Published in Cell on April 01, 1984
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Developmental regulation of alpha-fetoprotein genes in transgenic mice. Mol Cell Biol (1985) 1.94
High-frequency germ-line transmission of plasmid DNA sequences injected into fertilized zebrafish eggs. Proc Natl Acad Sci U S A (1991) 1.73
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Tissue-specific and developmentally regulated expression of a chimeric actin-globin gene in transgenic mice. Mol Cell Biol (1986) 1.35
Insertion of the bacterial gpt gene into the germ line of mice by retroviral infection. Proc Natl Acad Sci U S A (1985) 1.27
Analysis of the integrant in MyK-103 transgenic mice in which males fail to transmit the integrant. Mol Cell Biol (1987) 1.21
Insertional mutation in a transgenic mouse allelic with Purkinje cell degeneration. Proc Natl Acad Sci U S A (1989) 1.20
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Tissue-specific, inducible and functional expression of the E alpha d MHC class II gene in transgenic mice. EMBO J (1985) 1.13
Transcriptional insulation of the human keratin 18 gene in transgenic mice. Mol Cell Biol (1993) 1.11
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A foreign dihydrofolate reductase gene in transgenic mice acts as a dominant mutation. Mol Cell Biol (1986) 0.90
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Promoter efficiency depends upon intragenic sequences. Nucleic Acids Res (1987) 0.84
Correction of mouse ornithine transcarbamylase deficiency by gene transfer into the germ line. Nucleic Acids Res (1988) 0.83
Male sterility of transgenic mice carrying exogenous mouse interferon-beta gene under the control of the metallothionein enhancer-promoter. EMBO J (1988) 0.82
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Systemic resistance to methotrexate in transgenic mice carrying a mutant dihydrofolate reductase gene. Proc Natl Acad Sci U S A (1986) 0.77
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Germ-line transformation of mice. Annu Rev Genet (1986) 8.67
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Leptin-regulated endocannabinoids are involved in maintaining food intake. Nature (2001) 6.36
Erythroid-specific expression of human beta-globin genes in transgenic mice. EMBO J (1985) 5.84
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Regulation of metallothionein--thymidine kinase fusion plasmids injected into mouse eggs. Nature (1982) 5.14
A 12-base-pair DNA motif that is repeated several times in metallothionein gene promoters confers metal regulation to a heterologous gene. Proc Natl Acad Sci U S A (1984) 5.08
Structure of mouse metallothionein-I gene and its mRNA. Nature (1981) 5.06
Late endosomal membranes rich in lysobisphosphatidic acid regulate cholesterol transport. Nat Cell Biol (1999) 4.76
GAIP and RGS4 are GTPase-activating proteins for the Gi subfamily of G protein alpha subunits. Cell (1996) 4.76
A single erythroid-specific DNase I super-hypersensitive site activates high levels of human beta-globin gene expression in transgenic mice. Genes Dev (1989) 4.60
Differential regulation of metallothionein-thymidine kinase fusion genes in transgenic mice and their offspring. Cell (1982) 4.60
Inactivation of the mouse melanocortin-3 receptor results in increased fat mass and reduced lean body mass. Nat Genet (2000) 4.57
The mouse metallothionein-I gene is transcriptionally regulated by cadmium following transfection into human or mouse cells. Cell (1982) 4.55
An albumin enhancer located 10 kb upstream functions along with its promoter to direct efficient, liver-specific expression in transgenic mice. Genes Dev (1987) 4.48
Ovalbumin: a secreted protein without a transient hydrophobic leader sequence. Proc Natl Acad Sci U S A (1978) 4.46
Dramatic growth of mice that develop from eggs microinjected with metallothionein-growth hormone fusion genes. Nature (1982) 4.30
Somatic expression of herpes thymidine kinase in mice following injection of a fusion gene into eggs. Cell (1981) 4.23
Transcriptional regulation of the mouse metallothionein-I gene by heavy metals. J Biol Chem (1981) 4.20
Overexpression of TGF alpha in transgenic mice: induction of epithelial hyperplasia, pancreatic metaplasia, and carcinoma of the breast. Cell (1990) 4.05
Human gamma- to beta-globin gene switching in transgenic mice. Genes Dev (1990) 4.04
Metallothionein-human GH fusion genes stimulate growth of mice. Science (1983) 4.03
Cell lineage ablation in transgenic mice by cell-specific expression of a toxin gene. Cell (1987) 4.02
