Published in Nature on December 03, 1986
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Expression of a full-length cDNA for the human "MDR1" gene confers resistance to colchicine, doxorubicin, and vinblastine. Proc Natl Acad Sci U S A (1987) 4.43
Digital karyotyping identifies thymidylate synthase amplification as a mechanism of resistance to 5-fluorouracil in metastatic colorectal cancer patients. Proc Natl Acad Sci U S A (2004) 3.35
Topoisomerase levels determine chemotherapy response in vitro and in vivo. Proc Natl Acad Sci U S A (2008) 2.53
ATP-dependent transport of vinblastine in vesicles from human multidrug-resistant cells. Proc Natl Acad Sci U S A (1988) 2.44
The three mouse multidrug resistance (mdr) genes are expressed in a tissue-specific manner in normal mouse tissues. Mol Cell Biol (1989) 2.35
Discrete mutations introduced in the predicted nucleotide-binding sites of the mdr1 gene abolish its ability to confer multidrug resistance. Mol Cell Biol (1989) 2.18
Two members of the mouse mdr gene family confer multidrug resistance with overlapping but distinct drug specificities. Mol Cell Biol (1990) 2.07
Cloning and characterization of a second member of the mouse mdr gene family. Mol Cell Biol (1988) 2.06
Isolation of the human anionic glutathione S-transferase cDNA and the relation of its gene expression to estrogen-receptor content in primary breast cancer. Proc Natl Acad Sci U S A (1988) 1.86
Detection of P-glycoprotein isoforms by gene-specific monoclonal antibodies. Proc Natl Acad Sci U S A (1990) 1.81
Cell biological mechanisms of multidrug resistance in tumors. Proc Natl Acad Sci U S A (1994) 1.75
The gene encoding multidrug resistance is induced and expressed at high levels during pregnancy in the secretory epithelium of the uterus. Proc Natl Acad Sci U S A (1988) 1.69
A single amino acid substitution strongly modulates the activity and substrate specificity of the mouse mdr1 and mdr3 drug efflux pumps. Proc Natl Acad Sci U S A (1991) 1.68
A retrovirus carrying an MDR1 cDNA confers multidrug resistance and polarized expression of P-glycoprotein in MDCK cells. Proc Natl Acad Sci U S A (1988) 1.60
Molecular mechanisms of drug resistance. Biochem J (1990) 1.56
The human mdr3 gene encodes a novel P-glycoprotein homologue and gives rise to alternatively spliced mRNAs in liver. EMBO J (1987) 1.42
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Photoaffinity labeling of the multidrug-resistance-related P-glycoprotein with photoactive analogs of verapamil. Proc Natl Acad Sci U S A (1988) 1.32
Effect of calcium antagonists on the chemosensitivity of two multidrug-resistant human tumour cell lines which do not overexpress P-glycoprotein. Br J Cancer (1989) 1.30
Physical mapping, amplification, and overexpression of the mouse mdr gene family in multidrug-resistant cells. Mol Cell Biol (1990) 1.27
Structure and expression of the human MDR (P-glycoprotein) gene family. Mol Cell Biol (1989) 1.27
Homologues of the human multidrug resistance genes MRP and MDR contribute to heavy metal resistance in the soil nematode Caenorhabditis elegans. EMBO J (1996) 1.27
The role of P-glycoprotein in blood-brain barrier transport of morphine: transcortical microdialysis studies in mdr1a (-/-) and mdr1a (+/+) mice. Br J Pharmacol (1999) 1.25
Simultaneous expression of two P-glycoprotein genes in drug-sensitive Chinese hamster ovary cells. Mol Cell Biol (1987) 1.24
A P-glycoprotein protects Caenorhabditis elegans against natural toxins. EMBO J (1995) 1.23
Evolutionary analyses of ABC transporters of Dictyostelium discoideum. Eukaryot Cell (2002) 1.23
A monoclonal antibody-Pseudomonas toxin conjugate that specifically kills multidrug-resistant cells. Proc Natl Acad Sci U S A (1987) 1.21
