Light-dependent phosphorylation of rhodopsin by beta-adrenergic receptor kinase.

PubWeight™: 1.12‹?› | Rank: Top 10%

🔗 View Article (PMID 3014340)

Published in Nature on August 14, 1986

Authors

J L Benovic, F Mayor, R L Somers, M G Caron, R J Lefkowitz

Articles citing this

Sequence analyses of G-protein-coupled receptors: similarities to rhodopsin. Biochemistry (2003) 2.42

G protein-coupled receptor kinases: more than just kinases and not only for GPCRs. Pharmacol Ther (2011) 2.13

Molecular basis of transmembrane signal transduction in Dictyostelium discoideum. Microbiol Rev (1987) 1.70

Phosphorylation of cardiac Myosin-binding protein-C is a critical mediator of diastolic function. Circ Heart Fail (2015) 1.29

The receptor kinase family: primary structure of rhodopsin kinase reveals similarities to the beta-adrenergic receptor kinase. Proc Natl Acad Sci U S A (1991) 1.25

STE2 protein of Saccharomyces kluyveri is a member of the rhodopsin/beta-adrenergic receptor family and is responsible for recognition of the peptide ligand alpha factor. Proc Natl Acad Sci U S A (1988) 1.07

Endosomal generation of cAMP in GPCR signaling. Nat Chem Biol (2014) 1.03

The origin and evolution of G protein-coupled receptor kinases. PLoS One (2012) 1.00

The evolving impact of g protein-coupled receptor kinases in cardiac health and disease. Physiol Rev (2015) 0.97

Isolation of Drosophila genes encoding G protein-coupled receptor kinases. Proc Natl Acad Sci U S A (1991) 0.96

Inhibition of G-protein betagamma-subunit functions by phosducin-like protein. Proc Natl Acad Sci U S A (1996) 0.96

The beta 2-adrenergic receptors of human epidermoid carcinoma cells bear two different types of oligosaccharides which influence expression on the cell surface. Biochem J (1988) 0.89

Constitutively active rhodopsin mutants causing night blindness are effectively phosphorylated by GRKs but differ in arrestin-1 binding. Cell Signal (2013) 0.87

Molecular properties of muscarinic acetylcholine receptors. Proc Jpn Acad Ser B Phys Biol Sci (2013) 0.87

A pharmacological primer of biased agonism. Endocr Metab Immune Disord Drug Targets (2011) 0.86

Rapid desensitization of neonatal rat liver beta-adrenergic receptors. A role for beta-adrenergic receptor kinase. J Clin Invest (1994) 0.86

Light-induced currents in Xenopus oocytes expressing bovine rhodopsin. J Physiol (1993) 0.83

G Protein-coupled Receptor Kinases of the GRK4 Protein Subfamily Phosphorylate Inactive G Protein-coupled Receptors (GPCRs). J Biol Chem (2015) 0.83

Molecular modeling of G-protein coupled receptor kinase 2: docking and biochemical evaluation of inhibitors. AAPS PharmSci (2000) 0.81

Mapping the putative G protein-coupled receptor (GPCR) docking site on GPCR kinase 2: insights from intact cell phosphorylation and recruitment assays. J Biol Chem (2014) 0.79

G protein-coupled receptor kinases as regulators of dopamine receptor functions. Pharmacol Res (2016) 0.75

Introduction of Robert J. Lefkowitz. J Clin Invest (2011) 0.75

Paradigm Shift is the Normal State of Pharmacology. EC Pharmacol Toxicol (2016) 0.75

G protein-coupled receptor kinases: Past, present and future. Cell Signal (2017) 0.75

Articles by these authors

Dopamine receptors: from structure to function. Physiol Rev (1998) 8.90

Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes. Science (1999) 7.57

Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter. Nature (1996) 7.26

Cloning of the gene and cDNA for mammalian beta-adrenergic receptor and homology with rhodopsin. Nature (1986) 7.06

Beta-arrestin acts as a clathrin adaptor in endocytosis of the beta2-adrenergic receptor. Nature (1996) 6.32

A ternary complex model explains the agonist-specific binding properties of the adenylate cyclase-coupled beta-adrenergic receptor. J Biol Chem (1980) 6.06

Specific receptor sites for chemotactic peptides on human polymorphonuclear leukocytes. Proc Natl Acad Sci U S A (1977) 5.87

Model systems for the study of seven-transmembrane-segment receptors. Annu Rev Biochem (1991) 5.70

