Published in Proc Natl Acad Sci U S A on May 28, 1996
The Ca2+ concentration of the endoplasmic reticulum is a key determinant of ceramide-induced apoptosis: significance for the molecular mechanism of Bcl-2 action. EMBO J (2001) 3.85
Calcium and apoptosis: ER-mitochondria Ca2+ transfer in the control of apoptosis. Oncogene (2008) 3.63
Role of the human heat shock protein hsp70 in protection against stress-induced apoptosis. Mol Cell Biol (1997) 3.39
Signal transduction of stress via ceramide. Biochem J (1998) 2.86
A selective sphingosine kinase 1 inhibitor integrates multiple molecular therapeutic targets in human leukemia. Blood (2008) 2.22
Ceramide channels increase the permeability of the mitochondrial outer membrane to small proteins. J Biol Chem (2002) 1.94
The lipids C2- and C16-ceramide form large stable channels. Implications for apoptosis. J Biol Chem (2000) 1.73
A house divided: ceramide, sphingosine, and sphingosine-1-phosphate in programmed cell death. Biochim Biophys Acta (2006) 1.65
Ceramide forms channels in mitochondrial outer membranes at physiologically relevant concentrations. Mitochondrion (2006) 1.61
Human parvovirus B19 nonstructural (NS1) protein induces apoptosis in erythroid lineage cells. J Virol (1998) 1.61
Mitochondrial ceramide and the induction of apoptosis. J Bioenerg Biomembr (2005) 1.24
Anti-apoptotic Bcl-2 Family Proteins Disassemble Ceramide Channels. J Biol Chem (2008) 1.24
Ceramide accumulation precedes caspase-3 activation during apoptosis of A549 human lung adenocarcinoma cells. Am J Physiol Lung Cell Mol Physiol (2003) 1.20
Ordering of ceramide formation, caspase activation, and mitochondrial changes during CD95- and DNA damage-induced apoptosis. J Clin Invest (1999) 1.19
Cytokine response modifier A (CrmA) inhibits ceramide formation in response to tumor necrosis factor (TNF)-alpha: CrmA and Bcl-2 target distinct components in the apoptotic pathway. J Exp Med (1997) 1.15
Ceramide synthase-dependent ceramide generation and programmed cell death: involvement of salvage pathway in regulating postmitochondrial events. J Biol Chem (2011) 1.13
p53-dependent ceramide response to genotoxic stress. J Clin Invest (1998) 1.11
Inhibition of caspases inhibits the release of apoptotic bodies: Bcl-2 inhibits the initiation of formation of apoptotic bodies in chemotherapeutic agent-induced apoptosis. J Cell Biol (1999) 1.10
Role of the autotaxin-lysophosphatidate axis in cancer resistance to chemotherapy and radiotherapy. Biochim Biophys Acta (2012) 1.04
Ceramide and mitochondria in ischemia/reperfusion. J Cardiovasc Pharmacol (2009) 1.04
Inhibition of ceramide metabolism sensitizes human leukemia cells to inhibition of BCL2-like proteins. PLoS One (2013) 1.00
Sphingosine forms channels in membranes that differ greatly from those formed by ceramide. J Bioenerg Biomembr (2005) 0.96
Expression of ceramide glucosyltransferases, which are essential for glycosphingolipid synthesis, is only required in a small subset of C. elegans cells. J Cell Sci (2009) 0.93
Temporal relationships between ceramide production, caspase activation and mitochondrial dysfunction in cell lines with varying sensitivity to anti-Fas-induced apoptosis. Biochem J (2001) 0.93
Distinct sites of action of Bcl-2 and Bcl-xL in the ceramide pathway of apoptosis. Biochem J (1998) 0.90
Evidence against an early signalling role for ceramide in Fas-mediated apoptosis. Biochem J (1997) 0.89
Inhibition of the expression of ornithine decarboxylase and c-Myc by cell-permeant ceramide in difluoromethylornithine-resistant leukaemia cells. Biochem J (1997) 0.87
Regulation of membrane release in apoptosis. Biochem J (1998) 0.86
Plasma membrane ubiquinone controls ceramide production and prevents cell death induced by serum withdrawal. J Bioenerg Biomembr (1997) 0.86
Bioactive lipids and the control of Bax pro-apoptotic activity. Cell Death Dis (2014) 0.85
Ceramide and mitochondria in ischemic brain injury. Int J Biochem Mol Biol (2011) 0.84
Mechanisms involved in ceramide-induced cell cycle arrest in human hepatocarcinoma cells. World J Gastroenterol (2007) 0.83
