Published in Mol Cell Biol on November 01, 1985
Helper-free stocks of recombinant adeno-associated viruses: normal integration does not require viral gene expression. J Virol (1989) 6.69
Targeted integration of adeno-associated virus (AAV) into human chromosome 19. EMBO J (1991) 6.13
Transduction with recombinant adeno-associated virus for gene therapy is limited by leading-strand synthesis. J Virol (1996) 5.94
Adeno-associated virus general transduction vectors: analysis of proviral structures. J Virol (1988) 4.64
Stable gene transfer and expression of human blood coagulation factor IX after intramuscular injection of recombinant adeno-associated virus. Proc Natl Acad Sci U S A (1997) 3.84
Parvovirus replication. Microbiol Rev (1990) 3.37
Negative and positive regulation in trans of gene expression from adeno-associated virus vectors in mammalian cells by a viral rep gene product. Mol Cell Biol (1986) 3.34
Identification of the trans-acting Rep proteins of adeno-associated virus by antibodies to a synthetic oligopeptide. J Virol (1986) 3.09
Latent infection of KB cells with adeno-associated virus type 2. J Virol (1986) 2.88
In vivo model of adeno-associated virus vector persistence and rescue. J Virol (1996) 2.41
Genetic fate of recombinant adeno-associated virus vector genomes in muscle. J Virol (2003) 2.07
Adeno-associated virus vector integration junctions. J Virol (1997) 2.03
Adeno-associated virus as a vector for liver-directed gene therapy. J Virol (1998) 1.94
Regulated high level expression of a human gamma-globin gene introduced into erythroid cells by an adeno-associated virus vector. Proc Natl Acad Sci U S A (1992) 1.82
Adeno-associated virus: a vector system for efficient introduction and integration of DNA into a variety of mammalian cell types. Mol Cell Biol (1988) 1.72
Efficient gene transfer into nondividing cells by adeno-associated virus-based vectors. J Virol (1994) 1.63
Adeno-associated virus Rep protein inhibits human immunodeficiency virus type 1 production in human cells. J Virol (1991) 1.59
Novel adeno-associated virus vector vaccine restricts replication of simian immunodeficiency virus in macaques. J Virol (2005) 1.36
Mutational analysis of the adeno-associated virus rep gene. J Virol (1992) 1.35
Detection of adeno-associated virus type 2 sequences in the human genital tract. J Clin Microbiol (1997) 1.29
Recombinant adeno-associated virus (rAAV)-mediated expression of a human gamma-globin gene in human progenitor-derived erythroid cells. Proc Natl Acad Sci U S A (1994) 1.28
Adeno-associated virus 2-mediated high efficiency gene transfer into immature and mature subsets of hematopoietic progenitor cells in human umbilical cord blood. J Exp Med (1994) 1.26
Recombinant adeno-associated virus mediates a high level of gene transfer but less efficient integration in the K562 human hematopoietic cell line. J Virol (1997) 1.12
Efficient and sustained gene expression in primary T lymphocytes and primary and cultured tumor cells mediated by adeno-associated virus plasmid DNA complexed to cationic liposomes. Mol Cell Biol (1994) 1.08
Cardiac gene therapy with SERCA2a: from bench to bedside. J Mol Cell Cardiol (2010) 1.05
Adeno-associated virus vectors and hematology. Blood (1999) 1.03
Self-complementary adeno-associated viral vectors for gene therapy of hemophilia B: progress and challenges. Expert Rev Hematol (2011) 0.87
Reducing the risk of adeno-associated virus (AAV) vector mobilization with AAV type 5 vectors. J Virol (2009) 0.84
Cardiac gene therapy. Semin Thorac Cardiovasc Surg (2010) 0.83
Development of Novel Recombinant AAV Vectors and Strategies for the Potential Gene Therapy of Hemophilia. J Genet Syndr Gene Ther (2012) 0.82
Selective extraction of polyoma DNA from infected mouse cell cultures. J Mol Biol (1967) 106.91
Transformation of mammalian cells to antibiotic resistance with a bacterial gene under control of the SV40 early region promoter. J Mol Appl Genet (1982) 54.79
Characteristics of a human cell line transformed by DNA from human adenovirus type 5. J Gen Virol (1977) 41.93
Construction of a retrovirus packaging mutant and its use to produce helper-free defective retrovirus. Cell (1983) 25.46
