Published in EMBO J on October 01, 1987
Independent and tight regulation of transcriptional units in Escherichia coli via the LacR/O, the TetR/O and AraC/I1-I2 regulatory elements. Nucleic Acids Res (1997) 13.15
How do site-specific DNA-binding proteins find their targets? Nucleic Acids Res (2004) 6.17
Promoters largely determine the efficiency of repressor action. Proc Natl Acad Sci U S A (1988) 4.18
RNA polymerase-promoter interactions: the comings and goings of RNA polymerase. J Bacteriol (1998) 3.16
Promoter architecture in the flagellar regulon of Bacillus subtilis: high-level expression of flagellin by the sigma D RNA polymerase requires an upstream promoter element. Proc Natl Acad Sci U S A (1995) 1.60
Enhanced bacterial protein expression during auto-induction obtained by alteration of lac repressor dosage and medium composition. Biotechnol Prog (2007) 1.51
Defining the consensus sequences of E.coli promoter elements by random selection. Nucleic Acids Res (1988) 1.44
The influence of promoter architectures and regulatory motifs on gene expression in Escherichia coli. PLoS One (2014) 1.44
PL of coliphage lambda: an alternative solution for an efficient promoter. EMBO J (1988) 1.38
Dissecting the functional program of Escherichia coli promoters: the combined mode of action of Lac repressor and AraC activator. Nucleic Acids Res (2001) 1.23
Escherichia coli promoters: neural networks develop distinct descriptions in learning to search for promoters of different spacing classes. Nucleic Acids Res (1992) 1.22
The promoter-search mechanism of Escherichia coli RNA polymerase is dominated by three-dimensional diffusion. Nat Struct Mol Biol (2012) 1.19
Monitoring abortive initiation. Methods (2008) 1.15
Molecular cloning, expression, and characterization of endo-beta-1,4-glucanase genes from Bacillus polymyxa and Bacillus circulans. J Bacteriol (1990) 1.12
The main early and late promoters of Bacillus subtilis phage phi 29 form unstable open complexes with sigma A-RNA polymerase that are stabilized by DNA supercoiling. Nucleic Acids Res (1993) 1.11
Structure of open promoter complexes with Escherichia coli RNA polymerase as revealed by the DNase I footprinting technique: compilation analysis. Nucleic Acids Res (1995) 1.05
Quantitative sequence-activity models (QSAM)--tools for sequence design. Nucleic Acids Res (1993) 1.02
Genetic dissection of the consensus sequence for the class 2 and class 3 flagellar promoters. J Mol Biol (2008) 1.00
Identification of a cDNA for SSRP1, an HMG-box protein, by interaction with the c-Myc oncoprotein in a novel bacterial expression screen. Nucleic Acids Res (1995) 0.99
Mechanism of transcription activation at the comG promoter by the competence transcription factor ComK of Bacillus subtilis. J Bacteriol (2004) 0.94
Complete Bypass of Restriction Systems for Major Staphylococcus aureus Lineages. MBio (2015) 0.94
Location effects of a reporter gene on expression levels and on native protein synthesis in Lactococcus lactis and Saccharomyces cerevisiae. Appl Environ Microbiol (2001) 0.86
Open complex scrunching before nucleotide addition accounts for the unusual transcription start site of E. coli ribosomal RNA promoters. Proc Natl Acad Sci U S A (2016) 0.82
RNA polymerase: a nexus of gene regulation. Methods (2009) 0.82
Evidence against translational repression by the carboxyltransferase component of Escherichia coli acetyl coenzyme A carboxylase. J Bacteriol (2014) 0.80
Method for designing and optimizing random-search libraries for strain improvement. Appl Environ Microbiol (2010) 0.80
Bordetella pertussis fim3 gene regulation by BvgA: phosphorylation controls the formation of inactive vs. active transcription complexes. Proc Natl Acad Sci U S A (2015) 0.77