5-aminosalicyclic acid and olsalazine inhibit tumor growth in a rodent model of colorectal cancer. Dig Dis Sci (2000) 0.83
Recent advances in the immunobiology of ceramide. Exp Mol Pathol (2006) 0.83
Ceramide and glutathione define two independently regulated pathways of cell death initiated by p53 in Molt-4 leukaemia cells. Biochem J (2003) 0.82
Apoptosis and the activity of ceramide, Bax and Bcl-2 in the lungs of neonatal rats exposed to limited and prolonged hyperoxia. Respir Res (2006) 0.81
A novel submicron emulsion system loaded with vincristine-oleic acid ion-pair complex with improved anticancer effect: in vitro and in vivo studies. Int J Nanomedicine (2013) 0.81
Sphingolipids in the DNA damage response. Adv Biol Regul (2014) 0.80
Regulation of ceramide channel formation and disassembly: Insights on the initiation of apoptosis. Saudi J Biol Sci (2015) 0.79
Farnesol activates the intrinsic pathway of apoptosis and the ATF4-ATF3-CHOP cascade of ER stress in human T lymphoblastic leukemia Molt4 cells. Biochem Pharmacol (2015) 0.79
Regulation of beta-catenin and connexin-43 expression: targets for sphingolipids in colon cancer prevention. Mol Nutr Food Res (2009) 0.78
Transforming growth factor beta1 attenuates ceramide-induced CPP32/Yama activation and apoptosis in human leukaemic HL-60 cells. Biochem J (1997) 0.77
Complexation of c6-ceramide with cholesteryl phosphocholine - a potent solvent-free ceramide delivery formulation for cells in culture. PLoS One (2013) 0.76
Sphingolipids and mitochondrial apoptosis. J Bioenerg Biomembr (2016) 0.76
A rapid method of total lipid extraction and purification. Can J Biochem Physiol (1959) 173.74
The role of polyamines in the neutralization of bacteriophage deoxyribonucleic acid. J Biol Chem (1960) 21.21
Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death. Nature (1990) 14.46
Bcl-2 and the regulation of programmed cell death. J Cell Biol (1994) 7.88
The retinoblastoma protein is phosphorylated during specific phases of the cell cycle. Cell (1989) 6.68
Quantitative measurement of sn-1,2-diacylglycerols present in platelets, hepatocytes, and ras- and sis-transformed normal rat kidney cells. J Biol Chem (1986) 5.78
The sphingomyelin cycle and the second messenger function of ceramide. J Biol Chem (1994) 4.21
Bcl-2 oncoprotein blocks chemotherapy-induced apoptosis in a human leukemia cell line. Blood (1993) 2.96
Ionizing radiation acts on cellular membranes to generate ceramide and initiate apoptosis. J Exp Med (1994) 2.71
Identification of sphingomyelin turnover as an effector mechanism for the action of tumor necrosis factor alpha and gamma-interferon. Specific role in cell differentiation. J Biol Chem (1991) 2.63
Apoptotic signaling through CD95 (Fas/Apo-1) activates an acidic sphingomyelinase. J Exp Med (1994) 2.47
Ceramide: an intracellular signal for apoptosis. Trends Biochem Sci (1995) 2.28
Protein kinase C zeta isoform is critical for kappa B-dependent promoter activation by sphingomyelinase. J Biol Chem (1994) 2.20
Activation of the sphingomyelin signaling pathway in intact EL4 cells and in a cell-free system by IL-1 beta. Science (1993) 2.06
Role of ceramide as a lipid mediator of 1 alpha,25-dihydroxyvitamin D3-induced HL-60 cell differentiation. J Biol Chem (1990) 1.99
Characterization of a ceramide-activated protein kinase: stimulation by tumor necrosis factor alpha. Proc Natl Acad Sci U S A (1991) 1.99
Role for ceramide in cell cycle arrest. J Biol Chem (1995) 1.83
Activation of the sphingomyelin cycle through the low-affinity neurotrophin receptor. Science (1994) 1.71
Role for ceramide as an endogenous mediator of Fas-induced cytotoxicity. Proc Natl Acad Sci U S A (1995) 1.62
Interleukin-1-mediated PGE2 production and sphingomyelin metabolism. Evidence for the regulation of cyclooxygenase gene expression by sphingosine and ceramide. J Biol Chem (1992) 1.36
Changes in bioactive lipids, alkylacylglycerol and ceramide, occur in HIV-infected cells. Biochem Biophys Res Commun (1992) 1.29