Absence or pharmacological blocking of placental P-glycoprotein profoundly increases fetal drug exposure. J Clin Invest (1999) 1.21
Autonomously replicating episomes contain mdr1 genes in a multidrug-resistant human cell line. Mol Cell Biol (1989) 1.19
LEM1, an ATP-binding-cassette transporter, selectively modulates the biological potency of steroid hormones. Proc Natl Acad Sci U S A (1995) 1.19
Retroviral transfer of a murine cDNA for multidrug resistance confers pleiotropic drug resistance to cells without prior drug selection. Proc Natl Acad Sci U S A (1988) 1.16
Vincristine-resistant erythroleukemia cell line has marked increased sensitivity to hexamethylenebisacetamide-induced differentiation. Proc Natl Acad Sci U S A (1988) 1.12
Identification of members of the P-glycoprotein multigene family. Mol Cell Biol (1989) 1.12
Functional expression of mouse mdr1 in Escherichia coli. Proc Natl Acad Sci U S A (1993) 1.11
Multidrug resistance gene (P-glycoprotein) expression in the human fetus. Am J Pathol (1992) 1.08
Structural analysis of the mouse mdr1a (P-glycoprotein) promoter reveals the basis for differential transcript heterogeneity in multidrug-resistant J774.2 cells. Mol Cell Biol (1990) 1.08
Isolation and characterization of Drosophila multidrug resistance gene homologs. Mol Cell Biol (1991) 1.07
Overexpression of the multidrug resistance gene mdr3 in spontaneous and chemically induced mouse hepatocellular carcinomas. Mol Cell Biol (1990) 1.07
Membrane transport proteins associated with drug resistance expressed in human melanoma. Am J Pathol (1995) 1.04
Functional expression of mouse Mdr1 in an outer membrane permeability mutant of Escherichia coli. Proc Natl Acad Sci U S A (1996) 1.04
Distinct P-glycoprotein precursors are overproduced in independently isolated drug-resistant cell lines. Proc Natl Acad Sci U S A (1988) 1.02
Genetics of multidrug resistance. J Clin Invest (1988) 0.99
ABC transporters and their role in nucleoside and nucleotide drug resistance. Biochem Pharmacol (2012) 0.98
Mechanisms of resistance to photodynamic therapy. Curr Med Chem (2011) 0.96
Amplification and expression of mdr1 gene in a multidrug resistant variant of small cell lung cancer cell line NCI-H69. Br J Cancer (1989) 0.95
P-glycoprotein is not expressed in a majority of colorectal carcinomas and is not regulated by mutant p53 in vivo. Br J Cancer (1995) 0.95
WTH3 is a direct target of the p53 protein. Br J Cancer (2007) 0.93
Multidrug resistance after retroviral transfer of the human MDR1 gene correlates with P-glycoprotein density in the plasma membrane and is not affected by cytotoxic selection. Proc Natl Acad Sci U S A (1991) 0.93
Expression of a human multidrug resistance cDNA (MDR1) in the bone marrow of transgenic mice: resistance to daunomycin-induced leukopenia. Mol Cell Biol (1989) 0.92
Expression of the multidrug resistance-associated protein (MRP) gene in non-small-cell lung cancer. Br J Cancer (1995) 0.92
Mammalian multidrug-resistance gene: correlation of exon organization with structural domains and duplication of an ancestral gene. Proc Natl Acad Sci U S A (1989) 0.91
ABCB1 C3435T polymorphism and response to clopidogrel treatment in coronary artery disease (CAD) patients: a meta-analysis. PLoS One (2012) 0.91
Functional analysis of chimeric genes obtained by exchanging homologous domains of the mouse mdr1 and mdr2 genes. Mol Cell Biol (1991) 0.91
A comparison of membrane properties and composition between cell lines selected and transfected for multi-drug resistance. Br J Cancer (1992) 0.91
Stem cells and targeted approaches to melanoma cure. Mol Aspects Med (2013) 0.90
Fission yeast sts1+ gene encodes a protein similar to the chicken lamin B receptor and is implicated in pleiotropic drug-sensitivity, divalent cation-sensitivity, and osmoregulation. Mol Biol Cell (1992) 0.89
