Published in EMBO J on December 30, 1985
Merozoite surface coat precursor protein completely protects Aotus monkeys against Plasmodium falciparum malaria. Proc Natl Acad Sci U S A (1987) 3.31
Primary structure of the merozoite surface antigen 1 of Plasmodium vivax reveals sequences conserved between different Plasmodium species. Proc Natl Acad Sci U S A (1991) 1.95
Variation in the gene encoding a major merozoite surface antigen of the human malaria parasite Plasmodium falciparum. Nucleic Acids Res (1986) 1.69
A 75 kd merozoite surface protein of Plasmodium falciparum which is related to the 70 kd heat-shock proteins. EMBO J (1987) 1.63
Ability of recombinant or native proteins to protect monkeys against heterologous challenge with Plasmodium falciparum. Infect Immun (1991) 1.60
A naturally occurring gene encoding the major surface antigen precursor p190 of Plasmodium falciparum lacks tripeptide repeats. EMBO J (1987) 1.58
Human antibody response to the major merozoite surface antigen of Plasmodium falciparum is strain specific and short-lived. Infect Immun (1991) 1.55
A malaria protein exported into a new compartment within the host erythrocyte. EMBO J (1987) 1.49
Protection against malaria in Aotus monkeys immunized with a recombinant blood-stage antigen fused to a universal T-cell epitope: correlation of serum gamma interferon levels with protection. Infect Immun (1992) 1.45
Immunization with synthetic peptides of a Plasmodium falciparum surface antigen induces antimerozoite antibodies. Proc Natl Acad Sci U S A (1986) 1.32
Immunization of Aotus monkeys with Plasmodium falciparum blood-stage recombinant proteins. Proc Natl Acad Sci U S A (1990) 1.28
Major surface antigen p190 of Plasmodium falciparum: detection of common epitopes present in a variety of plasmodia isolates. EMBO J (1988) 1.17
Development of the human immune response against the major surface protein (gp190) of Plasmodium falciparum. Infect Immun (1989) 1.16
Third form of the precursor to the major merozoite surface antigens of Plasmodium falciparum. Mol Cell Biol (1988) 1.16
Evidence for clonal propagation in natural isolates of Plasmodium falciparum from Venezuela. Proc Natl Acad Sci U S A (2001) 1.14
Roles of conserved and allelic regions of the major merozoite surface protein (gp195) in immunity against Plasmodium falciparum. Infect Immun (1992) 1.14
The 11-1 gene of Plasmodium falciparum codes for distinct fast evolving repeats. EMBO J (1988) 1.08
The 3' portion of the gene for a Plasmodium yoelii merozoite surface antigen encodes the epitope recognized by a protective monoclonal antibody. Proc Natl Acad Sci U S A (1988) 1.06
Immunological cross-reactivity of the C-terminal 42-kilodalton fragment of Plasmodium falciparum merozoite surface protein 1 expressed in baculovirus. Infect Immun (1993) 0.99
Antibody and clinical responses in volunteers to immunization with malaria peptide-diptheria toxoid conjugates. Clin Exp Immunol (1995) 0.78
Conservation of antigen components from two recombinant hybrid proteins protective against malaria. Infect Immun (1993) 0.76
DNA sequencing with chain-terminating inhibitors. Proc Natl Acad Sci U S A (1977) 790.54
New M13 vectors for cloning. Methods Enzymol (1983) 90.74
Screening lambdagt recombinant clones by hybridization to single plaques in situ. Science (1977) 83.82
Human malaria parasites in continuous culture. Science (1976) 59.70
Unidirectional digestion with exonuclease III creates targeted breakpoints for DNA sequencing. Gene (1984) 56.23
Transfer of proteins across membranes. I. Presence of proteolytically processed and unprocessed nascent immunoglobulin light chains on membrane-bound ribosomes of murine myeloma. J Cell Biol (1975) 36.95
Signal sequences. The limits of variation. J Mol Biol (1985) 21.24
A putative signal peptidase recognition site and sequence in eukaryotic and prokaryotic signal peptides. J Mol Biol (1983) 16.07
