Published in J Virol on September 01, 1985
Isolation and characterization of deletion mutants of herpes simplex virus type 1 in the gene encoding immediate-early regulatory protein ICP4. J Virol (1985) 8.12
Immediate-early regulatory gene mutants define different stages in the establishment and reactivation of herpes simplex virus latency. J Virol (1989) 5.77
Deletion mutants in the gene encoding the herpes simplex virus type 1 immediate-early protein ICP0 exhibit impaired growth in cell culture. J Virol (1987) 5.71
Detection of herpes simplex virus type 1 transcripts during latent infection in mice. J Virol (1987) 5.12
A deletion mutant of the latency-associated transcript of herpes simplex virus type 1 reactivates from the latent state with reduced frequency. J Virol (1989) 4.85
Herpes simplex virus type 1 ICP27 deletion mutants exhibit altered patterns of transcription and are DNA deficient. J Virol (1989) 4.18
Alpha 4, the major regulatory protein of herpes simplex virus type 1, is stably and specifically associated with promoter-regulatory domains of alpha genes and of selected other viral genes. Proc Natl Acad Sci U S A (1986) 3.64
Herpes simplex virus type 1 ICP0 plays a critical role in the de novo synthesis of infectious virus following transfection of viral DNA. J Virol (1989) 3.63
Genetic evidence for two distinct transactivation functions of the herpes simplex virus alpha protein ICP27. J Virol (1990) 3.63
The herpes simplex virus type 1 regulatory protein ICP0 enhances virus replication during acute infection and reactivation from latency. J Virol (1993) 3.43
The herpes simplex virus type 1 alpha protein ICP27 can act as a trans-repressor or a trans-activator in combination with ICP4 and ICP0. J Virol (1988) 3.33
Construction and characterization of a herpes simplex virus type 1 mutant unable to transinduce immediate-early gene expression. J Virol (1989) 3.19
Physical and functional domains of the herpes simplex virus transcriptional regulatory protein ICP4. J Virol (1988) 3.14
Herpes simplex virus type 1 ICP0 regulates expression of immediate-early, early, and late genes in productively infected cells. J Virol (1992) 3.10
Binding of the herpes simplex virus immediate-early gene product ICP4 to its own transcription start site. J Virol (1987) 3.09
Gene-specific transactivation by herpes simplex virus type 1 alpha protein ICP27. J Virol (1988) 3.08
Herpes simplex virus inhibits host cell splicing, and regulatory protein ICP27 is required for this effect. J Virol (1994) 3.07
ICP27 mediates HSV RNA export by shuttling through a leucine-rich nuclear export signal and binding viral intronless RNAs through an RGG motif. Genes Dev (1998) 2.99
Persistence and expression of the herpes simplex virus genome in the absence of immediate-early proteins. J Virol (1998) 2.97
DNA-binding site of major regulatory protein alpha 4 specifically associated with promoter-regulatory domains of alpha genes of herpes simplex virus type 1. Proc Natl Acad Sci U S A (1986) 2.85
An activity specified by the osteosarcoma line U2OS can substitute functionally for ICP0, a major regulatory protein of herpes simplex virus type 1. J Virol (1995) 2.82
Expression of herpes simplex virus type 1 latency-associated transcripts in the trigeminal ganglia of mice during acute infection and reactivation of latent infection. J Virol (1988) 2.80
UL69 of human cytomegalovirus, an open reading frame with homology to ICP27 of herpes simplex virus, encodes a transactivator of gene expression. J Virol (1994) 2.69
Transcriptional control signals of a herpes simplex virus type 1 late (gamma 2) gene lie within bases -34 to +124 relative to the 5' terminus of the mRNA. Mol Cell Biol (1986) 2.65
A detailed mutational analysis of Vmw110, a trans-acting transcriptional activator encoded by herpes simplex virus type 1. EMBO J (1987) 2.56
The herpes simplex virus regulatory protein ICP27 contributes to the decrease in cellular mRNA levels during infection. J Virol (1994) 2.51
The promoter of the latency-associated transcripts of herpes simplex virus type 1 contains a functional cAMP-response element: role of the latency-associated transcripts and cAMP in reactivation of viral latency. Proc Natl Acad Sci U S A (1991) 2.47
Expression of herpes simplex virus ICP0 inhibits the induction of interferon-stimulated genes by viral infection. J Virol (2002) 2.38
Herpes simplex virus virion host shutoff protein: immune evasion mediated by a viral RNase? J Virol (2004) 2.35
The RGG box motif of the herpes simplex virus ICP27 protein mediates an RNA-binding activity and determines in vivo methylation. J Virol (1996) 2.35
A LAT-associated function reduces productive-cycle gene expression during acute infection of murine sensory neurons with herpes simplex virus type 1. J Virol (1997) 2.35
