Published in J Biol Chem on July 05, 1986
Inhibition of NIH 3T3 cell proliferation by a mutant ras protein with preferential affinity for GDP. Mol Cell Biol (1988) 7.06
Macrophage PPAR gamma is required for normal skeletal muscle and hepatic insulin sensitivity and full antidiabetic effects of thiazolidinediones. J Clin Invest (2007) 4.86
Fatty acid-induced beta cell apoptosis: a link between obesity and diabetes. Proc Natl Acad Sci U S A (1998) 4.72
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Effect of a dominant inhibitory Ha-ras mutation on mitogenic signal transduction in NIH 3T3 cells. Mol Cell Biol (1990) 2.46
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Deregulated expression of human c-jun transforms primary rat embryo cells in cooperation with an activated c-Ha-ras gene and transforms rat-1a cells as a single gene. Proc Natl Acad Sci U S A (1989) 2.13
Myocardial expression of a constitutively active alpha 1B-adrenergic receptor in transgenic mice induces cardiac hypertrophy. Proc Natl Acad Sci U S A (1994) 2.05
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Opposing effects of a ras oncogene on growth factor-stimulated phosphoinositide hydrolysis: desensitization to platelet-derived growth factor and enhanced sensitivity to bradykinin. Proc Natl Acad Sci U S A (1987) 1.52
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Functional expression of Fas and Fas ligand on human gut lamina propria T lymphocytes. A potential role for the acidic sphingomyelinase pathway in normal immunoregulation. J Clin Invest (1996) 1.36
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Inositol phospholipid metabolism may trigger flagellar excision in Chlamydomonas reinhardtii. J Cell Biol (1992) 1.34
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Enhanced superoxide release and elevated protein kinase C activity in neutrophils from diabetic patients: association with periodontitis. J Leukoc Biol (2005) 1.31
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Phospholipase D activation is functionally linked to superoxide generation in the human neutrophil. Biochem J (1989) 1.28
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Inhibition of carnitine palmitoyltransferase-1 activity alleviates insulin resistance in diet-induced obese mice. Diabetes (2012) 1.26
v-Src increases diacylglycerol levels via a type D phospholipase-mediated hydrolysis of phosphatidylcholine. Mol Cell Biol (1991) 1.26
Role of the ceramide-signaling pathway in cytokine responses to P-fimbriated Escherichia coli. J Exp Med (1996) 1.26
Calcium influx stimulates a second pathway for sustained diacylglycerol production in leukocytes activated by chemoattractants. Proc Natl Acad Sci U S A (1988) 1.25
Retinoblastoma gene product as a downstream target for a ceramide-dependent pathway of growth arrest. Proc Natl Acad Sci U S A (1995) 1.24
Demethoxyviridin and wortmannin block phospholipase C and D activation in the human neutrophil. Br J Pharmacol (1991) 1.22
A pathway in the yeast cell division cycle linking protein kinase C (Pkc1) to activation of Cdc28 at START. EMBO J (1996) 1.21
Transmembrane signaling by interferon alpha involves diacylglycerol production and activation of the epsilon isoform of protein kinase C in Daudi cells. Proc Natl Acad Sci U S A (1991) 1.19
Stimulation of DNA synthesis by natural ceramide 1-phosphate. Biochem J (1997) 1.19
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Interferon-alpha selectively activates the beta isoform of protein kinase C through phosphatidylcholine hydrolysis. Proc Natl Acad Sci U S A (1990) 1.19
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Role of diacylglycerol kinase alpha in the attenuation of receptor signaling. J Cell Biol (2001) 1.18
Dietary omega-3 polyunsaturated fatty acids inhibit phosphoinositide formation and chemotaxis in neutrophils. J Clin Invest (1993) 1.17
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Evidence for a role of phosphatidylcholine-hydrolysing phospholipase C in the regulation of protein kinase C by ras and src oncogenes. EMBO J (1990) 1.16