Reactive oxygen species and the regulation of cell death by the Bcl-2 gene family. Biochim Biophys Acta (1995) 1.26
Retinoblastoma gene product as a downstream target for a ceramide-dependent pathway of growth arrest. Proc Natl Acad Sci U S A (1995) 1.24
Ceramide: a stress signal and mediator of growth suppression and apoptosis. J Cell Biochem (1995) 1.23
Ceramide mediates the apoptotic response of WEHI 231 cells to anti-immunoglobulin, corticosteroids and irradiation. Biochem Biophys Res Commun (1994) 1.04
1-beta-D-Arabinofuranosylcytosine stimulates ceramide and diglyceride formation in HL-60 cells. J Biol Chem (1994) 1.03
Bcl-xL rescues WEHI 231 B lymphocytes from oxidant-mediated death following diverse apoptotic stimuli. J Immunol (1995) 1.01
Retinoblastoma protein dephosphorylation induced by D-erythro-sphingosine. J Biol Chem (1992) 0.97
Ceramide-activated protein phosphatase: partial purification and relationship to protein phosphatase 2A. Adv Lipid Res (1993) 0.94
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature (2002) 28.79
Mitochondria and apoptosis. Science (1998) 23.41
Tumor suppressor p53 is a direct transcriptional activator of the human bax gene. Cell (1995) 14.90
Regulation of cell death protease caspase-9 by phosphorylation. Science (1998) 11.26
IAP family proteins--suppressors of apoptosis. Genes Dev (1999) 9.96
Mitochondrial control of cell death. Nat Med (2000) 9.17
X-linked IAP is a direct inhibitor of cell-death proteases. Nature (1997) 8.26
Somatic frameshift mutations in the BAX gene in colon cancers of the microsatellite mutator phenotype. Science (1997) 7.31
Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo. Oncogene (1994) 7.24
Bax directly induces release of cytochrome c from isolated mitochondria. Proc Natl Acad Sci U S A (1998) 6.69
Apoptosis in the failing human heart. N Engl J Med (1997) 6.35
Ordering the cytochrome c-initiated caspase cascade: hierarchical activation of caspases-2, -3, -6, -7, -8, and -10 in a caspase-9-dependent manner. J Cell Biol (1999) 6.24
Investigation of the subcellular distribution of the bcl-2 oncoprotein: residence in the nuclear envelope, endoplasmic reticulum, and outer mitochondrial membranes. Cancer Res (1993) 5.83
Programmed cell death induced by ceramide. Science (1993) 5.43
IAP-family protein survivin inhibits caspase activity and apoptosis induced by Fas (CD95), Bax, caspases, and anticancer drugs. Cancer Res (1998) 5.41
IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases. EMBO J (1998) 5.28
Bax and adenine nucleotide translocator cooperate in the mitochondrial control of apoptosis. Science (1998) 4.84
Conversion of lytic to persistent alphavirus infection by the bcl-2 cellular oncogene. Nature (1993) 4.81
Alterations in T4 (CD4) protein and mRNA synthesis in cells infected with HIV. Science (1986) 4.79
The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases. EMBO J (1997) 4.66
Siah-1, SIP, and Ebi collaborate in a novel pathway for beta-catenin degradation linked to p53 responses. Mol Cell (2001) 4.62
Cytochrome c release and apoptosis induced by mitochondrial targeting of nuclear orphan receptor TR3. Science (2000) 4.57
Cloning and functional analysis of BAG-1: a novel Bcl-2-binding protein with anti-cell death activity. Cell (1995) 4.53
Ca2+-induced apoptosis through calcineurin dephosphorylation of BAD. Science (1999) 4.43
Cell-free apoptosis in Xenopus egg extracts: inhibition by Bcl-2 and requirement for an organelle fraction enriched in mitochondria. Cell (1994) 4.32
Expression of apoptosis-regulating proteins in chronic lymphocytic leukemia: correlations with In vitro and In vivo chemoresponses. Blood (1998) 4.07
Bcl-2 targets the protein kinase Raf-1 to mitochondria. Cell (1996) 4.04
Bcl-2 prolongs cell survival after Bax-induced release of cytochrome c. Nature (1998) 4.02
Bcl-2 blocks apoptosis in cells lacking mitochondrial DNA. Nature (1993) 4.00
Anchorage dependence, integrins, and apoptosis. Cell (1994) 3.96
Cleavage of human inhibitor of apoptosis protein XIAP results in fragments with distinct specificities for caspases. EMBO J (1999) 3.51