A herpes simplex virus type 1 immediate-early gene product, IE63, regulates small nuclear ribonucleoprotein distribution. Proc Natl Acad Sci U S A (1993) 2.31
Herpes simplex virus IE63 acts at the posttranscriptional level to stimulate viral mRNA 3' processing. J Virol (1992) 2.29
A novel class of transcripts expressed with late kinetics in the absence of ICP4 spans the junction between the long and short segments of the herpes simplex virus type 1 genome. J Virol (1993) 2.28
Shuttling of the herpes simplex virus type 1 regulatory protein ICP27 between the nucleus and cytoplasm mediates the expression of late proteins. J Virol (1997) 2.27
A cellular function can enhance gene expression and plating efficiency of a mutant defective in the gene for ICP0, a transactivating protein of herpes simplex virus type 1. J Virol (1991) 2.25
ICP4, the major transcriptional regulatory protein of herpes simplex virus type 1, forms a tripartite complex with TATA-binding protein and TFIIB. J Virol (1993) 2.16
RNA polymerase II is aberrantly phosphorylated and localized to viral replication compartments following herpes simplex virus infection. J Virol (1994) 2.12
Varicella-zoster virus open reading frame 61 protein is functionally homologous to herpes simplex virus type 1 ICP0. J Virol (1992) 2.09
The herpes simplex virus type 1 regulatory protein ICP27 is required for the prevention of apoptosis in infected human cells. J Virol (1999) 2.06
Separation of requirements for protein-DNA complex assembly from those for functional activity in the herpes simplex virus regulatory protein Vmw65. J Virol (1989) 2.06
The herpes simplex virus immediate-early protein ICP0 affects transcription from the viral genome and infected-cell survival in the absence of ICP4 and ICP27. J Virol (1997) 2.06
Evidence for a novel regulatory pathway for herpes simplex virus gene expression in trigeminal ganglion neurons. J Virol (1993) 2.01
The regions important for the activator and repressor functions of herpes simplex virus type 1 alpha protein ICP27 map to the C-terminal half of the molecule. J Virol (1989) 1.99
Herpes simplex virus immediate-early promoters are responsive to virus and cell trans-acting factors. J Virol (1987) 1.96
Replacement mutagenesis of the human cytomegalovirus genome: US10 and US11 gene products are nonessential. J Virol (1991) 1.96
Global analysis of herpes simplex virus type 1 transcription using an oligonucleotide-based DNA microarray. J Virol (2000) 1.95
Herpes simplex viruses with mutations in the gene encoding ICP0 are defective in gene expression. J Virol (1992) 1.92
Construction and properties of a viable herpes simplex virus 1 recombinant lacking coding sequences of the alpha 47 gene. J Virol (1986) 1.89
Identification of nuclear and nucleolar localization signals in the herpes simplex virus regulatory protein ICP27. J Virol (1995) 1.85
The regions of the herpes simplex virus type 1 immediate early protein Vmw175 required for site specific DNA binding closely correspond to those involved in transcriptional regulation. Nucleic Acids Res (1988) 1.78
Cell lines containing varicella-zoster virus open reading frame 62 and expressing the "IE" 175 protein complement ICP4 mutants of herpes simplex virus type 1. J Virol (1988) 1.78
Identification of a promoter mapping within the reiterated sequences that flank the herpes simplex virus type 1 UL region. J Virol (1993) 1.77
ICP27 recruits Aly/REF but not TAP/NXF1 to herpes simplex virus type 1 transcription sites although TAP/NXF1 is required for ICP27 export. J Virol (2005) 1.77
Association of ICP0 but not ICP27 with purified virions of herpes simplex virus type 1. J Virol (1992) 1.76
A mutant herpesvirus protein leads to a block in nuclear localization of other viral proteins. Mol Cell Biol (1986) 1.75
A specific subform of the human cytomegalovirus transactivator protein pUL69 is contained within the tegument of virus particles. J Virol (1996) 1.74
Activation of gene expression by herpes simplex virus type 1 ICP0 occurs at the level of mRNA synthesis. J Virol (1997) 1.72
Repression of gene expression upon infection of cells with herpes simplex virus type 1 mutants impaired for immediate-early protein synthesis. J Virol (1997) 1.70
Regulation of the herpes simplex virus type 1 late (gamma 2) glycoprotein C gene: sequences between base pairs -34 to +29 control transient expression and responsiveness to transactivation by the products of the immediate early (alpha) 4 and 0 genes. Nucleic Acids Res (1987) 1.68
Cooperativity among herpes simplex virus type 1 immediate-early regulatory proteins: ICP4 and ICP27 affect the intracellular localization of ICP0. J Virol (1994) 1.66