Selection for animal cells that express the Escherichia coli gene coding for xanthine-guanine phosphoribosyltransferase. Proc Natl Acad Sci U S A (1981) 22.21
DNA-mediated transfer of the adenine phosphoribosyltransferase locus into mammalian cells. Proc Natl Acad Sci U S A (1979) 21.22
Construction and applications of a highly transmissible murine retrovirus shuttle vector. Cell (1984) 13.91
Nucleotide sequence and exact localization of the neomycin phosphotransferase gene from transposon Tn5. Gene (1982) 13.62
A new dominant hybrid selective marker for higher eukaryotic cells. J Mol Biol (1981) 9.51
High efficiency DNA-mediated transformation of primate cells. Science (1983) 8.09
Vaccinia virus: a selectable eukaryotic cloning and expression vector. Proc Natl Acad Sci U S A (1982) 7.81
Nucleotide sequence and organization of the adeno-associated virus 2 genome. J Virol (1983) 7.52
Definition of a novel promoter for the major adenovirus-associated virus mRNA. Cell (1980) 7.42
Studies of small DNA viruses found in various adenovirus preparations: physical, biological, and immunological characteristics. Proc Natl Acad Sci U S A (1966) 7.35
Construction of poxviruses as cloning vectors: insertion of the thymidine kinase gene from herpes simplex virus into the DNA of infectious vaccinia virus. Proc Natl Acad Sci U S A (1982) 7.04
Genetics of adeno-associated virus: isolation and preliminary characterization of adeno-associated virus type 2 mutants. J Virol (1984) 5.89
Evidence for a single-stranded adenovirus-associated virus genome: formation of a DNA density hybrid on release of viral DNA. Proc Natl Acad Sci U S A (1969) 5.78
Cloning of adeno-associated virus into pBR322: rescue of intact virus from the recombinant plasmid in human cells. Proc Natl Acad Sci U S A (1982) 5.73
Rescue of adeno-associated virus from recombinant plasmids: gene correction within the terminal repeats of AAV. Cell (1983) 5.27
Integration of the adeno-associated virus genome into cellular DNA in latently infected human Detroit 6 cells. J Virol (1980) 5.09
Genetic analysis of adeno-associated virus: properties of deletion mutants constructed in vitro and evidence for an adeno-associated virus replication function. J Virol (1984) 4.98
E1A control of gene expression is mediated by sequences 5' to the transcriptional starts of the early viral genes. Mol Cell Biol (1983) 4.84
Expression of a transposable antibiotic resistance element in Saccharomyces. Nature (1980) 4.66
Concatemers of alternating plus and minus strands are intermediates in adenovirus-associated virus DNA synthesis. Proc Natl Acad Sci U S A (1976) 4.62
Cloning of infectious adeno-associated virus genomes in bacterial plasmids. Gene (1983) 4.15
Prospects for human gene therapy. Science (1984) 3.93
Use of adeno-associated virus as a mammalian DNA cloning vector: transduction of neomycin resistance into mammalian tissue culture cells. Proc Natl Acad Sci U S A (1984) 3.92
Spliced adenovirus-associated virus RNA. Proc Natl Acad Sci U S A (1979) 2.99
Mapping of the 5' termini of two adeno-associated virus 2 RNAs in the left half of the genome. J Virol (1982) 2.75
Adenovirus-associated virus multiplication. VII. Helper requirement for viral deoxyribonucleic acid and ribonucleic acid synthesis. J Virol (1972) 2.74
Introduction and recovery of a selectable bacterial gene from the genome of mammalian cells. Mol Cell Biol (1982) 2.59
Establishment and characterization of KB cell lines latently infected with adeno-associated virus type 1. Virology (1977) 2.53
Replication of adeno-associated virus DNA. Complementation of naturally occurring rep- mutants by a wild-type genome or an ori- mutant and correction of terminal palindrome deletions. J Mol Biol (1984) 2.51
Adeno-associated virus autointerference. Virology (1979) 2.43
Loss of intervening sequences in genomic mouse alpha-globin DNA inserted in an infectious retrovirus vector. Nature (1982) 2.38
A human parvovirus, adeno-associated virus, as a eucaryotic vector: transient expression and encapsidation of the procaryotic gene for chloramphenicol acetyltransferase. Mol Cell Biol (1984) 2.36
