Published in Nucleic Acids Res on August 11, 1986
Herpes simplex virus type 1 ICP0 plays a critical role in the de novo synthesis of infectious virus following transfection of viral DNA. J Virol (1989) 3.63
The herpes simplex virus type 1 alpha protein ICP27 can act as a trans-repressor or a trans-activator in combination with ICP4 and ICP0. J Virol (1988) 3.33
Physical and functional domains of the herpes simplex virus transcriptional regulatory protein ICP4. J Virol (1988) 3.14
Binding of the herpes simplex virus immediate-early gene product ICP4 to its own transcription start site. J Virol (1987) 3.09
Activities of herpes simplex virus type 1 (HSV-1) ICP4 genes specifying nonsense peptides. Nucleic Acids Res (1987) 2.99
The herpes simplex virus 1 protein kinase US3 is required for protection from apoptosis induced by the virus. Proc Natl Acad Sci U S A (1997) 2.98
Host cell proteins bind to the cis-acting site required for virion-mediated induction of herpes simplex virus 1 alpha genes. Proc Natl Acad Sci U S A (1987) 2.90
The varicella-zoster virus immediate-early protein IE62 is a major component of virus particles. J Virol (1992) 2.80
Molecular analysis of the transcriptional regulatory region of an early baculovirus gene. J Virol (1989) 2.31
The herpes simplex virus major regulatory protein ICP4 blocks apoptosis induced by the virus or by hyperthermia. Proc Natl Acad Sci U S A (1996) 2.23
ICP4, the major transcriptional regulatory protein of herpes simplex virus type 1, forms a tripartite complex with TATA-binding protein and TFIIB. J Virol (1993) 2.16
Herpes simplex virus immediate-early protein ICP22 is required for viral modification of host RNA polymerase II and establishment of the normal viral transcription program. J Virol (1995) 2.13
The regions important for the activator and repressor functions of herpes simplex virus type 1 alpha protein ICP27 map to the C-terminal half of the molecule. J Virol (1989) 1.99
Herpes simplex virus immediate-early promoters are responsive to virus and cell trans-acting factors. J Virol (1987) 1.96
The regions of the herpes simplex virus type 1 immediate early protein Vmw175 required for site specific DNA binding closely correspond to those involved in transcriptional regulation. Nucleic Acids Res (1988) 1.78
Human cytomegalovirus immediate-early gene 2 protein interacts with itself and with several novel cellular proteins. J Virol (1993) 1.73
Differentiation and DNA contact points of host proteins binding at the cis site for virion-mediated induction of alpha genes of herpes simplex virus 1. J Virol (1988) 1.68
The regulation of synthesis and properties of the protein product of open reading frame P of the herpes simplex virus 1 genome. J Virol (1995) 1.63
Association of herpes simplex virus regulatory protein ICP4 with sequences spanning the ICP4 gene transcription initiation site. Nucleic Acids Res (1988) 1.60
Repression of the herpes simplex virus 1 alpha 4 gene by its gene product occurs within the context of the viral genome and is associated with all three identified cognate sites. Proc Natl Acad Sci U S A (1993) 1.56
Interaction of the viral activator protein ICP4 with TFIID through TAF250. Mol Cell Biol (1996) 1.56
Dissection of immediate-early gene promoters from herpes simplex virus: sequences that respond to the virus transcriptional activators. J Virol (1987) 1.53
The ICP4 binding sites in the herpes simplex virus type 1 glycoprotein D (gD) promoter are not essential for efficient gD transcription during virus infection. J Virol (1992) 1.51
Characterization of the DNA-binding properties of herpes simplex virus regulatory protein ICP4. J Virol (1989) 1.51
Functional interactions between herpes simplex virus immediate-early proteins during infection: gene expression as a consequence of ICP27 and different domains of ICP4. J Virol (1995) 1.48
Physical interaction between the herpes simplex virus type 1 immediate-early regulatory proteins ICP0 and ICP4. J Virol (1994) 1.45
Functional relevance of specific interactions between herpes simplex virus type 1 ICP4 and sequences from the promoter-regulatory domain of the viral thymidine kinase gene. J Virol (1990) 1.44
Site-specific binding of the human cytomegalovirus IE2 86-kilodalton protein to an early gene promoter. J Virol (1994) 1.44
Phenotypic properties of herpes simplex virus 1 containing a derepressed open reading frame P gene. J Virol (1996) 1.44
