl Acad Sci U S A (1981) 1.87
Isolation and characterization of metastatic variants from human transitional cell carcinoma passaged by orthotopic implantation in athymic nude mice. J Urol (1995) 1.82
Expression of interleukin-8 correlates with vascularity in human gastric carcinomas. Am J Pathol (1998) 1.75
Angiogenesis and metastasis. Eur J Cancer (1996) 1.72
Level and function of epidermal growth factor receptor predict the metastatic potential of human colon carcinoma cells. Clin Cancer Res (1995) 1.71
Inhibition of murine melanoma experimental metastasis by recombinant desulfatohirudin, a highly specific thrombin inhibitor. Cancer Res (1991) 1.70
The effect of human recombinant macrophage colony-stimulating factor (CSF-1) on the murine mononuclear phagocyte system in vivo. J Immunol (1988) 1.63
In vivo selection of human renal cell carcinoma cells with high metastatic potential in nude mice. Clin Exp Metastasis (1989) 1.62
Destruction of bystander cells by tumor cells transfected with inducible nitric oxide (NO) synthase gene. J Natl Cancer Inst (1997) 1.55
Angiogenesis and breast cancer metastasis. Lancet (1995) 1.55
Expression of interleukin-8 correlates with angiogenesis, tumorigenicity, and metastasis of human prostate cancer cells implanted orthotopically in nude mice. Neoplasia (2001) 1.52
Evidence for the clonal origin of spontaneous metastases. Science (1982) 1.52
Orthotopic and ectopic organ environments differentially influence the sensitivity of murine colon carcinoma cells to doxorubicin and 5-fluorouracil. Int J Cancer (1992) 1.50
Role of natural killer cells in the destruction of circulating tumor emboli. J Natl Cancer Inst (1980) 1.49
Nuclear factor-kappaB activity correlates with growth, angiogenesis, and metastasis of human melanoma cells in nude mice. Clin Cancer Res (2000) 1.48
Acidic pH-induced elevation in interleukin 8 expression by human ovarian carcinoma cells. Cancer Res (2000) 1.47
Metastatic behavior of tumor cells isolated from primary and metastatic human colorectal carcinomas implanted into different sites in nude mice. Cancer Res (1986) 1.47
Constitutive and inducible interleukin 8 expression by hypoxia and acidosis renders human pancreatic cancer cells more tumorigenic and metastatic. Clin Cancer Res (1999) 1.45
Increasing metastatic potential is associated with increasing genetic instability of clones isolated from murine neoplasms. Proc Natl Acad Sci U S A (1981) 1.44
Tyrosine phosphorylation of mitogen-activated protein kinases is necessary for activation of murine macrophages by natural and synthetic bacterial products. J Exp Med (1993) 1.44
Characterization in vivo and in vitro of tumor cells selected for resistance to syngeneic lymphocyte-mediated cytotoxicity. Cancer Res (1976) 1.44
Macrophages and metastasis--a biological approach to cancer therapy. Cancer Res (1985) 1.43
Specific chromosomal defects associated with metastatic potential in K-1735 melanoma clones. Involvement of chromosomes 4 and 14. Cancer Genet Cytogenet (1991) 1.41
Involvement of macrophages in the eradication of established metastases following intravenous injection of liposomes containing macrophage activators. Cancer Res (1982) 1.40
Experimental nude mouse model of human colorectal cancer liver metastases. J Natl Cancer Inst (1986) 1.38
Organ-specific modulation of steady-state mdr gene expression and drug resistance in murine colon cancer cells. J Natl Cancer Inst (1994) 1.37
Transfection with the inducible nitric oxide synthase gene suppresses tumorigenicity and abrogates metastasis by K-1735 murine melanoma cells. J Exp Med (1995) 1.37
Demonstration of multiple phenotypic diversity in a murine melanoma of recent origin. J Natl Cancer Inst (1981) 1.37
Expression of vascular endothelial growth factor is necessary but not sufficient for production and growth of brain metastasis. Cancer Res (2000) 1.36
Eradication of spontaneous metastases and activation of alveolar macrophages by intravenous injection of liposomes containing muramyl dipeptide. Proc Natl Acad Sci U S A (1981) 1.34
Evidence that intravenously derived murine pulmonary melanoma metastases can originate from the expansion of a single tumor cell. Cancer Res (1986) 1.33
Relationship of host immune status to tumor cell arrest, distribution, and survival in experimental metastasis. Cancer (1977) 1.33
Interleukin 8: an autocrine growth factor for human ovarian cancer. Oncol Res (2000) 1.33
