Published in Proc Natl Acad Sci U S A on August 01, 1986
Differential plasmid rescue from transgenic mouse DNAs into Escherichia coli methylation-restriction mutants. Proc Natl Acad Sci U S A (1990) 10.46
Malignant melanoma in transgenic mice. Proc Natl Acad Sci U S A (1991) 1.58
Expression of a foreign gene in a line of transgenic mice is modulated by a chromosomal position effect. Mol Cell Biol (1990) 1.41
Prenatal lethality in a transgenic mouse line is the result of a chromosomal translocation. Proc Natl Acad Sci U S A (1988) 1.17
Enzymatic engineering of the porcine genome with transposons and recombinases. BMC Biotechnol (2007) 1.14
Mosaic expression of a tyrosinase fusion gene in albino mice yields a heritable striped coat color pattern in transgenic homozygotes. Proc Natl Acad Sci U S A (1991) 1.09
"Parahomologous" gene targeting in Drosophila cells: an efficient, homology-dependent pathway of illegitimate recombination near a target site. Genetics (1997) 1.04
Efficient mammalian germline transgenesis by cis-enhanced Sleeping Beauty transposition. Transgenic Res (2010) 1.04
Structure, expression, and chromosome location of the gene for the beta subunit of brain-specific Ca2+/calmodulin-dependent protein kinase II identified by transgene integration in an embryonic lethal mouse mutant. Mol Cell Biol (1992) 0.98
Cellular DNA rearrangements and early developmental arrest caused by DNA insertion in transgenic mouse embryos. Mol Cell Biol (1987) 0.97
Pigs taking wing with transposons and recombinases. Genome Biol (2007) 0.94
Direct sequencing of PCR-amplified junction fragments from tandemly repeated transgenes. Nucleic Acids Res (1990) 0.83
Mys retrotransposons in Peromyscus leucopus and transgenic Mus musculus. Nucleic Acids Res (1988) 0.79
Homologous illegitimate random integration of foreign DNA into the X chromosome of a transgenic mouse line. BMC Mol Biol (2010) 0.78
One-step knockin for inducible expression in mouse embryonic stem cells. Genesis (2011) 0.75
Detection of specific sequences among DNA fragments separated by gel electrophoresis. J Mol Biol (1975) 503.08
Efficient transfer of large DNA fragments from agarose gels to diazobenzyloxymethyl-paper and rapid hybridization by using dextran sulfate. Proc Natl Acad Sci U S A (1979) 72.18
Patterns of integration of DNA microinjected into cultured mammalian cells: evidence for homologous recombination between injected plasmid DNA molecules. Mol Cell Biol (1982) 7.49
Retroviruses as mutagens: insertion and excision of a nontransforming provirus alter expression of a resident transforming provirus. Cell (1981) 4.66
Ubiquitous transposon-like repeats B1 and B2 of the mouse genome: B2 sequencing. Nucleic Acids Res (1982) 4.35
Somatic expression of herpes thymidine kinase in mice following injection of a fusion gene into eggs. Cell (1981) 4.23
Embryonic lethal mutation in mice induced by retrovirus insertion into the alpha 1(I) collagen gene. Nature (1983) 4.14
Transfected DNA is mutated in monkey, mouse, and human cells. Mol Cell Biol (1984) 3.63
Genetic control of morphogenetic and biochemical differentiation: lethal albino deletions in the mouse. Cell (1979) 3.50
Constitutive fragile sites and cancer. Science (1984) 3.30
Introduction of a mu immunoglobulin gene into the mouse germ line: specific expression in lymphoid cells and synthesis of functional antibody. Cell (1984) 3.24
An inherited limb deformity created by insertional mutagenesis in a transgenic mouse. Nature (1985) 3.05
The human beta-globin gene and a functional viral thymidine kinase gene in developing mice. Proc Natl Acad Sci U S A (1981) 2.93