Channel formation by antiapoptotic protein Bcl-2. Proc Natl Acad Sci U S A (1997) 3.45
Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes. Cell Death Differ (2009) 3.44
Bcl-2 family proteins and cancer. Oncogene (2008) 3.42
Apoptotic and necrotic myocyte cell deaths are independent contributing variables of infarct size in rats. Lab Invest (1996) 3.42
Caspase-9 can be activated without proteolytic processing. J Biol Chem (1999) 3.20
Changes in intramitochondrial and cytosolic pH: early events that modulate caspase activation during apoptosis. Nat Cell Biol (2000) 3.20
Sequential expression of protooncogenes during lectin-stimulated mitogenesis of normal human lymphocytes. Proc Natl Acad Sci U S A (1986) 3.19
Bax inhibitor-1, a mammalian apoptosis suppressor identified by functional screening in yeast. Mol Cell (1998) 3.09
FAP-1: a protein tyrosine phosphatase that associates with Fas. Science (1995) 3.06
Sphingosine inhibition of protein kinase C activity and of phorbol dibutyrate binding in vitro and in human platelets. J Biol Chem (1986) 3.05
Identification of a p53-dependent negative response element in the bcl-2 gene. Cancer Res (1994) 3.02
An evolutionarily conserved family of Hsp70/Hsc70 molecular chaperone regulators. J Biol Chem (1999) 2.97
Immunohistochemical analysis of bcl-2, bax, bcl-X, and mcl-1 expression in prostate cancers. Am J Pathol (1996) 2.97
Oocyte apoptosis is suppressed by disruption of the acid sphingomyelinase gene or by sphingosine-1-phosphate therapy. Nat Med (2000) 2.96
Bcl-2 oncoprotein blocks chemotherapy-induced apoptosis in a human leukemia cell line. Blood (1993) 2.96
Pro-caspase-3 is a major physiologic target of caspase-8. J Biol Chem (1998) 2.93
BAG-1 modulates the chaperone activity of Hsp70/Hsc70. EMBO J (1997) 2.91
The alpha 5 beta 1 integrin supports survival of cells on fibronectin and up-regulates Bcl-2 expression. Proc Natl Acad Sci U S A (1995) 2.90
Bcl-2 decreases the free Ca2+ concentration within the endoplasmic reticulum. Proc Natl Acad Sci U S A (2000) 2.87
Expression and prognostic significance of IAP-family genes in human cancers and myeloid leukemias. Clin Cancer Res (2000) 2.86
Comparison of chemical inhibitors of antiapoptotic Bcl-2-family proteins. Cell Death Differ (2006) 2.85
The central executioner of apoptosis: multiple connections between protease activation and mitochondria in Fas/APO-1/CD95- and ceramide-induced apoptosis. J Exp Med (1997) 2.83
Proapoptotic protein Bax heterodimerizes with Bcl-2 and homodimerizes with Bax via a novel domain (BH3) distinct from BH1 and BH2. J Biol Chem (1996) 2.79
Apoptotic crosstalk between the endoplasmic reticulum and mitochondria controlled by Bcl-2. Oncogene (2000) 2.78
Ceramide activates heterotrimeric protein phosphatase 2A. J Biol Chem (1993) 2.77
BNIP3 heterodimerizes with Bcl-2/Bcl-X(L) and induces cell death independent of a Bcl-2 homology 3 (BH3) domain at both mitochondrial and nonmitochondrial sites. J Biol Chem (2000) 2.68
A single BIR domain of XIAP sufficient for inhibiting caspases. J Biol Chem (1998) 2.64
Immunohistochemical analysis of in vivo patterns of Bcl-X expression. Cancer Res (1994) 2.63
Lysosomal protease pathways to apoptosis. Cleavage of bid, not pro-caspases, is the most likely route. J Biol Chem (2000) 2.62
The HIV-1 viral protein R induces apoptosis via a direct effect on the mitochondrial permeability transition pore. J Exp Med (2000) 2.62
Molecular chaperone targeting and regulation by BAG family proteins. Nat Cell Biol (2001) 2.61
Unequal death in T helper cell (Th)1 and Th2 effectors: Th1, but not Th2, effectors undergo rapid Fas/FasL-mediated apoptosis. J Exp Med (1997) 2.59
Immunohistochemical determination of in vivo distribution of Bax, a dominant inhibitor of Bcl-2. Am J Pathol (1994) 2.57
Role of phospholipase in generating lipid second messengers in signal transduction. FASEB J (1991) 2.56
The permeability transition pore complex: a target for apoptosis regulation by caspases and bcl-2-related proteins. J Exp Med (1998) 2.51