Binding of the herpes simplex virus major regulatory protein to viral DNA. Proc Natl Acad Sci U S A (1989) 1.41
ICP4-binding sites in the promoter and coding regions of the herpes simplex virus gD gene contribute to activation of in vitro transcription by ICP4. J Virol (1989) 1.40
Physical and functional interactions between herpes simplex virus immediate-early proteins ICP4 and ICP27. J Virol (1997) 1.38
The replication cycle of varicella-zoster virus: analysis of the kinetics of viral protein expression, genome synthesis, and virion assembly at the single-cell level. J Virol (2009) 1.38
Herpes simplex virus transactivator ICP4 operationally substitutes for the cellular transcription factor Sp1 for efficient expression of the viral thymidine kinase gene. J Virol (1991) 1.37
Guanylylation and adenylylation of the alpha regulatory proteins of herpes simplex virus require a viral beta or gamma function. J Virol (1993) 1.37
DNA binding and gene regulation by the herpes simplex virus type 1 protein ICP4 and involvement of the TATA element. J Virol (1989) 1.27
Activities of heterodimers composed of DNA-binding- and transactivation-deficient subunits of the herpes simplex virus regulatory protein ICP4. J Virol (1991) 1.27
Characterization of the regulatory functions of the equine herpesvirus 1 immediate-early gene product. J Virol (1992) 1.25
Herpes simplex virus infected cell polypeptide 4 preferentially represses Sp1-activated over basal transcription from its own promoter. Proc Natl Acad Sci U S A (1993) 1.25
Requirements for activation of the herpes simplex virus glycoprotein C promoter in vitro by the viral regulatory protein ICP4. J Virol (1994) 1.22
DNA binding by the herpes simplex virus type 1 ICP4 protein is necessary for efficient down regulation of the ICP0 promoter. J Virol (1989) 1.21
Codons 262 to 490 from the herpes simplex virus ICP4 gene are sufficient to encode a sequence-specific DNA binding protein. Nucleic Acids Res (1990) 1.21
Intragenic complementation among partial peptides of herpes simplex virus regulatory protein ICP4. J Virol (1989) 1.20
A second-site revertant of a defective herpes simplex virus ICP4 protein with restored regulatory activities and impaired DNA-binding properties. J Virol (1991) 1.19
Expression of a cellular gene cloned in herpes simplex virus: rabbit beta-globin is regulated as an early viral gene in infected fibroblasts. J Virol (1987) 1.19
Role for DNA-protein interaction in activation of the herpes simplex virus glycoprotein D gene. J Virol (1988) 1.18
Role of protein kinase A and the serine-rich region of herpes simplex virus type 1 ICP4 in viral replication. J Virol (1996) 1.17
Repression of activator-mediated transcription by herpes simplex virus ICP4 via a mechanism involving interactions with the basal transcription factors TATA-binding protein and TFIIB. Mol Cell Biol (1995) 1.17
Polyamines alter sequence-specific DNA-protein interactions. Nucleic Acids Res (1995) 1.14
Relationship between TATA-binding protein and herpes simplex virus type 1 ICP4 DNA-binding sites in complex formation and repression of transcription. J Virol (1995) 1.11
Binding of ICP4, TATA-binding protein, and RNA polymerase II to herpes simplex virus type 1 immediate-early, early, and late promoters in virus-infected cells. J Virol (2007) 1.11
The product of ORF O located within the domain of herpes simplex virus 1 genome transcribed during latent infection binds to and inhibits in vitro binding of infected cell protein 4 to its cognate DNA site. Proc Natl Acad Sci U S A (1997) 1.11
Herpes simplex virus immediate-early proteins ICP0 and ICP4 activate the endogenous human alpha-globin gene in nonerythroid cells. J Virol (1997) 1.10
ICP4, the major regulatory protein of herpes simplex virus, shares features common to GTP-binding proteins and is adenylated and guanylated. J Virol (1991) 1.09
Regulation of cellular genes transduced by herpes simplex virus. J Virol (1989) 1.07
Regulation of transcription in vitro from herpes simplex virus genes. J Virol (1986) 1.06
Identification of immediate-early-type cis-response elements in the promoter for the ribonucleotide reductase large subunit from herpes simplex virus type 2. J Virol (1989) 1.04
The polyserine tract of herpes simplex virus ICP4 is required for normal viral gene expression and growth in murine trigeminal ganglia. J Virol (1998) 1.04
Differences in the poly(ADP-ribosyl)ation patterns of ICP4, the herpes simplex virus major regulatory protein, in infected cells and in isolated nuclei. J Virol (1992) 1.03