Transhydrogenase promotes the robustness and evolvability of E. coli deficient in NADPH production. PLoS Genet (2015) 0.77
A simple model for Lutz and Bujard's controllable promoters and its application for analyzing a simple genetic oscillator. In Silico Biol (2015) 0.75
Cell-free synthesis of functional phospholipase A1 from Serratia sp. Biotechnol Biofuels (2016) 0.75
RIP-Seq Suggests Translational Regulation by L7Ae in Archaea. MBio (2017) 0.75
Compilation and analysis of Escherichia coli promoter DNA sequences. Nucleic Acids Res (1983) 38.72
Diffusion-driven mechanisms of protein translocation on nucleic acids. 1. Models and theory. Biochemistry (1981) 9.05
Protein-nucleic acid interactions in transcription: a molecular analysis. Annu Rev Biochem (1984) 8.31
Escherichia coli promoter sequences predict in vitro RNA polymerase selectivity. Nucleic Acids Res (1984) 8.00
Rate-limiting steps in RNA chain initiation. Proc Natl Acad Sci U S A (1980) 5.71
Spacer mutations in the lac ps promoter. Proc Natl Acad Sci U S A (1982) 5.19
Transcription from efficient promoters can interfere with plasmid replication and diminish expression of plasmid specified genes. EMBO J (1982) 4.26
Promoters of Escherichia coli: a hierarchy of in vivo strength indicates alternate structures. EMBO J (1986) 3.89
Functional dissection of Escherichia coli promoters: information in the transcribed region is involved in late steps of the overall process. EMBO J (1986) 3.33
RNA chain growth rates in Escherichia coli. J Mol Biol (1969) 2.87
Interaction of Escherichia coli RNA polymerase with promoters of several coliphage and plasmid DNAs. Proc Natl Acad Sci U S A (1979) 2.58
Nucleotide sequence of the three major early promoters of bacteriophage T7. Nucleic Acids Res (1979) 2.32
Binding of Escherichia coli RNA polymerase holoenzyme to bacteriophage T7 DNA. Measurements of the rate of open complex formation at T7 promoter A. J Mol Biol (1982) 1.18
Tight control of gene expression in mammalian cells by tetracycline-responsive promoters. Proc Natl Acad Sci U S A (1992) 35.45
Transcriptional activation by tetracyclines in mammalian cells. Science (1995) 13.90
Independent and tight regulation of transcriptional units in Escherichia coli via the LacR/O, the TetR/O and AraC/I1-I2 regulatory elements. Nucleic Acids Res (1997) 13.15
Isolation of large molecular weight DNA from agarose gels for further digestion by restriction enzymes. FEBS Lett (1975) 9.87
Organization of transcriptional signals in plasmids pBR322 and pACYC184. Proc Natl Acad Sci U S A (1981) 8.77
Acceleration of the G1/S phase transition by expression of cyclins D1 and E with an inducible system. Mol Cell Biol (1994) 7.40
Exploring the sequence space for tetracycline-dependent transcriptional activators: novel mutations yield expanded range and sensitivity. Proc Natl Acad Sci U S A (2000) 5.99
Doxycycline-mediated quantitative and tissue-specific control of gene expression in transgenic mice. Proc Natl Acad Sci U S A (1996) 5.93
Temporal control of gene expression in transgenic mice by a tetracycline-responsive promoter. Proc Natl Acad Sci U S A (1994) 5.71
A novel in vitro transcription-translation system: accurate and efficient synthesis of single proteins from cloned DNA sequences. EMBO J (1984) 4.50
Transcription from efficient promoters can interfere with plasmid replication and diminish expression of plasmid specified genes. EMBO J (1982) 4.26
A T5 promoter-based transcription-translation system for the analysis of proteins in vitro and in vivo. Methods Enzymol (1987) 4.21
Promoters largely determine the efficiency of repressor action. Proc Natl Acad Sci U S A (1988) 4.18
Promoters of Escherichia coli: a hierarchy of in vivo strength indicates alternate structures. EMBO J (1986) 3.89