Compilation of published signal sequences. Nucleic Acids Res (1984) 11.33
Mechanisms for the incorporation of proteins in membranes and organelles. J Cell Biol (1982) 9.67
Structure of the gene encoding the immunodominant surface antigen on the sporozoite of the human malaria parasite Plasmodium falciparum. Science (1984) 8.18
Mechanisms of protein localization. Microbiol Rev (1983) 6.12
Graphic methods to determine the function of nucleic acid sequences. Nucleic Acids Res (1984) 6.08
Immunization against blood-stage rodent malaria using purified parasite antigens. Nature (1981) 4.40
Biosynthesis and processing of a Plasmodium falciparum schizont antigen recognized by immune serum and a monoclonal antibody. J Exp Med (1982) 3.88
Primary structure of the precursor to the three major surface antigens of Plasmodium falciparum merozoites. Nature (1985) 3.19
Conserved sequences flank variable tandem repeats in two S-antigen genes of Plasmodium falciparum. Cell (1985) 2.77
Major surface antigen gene of a human malaria parasite cloned and expressed in bacteria. Nature (1984) 2.74
Structure of the plasmodium knowlesi gene coding for the circumsporozoite protein. Cell (1983) 2.60
The three major antigens on the surface of Plasmodium falciparum merozoites are derived from a single high molecular weight precursor. J Exp Med (1984) 2.40
Monoclonal antibodies against a specific surface determinant on malarial (Plasmodium knowlesi) merozoites block erythrocyte invasion. J Immunol (1981) 2.33
The establishment of genomic DNA libraries for the human malaria parasite Plasmodium falciparum and identification of individual clones by hybridisation. Mol Biochem Parasitol (1982) 2.28
Resistance of ten Thai isolates of Plasmodium falciparum to chloroquine and pyrimethamine by in vitro tests. Trans R Soc Trop Med Hyg (1981) 2.26
Antimalarial immunity in Saimiri monkeys. Immunization with surface components of asexual blood stages. J Exp Med (1984) 2.16
Polymorphism of a high molecular weight schizont antigen of the human malaria parasite Plasmodium falciparum. J Exp Med (1985) 2.15
Antigenic diversity in the human malaria parasite Plasmodium falciparum. Science (1982) 2.09
Antigens of the erythrocytes stages of the human malaria parasite Plasmodium falciparum detected by monoclonal antibodies. Mol Biochem Parasitol (1983) 2.00
The genome of Plasmodium falciparum. I: DNA base composition. Nucleic Acids Res (1982) 1.81
Subcellular distribution of signal recognition particle and 7SL-RNA determined with polypeptide-specific antibodies and complementary DNA probe. J Cell Biol (1983) 1.79
Monoclonal antibodies that protect in vivo against Plasmodium chabaudi recognize a 250,000-dalton parasite polypeptide. Infect Immun (1982) 1.56
Primary structure and genomic organization of the histidine-rich protein of the malaria parasite Plasmodium lophurae. Nature (1985) 1.47
Evidence for immunological cross-reaction between sporozoites and blood stages of a human malaria parasite. Nature (1984) 1.33
Cloning and expression in Escherichia coli of a surface antigen of Plasmodium falciparum merozoites. EMBO J (1985) 1.20
The gene for an exported antigen of the malaria parasite Plasmodium falciparum cloned and expressed in Escherichia coli. Nucleic Acids Res (1985) 1.18
Plasmodium falciparum malaria: band 3 as a possible receptor during invasion of human erythrocytes. Science (1985) 1.13
Characterisation and translation studies of messenger RNA from the human malaria parasite Plasmodium falciparum and construction of a cDNA library. Mol Biochem Parasitol (1984) 1.02
Plasmodium falciparum: characterization of defined antigens by monoclonal antibodies. Clin Exp Immunol (1980) 1.00
Expression of cloned cDNA for a major surface antigen of Plasmodium falciparum merozoites. FEBS Lett (1984) 0.94