Expression of genes introduced into cells by retroviral infection is more efficient than that of genes introduced into cells by DNA transfection. J Virol (1984) 2.28
Infection of eucaryotic cells by helper-independent recombinant adenoviruses: early region 1 is not obligatory for integration of viral DNA. J Virol (1984) 2.28
Characterization and molecular cloning of a human parvovirus genome. Science (1984) 2.12
Molecular cloning of adeno-associated virus variant genomes and generation of infectious virus by recombination in mammalian cells. J Biol Chem (1984) 1.99
Adeno-associated virus RNA transcription in vivo. Eur J Biochem (1981) 1.83
Infectious and selectable retrovirus containing an inducible rat growth hormone minigene. Science (1984) 1.80
Cloning vectors derived from animal viruses. J Gen Virol (1983) 1.22
Transfer of genes into hematopoietic cells using recombinant DNA viruses. Proc Natl Acad Sci U S A (1985) 1.12
The chromosome of bacteriophage T5. I. Analysis of the single-stranded DNA fragments by agarose gel electrophoresis. J Mol Biol (1972) 7.98
Isolation of the virus of herpes simplex and the demonstration of intranuclear inclusions in a case of acute encephalitis. Am J Pathol (1941) 6.38
Genetic analysis of adeno-associated virus: properties of deletion mutants constructed in vitro and evidence for an adeno-associated virus replication function. J Virol (1984) 4.98
Cloning of infectious adeno-associated virus genomes in bacterial plasmids. Gene (1983) 4.15
Cell-mediated immunity to a human liver-specific antigen in patients with active chronic hepatitis and primary biliary cirrhosis. Lancet (1972) 3.90
Characteristics and taxonomy of Parvoviridae. Intervirology (1985) 3.70
Stable in vivo expression of the cystic fibrosis transmembrane conductance regulator with an adeno-associated virus vector. Proc Natl Acad Sci U S A (1993) 3.59
Negative and positive regulation in trans of gene expression from adeno-associated virus vectors in mammalian cells by a viral rep gene product. Mol Cell Biol (1986) 3.34
Investigation and control of an outbreaks of legionnaires' disease in a district general hospital. Lancet (1981) 3.14
Identification of the trans-acting Rep proteins of adeno-associated virus by antibodies to a synthetic oligopeptide. J Virol (1986) 3.09
Defective regulation of outwardly rectifying Cl- channels by protein kinase A corrected by insertion of CFTR. Nature (1992) 3.06
Expression of the cystic fibrosis transmembrane conductance regulator from a novel adeno-associated virus promoter. J Biol Chem (1993) 3.02
Spliced adenovirus-associated virus RNA. Proc Natl Acad Sci U S A (1979) 2.99
Self-complementarity of terminal sequences within plus or minus strands of adenovirus-associated virus DNA. Proc Natl Acad Sci U S A (1973) 2.96
Mutagenesis of an AUG codon in the adeno-associated virus rep gene: effects on viral DNA replication. Virology (1989) 2.91
Thermal stability and protein structure. Biochemistry (1979) 2.73
Replication of adeno-associated virus DNA. Complementation of naturally occurring rep- mutants by a wild-type genome or an ori- mutant and correction of terminal palindrome deletions. J Mol Biol (1984) 2.51
Adeno-associated virus autointerference. Virology (1979) 2.43
In vivo model of adeno-associated virus vector persistence and rescue. J Virol (1996) 2.41
A human parvovirus, adeno-associated virus, as a eucaryotic vector: transient expression and encapsidation of the procaryotic gene for chloramphenicol acetyltransferase. Mol Cell Biol (1984) 2.36
Adeno-associated virus vectors for gene therapy. Gene Ther (1995) 2.32
Escherichia coli O157:H7 infection from a manured garden. Lancet (1993) 2.27
Identification of a DNA-binding domain in the amino terminus of adeno-associated virus Rep proteins. J Virol (1993) 2.22
Absence of HIV transmission from an infected orthopedic surgeon. A 13-year look-back study. JAMA (1993) 2.21
THE ISOLATION OF THE ST. LOUIS ENCEPHALITIS VIRUS FROM CHICKEN MITES (DERMANYSSUS GALLINAE) IN NATURE. Science (1944) 2.17
Eukaryotic translational control: adeno-associated virus protein synthesis is affected by a mutation in the adenovirus DNA-binding protein. Proc Natl Acad Sci U S A (1981) 2.08
Cell-mediated immune responses in chronic liver diseases. Br Med J (1972) 2.05