A tumour promoter, 12-O-tetradecanoylphorbol 13-acetate, increases cellular 1,2-diacylglycerol content through a mechanism other than phosphoinositide hydrolysis in Swiss-mouse 3T3 fibroblasts. Biochem J (1987) 1.16
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Cytokine response modifier A (CrmA) inhibits ceramide formation in response to tumor necrosis factor (TNF)-alpha: CrmA and Bcl-2 target distinct components in the apoptotic pathway. J Exp Med (1997) 1.15
Elevated phosphocholine concentration in ras-transformed NIH 3T3 cells arises from increased choline kinase activity, not from phosphatidylcholine breakdown. Mol Cell Biol (1989) 1.14
Escherichia coli hemolysin is a potent inductor of phosphoinositide hydrolysis and related metabolic responses in human neutrophils. J Clin Invest (1991) 1.13
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The temporal relationship between phospholipase activation, diradylglycerol formation and superoxide production in the human neutrophil. Biochem J (1990) 1.13
Myocardial ATGL overexpression decreases the reliance on fatty acid oxidation and protects against pressure overload-induced cardiac dysfunction. Mol Cell Biol (2011) 1.13
Examination of 'lipotoxicity' in skeletal muscle of high-fat fed and ob/ob mice. J Physiol (2009) 1.13
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Cloning and expression of a human choline/ethanolaminephosphotransferase: synthesis of phosphatidylcholine and phosphatidylethanolamine. Biochem J (1999) 1.10
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Dexamethasone-dependent inhibition of differentiation of C2 myoblasts bearing steroid-inducible N-ras oncogenes. J Cell Biol (1988) 1.09
The biochemistry of ras p21. Biochem J (1991) 1.08
HSP72 is a mitochondrial stress sensor critical for Parkin action, oxidative metabolism, and insulin sensitivity in skeletal muscle. Diabetes (2013) 1.07
The regulation of phospholipase D activity and its role in sn-1,2-diradylglycerol formation in bombesin- and phorbol 12-myristate 13-acetate-stimulated Swiss 3T3 cells. Biochem J (1991) 1.05
Coupling of the thrombin receptor to G12 may account for selective effects of thrombin on gene expression and DNA synthesis in 1321N1 astrocytoma cells. Mol Biol Cell (1996) 1.04
NIH-3T3 cells transformed by the EJ-ras oncogene exhibit reduced platelet-derived growth factor-mediated Ca2+ mobilization. Proc Natl Acad Sci U S A (1988) 1.04
1,25(OH)2 vitamin D3 stimulates membrane phosphoinositide turnover, activates protein kinase C, and increases cytosolic calcium in rat colonic epithelium. J Clin Invest (1990) 1.03
Cells that overproduce protein kinase C are more susceptible to transformation by an activated H-ras oncogene. Mol Cell Biol (1989) 1.03
Sex-related survival differences in murine cardiomyopathy are associated with differences in TNF-receptor expression. J Clin Invest (2000) 1.03
Regulation of Clostridium perfringens alpha-toxin-activated phospholipase C in rabbit erythrocyte membranes. Infect Immun (1994) 1.03
The phase behavior of mixed aqueous dispersions of dipalmitoyl derivatives of phosphatidylcholine and diacylglycerol. Biophys J (1994) 1.02
Lipid lateral heterogeneity in phosphatidylcholine/phosphatidylserine/diacylglycerol vesicles and its influence on protein kinase C activation. Biophys J (1996) 1.01
Sustained increase in 1,2-diacylglycerol precedes DNA synthesis in epidermal-growth-factor-stimulated fibroblasts. Evidence for stimulated phosphatidylcholine hydrolysis. Biochem J (1990) 1.01
Neurotensin stimulates inositol trisphosphate-mediated calcium mobilization but not protein kinase C activation in HT29 cells. Involvement of a G-protein. Biochem J (1989) 1.01
Light-Stimulated Inositol Phospholipid Turnover in Samanea saman Pulvini : Increased Levels of Diacylglycerol. Plant Physiol (1989) 1.00
NIH 3T3 cells stably transfected with the gene encoding phosphatidylcholine-hydrolyzing phospholipase C from Bacillus cereus acquire a transformed phenotype. Mol Cell Biol (1994) 0.99