Evidence for a malarial parasite interaction site on the major transmembrane protein of the human erythrocyte. Science (1985) 0.93
Tight control of gene expression in mammalian cells by tetracycline-responsive promoters. Proc Natl Acad Sci U S A (1992) 35.45
Transcriptional activation by tetracyclines in mammalian cells. Science (1995) 13.90
Independent and tight regulation of transcriptional units in Escherichia coli via the LacR/O, the TetR/O and AraC/I1-I2 regulatory elements. Nucleic Acids Res (1997) 13.15
The small GTPase rab5 functions as a regulatory factor in the early endocytic pathway. Cell (1992) 10.53
Isolation of large molecular weight DNA from agarose gels for further digestion by restriction enzymes. FEBS Lett (1975) 9.87
Organization of transcriptional signals in plasmids pBR322 and pACYC184. Proc Natl Acad Sci U S A (1981) 8.77
Acceleration of the G1/S phase transition by expression of cyclins D1 and E with an inducible system. Mol Cell Biol (1994) 7.40
Exploring the sequence space for tetracycline-dependent transcriptional activators: novel mutations yield expanded range and sensitivity. Proc Natl Acad Sci U S A (2000) 5.99
Doxycycline-mediated quantitative and tissue-specific control of gene expression in transgenic mice. Proc Natl Acad Sci U S A (1996) 5.93
Temporal control of gene expression in transgenic mice by a tetracycline-responsive promoter. Proc Natl Acad Sci U S A (1994) 5.71
Identification of a retinoic acid responsive element in the retinoic acid receptor beta gene. Nature (1990) 5.50
Allelic dimorphism in a surface antigen gene of the malaria parasite Plasmodium falciparum. J Mol Biol (1987) 5.12
New controlling element in the Lac operon of E. coli. Nature (1968) 4.63
A novel in vitro transcription-translation system: accurate and efficient synthesis of single proteins from cloned DNA sequences. EMBO J (1984) 4.50
Transcription from efficient promoters can interfere with plasmid replication and diminish expression of plasmid specified genes. EMBO J (1982) 4.26
A T5 promoter-based transcription-translation system for the analysis of proteins in vitro and in vivo. Methods Enzymol (1987) 4.21
Promoters largely determine the efficiency of repressor action. Proc Natl Acad Sci U S A (1988) 4.18
1997 Volvo Award winner in clinical studies. Degenerative lumbar spondylolisthesis with spinal stenosis: a prospective, randomized study comparing decompressive laminectomy and arthrodesis with and without spinal instrumentation. Spine (Phila Pa 1976) (1997) 4.17
Promoters of Escherichia coli: a hierarchy of in vivo strength indicates alternate structures. EMBO J (1986) 3.89
Pyrimethamine-sulfadoxine resistance in Plasmodium falciparum: what next? Trends Parasitol (2001) 3.84
Cloning and analysis of strong promoters is made possible by the downstream placement of a RNA termination signal. Proc Natl Acad Sci U S A (1981) 3.77
Mutational alteration of the maximal level of Lac operon expression. Cold Spring Harb Symp Quant Biol (1966) 3.71
Regulated expression of foreign genes in mammalian cells under the control of coliphage T3 RNA polymerase and lac repressor. Proc Natl Acad Sci U S A (1989) 3.70
Physical mapping of the HindIII, EcoRI, Sal and Sma restriction endonuclease cleavage fragments from bacteriophage T5 DNA. Mol Gen Genet (1976) 3.66
Physical interaction between heat shock proteins DnaK, DnaJ, and GrpE and the bacterial heat shock transcription factor sigma 32. Cell (1992) 3.46
Sequence variation of the hydroxymethyldihydropterin pyrophosphokinase: dihydropteroate synthase gene in lines of the human malaria parasite, Plasmodium falciparum, with differing resistance to sulfadoxine. Eur J Biochem (1994) 3.34
Functional dissection of Escherichia coli promoters: information in the transcribed region is involved in late steps of the overall process. EMBO J (1986) 3.33
Bacterial transcript imaging by hybridization of total RNA to oligonucleotide arrays. Nat Biotechnol (1998) 3.29