Mutant immunoglobulin genes have repetitive DNA elements inserted into their intervening sequences. Proc Natl Acad Sci U S A (1982) 2.44
Genetic analysis of the proximal portion of the mouse t complex: evidence for a second inversion within t haplotypes. Cell (1986) 2.40
A structure for amplified DNA. Cell (1983) 1.88
Insertion mutagenesis of embryonal carcinoma cells by retroviruses. Science (1985) 1.82
Gene mapping within the T/t complex of the mouse. II. Anomalous position of the H-2 complex in t haplotypes. Cell (1982) 1.73
Structure of genes for human growth hormone and chorionic somatomammotropin. Proc Natl Acad Sci U S A (1979) 1.71
Transmission distortion and mosaicism in an unusual transgenic mouse pedigree. Cell (1984) 1.71
Tissue-specific expression in transgenic mice of a fused gene containing RSV terminal sequences. Science (1986) 1.64
Prenatal lethalities in mice homozygous for human growth hormone gene sequences integrated in the germ line. Cell (1983) 1.63
Association of the lethal yellow (Ay) coat color mutation with an ecotropic murine leukemia virus genome. Proc Natl Acad Sci U S A (1983) 1.60
Dilute-coat-color locus of mice: nucleotide sequence analysis of the d+2J and d+Ha revertant alleles. Mol Cell Biol (1984) 1.39
Effect of chromosomal position on amplification of transfected genes in animal cells. Nature (1984) 1.38
Cloning of V region fragments from mouse liver DNA and localization of repetitive DNA sequences in the vicinity of immunoglobulin gene segments. Nucleic Acids Res (1980) 1.29
An insertional mutation in a transgenic mouse line results in developmental arrest at day 5 of gestation. Cold Spring Harb Symp Quant Biol (1985) 1.02
Rearrangements of host and viral DNA in mouse cells transformed by simian virus 40. J Mol Biol (1984) 0.93
Early developmental mutations due to DNA rearrangements in transgenic mouse embryos. Cold Spring Harb Symp Quant Biol (1985) 0.84
Construction and characterization of new cloning vehicles. IV. Deletion derivatives of pBR322 and pBR325. Gene (1980) 12.14
Normal genetically mosaic mice produced from malignant teratocarcinoma cells. Proc Natl Acad Sci U S A (1975) 7.27
Receptor-mediated endocytosis of transferrin in developmentally totipotent mouse teratocarcinoma stem cells. J Biol Chem (1981) 4.86
Construction and characterization of new cloning vehicles. VI. Plasmid pBR329, a new derivative of pBR328 lacking the 482-base-pair inverted duplication. Gene (1982) 4.36
Totipotency and normal differentiation of single teratocarcinoma cells cloned by injection into blastocysts. Proc Natl Acad Sci U S A (1976) 3.12
The human beta-globin gene and a functional viral thymidine kinase gene in developing mice. Proc Natl Acad Sci U S A (1981) 2.93
Gene control of mammalian pigmentary differentiation. I. Clonal origin of melanocytes. Proc Natl Acad Sci U S A (1967) 2.45
Gene expression in neoplasia and differentiation. Harvey Lect (1978) 2.44
Distortion of proximodistal information causes JNK-dependent apoptosis in Drosophila wing. Nature (1999) 2.42
Ordering of mouse immunoglobulin heavy chain genes by molecular cloning. Nature (1981) 2.28
Inverted terminal repeat sequence in the macronuclear DNA of Stylonychia pustulata. Gene (1980) 2.28
Simian virus 40 DNA sequences in DNA of healthy adult mice derived from preimplantation blastocysts injected with viral DNA. Proc Natl Acad Sci U S A (1974) 2.26
"Intrinsic" immunological tolerance in allophenic mice. Science (1967) 2.10
A protein kinase similar to MAP kinase activator acts downstream of the raf kinase in Drosophila. Cell (1993) 2.10