Sensitivity to leptin and susceptibility to seizures of mice lacking neuropeptide Y. Nature (1996) 3.99
Two 3' sequences direct adult erythroid-specific expression of human beta-globin genes in transgenic mice. Proc Natl Acad Sci U S A (1987) 3.81
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DNA methylation controls the inducibility of the mouse metallothionein-I gene lymphoid cells. Cell (1981) 3.67
Dissection of thymocyte signaling pathways by in vivo expression of pertussis toxin ADP-ribosyltransferase. EMBO J (1990) 3.62
Molecular pathogenesis of hepatocellular carcinoma in hepatitis B virus transgenic mice. Cell (1989) 3.60
Transgenic mice harboring SV40 T-antigen genes develop characteristic brain tumors. Cell (1984) 3.56
Diversity of alpha-fetoprotein gene expression in mice is generated by a combination of separate enhancer elements. Science (1987) 3.44
Fatal familial insomnia, a prion disease with a mutation at codon 178 of the prion protein gene. N Engl J Med (1992) 3.41
Building a metal-responsive promoter with synthetic regulatory elements. Mol Cell Biol (1985) 3.39
Response of melanocortin-4 receptor-deficient mice to anorectic and orexigenic peptides. Nat Genet (1999) 3.37
Heterologous introns can enhance expression of transgenes in mice. Proc Natl Acad Sci U S A (1991) 3.34
beta-Amyloid precursor protein-deficient mice show reactive gliosis and decreased locomotor activity. Cell (1995) 3.33
Complete hepatic regeneration after somatic deletion of an albumin-plasminogen activator transgene. Cell (1991) 3.31
A practical approach for quantitating specific mRNAs by solution hybridization. Anal Biochem (1983) 3.30
Attenuation of the obesity syndrome of ob/ob mice by the loss of neuropeptide Y. Science (1996) 3.28
Immunobiology and pathogenesis of hepatocellular injury in hepatitis B virus transgenic mice. Science (1990) 3.26
Regulation, linkage, and sequence of mouse metallothionein I and II genes. Mol Cell Biol (1984) 3.25
Replacement of diseased mouse liver by hepatic cell transplantation. Science (1994) 3.18
Isolation and characterization of the mouse metallothionein-I gene. Proc Natl Acad Sci U S A (1980) 3.17
The effect of cells transferred into the mouse blastocyst on subsequent development. J Exp Med (1974) 3.17
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Amplification of the metallothionein-I gene in cadmium-resistant mouse cells. Proc Natl Acad Sci U S A (1981) 3.11
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Expression of hepatitis B virus large envelope polypeptide inhibits hepatitis B surface antigen secretion in transgenic mice. J Virol (1986) 2.94
Augmented inverse probability weighted estimator for Cox missing covariate regression. Biometrics (2001) 2.93
beta1- and alpha6-integrin are surface markers on mouse spermatogonial stem cells. Proc Natl Acad Sci U S A (1999) 2.91
Dopamine-deficient mice are severely hypoactive, adipsic, and aphagic. Cell (1995) 2.89
Correlation of procollagen mRNA levels in normal and transformed chick embryo fibroblasts with different rates of procollagen synthesis. Biochemistry (1978) 2.85
Noradrenaline is essential for mouse fetal development. Nature (1995) 2.84
Specific expression of an elastase-human growth hormone fusion gene in pancreatic acinar cells of transgenic mice. Nature (1985) 2.77
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Quantitation of parameters that determine the rate of ovalbumin synthesis. Cell (1975) 2.74
Modulation of ovalbumin synthesis by estradiol-17 beta and actinomycin D as studied in explants of chick oviduct in culture. J Biol Chem (1971) 2.73
Rapid deubiquitination of nucleosomal histones in human tumor cells caused by proteasome inhibitors and stress response inducers: effects on replication, transcription, translation, and the cellular stress response. Biochemistry (1997) 2.73
Tissue-specific expression of the rat pancreatic elastase I gene in transgenic mice. Cell (1984) 2.59
Identification of multiple metal regulatory elements in mouse metallothionein-I promoter by assaying synthetic sequences. Nature (1985) 2.58
Transcriptional regulation of mouse liver metallothionein-I gene by glucocorticoids. Nature (1981) 2.58
Ethanol consumption and resistance are inversely related to neuropeptide Y levels. Nature (1998) 2.57
Enterovirus 71 from fatal and nonfatal cases of hand, foot and mouth disease epidemics in Malaysia, Japan and Taiwan in 1997-1998. Jpn J Infect Dis (1999) 2.52