Cloning and analysis of strong promoters is made possible by the downstream placement of a RNA termination signal. Proc Natl Acad Sci U S A (1981) 3.77
Regulated expression of foreign genes in mammalian cells under the control of coliphage T3 RNA polymerase and lac repressor. Proc Natl Acad Sci U S A (1989) 3.70
Physical mapping of the HindIII, EcoRI, Sal and Sma restriction endonuclease cleavage fragments from bacteriophage T5 DNA. Mol Gen Genet (1976) 3.66
Physical interaction between heat shock proteins DnaK, DnaJ, and GrpE and the bacterial heat shock transcription factor sigma 32. Cell (1992) 3.46
Functional dissection of Escherichia coli promoters: information in the transcribed region is involved in late steps of the overall process. EMBO J (1986) 3.33
Co-regulation of two gene activities by tetracycline via a bidirectional promoter. Nucleic Acids Res (1995) 3.24
Electron microscopy of size and shape of viral DNA in solutions of different ionic strengths. J Mol Biol (1967) 3.16
Conditional expression and signaling of a specifically designed Gi-coupled receptor in transgenic mice. Nat Biotechnol (1999) 3.04
Tetracycline-controlled transcription in eukaryotes: novel transactivators with graded transactivation potential. Nucleic Acids Res (1997) 2.90
Control of gene activity in higher eukaryotic cells by prokaryotic regulatory elements. Trends Biochem Sci (1993) 2.80
A chimeric transactivator allows tetracycline-responsive gene expression in whole plants. Plant J (1994) 2.73
Tet repressor-based system for regulated gene expression in eukaryotic cells: principles and advances. Methods Enzymol (2000) 2.72
Plasmids controlling synthesis of hemolysin in Escherichia coli: molecular properties. J Bacteriol (1974) 2.71
RNA polymerase II transcription blocked by Escherichia coli lac repressor. Science (1990) 2.65
Interaction of Escherichia coli RNA polymerase with promoters of several coliphage and plasmid DNAs. Proc Natl Acad Sci U S A (1979) 2.58
A cycle of binding and release of the DnaK, DnaJ and GrpE chaperones regulates activity of the Escherichia coli heat shock transcription factor sigma32. EMBO J (1996) 2.55
Electron microscopy of single-stranded DNA. J Mol Biol (1970) 2.42
An electron microscopic method for studying nucleic acid-protein complexes. Visualization of RNA polymerase bound to the DNA of bacteriophages T7 and T3. Biopolymers (1974) 2.24
Tightly regulated and inducible expression of dominant interfering dynamin mutant in stably transformed HeLa cells. Methods Enzymol (1995) 2.19
A tetracycline controlled activation/repression system with increased potential for gene transfer into mammalian cells. J Gene Med (2000) 2.18
lac Repressor blocks transcribing RNA polymerase and terminates transcription. Proc Natl Acad Sci U S A (1986) 2.07
Location of single-strand interruptions in the DNA of bacteriophage T5. Proc Natl Acad Sci U S A (1969) 2.06
Electron microscopic analysis of in vitro transcriptional complexes: mapping of promoters of the coliphage T5 genome. Mol Gen Genet (1978) 2.03
The size of the rII region of bacteriophage T4. Virology (1970) 2.02
Subregions of a conserved part of the HIV gp41 transmembrane protein are differentially recognized by antibodies of infected individuals. EMBO J (1986) 2.01
Promoters recognized by Escherichia coli RNA polymerase selected by function: highly efficient promoters from bacteriophage T5. J Bacteriol (1985) 1.97
Structure and function of the genome of coliphage T5. 1. The physical structure of the chromosome of T5 + . Eur J Biochem (1973) 1.90
Strict control of human immunodeficiency virus type 1 replication by a genetic switch: Tet for Tat. J Virol (2001) 1.89
High susceptibility to bacterial infection, but no liver dysfunction, in mice compromised for hepatocyte NF-kappaB activation. Nat Med (2000) 1.82