The ICP22 protein of equine herpesvirus 1 cooperates with the IE protein to regulate viral gene expression. J Virol (1997) 1.03
Mutational analysis of the ICP4 binding sites in the 5' transcribed noncoding domains of the herpes simplex virus 1 UL 49.5 gamma 2 gene. J Virol (1992) 1.01
Transcriptionally active immediate-early protein of pseudorabies virus binds to specific sites on class II gene promoters. J Virol (1989) 1.00
Herpes simplex virus 1 ICP4 forms complexes with TFIID and mediator in virus-infected cells. J Virol (2011) 1.00
The interaction of ICP4 with cell/infected-cell factors and its state of phosphorylation modulate differential recognition of leader sequences in herpes simplex virus DNA. EMBO J (1991) 0.99
Mutational analysis of varicella-zoster virus major immediate-early protein IE62. Nucleic Acids Res (1995) 0.96
Purification of the DNA binding domain of herpes simplex virus type 1 immediate-early protein Vmw175 as a homodimer and extensive mutagenesis of its DNA recognition site. Nucleic Acids Res (1991) 0.95
Mammalian alphaherpesvirus miRNAs. Biochim Biophys Acta (2011) 0.93
Association of a major transcriptional regulatory protein, ICP4, of herpes simplex virus type 1 with the plasma membrane of virus-infected cells. J Virol (1991) 0.92
Nucleotides within both proximal and distal parts of the consensus sequence are important for specific DNA recognition by the herpes simplex virus regulatory protein ICP4. Nucleic Acids Res (1991) 0.92
Repression of the alpha0 gene by ICP4 during a productive herpes simplex virus infection. J Virol (1996) 0.92
The major transcriptional regulatory protein of herpes simplex virus type 1 includes a protease resistant DNA binding domain. Nucleic Acids Res (1990) 0.92
Live covisualization of competing adeno-associated virus and herpes simplex virus type 1 DNA replication: molecular mechanisms of interaction. J Virol (2007) 0.90
Herpes simplex virus type 1 polypeptide ICP4 bends DNA. Nucleic Acids Res (1992) 0.89
The DNA binding domains of the varicella-zoster virus gene 62 and herpes simplex virus type 1 ICP4 transactivator proteins heterodimerize and bind to DNA. Nucleic Acids Res (1994) 0.88
Mutation of a single lysine residue severely impairs the DNA recognition and regulatory functions of the VZV gene 62 transactivator protein. Nucleic Acids Res (1994) 0.88
The high mobility group protein 1 is a coactivator of herpes simplex virus ICP4 in vitro. J Virol (1998) 0.88
Identification of a promoter-specific transactivation domain in the herpes simplex virus regulatory protein ICP4. J Virol (1997) 0.87
DNA-dependent oligomerization of herpes simplex virus type 1 regulatory protein ICP4. J Virol (2007) 0.86
Temperature-dependent conformational changes in herpes simplex virus ICP4 that affect transcription activation. J Virol (2003) 0.85
Induction of transcription by a viral regulatory protein depends on the relative strengths of functional TATA boxes. Mol Cell Biol (1995) 0.85
Herpes simplex virus 1 open reading frames O and P are not necessary for establishment of latent infection in mice. J Virol (2000) 0.84
Requirement of the N-terminal activation domain of herpes simplex virus ICP4 for viral gene expression. J Virol (2012) 0.84
Temporal association of herpes simplex virus ICP4 with cellular complexes functioning at multiple steps in PolII transcription. PLoS One (2013) 0.83
Localization of a 34-amino-acid segment implicated in dimerization of the herpes simplex virus type 1 ICP4 polypeptide by a dimerization trap. J Virol (1994) 0.83
Role of the IE62 consensus binding site in transactivation by the varicella-zoster virus IE62 protein. J Virol (2010) 0.83
Update on emerging antivirals for the management of herpes simplex virus infections: a patenting perspective. Recent Pat Antiinfect Drug Discov (2013) 0.81
The N terminus and C terminus of herpes simplex virus 1 ICP4 cooperate to activate viral gene expression. J Virol (2012) 0.80
Herpesvirus Late Gene Expression: A Viral-Specific Pre-initiation Complex Is Key. Front Microbiol (2016) 0.79
Differential contribution of herpes simplex virus type 1 gene products and cellular factors to the activation of human immunodeficiency virus type 1 provirus. J Virol (1993) 0.78
Replication-Coupled Recruitment of Viral and Cellular Factors to Herpes Simplex Virus Type 1 Replication Forks for the Maintenance and Expression of Viral Genomes. PLoS Pathog (2017) 0.78