p38 mitogen-activated protein kinase can be involved in transforming growth factor beta superfamily signal transduction in Drosophila wing morphogenesis. Mol Cell Biol (1999) 1.83
Handicapped retroviral vectors efficiently transduce foreign genes into hematopoietic stem cells. Proc Natl Acad Sci U S A (1987) 1.81
Clonal contributions of small numbers of retrovirally marked hematopoietic stem cells engrafted in unirradiated neonatal W/Wv mice. Proc Natl Acad Sci U S A (1989) 1.81
Clonal origins of somites and their muscle derivatives: evidence from allophenic mice. Dev Biol (1972) 1.77
Experimental Study of the Developing Mammalian Egg: Removal of the Zona Pellucida. Science (1962) 1.76
Gene control of mammalian differentiation. Annu Rev Genet (1974) 1.68
Prevention of genetic anemias in mice by microinjection of normal hematopoietic stem cells into the fetal placenta. Proc Natl Acad Sci U S A (1979) 1.66
Mosaic mice with teratocarcinoma-derived mutant cells deficient in hypoxanthine phosphoribosyltransferase. Proc Natl Acad Sci U S A (1977) 1.66
Prenatal lethalities in mice homozygous for human growth hormone gene sequences integrated in the germ line. Cell (1983) 1.63
Leucine-rich repeats and carboxyl terminus are required for interaction of yeast adenylate cyclase with RAS proteins. Proc Natl Acad Sci U S A (1990) 1.63
Cloning of mouse immunoglobulin epsilon gene and its location within the heavy chain gene cluster. Proc Natl Acad Sci U S A (1981) 1.62
Clonal basis of mammalian differentiation. Symp Soc Exp Biol (1971) 1.60
Increased replication of HTLV-I in HTLV-I-associated myelopathy. Ann Neurol (1989) 1.60
Introduction of a viral thymidine kinase gene and the human beta-globin gene into developmentally multipotential mouse teratocarcinoma cells. Proc Natl Acad Sci U S A (1980) 1.58
Malignant melanoma in transgenic mice. Proc Natl Acad Sci U S A (1991) 1.58
Normal mammalian muscle differentiation and gene control of isocitrate dehydrogenase synthesis. Proc Natl Acad Sci U S A (1967) 1.58
PCR analysis of the cryI insecticidal crystal family genes from Bacillus thuringiensis. Appl Environ Microbiol (1994) 1.55
Rearrangements of immunoglobulin genes during differentiation and evolution. Immunol Rev (1981) 1.54
CSF hypocretin levels in Guillain-Barré syndrome and other inflammatory neuropathies. Neurology (2003) 1.50
Absence of myocardial 123I-BMIPP uptake in the presence of a normal coronary angiogram and normokinetics on a left ventriculogram. Jpn Circ J (1997) 1.48
Monoclonal derivation of mouse myeloid and lymphoid lineages from totipotent hematopoietic stem cells experimentally engrafted in fetal hosts. Proc Natl Acad Sci U S A (1984) 1.47
Development of adult bone marrow stem cells in H-2-compatible and -incompatible mouse fetuses. J Exp Med (1984) 1.46
A Drosophila MAPKKK, D-MEKK1, mediates stress responses through activation of p38 MAPK. EMBO J (2001) 1.42
Earliest evidence for the use of pottery. Nature (2013) 1.42
Hermaphroditism, sex chromosomal mosaicism and germ cell selection in allophenic mice. J Anim Sci (1968) 1.40
Urinary albumin excretion in short children treated with recombinant human growth hormone. Clin Nephrol (1996) 1.39
Long terminal repeat-like elements flank a human immunoglobulin epsilon pseudogene that lacks introns. EMBO J (1982) 1.39
Teratocarcinomas and other neoplasms as developmental defects in gene expression. Adv Cancer Res (1981) 1.37
Gene control of hematopoiesis. I. Erythrocyte mosaicism and permanent immunological tolerance in allophenic mice. J Exp Med (1969) 1.36