Defective-interfering particles of the human parvovirus adeno-associated virus. Virology (1979) 2.05
Alternate mRNA splicing is required for synthesis of adeno-associated virus VP1 capsid protein. J Virol (1988) 2.03
Molecular cloning of adeno-associated virus variant genomes and generation of infectious virus by recombination in mammalian cells. J Biol Chem (1984) 1.99
Anaesthesia without induction rooms. Anaesthesia (2001) 1.97
Changes in leucocyte migration after renal transplantation. Br Med J (1969) 1.91
Adenovirus-associated virus multiplication. IX. Extent of transcription of the viral genome in vivo. J Virol (1972) 1.87
The physicochemical properties of infectious hepatitis A virions. J Gen Virol (1981) 1.86
Characterization of adeno-associated virus rep proteins in human cells by antibodies raised against rep expressed in Escherichia coli. Virology (1987) 1.85
Adeno-associated virus rep proteins produced in insect and mammalian expression systems: wild-type and dominant-negative mutant proteins bind to the viral replication origin. Virology (1991) 1.84
Gene expression from adeno-associated virus vectors in airway epithelial cells. Am J Respir Cell Mol Biol (1992) 1.83
Adeno-associated virus RNA transcription in vivo. Eur J Biochem (1981) 1.83
Separate helper functions provided by adenovirus for adenovirus-associated virus multiplication. Nat New Biol (1973) 1.82
Nucleotide sequence of classical swine fever virus strain Alfort/187 and transcription of infectious RNA from stably cloned full-length cDNA. J Virol (1996) 1.81
Regulation of adeno-associated virus gene expression in 293 cells: control of mRNA abundance and translation. J Virol (1988) 1.80
Effect of deletions in adenovirus early region 1 genes upon replication of adeno-associated virus. J Virol (1982) 1.76
Evaluation of the leucocyte migration test as a measure of delayed hypersensitivty in man. Suppression of migration inhibition by puromycin. Clin Exp Immunol (1972) 1.71
Assembly of adeno-associated virus. Virology (1980) 1.71
Properties of an adenovirus type 2 mutant, Ad2dl807, having a deletion near the right-hand genome terminus: failure to help AAV replication. Virology (1983) 1.69
Some properties of DNA from phage-infected bacteria. J Gen Physiol (1966) 1.68
Adenovirus-associated virus multiplication. 8. Analysis of in vivo transcription induced by complete or partial helper viruses. J Virol (1972) 1.65
Yeast mitochondria contain ATP-sensitive, reversible actin-binding activity. Mol Biol Cell (1994) 1.65
Hepatic disorders associated with liver-kidney microsomal antibodies. Br Med J (1974) 1.64
Replication of a human parvovirus nonsense mutant in mammalian cells containing an inducible amber suppressor. Virology (1989) 1.63
The chromosome of bacteriophage T5. II. Arrangement of the single-stranded DNA fragments in the T5 + and T5st(O) chromosomes. J Mol Biol (1972) 1.61
Adeno-associated virus Rep protein inhibits human immunodeficiency virus type 1 production in human cells. J Virol (1991) 1.59
A phase I study of aerosolized administration of tgAAVCF to cystic fibrosis subjects with mild lung disease. Hum Gene Ther (2001) 1.58
Transcription in vivo of a defective parvovirus: sedimentation and electrophoretic analysis of RNA synthesized by adenovirus-associated virus and its helper adenovirus. Virology (1974) 1.57
Mutation of a consensus purine nucleotide binding site in the adeno-associated virus rep gene generates a dominant negative phenotype for DNA replication. J Virol (1990) 1.56
Tumors of the Islands of Langerhans and Hypoglycemia. Am J Pathol (1931) 1.55
Inhibition of cellular transformation by the adeno-associated virus rep gene. Virology (1991) 1.55
Adenovirus helper function for growth of adeno-associated virus: effect of temperature-sensitive mutations in adenovirus early gene region 2. J Virol (1980) 1.54
Adeno-associated virus rep protein synthesis during productive infection. J Virol (1989) 1.54
Water fittings as sources of Legionella pneumophila in a hospital plumbing system. Lancet (1984) 1.49
Analysis of adeno-associated virus (AAV) wild-type and mutant Rep proteins for their abilities to negatively regulate AAV p5 and p19 mRNA levels. J Virol (1994) 1.48