Modulation of myosin A expression by a newly established tetracycline repressor-based inducible system in Toxoplasma gondii. Nucleic Acids Res (2001) 1.78
Inducible gene expression systems for higher eukaryotic cells. Curr Opin Biotechnol (1994) 1.69
Polymorphism of the precursor for the major surface antigens of Plasmodium falciparum merozoites: studies at the genetic level. EMBO J (1985) 1.69
Generation of conditional mutants in higher eukaryotes by switching between the expression of two genes. Proc Natl Acad Sci U S A (1999) 1.67
Stalling of Escherichia coli RNA polymerase in the +6 to +12 region in vivo is associated with tight binding to consensus promoter elements. J Mol Biol (1994) 1.66
Isolation of covalently closed circular deoxyribonucleic acid from Streptomyces coelicolor A3(2). J Bacteriol (1975) 1.63
Human antibody response to the major merozoite surface antigen of Plasmodium falciparum is strain specific and short-lived. Infect Immun (1991) 1.55
Photinus pyralis luciferase: vectors that contain a modified luc coding sequence allowing convenient transfer into other systems. Gene (1994) 1.54
Displacement of housekeeping proteasome subunits by MHC-encoded LMPs: a newly discovered mechanism for modulating the multicatalytic proteinase complex. EMBO J (1994) 1.53
Regulation of coliphage T3 and T7 RNA polymerases by the lac repressor-operator system. Gene (1989) 1.46
Doxycycline control of prion protein transgene expression modulates prion disease in mice. Proc Natl Acad Sci U S A (1998) 1.45
Anhydrotetracycline, a novel effector for tetracycline controlled gene expression systems in eukaryotic cells. Nucleic Acids Res (1993) 1.40
PL of coliphage lambda: an alternative solution for an efficient promoter. EMBO J (1988) 1.38
Interaction of E. coli RNA polymerase with promotors of coliphage T5: the rates of complex formation and decay and their correlation with in vitro and in vivo transcriptional activity. Mol Gen Genet (1977) 1.35
Vaccine candidate MSP-1 from Plasmodium falciparum: a redesigned 4917 bp polynucleotide enables synthesis and isolation of full-length protein from Escherichia coli and mammalian cells. Nucleic Acids Res (1999) 1.34
Nonpolymorphic regions of p190, a protein of the Plasmodium falciparum erythrocytic stage, contain both T and B cell epitopes. J Immunol (1988) 1.31
A prospective study of the association between the human humoral immune response to Plasmodium falciparum blood stage antigen gp190 and control of malarial infections. Infect Immun (1993) 1.30
Electron microscopy of DNA: determination of absolute molecular weights and linear density. Mol Gen Genet (1977) 1.27
Efficacy of tetracycline-controlled gene expression is influenced by cell type: commentary. Biotechniques (1995) 1.27
Context-dependent effects of upstream A-tracts. Stimulation or inhibition of Escherichia coli promoter function. J Mol Biol (1994) 1.24
Identification of mammalian cell clones exhibiting highly regulated expression from inducible promoters. Trends Genet (1995) 1.23
Dissecting the functional program of Escherichia coli promoters: the combined mode of action of Lac repressor and AraC activator. Nucleic Acids Res (2001) 1.23
Studies on circular DNA. II. Number of tertiary turns in papilloma DNA. J Mol Biol (1968) 1.20
Epitopes recognized by human T cells map within the conserved part of the GP190 of P. falciparum. Science (1988) 1.19
Structure and function of the genome of coliphage T5. 2. Regions of transcription of the chromosome. Eur J Biochem (1973) 1.19
Development of the human immune response against the major surface protein (gp190) of Plasmodium falciparum. Infect Immun (1989) 1.16
Long-term, noninvasive imaging of regulated gene expression in living mice. Genesis (2001) 1.16
Efficient utilization of Escherichia coli transcriptional signals in Bacillus subtilis. J Mol Biol (1985) 1.13