CSF hypocretin/orexin levels in narcolepsy and other neurological conditions. Neurology (2001) 1.35
The Drosophila RBP-J kappa gene encodes the binding protein for the immunoglobulin J kappa recombination signal sequence. J Biol Chem (1991) 1.34
Totipotent hematopoietic stem cells: normal self-renewal and differentiation after transplantation between mouse fetuses. Cell (1982) 1.33
Requirement of voltage-dependent anion channel 2 for pro-apoptotic activity of Bax. Oncogene (2009) 1.32
Drosophila proliferating cell nuclear antigen (cyclin) gene: structure, expression during development, and specific binding of homeodomain proteins to its 5'-flanking region. Mol Cell Biol (1990) 1.31
Cloning of human immunoglobulin epsilon chain genes: evidence for multiple C epsilon genes. Proc Natl Acad Sci U S A (1982) 1.30
Long- and short-lived murine hematopoietic stem cell clones individually identified with retroviral integration markers. Blood (1990) 1.30
Base substitution at different alternative splice donor sites of the tyrosinase gene in murine albinism. Genomics (1996) 1.28
cDNA cloning of PG-M, a large chondroitin sulfate proteoglycan expressed during chondrogenesis in chick limb buds. Alternative spliced multiforms of PG-M and their relationships to versican. J Biol Chem (1993) 1.27
Contact-mediated myogenesis and increased acetylcholinesterase activity in primary cultures of mouse teratocarcinoma cells. Proc Natl Acad Sci U S A (1974) 1.26
Pure-strain and genetically mosaic liver tumors histochemically identified with the -glucuronidase marker in allophenic mice. Proc Natl Acad Sci U S A (1971) 1.26
Histocompatibility antigens on melanoblasts and hair follicle cells. Cell-localized homograft rejection in allophenic skin grafts. Transplantation (1970) 1.24
Characterization of a site-specific restriction endonuclease SphI from Streptomyces phaeochromogenes. Gene (1980) 1.24
Induction of angiogenesis in chick yolk-sac membrane by polyamines and its inhibition by tissue inhibitors of metalloproteinases (TIMP and TIMP-2). Biochem Biophys Res Commun (1990) 1.23
Teratocarcinoma cells as vehicles for introducing specific mutant mitochondrial genes into mice. Proc Natl Acad Sci U S A (1978) 1.23
Venous air embolism during hepatic resection. Anesthesiology (1990) 1.23
Melanosis and associated tumors in transgenic mice. Proc Natl Acad Sci U S A (1991) 1.22
Involvement of JNK in the regulation of autophagic cell death. Oncogene (2010) 1.22
A novel Drosophila receptor tyrosine kinase expressed specifically in the nervous system. Unique structural features and implication in developmental signaling. J Biol Chem (1997) 1.21
MRI measurements of normal extraocular muscles and other orbital structures. Graefes Arch Clin Exp Ophthalmol (2000) 1.20
Transfer of nonselectable genes into mouse teratocarcinoma cells and transcription of the transferred human beta-globin gene. Mol Cell Biol (1982) 1.19
Regulation of JNK by Src during Drosophila development. Science (2000) 1.18
De novo synthesis of sphingolipids is required for cell survival by down-regulating c-Jun N-terminal kinase in Drosophila imaginal discs. Mol Cell Biol (1999) 1.18
Cloning, sequencing, and expression in Ficoll-generated minicells of an Escherichia coli heat-stable enterotoxin gene. Plasmid (1988) 1.18
A novel Drosophila nuclear protein serine/threonine kinase expressed in the germline during its establishment. Mech Dev (1998) 1.16
Cardiac dysfunction with Becker muscular dystrophy. Am Heart J (1996) 1.16
Prognostic factors in primary gastrointestinal leiomyosarcoma: a retrospective study. World J Surg (1992) 1.15