Application of the leucocyte migration test to the diagnosis of rejection after liver transplantation. Transplantation (1971) 1.47
Effects of food intake on numbers of salmonellae and Escherichia coli in rumen and faeces of sheep. J Appl Bacteriol (1969) 1.47
Safety and biological efficacy of an adeno-associated virus vector-cystic fibrosis transmembrane regulator (AAV-CFTR) in the cystic fibrosis maxillary sinus. Laryngoscope (1999) 1.47
Specific cleavage of adenovirus-associated virus DNA by restriction endonuclease R-EcoRI--characterization of cleavage products. Virology (1975) 1.46
Marathon performance in relation to maximal aerobic power and training indices. Med Sci Sports Exerc (1981) 1.46
Safety of single-dose administration of an adeno-associated virus (AAV)-CFTR vector in the primate lung. Gene Ther (1996) 1.45
Histocompatibility antigens in active chronic hepatitis and primary biliary cirrhosis. Br Med J (1974) 1.45
Serum immunosuppressive activity due to azathioprine and its relation to hepatic function after liver transplantation. Lancet (1970) 1.44
Genome localization of simian virus 40 RNA species. J Virol (1976) 1.41
Chromosome-mediated gene transfer between closely realted strains of cultured mouse cells. Proc Natl Acad Sci U S A (1976) 1.40
On the interruption of pregnancy in the rat by the injection of ovarian follicular extract. Bull Johns Hopkins Hosp (1926) 1.37
Gelatin-induced reversion of protoplasts of Bacillus subtilis to the bacillary form: photomicrographic study. J Bacteriol (1968) 1.37
Genome localization of adeno-associated virus RNA. J Virol (1976) 1.36
In vitro resolution of adeno-associated virus DNA hairpin termini by wild-type Rep protein is inhibited by a dominant-negative mutant of rep. J Virol (1992) 1.36
Gene expression in adeno-associated virus vectors: the effects of chimeric mRNA structure, helper virus, and adenovirus VA1 RNA. Virology (1987) 1.35
Targeted integration of transfected and infected adeno-associated virus vectors containing the neomycin resistance gene. Gene Ther (1994) 1.35
The generation time, lag time, and minimum temperature of growth of coliform organisms on meat, and the implications for codes of practice in abattoirs. J Hyg (Lond) (1985) 1.34
An improved system for packaging recombinant adeno-associated virus vectors capable of in vivo transduction. Gene Ther (1995) 1.32
Cloning of the human parvovirus B19 genome and structural analysis of its palindromic termini. Virology (1990) 1.31
Organization of the adeno-associated virus (AAV) capsid gene: mapping of a minor spliced mRNA coding for virus capsid protein 1. Virology (1988) 1.31
Inhibition of adenovirus oncogenicity in hamsters by adeno-associated virus DNA. J Natl Cancer Inst (1981) 1.30
Mass human exposure to rabies in New Hampshire: exposures, treatment, and cost. Am J Public Health (1996) 1.28
An outbreak of Yersinia enterocolitica O:8 infections associated with pasteurized milk. J Infect Dis (2000) 1.26
Intracellular distribution and polyadenylate content of adeno-associated virus RNA sequences. Virology (1976) 1.23
Vero cells injected with adenovirus type 2 mRNA produce authentic viral polypeptide patterns: early mRNA promotes growth of adenovirus-associated virus. Proc Natl Acad Sci U S A (1980) 1.23
Parvovirus RNA transcripts containing sequences not present in mature mRNA: a method for isolation of putative mRNA precursor sequences. Proc Natl Acad Sci U S A (1979) 1.23
Recovery from experimental parkinsonism in primates with GM1 ganglioside treatment. Science (1992) 1.22
Influence of Hydrogen Peroxide upon Carbon Dioxide Photoassimilation in the Spinach Chloroplast: I. HYDROGEN PEROXIDE GENERATED BY BROKEN CHLOROPLASTS IN AN "INTACT" CHLOROPLAST PREPARATION IS A CAUSAL AGENT OF THE WARBURG EFFECT. Plant Physiol (1980) 1.21
Fractionation of deoxyribonucleic acid from phage-infected bacteria. Biochem J (1966) 1.21
Nuclear oestrogen receptors and treatment of breast cancer. Lancet (1977) 1.20
Adeno-associated virus replication. The effect of L-canavanine or a helper virus mutation on accumulation of viral capsids and progeny single-stranded DNA. J Biol Chem (1981) 1.20