Tetracycline-regulated gene expression following direct gene transfer into mouse skeletal muscle. Somat Cell Mol Genet (1995) 1.13
Gene therapy progress and prospects: transcription regulatory systems. Gene Ther (2004) 1.10
Tetracycline-regulated gene expression in the brain. Curr Opin Neurobiol (2000) 1.09
Tight control of gene expression by a helper-dependent adenovirus vector carrying the rtTA2(s)-M2 tetracycline transactivator and repressor system. Gene Ther (2002) 1.05
Determinants for protein translocation across mammalian endoplasmic reticulum. Membrane insertion of truncated and full-length prelysozyme molecules. Eur J Biochem (1986) 1.04
Structure and function of the genome of coliphage T5. Transcription in vitro of the "nicked" and "nick-free" T5+ DNA. Eur J Biochem (1975) 0.99
The B lymphocyte-specific coactivator BOB.1/OBF.1 is required at multiple stages of B-cell development. Mol Cell Biol (2001) 0.98
Doxycycline-regulated lentiviral vector system with a novel reverse transactivator rtTA2S-M2 shows a tight control of gene expression in vitro and in vivo. Gene Ther (2003) 0.96
Use of tetracycline-controlled gene expression systems to study mammalian cell cycle. Methods Enzymol (1997) 0.95
Plasmodium falciparum: variations within the C-terminal region of merozoite surface antigen-1. Exp Parasitol (1995) 0.94
Analysis of the human antibody response to thrombospondin-related anonymous protein of Plasmodium falciparum. Infect Immun (1993) 0.93
Controlling genes with tetracyclines. J Gene Med (2000) 0.91
Membrane-associated proteases process Plasmodium falciparum merozoite surface antigen-1 (MSA1) to fragment gp41. Mol Biochem Parasitol (1992) 0.90
Fluorinated pyrimidines. XXVII. Attempts to determine transcription errors during the formation of fluorouracil-containing messenger ribonucleic acid. Biochemistry (1966) 0.90
Epitopes of the human malaria parasite P. falciparum carried on the surface of HBsAg particles elicit an immune response against the parasite. Vaccine (1991) 0.88
A new tool for the serodiagnosis of acute Plasmodium falciparum malaria in individuals with primary infection. J Immunol Methods (1989) 0.87
Regulated and prolonged expression of mIFN(alpha) in immunocompetent mice mediated by a helper-dependent adenovirus vector. Gene Ther (2001) 0.84
A direct and rapid sequencing strategy for the Plasmodium falciparum antigen gene gp190/MSA1. Mol Biochem Parasitol (1995) 0.82
Liver-specific expression of interferon gamma following adenoviral gene transfer controls hepatitis B virus replication in mice. Gene Ther (2005) 0.82
Insertion of transcriptional elements outside the replication region can interfere with replication, maintenance, and stability of Co1E1-derived plasmids. Basic Life Sci (1985) 0.80
Promoter sites in the genome of B. subtilis phage SPP1. Mol Gen Genet (1981) 0.80
Epitope analysis of human T-cell response to MSP-1 of Plasmodium falciparum in malaria-nonexposed individuals. Int Arch Allergy Immunol (1997) 0.80
Double-length, circular, single-stranded DNA from filamentous phage. J Virol (1974) 0.78
The T cell reactivity against the major merozoite protein of Plasmodium falciparum. Immunol Lett (1990) 0.78
Analysis of recombinant merozoite surface protein-1 of Plasmodium falciparum expressed in mammalian cells. Mol Biochem Parasitol (1999) 0.77
Studies on circular deoxyribonucleic acid. I. Isolation of bovine papilloma virus and characterization of its deoxyribonucleic acid. J Virol (1967) 0.76
[Genome structure and transcription control in bacteriophage T5+]. Hoppe Seylers Z Physiol Chem (1972) 0.75
The human antibody response against the major merozoite surface antigen of P. falciparum is mainly directed against non-conserved sequences. Behring Inst Mitt (1991) 0.75