The use of fluorescence microscopy to study the association between herpesviruses and intrinsic resistance factors. Viruses (2011) 0.76
Sequencing end-labeled DNA with base-specific chemical cleavages. Methods Enzymol (1980) 287.68
A rapid alkaline extraction procedure for screening recombinant plasmid DNA. Nucleic Acids Res (1979) 214.95
Complete nucleotide sequence of the Escherichia coli plasmid pBR322. Cold Spring Harb Symp Quant Biol (1979) 43.48
Analysis of restriction fragments of T7 DNA and determination of molecular weights by electrophoresis in neutral and alkaline gels. J Mol Biol (1977) 33.84
DNAse footprinting: a simple method for the detection of protein-DNA binding specificity. Nucleic Acids Res (1978) 30.43
Regulation of herpesvirus macromolecular synthesis. I. Cascade regulation of the synthesis of three groups of viral proteins. J Virol (1974) 26.25
Control of herpes simplex virus type 1 mRNA synthesis in cells infected with wild-type virus or the temperature-sensitive mutant tsK. J Virol (1979) 11.34
Anatomy of herpes simplex virus (HSV) DNA. X. Mapping of viral genes by analysis of polypeptides and functions specified by HSV-1 X HSV-2 recombinants. J Virol (1978) 11.19
Fine-structure mapping and functional analysis of temperature-sensitive mutants in the gene encoding the herpes simplex virus type 1 immediate early protein VP175. J Virol (1980) 9.30
A herpes simplex virus type 1 function continuously required for early and late virus RNA synthesis. Nature (1980) 8.47
Characterization of the herpes simplex virion-associated factor responsible for the induction of alpha genes. J Virol (1983) 8.31
Regulation of herpesvirus macromolecular synthesis. V. Properties of alpha polypeptides made in HSV-1 and HSV-2 infected cells. Virology (1977) 8.24
Evidence for a direct role for both the 175,000- and 110,000-molecular-weight immediate-early proteins of herpes simplex virus in the transactivation of delayed-early promoters. J Virol (1985) 7.39
Structural features of the herpes simplex virus alpha gene 4, 0, and 27 promoter-regulatory sequences which confer alpha regulation on chimeric thymidine kinase genes. J Virol (1982) 7.35
Trans activation of transcription by herpes virus products: requirement for two HSV-1 immediate-early polypeptides for maximum activity. EMBO J (1984) 7.33
Activation of gene expression by adenovirus and herpesvirus regulatory genes acting in trans and by a cis-acting adenovirus enhancer element. Cell (1983) 5.91
Stimulation of expression of a herpes simplex virus DNA-binding protein by two viral functions. Mol Cell Biol (1985) 5.76
Three trans-acting regulatory proteins of herpes simplex virus modulate immediate-early gene expression in a pathway involving positive and negative feedback regulation. J Virol (1985) 5.63
Control of protein synthesis in herpesvirus-infected cells: analysis of the polypeptides induced by wild type and sixteen temperature-sensitive mutants of HSV strain 17. J Gen Virol (1976) 5.47
Identification of immediate early genes from herpes simplex virus that transactivate the virus thymidine kinase gene. Proc Natl Acad Sci U S A (1985) 5.40
Separation and characterization of herpes simplex virus type 1 immediate-early mRNA's. J Virol (1979) 5.21
The distal transcription signals of the herpesvirus tk gene share a common hexanucleotide control sequence. Cell (1984) 5.10
Binding of a simian virus 40 T antigen-related protein to DNA. J Mol Biol (1981) 4.76
Activation of immediate-early, early, and late promoters by temperature-sensitive and wild-type forms of herpes simplex virus type 1 protein ICP4. Mol Cell Biol (1985) 4.74
Complete DNA sequence of the short repeat region in the genome of herpes simplex virus type 1. Nucleic Acids Res (1986) 4.55
Herpes simplex virus type-1 glycoprotein D gene: nucleotide sequence and expression in Escherichia coli. Science (1982) 4.28
The specificity of five DNAases as studied by the analysis of 5'-terminal doublets. Eur J Biochem (1975) 3.85
Evidence that herpes simplex virus DNA is transcribed by cellular RNA polymerase B. J Virol (1977) 3.82
Alpha 4, the major regulatory protein of herpes simplex virus type 1, is stably and specifically associated with promoter-regulatory domains of alpha genes and of selected other viral genes. Proc Natl Acad Sci U S A (1986) 3.64
Isolation and characterization of a large molecular-weight polypeptide of herpes simplex virus type 1. Virology (1974) 3.32