Integrin activation by R-ras. Cell (1996) 2.50
Immediate early up-regulation of bax expression by p53 but not TGF beta 1: a paradigm for distinct apoptotic pathways. Oncogene (1994) 2.49
An informatics approach identifying markers of chemosensitivity in human cancer cell lines. Cancer Res (2000) 2.47
bcl-2 gene hypomethylation and high-level expression in B-cell chronic lymphocytic leukemia. Blood (1993) 2.45
p21-activated kinase 1 phosphorylates the death agonist bad and protects cells from apoptosis. Mol Cell Biol (2000) 2.42
Characterization of the 13q14 tumor suppressor locus in CLL: identification of ALT1, an alternative splice variant of the LEU2 gene. Cancer Res (2001) 2.41
Regulation of bcl-2 proto-oncogene expression during normal human lymphocyte proliferation. Science (1987) 2.36
Structure-function analysis of Bcl-2 protein. Identification of conserved domains important for homodimerization with Bcl-2 and heterodimerization with Bax. J Biol Chem (1995) 2.35
Apoptosis in the terminal endbud of the murine mammary gland: a mechanism of ductal morphogenesis. Development (1996) 2.35
Sphingomyelin turnover induced by vitamin D3 in HL-60 cells. Role in cell differentiation. J Biol Chem (1989) 2.32
Elevated expression of the apoptotic regulator Mcl-1 at the time of leukemic relapse. Blood (1998) 2.31
Reduced expression of proapoptotic gene BAX is associated with poor response rates to combination chemotherapy and shorter survival in women with metastatic breast adenocarcinoma. Cancer Res (1995) 2.31
Lysosphingolipids inhibit protein kinase C: implications for the sphingolipidoses. Science (1987) 2.29
Ceramide: an intracellular signal for apoptosis. Trends Biochem Sci (1995) 2.28
Structure-function comparisons of the proapoptotic protein Bax in yeast and mammalian cells. Mol Cell Biol (1996) 2.24
Bcl-2 interacting protein, BAG-1, binds to and activates the kinase Raf-1. Proc Natl Acad Sci U S A (1996) 2.21
Age-associated cardiac dysfunction in Drosophila melanogaster. Circ Res (2001) 2.20
The AKT kinase is activated in multiple myeloma tumor cells. Blood (2001) 2.20
MEK/ERK signaling pathway regulates the expression of Bcl-2, Bcl-X(L), and Mcl-1 and promotes survival of human pancreatic cancer cells. J Cell Biochem (2000) 2.19
Ceramide and apoptosis. Trends Biochem Sci (1999) 2.19
Immunohistochemical analysis of in vivo patterns of expression of CPP32 (Caspase-3), a cell death protease. Cancer Res (1997) 2.16
bcl-2 gene transfer increases relative resistance of S49.1 and WEHI7.2 lymphoid cells to cell death and DNA fragmentation induced by glucocorticoids and multiple chemotherapeutic drugs. Cancer Res (1992) 2.15
Activation of protein kinase C by Triton X-100 mixed micelles containing diacylglycerol and phosphatidylserine. J Biol Chem (1985) 2.11
Toso, a cell surface, specific regulator of Fas-induced apoptosis in T cells. Immunity (1998) 2.11
Protein kinase inhibitors flavopiridol and 7-hydroxy-staurosporine down-regulate antiapoptosis proteins in B-cell chronic lymphocytic leukemia. Blood (2000) 2.11
Structure-function analysis of the Bcl-2 oncoprotein. Addition of a heterologous transmembrane domain to portions of the Bcl-2 beta protein restores function as a regulator of cell survival. J Biol Chem (1993) 2.07
Control of mitochondrial membrane permeabilization by adenine nucleotide translocator interacting with HIV-1 viral protein rR and Bcl-2. J Exp Med (2001) 2.07
Role of ceramide as a lipid mediator of 1 alpha,25-dihydroxyvitamin D3-induced HL-60 cell differentiation. J Biol Chem (1990) 1.99
p53-inducible human homologue of Drosophila seven in absentia (Siah) inhibits cell growth: suppression by BAG-1. EMBO J (1998) 1.99
Human Daxx regulates Fas-induced apoptosis from nuclear PML oncogenic domains (PODs). EMBO J (1999) 1.99
BAG-1: a novel biomarker predicting long-term survival in early-stage breast cancer. J Clin Oncol (2001) 1.97
A novel member of the TRAF family of putative signal transducing proteins binds to the cytosolic domain of CD40. FEBS Lett (1995) 1.97