Co-regulation of two gene activities by tetracycline via a bidirectional promoter. Nucleic Acids Res (1995) 3.24
Electron microscopy of size and shape of viral DNA in solutions of different ionic strengths. J Mol Biol (1967) 3.16
Conditional expression and signaling of a specifically designed Gi-coupled receptor in transgenic mice. Nat Biotechnol (1999) 3.04
Allelic exchange at the endogenous genomic locus in Plasmodium falciparum proves the role of dihydropteroate synthase in sulfadoxine-resistant malaria. EMBO J (1998) 2.94
Tetracycline-controlled transcription in eukaryotes: novel transactivators with graded transactivation potential. Nucleic Acids Res (1997) 2.90
Sulfadoxine resistance in the human malaria parasite Plasmodium falciparum is determined by mutations in dihydropteroate synthetase and an additional factor associated with folate utilization. Mol Microbiol (1997) 2.88
Control of gene activity in higher eukaryotic cells by prokaryotic regulatory elements. Trends Biochem Sci (1993) 2.80
F-prime factor formation in E. coli K12. Genet Res (1966) 2.80
Repression of transcription mediated at a thyroid hormone response element by the v-erb-A oncogene product. Nature (1989) 2.78
Resistance to antifolates in Plasmodium falciparum monitored by sequence analysis of dihydropteroate synthetase and dihydrofolate reductase alleles in a large number of field samples of diverse origins. Mol Biochem Parasitol (1997) 2.77
Major surface antigen gene of a human malaria parasite cloned and expressed in bacteria. Nature (1984) 2.74
A chimeric transactivator allows tetracycline-responsive gene expression in whole plants. Plant J (1994) 2.73
Tet repressor-based system for regulated gene expression in eukaryotic cells: principles and advances. Methods Enzymol (2000) 2.72
Plasmids controlling synthesis of hemolysin in Escherichia coli: molecular properties. J Bacteriol (1974) 2.71
Transcript imaging of the development of human T helper cells using oligonucleotide arrays. Nat Genet (2000) 2.71
RNA polymerase II transcription blocked by Escherichia coli lac repressor. Science (1990) 2.65
Interaction of Escherichia coli RNA polymerase with promoters of several coliphage and plasmid DNAs. Proc Natl Acad Sci U S A (1979) 2.58
A cycle of binding and release of the DnaK, DnaJ and GrpE chaperones regulates activity of the Escherichia coli heat shock transcription factor sigma32. EMBO J (1996) 2.55
Rapid and label-free nanomechanical detection of biomarker transcripts in human RNA. Nat Nanotechnol (2006) 2.53
Electron microscopy of single-stranded DNA. J Mol Biol (1970) 2.42
AN EPIDEMIC OF JAUNDICE. Can Med Assoc J (1913) 2.40
Episomes. Annu Rev Microbiol (1967) 2.36
The establishment of genomic DNA libraries for the human malaria parasite Plasmodium falciparum and identification of individual clones by hybridisation. Mol Biochem Parasitol (1982) 2.28
An electron microscopic method for studying nucleic acid-protein complexes. Visualization of RNA polymerase bound to the DNA of bacteriophages T7 and T3. Biopolymers (1974) 2.24
Identification of a single promoter in E. coli for rplJ, rplL and rpoBC. Nature (1978) 2.22
Tightly regulated and inducible expression of dominant interfering dynamin mutant in stably transformed HeLa cells. Methods Enzymol (1995) 2.19
A tetracycline controlled activation/repression system with increased potential for gene transfer into mammalian cells. J Gene Med (2000) 2.18
A myosin-like dimerization helix and an extra-large homeodomain are essential elements of the tripartite DNA binding structure of LFB1. Cell (1990) 2.09
lac Repressor blocks transcribing RNA polymerase and terminates transcription. Proc Natl Acad Sci U S A (1986) 2.07
Promoter recognition and promoter strength in the Escherichia coli system. EMBO J (1987) 2.07
Location of single-strand interruptions in the DNA of bacteriophage T5. Proc Natl Acad Sci U S A (1969) 2.06