Immobilization of Escherichia coli cells containing aspartase activity with kappa-carrageenan. Enzymic properties and application for L-aspartic acid production. Biochim Biophys Acta (1979) 1.15
Structure and expression during development of Drosophila melanogaster gene for DNA polymerase alpha. Nucleic Acids Res (1991) 1.15
Transcriptional regulation of the Drosophila CycA gene by the DNA replication-related element (DRE) and DRE binding factor (DREF). Nucleic Acids Res (1996) 1.14
The role of open lung biopsy in the management and outcome of patients with diffuse lung disease. Ann Thorac Surg (1998) 1.14
Hyaluronan oligosaccharides perturb cartilage matrix homeostasis and induce chondrocytic chondrolysis. Arthritis Rheum (2000) 1.13
Clonal coat color variation due to a transforming gene expressed in melanocytes of transgenic mice. Proc Natl Acad Sci U S A (1991) 1.12
Successive generations of mice produced from an established culture line of euploid teratocarcinoma cells. Proc Natl Acad Sci U S A (1981) 1.12
Missense and nonsense mutations in the lysosomal alpha-mannosidase gene (MANB) in severe and mild forms of alpha-mannosidosis. Am J Hum Genet (1998) 1.11
Somatic cell origin of teratocarcinomas. Proc Natl Acad Sci U S A (1978) 1.11
Analysis of the function of the 70-kilodalton cyclase-associated protein (CAP) by using mutants of yeast adenylyl cyclase defective in CAP binding. Mol Cell Biol (1993) 1.07
Structure of the human immunoglobulin C epsilon 2 gene, a truncated pseudogene: implications for its evolutionary origin. Proc Natl Acad Sci U S A (1983) 1.06
Ultrasensitive nanoparticle detection using a portable whispering gallery mode biosensor driven by a periodically poled lithium-niobate frequency doubled distributed feedback laser. Rev Sci Instrum (2010) 1.06
Alternative cell fate choice induced by low-level expression of a regulator of protein phosphatase 2A in the Drosophila peripheral nervous system. Development (1994) 1.06
Cloning and characterization of a cDNA coding for mouse placental alkaline phosphatase. Proc Natl Acad Sci U S A (1987) 1.05
Promoter CpG methylation in cancer cells contributes to the regulation of MUC4. Br J Cancer (2009) 1.05
Organization and reorganization of immunoglobulin heavy-chain genes. Cold Spring Harb Symp Quant Biol (1981) 1.04
Thiazolidinedione derivative improves fat distribution and multiple risk factors in subjects with visceral fat accumulation--double-blind placebo-controlled trial. Diabetes Res Clin Pract (2001) 1.04
Protein patterns of developmentally totipotent mouse teratocarcinoma cells and normal early embryo cells. Dev Biol (1978) 1.02
Effect of the CYP2D6*10 genotype on venlafaxine pharmacokinetics in healthy adult volunteers. Br J Clin Pharmacol (1999) 1.02
Human beta-globin gene sequences injected into mouse eggs, retained in adults, and transmitted to progeny. Science (1982) 1.01
Mosaicism of tyrosinase-locus transcription and chromatin structure in dark vs. light melanocyte clones of homozygous chinchilla-mottled mice. Dev Genet (1991) 1.01
Identification and characterization of Drosophila homolog of Rho-kinase. Gene (1999) 1.00
Isolation and characterization of variant cDNAs encoding mouse tyrosinase. Biochem Biophys Res Commun (1989) 0.99
Inhibition of hyaluronan retention by 4-methylumbelliferone suppresses osteosarcoma cells in vitro and lung metastasis in vivo. Br J Cancer (2011) 0.99
Interleukin-18 activates the IRAK-TRAF6 pathway in mouse EL-4 cells. Biochem Biophys Res Commun (1998) 0.98
Efficient entanglement distribution over 200 kilometers. Opt Express (2009) 0.98