A detailed analysis of an HSV-1 early promoter: sequences involved in trans-activation by viral immediate-early gene products are not early-gene specific. Nucleic Acids Res (1984) 3.31
Activation of early adenovirus transcription by the herpesvirus immediate early gene: evidence for a common cellular control factor. Proc Natl Acad Sci U S A (1982) 3.29
Analysis of DNA sequences which regulate the transcription of a herpes simplex virus immediate early gene. J Virol (1984) 3.03
Expression of recombinant genes containing herpes simplex virus delayed-early and immediate-early regulatory regions and trans activation by herpesvirus infection. J Virol (1984) 3.00
DNA sequence elements required for regulated expression of the HSV-1 glycoprotein D gene lie within 83 bp of the RNA capsites. Nucleic Acids Res (1983) 2.81
Cells that constitutively express the herpes simplex virus immediate-early protein ICP4 allow efficient activation of viral delayed-early genes in trans. J Virol (1985) 2.40
Isolation of herpes simplex virus regulatory protein ICP4 as a homodimeric complex. J Virol (1985) 2.20
DNA-binding properties of a herpes simplex virus immediate early protein. J Virol (1982) 2.17
Expression of herpes simplex virus beta and gamma genes integrated in mammalian cells and their induction by an alpha gene product. Mol Cell Biol (1983) 2.15
Transactivation of a late herpes simplex virus promoter. Mol Cell Biol (1984) 1.53
In vitro stimulation of specific RNA polymerase II-mediated transcription by the pseudorabies virus immediate early protein. Cell (1985) 1.46
Accumulation of herpes simplex virus type 1 RNAs of different kinetic classes in the cytoplasm of infected cells. J Virol (1985) 1.36
Control of expression of the herpes simplex virus thymidine kinase gene in biochemically transformed cells. J Gen Virol (1984) 1.11
A restriction enzyme from Hemophilus influenzae. I. Purification and general properties. J Mol Biol (1970) 19.69
Herpes simplex virus phosphoproteins. I. Phosphate cycles on and off some viral polypeptides and can alter their affinity for DNA. J Virol (1980) 5.69
Isolation and characterization of mutants of Haemophilus influenzae deficient in an adenosine 5'-triphosphate-dependent deoxyribonuclease activity. J Bacteriol (1975) 2.49
Isolation of herpes simplex virus regulatory protein ICP4 as a homodimeric complex. J Virol (1985) 2.20
Herpes simplex virus immediate early infected-cell polypeptide 4 binds to DNA and promotes transcription. Proc Natl Acad Sci U S A (1986) 2.07
Association of herpes simplex virus regulatory protein ICP4 with sequences spanning the ICP4 gene transcription initiation site. Nucleic Acids Res (1988) 1.60
Characterization of the DNA-binding properties of herpes simplex virus regulatory protein ICP4. J Virol (1989) 1.51
ICP4-binding sites in the promoter and coding regions of the herpes simplex virus gD gene contribute to activation of in vitro transcription by ICP4. J Virol (1989) 1.40
Codons 262 to 490 from the herpes simplex virus ICP4 gene are sufficient to encode a sequence-specific DNA binding protein. Nucleic Acids Res (1990) 1.21
Binding and repression of the latency-associated promoter of herpes simplex virus by the immediate early 175K protein. J Gen Virol (1994) 1.15
Mechanism of DNA degradation by the ATP-dependent DNase from Hemophilus influenzae Rd. J Biol Chem (1976) 1.09
Regulation of transcription in vitro from herpes simplex virus genes. J Virol (1986) 1.06
Characterization of a herpes simplex virus regulatory protein: aggregation and phosphorylation of a temperature-sensitive variant of ICP 4. Arch Virol (1986) 1.03
Interferon coordinately inhibits the disruption of PML-positive ND10 and immediate-early gene expression by herpes simplex virus. J Interferon Cytokine Res (2000) 1.00
The interaction of ICP4 with cell/infected-cell factors and its state of phosphorylation modulate differential recognition of leader sequences in herpes simplex virus DNA. EMBO J (1991) 0.99
Binding of the ATP-dependent DNase from Hemophilus influenzae to duplex DNA molecules. J Biol Chem (1976) 0.97
Identification of a promoter-specific transactivation domain in the herpes simplex virus regulatory protein ICP4. J Virol (1997) 0.87
Negative effect of sequential serine codons on expression of foreign genes in Escherichia coli. Protein Expr Purif (1996) 0.77
A restriction enzyme from Hemophilus influenzae. I. Purification and general properties. 1970. Biotechnology (1992) 0.75