G protein-coupled receptor kinases. Annu Rev Biochem (1998) 5.53

Switching of the coupling of the beta2-adrenergic receptor to different G proteins by protein kinase A. Nature (1997) 5.31

Beta-arrestin 2: a receptor-regulated MAPK scaffold for the activation of JNK3. Science (2000) 5.20

Regulation of receptor fate by ubiquitination of activated beta 2-adrenergic receptor and beta-arrestin. Science (2001) 5.05

Mice with reduced NMDA receptor expression display behaviors related to schizophrenia. Cell (1999) 4.93

Enhanced myocardial function in transgenic mice overexpressing the beta 2-adrenergic receptor. Science (1994) 4.84

Role of serotonin in the paradoxical calming effect of psychostimulants on hyperactivity. Science (1999) 4.70

Cloning of the cDNA for the human beta 1-adrenergic receptor. Proc Natl Acad Sci U S A (1987) 4.66

cDNA for the human beta 2-adrenergic receptor: a protein with multiple membrane-spanning domains and encoded by a gene whose chromosomal location is shared with that of the receptor for platelet-derived growth factor. Proc Natl Acad Sci U S A (1987) 4.61

Activation and targeting of extracellular signal-regulated kinases by beta-arrestin scaffolds. Proc Natl Acad Sci U S A (2001) 4.56

beta-Arrestin: a protein that regulates beta-adrenergic receptor function. Science (1990) 4.53

A mutation-induced activated state of the beta 2-adrenergic receptor. Extending the ternary complex model. J Biol Chem (1993) 4.52

Differential affinities of visual arrestin, beta arrestin1, and beta arrestin2 for G protein-coupled receptors delineate two major classes of receptors. J Biol Chem (2000) 4.46

Role of beta-arrestin in mediating agonist-promoted G protein-coupled receptor internalization. Science (1996) 4.38

Cardiac function in mice overexpressing the beta-adrenergic receptor kinase or a beta ARK inhibitor. Science (1995) 4.18

Turning off the signal: desensitization of beta-adrenergic receptor function. FASEB J (1990) 4.05

Enhanced morphine analgesia in mice lacking beta-arrestin 2. Science (1999) 4.04

The role of receptor kinases and arrestins in G protein-coupled receptor regulation. Annu Rev Pharmacol Toxicol (1998) 3.87

Regulation of transmembrane signaling by receptor phosphorylation. Cell (1987) 3.74

Molecular mechanisms of receptor desensitization using the beta-adrenergic receptor-coupled adenylate cyclase system as a model. Nature (1985) 3.74

Chimeric alpha 2-,beta 2-adrenergic receptors: delineation of domains involved in effector coupling and ligand binding specificity. Science (1988) 3.60

Cloning, sequencing, and expression of the gene coding for the human platelet alpha 2-adrenergic receptor. Science (1987) 3.47

Role of beta gamma subunits of G proteins in targeting the beta-adrenergic receptor kinase to membrane-bound receptors. Science (1992) 3.45

The beta2-adrenergic receptor/betaarrestin complex recruits the clathrin adaptor AP-2 during endocytosis. Proc Natl Acad Sci U S A (1999) 3.43

Mu-opioid receptor desensitization by beta-arrestin-2 determines morphine tolerance but not dependence. Nature (2000) 3.42

The beta2-adrenergic receptor interacts with the Na+/H+-exchanger regulatory factor to control Na+/H+ exchange. Nature (1998) 3.41

Beta-adrenergic receptor kinase: identification of a novel protein kinase that phosphorylates the agonist-occupied form of the receptor. Proc Natl Acad Sci U S A (1986) 3.38

An intronless gene encoding a potential member of the family of receptors coupled to guanine nucleotide regulatory proteins. Nature (1987) 3.33

International Union of Pharmacology nomenclature of adrenoceptors. Pharmacol Rev (1994) 3.26

Do bicycle safety helmets reduce severity of head injury in real crashes? Accid Anal Prev (1987) 3.26

Validation and statistical analysis of a computer modeling method for quantitative analysis of radioligand binding data for mixtures of pharmacological receptor subtypes. Mol Pharmacol (1982) 3.23

Activation of the cloned muscarinic potassium channel by G protein beta gamma subunits. Nature (1994) 3.21

Molecular cloning and expression of the cDNA for the hamster alpha 1-adrenergic receptor. Proc Natl Acad Sci U S A (1988) 3.18

Cocaine self-administration in dopamine-transporter knockout mice. Nat Neurosci (1998) 3.16