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Evidence for coupling of Clostridium perfringens alpha-toxin-induced hemolysis to stimulated phosphatidic acid formation in rabbit erythrocytes. Infect Immun (1993) 0.97
Phosphatidylcholine synthesis influences the diacylglycerol homeostasis required for SEC14p-dependent Golgi function and cell growth. Mol Biol Cell (2001) 0.97
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Diacylglycerol production in Xenopus laevis oocytes after microinjection of p21ras proteins is a consequence of activation of phosphatidylcholine metabolism. Mol Cell Biol (1990) 0.96
Serum stimulation of NIH 3T3 cells induces the production of lipids able to inhibit GTPase-activating protein activity. Mol Cell Biol (1990) 0.95
Transformation stimulates glucose transporter gene expression in the absence of protein kinase C. Proc Natl Acad Sci U S A (1989) 0.95
Regulation of the CDP-choline pathway by sterol regulatory element binding proteins involves transcriptional and post-transcriptional mechanisms. Biochem J (2003) 0.94
Epidermal growth factor increases sn-1,2-diacylglycerol levels and activates phospholipase D-catalysed phosphatidylcholine breakdown in Swiss 3T3 cells in the absence of inositol-lipid hydrolysis. Biochem J (1992) 0.94
Role of phosphatidylinositide metabolism in ras-induced Xenopus oocyte maturation. Mol Cell Biol (1990) 0.94
Phorbol ester and bryostatin differentially regulate the hydrolysis of phosphatidylethanolamine in Ha-ras- and raf-oncogene-transformed NIH 3T3 cells. Biochem J (1991) 0.94
Regulation of plasma ceramide levels with fatty acid oversupply: evidence that the liver detects and secretes de novo synthesised ceramide. Diabetologia (2012) 0.93
Diacylglycerol kinase from suspension cultured plant cells : characterization and subcellular localization. Plant Physiol (1992) 0.93
Effect of inhibition of angiotensin converting enzyme and/or neutral endopeptidase on vascular and neural complications in high fat fed/low dose streptozotocin-diabetic rats. Eur J Pharmacol (2011) 0.92
Characterization and quantification of diacylglycerol species in biological extracts after one-step derivatization: a shotgun lipidomics approach. Anal Chem (2014) 0.91
Thyroid-stimulating hormone and insulin-like growth factor-1 synergize to elevate 1,2-diacylglycerol in rat thyroid cells. Stimulation of DNA synthesis via interaction between lipid and adenylyl cyclase signal transduction systems. J Clin Invest (1988) 0.91
Transfected human beta-polymerase promoter contains a ras-responsive element. Mol Cell Biol (1990) 0.90
Inhibition of myogenesis by the H-ras oncogene: implication of a role for protein kinase C. J Cell Biol (1991) 0.90
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Phorbol diester receptor copurifies with protein kinase C. Proc Natl Acad Sci U S A (1983) 6.25
Isolation and Characterization of a Starchless Mutant of Arabidopsis thaliana (L.) Heynh Lacking ADPglucose Pyrophosphorylase Activity. Plant Physiol (1988) 5.03
Subcellular localization of the starch degradative and biosynthetic enzymes of spinach leaves. Plant Physiol (1979) 4.61
Functions of sphingolipids and sphingolipid breakdown products in cellular regulation. Science (1989) 4.44
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Cloning and expression of multiple protein kinase C cDNAs. Cell (1986) 4.23
Regulation of starch biosynthesis in plant leaves: activation and inhibition of ADPglucose pyrophosphorylase. Plant Physiol (1968) 4.23
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Mutants of Escherichia coli defective in membrane phospholipid synthesis: macromolecular synthesis in an sn-glycerol 3-phosphate acyltransferase Km mutant. J Bacteriol (1974) 3.47
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Regulation of the Amount of Starch in Plant Tissues by ADP Glucose Pyrophosphorylase. Science (1992) 3.44
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Purification of Spinach Leaf ADPglucose Pyrophosphorylase. Plant Physiol (1981) 2.81
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