The serum-inducible mouse gene Krox-24 encodes a sequence-specific transcriptional activator. Mol Cell Biol (1990) 2.04
Measuring and modelling surgical bed usage. Ann R Coll Surg Engl (2000) 2.03
Electron microscopic analysis of in vitro transcriptional complexes: mapping of promoters of the coliphage T5 genome. Mol Gen Genet (1978) 2.03
The size of the rII region of bacteriophage T4. Virology (1970) 2.02
Subregions of a conserved part of the HIV gp41 transmembrane protein are differentially recognized by antibodies of infected individuals. EMBO J (1986) 2.01
Antigens of the erythrocytes stages of the human malaria parasite Plasmodium falciparum detected by monoclonal antibodies. Mol Biochem Parasitol (1983) 2.00
Promoters recognized by Escherichia coli RNA polymerase selected by function: highly efficient promoters from bacteriophage T5. J Bacteriol (1985) 1.97
Amino-terminal domain of NF1 binds to DNA as a dimer and activates adenovirus DNA replication. EMBO J (1990) 1.95
Structure and function of the genome of coliphage T5. 1. The physical structure of the chromosome of T5 + . Eur J Biochem (1973) 1.90
Strict control of human immunodeficiency virus type 1 replication by a genetic switch: Tet for Tat. J Virol (2001) 1.89
High susceptibility to bacterial infection, but no liver dysfunction, in mice compromised for hepatocyte NF-kappaB activation. Nat Med (2000) 1.82
Obesity and asthma in 11-12 year old New Zealand children in 1989 and 2000. Thorax (2005) 1.82
Modulation of myosin A expression by a newly established tetracycline repressor-based inducible system in Toxoplasma gondii. Nucleic Acids Res (2001) 1.78
Evidence for a lambda transducing phage carrying the genes for the beta and beta' subunits of Escherichia coli RNA polymerase. Mol Gen Genet (1974) 1.75
Characterisation of the dihydrofolate reductase-thymidylate synthetase gene from human malaria parasites highly resistant to pyrimethamine. Gene (1989) 1.70
Inducible gene expression systems for higher eukaryotic cells. Curr Opin Biotechnol (1994) 1.69
A new method for selecting RNA polymerase mutants. J Mol Biol (1970) 1.68
Generation of conditional mutants in higher eukaryotes by switching between the expression of two genes. Proc Natl Acad Sci U S A (1999) 1.67
Stalling of Escherichia coli RNA polymerase in the +6 to +12 region in vivo is associated with tight binding to consensus promoter elements. J Mol Biol (1994) 1.66
Pyrimethamine resistant mutations in Plasmodium falciparum. Mol Biochem Parasitol (1992) 1.66
Isolation of covalently closed circular deoxyribonucleic acid from Streptomyces coelicolor A3(2). J Bacteriol (1975) 1.63
Glucocorticoid receptor binds cooperatively to adjacent recognition sites. EMBO J (1989) 1.61
Yeast may not contain histone H1: the only known 'histone H1-like' protein in Saccharomyces cerevisiae is a mitochondrial protein. Nucleic Acids Res (1984) 1.61
Characterisation of a repetitive DNA sequence from the malaria parasite, Plasmodium falciparum. Mol Biochem Parasitol (1986) 1.61
Seat belts and risk compensation. Br Med J (Clin Res Ed) (1985) 1.57
Human antibody response to the major merozoite surface antigen of Plasmodium falciparum is strain specific and short-lived. Infect Immun (1991) 1.55
Photinus pyralis luciferase: vectors that contain a modified luc coding sequence allowing convenient transfer into other systems. Gene (1994) 1.54
Displacement of housekeeping proteasome subunits by MHC-encoded LMPs: a newly discovered mechanism for modulating the multicatalytic proteinase complex. EMBO J (1994) 1.53
A malaria protein exported into a new compartment within the host erythrocyte. EMBO J (1987) 1.49
Cloning and characterisation of the rRNA genes from the human malaria parasite Plasmodium falciparum. Nucleic Acids Res (1983) 1.47
Occipital condyle fractures. Neurosurgery (1997) 1.47