Correlation of growth capacity of human tumor cells in hard agarose with their in vivo proliferative capacity at specific metastatic sites. J Natl Cancer Inst (1989) 1.32
Analysis of the fate of systemically administered liposomes and implications for their use in drug delivery. Cancer Res (1982) 1.32
Differential permeability of the blood-brain barrier in experimental brain metastases produced by human neoplasms implanted into nude mice. Am J Pathol (1992) 1.31
Inhibition of pulmonary metastasis by intravenous injection of specifically activated macrophages. Cancer Res (1974) 1.30
Angiogenic molecules and cancer metastasis. In Vivo (1998) 1.30
Inhibition of malignant ascites and growth of human ovarian carcinoma by oral administration of a potent inhibitor of the vascular endothelial growth factor receptor tyrosine kinases. Int J Oncol (2000) 1.28
Angiogenic heterogeneity: regulation of neoplastic angiogenesis by the organ microenvironment. J Natl Cancer Inst (2001) 1.28
Therapy of spontaneous metastases by intravenous injection of liposomes containing lymphokines. Science (1980) 1.28
Natural and recombinant human interleukin 1-beta is cytotoxic for human melanoma cells. J Immunol (1986) 1.27
Modulation of the invasive phenotype of human colon carcinoma cells by organ specific fibroblasts of nude mice. Differentiation (1992) 1.26
Transfection of interleukin-8 increases angiogenesis and tumorigenesis of human gastric carcinoma cells in nude mice. Br J Cancer (1999) 1.26
Production of experimental malignant pleural effusions is dependent on invasion of the pleura and expression of vascular endothelial growth factor/vascular permeability factor by human lung cancer cells. Am J Pathol (2000) 1.26
Characterization of human colon carcinoma variant cells selected for sialyl Lex carbohydrate antigen: liver colonization and adhesion to vascular endothelial cells. Exp Cell Res (1995) 1.25
Differentiation-dependent expression of phosphatidylserine in mammalian plasma membranes: quantitative assessment of outer-leaflet lipid by prothrombinase complex formation. Proc Natl Acad Sci U S A (1989) 1.24
Clonal expansion of cells with trisomy of chromosomes 12 and X in an EBV-transformed lymphoblastoid cell line and establishment of a tumorigenic monoclonal cell line (48,XX,+X,+12). Cytogenet Cell Genet (1993) 1.24
Inhibition of basic fibroblast growth factor expression, angiogenesis, and growth of human bladder carcinoma in mice by systemic interferon-alpha administration. Cancer Res (1998) 1.24
Direct correlation between MUC18 expression and metastatic potential of human melanoma cells. Melanoma Res (1993) 1.23
Design of liposomes to improve delivery of macrophage-augmenting agents to alveolar macrophages. Cancer Res (1980) 1.23
Genetic control of cancer metastasis. J Natl Cancer Inst (1990) 1.23
Correlation of metastasis-related gene expression with metastatic potential in human prostate carcinoma cells implanted in nude mice using an in situ messenger RNA hybridization technique. Am J Pathol (1997) 1.23
Hypoxia-induced elevation in interleukin-8 expression by human ovarian carcinoma cells. Cancer Res (1999) 1.23
A rapid colorimetric in situ messenger RNA hybridization technique for analysis of epidermal growth factor receptor in paraffin-embedded surgical specimens of human colon carcinomas. Cancer Res (1993) 1.22
Role of nitric oxide in lysis of tumor cells by cytokine-activated endothelial cells. Cancer Res (1991) 1.22
Regulation of interleukin-8 expression in human melanoma cells by the organ environment. Cancer Res (1995) 1.21
Different growth pattern and biologic behavior of human renal cell carcinoma implanted into different organs of nude mice. J Natl Cancer Inst (1987) 1.21
Inhibition of growth and metastasis of human pancreatic cancer growing in nude mice by PTK 787/ZK222584, an inhibitor of the vascular endothelial growth factor receptor tyrosine kinases. Cancer Biother Radiopharm (2001) 1.21
Activation in vitro of mouse macrophages by syngeneic, allogeneic, or xenogeneic lymphocyte supernatants. J Natl Cancer Inst (1975) 1.20
Inverse correlation between expression of inducible nitric oxide synthase activity and production of metastasis in K-1735 murine melanoma cells. Cancer Res (1994) 1.19
Increased adherence of sickled and phosphatidylserine-enriched human erythrocytes to cultured human peripheral blood monocytes. J Clin Invest (1985) 1.18