Herpes simplex virus type 1 immediate-early protein Vmw110 inhibits progression of cells through mitosis and from G(1) into S phase of the cell cycle. J Virol (1999) 1.66
Induction and prevention of apoptosis in human HEp-2 cells by herpes simplex virus type 1. J Virol (1999) 1.64
Varicella-zoster virus complements herpes simplex virus type 1 temperature-sensitive mutants. J Virol (1987) 1.64
Herpes simplex virus type 1 and bovine herpesvirus 1 latency. Clin Microbiol Rev (2003) 1.62
Herpes simplex ICP27 mutant viruses exhibit reduced expression of specific DNA replication genes. J Virol (1996) 1.61
The acidic amino-terminal region of herpes simplex virus type 1 alpha protein ICP27 is required for an essential lytic function. J Virol (1993) 1.59
Herpes simplex virus alpha protein ICP27 possesses separable positive and negative regulatory activities. J Virol (1989) 1.59
The control of herpes simplex virus type-1 late gene transcription: a 'TATA-box'/cap site region is sufficient for fully efficient regulated activity. Nucleic Acids Res (1986) 1.58
Regulation of herpes simplex virus poly (A) site usage and the action of immediate-early protein IE63 in the early-late switch. J Virol (1996) 1.57
Characterization and nucleotide sequence of two herpes simplex virus 1 genes whose products modulate alpha-trans-inducing factor-dependent activation of alpha genes. J Virol (1987) 1.57
Activation of the human immunodeficiency virus by herpes simplex virus type 1. J Virol (1987) 1.55
A major transcriptional regulatory protein (ICP4) of herpes simplex virus type 1 is associated with purified virions. J Virol (1989) 1.55
Analysis of the herpes simplex virus type 1 promoter controlling the expression of UL38, a true late gene involved in capsid assembly. J Virol (1991) 1.54
Varicella-zoster virus open reading frame 4 protein is functionally distinct from and does not complement its herpes simplex virus type 1 homolog, ICP27. J Virol (1994) 1.52
Expression of herpes simplex virus type 1 major DNA-binding protein, ICP8, in transformed cell lines: complementation of deletion mutants and inhibition of wild-type virus. J Virol (1987) 1.51
Herpes simplex virus type 1 oriL is not required for virus replication or for the establishment and reactivation of latent infection in mice. J Virol (1987) 1.51
Functional interactions between herpes simplex virus immediate-early proteins during infection: gene expression as a consequence of ICP27 and different domains of ICP4. J Virol (1995) 1.48
Repression of host RNA polymerase II transcription by herpes simplex virus type 1. J Virol (1997) 1.46
Amino acid substitution mutations in the herpes simplex virus ICP27 protein define an essential gene regulation function. J Virol (1994) 1.45
Mutational analysis of the herpes simplex virus type 1 ICP0 C3HC4 zinc ring finger reveals a requirement for ICP0 in the expression of the essential alpha27 gene. J Virol (1997) 1.45
Physical interaction between the herpes simplex virus type 1 immediate-early regulatory proteins ICP0 and ICP4. J Virol (1994) 1.45
Association of herpes simplex virus type 1 ICP8 and ICP27 proteins with cellular RNA polymerase II holoenzyme. J Virol (2002) 1.43
Functional interaction between pleiotropic transactivator pUL69 of human cytomegalovirus and the human homolog of yeast chromatin regulatory protein SPT6. J Virol (2000) 1.41
Prolonged gene expression and cell survival after infection by a herpes simplex virus mutant defective in the immediate-early genes encoding ICP4, ICP27, and ICP22. J Virol (1996) 1.40
Herpes simplex virus IE63 (ICP27) protein interacts with spliceosome-associated protein 145 and inhibits splicing prior to the first catalytic step. J Virol (2001) 1.38
Evaluation of colocalization interactions between the IE110, IE175, and IE63 transactivator proteins of herpes simplex virus within subcellular punctate structures. J Virol (1995) 1.38
Physical and functional interactions between herpes simplex virus immediate-early proteins ICP4 and ICP27. J Virol (1997) 1.38
Structure and expression of murine cytomegalovirus immediate-early gene 2. J Virol (1991) 1.37
Two herpes simplex virus type 1 latency-active promoters differ in their contributions to latency-associated transcript expression during lytic and latent infections. J Virol (1995) 1.37
Mapping of intracellular localization domains and evidence for colocalization interactions between the IE110 and IE175 nuclear transactivator proteins of herpes simplex virus. J Virol (1994) 1.37
Restricted expression of herpes simplex virus lytic genes during establishment of latent infection by thymidine kinase-negative mutant viruses. J Virol (1990) 1.35
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