Profound neuronal plasticity in response to inactivation of the dopamine transporter. Proc Natl Acad Sci U S A (1998) 3.12

A beta-arrestin/green fluorescent protein biosensor for detecting G protein-coupled receptor activation. J Biol Chem (1997) 3.12

Role for G protein-coupled receptor kinase in agonist-specific regulation of mu-opioid receptor responsiveness. Proc Natl Acad Sci U S A (1998) 3.07

Association of beta-arrestin with G protein-coupled receptors during clathrin-mediated endocytosis dictates the profile of receptor resensitization. J Biol Chem (1999) 3.02

Beta-arrestin2, a novel member of the arrestin/beta-arrestin gene family. J Biol Chem (1992) 2.97

Palmitoylation of the human beta 2-adrenergic receptor. Mutation of Cys341 in the carboxyl tail leads to an uncoupled nonpalmitoylated form of the receptor. J Biol Chem (1989) 2.95

A family of receptors coupled to guanine nucleotide regulatory proteins. Biochemistry (1987) 2.91

Binding of G protein beta gamma-subunits to pleckstrin homology domains. J Biol Chem (1994) 2.91

Molecular basis for interactions of G protein betagamma subunits with effectors. Science (1998) 2.88

Regulation of tyrosine kinase cascades by G-protein-coupled receptors. Curr Opin Cell Biol (1999) 2.86

beta-Arrestin 1 and 2 differentially regulate heptahelical receptor signaling and trafficking. Proc Natl Acad Sci U S A (2001) 2.86

HIV-1-induced cell fusion is mediated by multiple regions within both the viral envelope and the CCR-5 co-receptor. EMBO J (1997) 2.86

Cloning and expression of a functional serotonin transporter from rat brain. Nature (1991) 2.86

Cloning and expression of a human kidney cDNA for an alpha 2-adrenergic receptor subtype. Proc Natl Acad Sci U S A (1988) 2.78

Expression of a beta-adrenergic receptor kinase 1 inhibitor prevents the development of myocardial failure in gene-targeted mice. Proc Natl Acad Sci U S A (1998) 2.76

Agonist-promoted ubiquitination of the G protein-coupled receptor CXCR4 mediates lysosomal sorting. J Biol Chem (2001) 2.72

Mechanisms of amphetamine action revealed in mice lacking the dopamine transporter. J Neurosci (1998) 2.72

A C-terminal motif found in the beta2-adrenergic receptor, P2Y1 receptor and cystic fibrosis transmembrane conductance regulator determines binding to the Na+/H+ exchanger regulatory factor family of PDZ proteins. Proc Natl Acad Sci U S A (1998) 2.68

Receptor-tyrosine-kinase- and G beta gamma-mediated MAP kinase activation by a common signalling pathway. Nature (1995) 2.64

Targeting the receptor-Gq interface to inhibit in vivo pressure overload myocardial hypertrophy. Science (1998) 2.64

Identification of beta-adrenergic receptors in human lymphocytes by (-) (3H) alprenolol binding. J Clin Invest (1976) 2.58

Arrestin interactions with G protein-coupled receptors. Direct binding studies of wild type and mutant arrestins with rhodopsin, beta 2-adrenergic, and m2 muscarinic cholinergic receptors. J Biol Chem (1995) 2.55

International Union of Pharmacology. X. Recommendation for nomenclature of alpha 1-adrenoceptors: consensus update. Pharmacol Rev (1995) 2.53

Cellular expression of the carboxyl terminus of a G protein-coupled receptor kinase attenuates G beta gamma-mediated signaling. J Biol Chem (1994) 2.53

Dual modulation of cell survival and cell death by beta(2)-adrenergic signaling in adult mouse cardiac myocytes. Proc Natl Acad Sci U S A (2001) 2.52

Five members of a novel Ca(2+)-binding protein (CABP) subfamily with similarity to calmodulin. J Biol Chem (2000) 2.47

Hyperactivity and impaired response habituation in hyperdopaminergic mice. Proc Natl Acad Sci U S A (2001) 2.46

Essential role for G protein-coupled receptor endocytosis in the activation of mitogen-activated protein kinase. J Biol Chem (1998) 2.45

The beta(2)-adrenergic receptor mediates extracellular signal-regulated kinase activation via assembly of a multi-receptor complex with the epidermal growth factor receptor. J Biol Chem (2000) 2.44

Multiple pathways of rapid beta 2-adrenergic receptor desensitization. Delineation with specific inhibitors. J Biol Chem (1990) 2.42