Expression of hamster P-glycoprotein and multidrug resistance in DNA-mediated transformants of mouse LTA cells. Mol Cell Biol (1987) 0.89
Cloning and regulation of the rat mdr2 gene. Nucleic Acids Res (1993) 0.88
Different vimentin expression in two clones derived from a human colocarcinoma cell line (LoVo) showing different sensitivity to doxorubicin. Br J Cancer (1995) 0.88
Functional expression of P-glycoprotein encoded by the mouse mdr3 gene in yeast cells. Proc Natl Acad Sci U S A (1993) 0.87
Characteristics of erythroleukemia cells selected for vincristine resistance that have accelerated inducer-mediated differentiation. Proc Natl Acad Sci U S A (1991) 0.86
The multidrug-resistance gene MDR1 is expressed in human glial tumors. Acta Neuropathol (1991) 0.86
Modulation of doxorubicin resistance in a doxorubicin-resistant human leukaemia cell by an immunoliposome targeting transferring receptor. Br J Cancer (1997) 0.85
Molecular analysis of the multidrug transporter, P-glycoprotein. Cytotechnology (1998) 0.85
Characterisation of a LoVo subline resistant to a benzoyl mustard derivative of distamycin A (FCE 24517). Br J Cancer (1993) 0.85
EAPP: gatekeeper at the crossroad of apoptosis and p21-mediated cell-cycle arrest. Oncogene (2011) 0.85
Cross resistance pattern towards anticancer drugs of a human carcinoma multidrug-resistant cell line. Br J Cancer (1988) 0.84
Reduced topoisomerase II activity in multidrug-resistant human non-small cell lung cancer cell lines. Br J Cancer (1995) 0.84
Cell-specific activity of cis-acting regulatory elements in the promoter of the mouse multidrug resistance gene mdr1. Mol Cell Biol (1990) 0.84
Profiles of multidrug resistance protein-1 in the peripheral blood mononuclear cells of patients with refractory epilepsy. PLoS One (2012) 0.84
Differential recognition of mdr1a and mdr1b gene products in multidrug resistant mouse tumour cell lines by different monoclonal antibodies. Br J Cancer (1992) 0.83
Dual roles of nitric oxide in the regulation of tumor cell response and resistance to photodynamic therapy. Redox Biol (2015) 0.83
mdm2 gene mediates the expression of mdr1 gene and P-glycoprotein in a human glioblastoma cell line. Br J Cancer (1996) 0.83
Decreased expression of the amplified mdr1 gene in revertants of multidrug-resistant human myelogenous leukemia K562 occurs without loss of amplified DNA. Mol Cell Biol (1987) 0.82
Anti-P-glycoprotein antibody-induced apoptosis of activated peripheral blood lymphocytes: a possible role of P-glycoprotein in lymphocyte survival. J Clin Immunol (2001) 0.82
Interaction of multidrug-resistant Chinese hamster ovary cells with amphiphiles. Br J Cancer (1993) 0.82
Sensitivity of K562 human chronic myelogenous leukemia blast cells transfected with a human multidrug resistance cDNA to cytotoxic drugs and differentiating agents. J Clin Invest (1993) 0.81
Functional expression of murine multidrug resistance in Xenopus laevis oocytes. Proc Natl Acad Sci U S A (1990) 0.81
Conversion of differentiation inducer resistance to differentiation inducer sensitivity in erythroleukemia cells. Mol Cell Biol (1990) 0.81
Evaluation of (64)Cu(DO3A-xy-TPEP) as a potential PET radiotracer for monitoring tumor multidrug resistance. Bioconjug Chem (2009) 0.80
Methylation of WTH3, a possible drug resistant gene, inhibits p53 regulated expression. BMC Cancer (2008) 0.80
Activation of the mouse mdr3 gene by insertion of retroviruses in multidrug-resistant P388 tumor cells. Mol Cell Biol (1993) 0.80
Effects of sertraline and fluoxetine on p-glycoprotein at barrier sites: in vivo and in vitro approaches. PLoS One (2013) 0.80
Detection of drug resistance in human ovarian carcinoma. Arch Gynecol Obstet (1989) 0.80
A possible role for a mammalian facilitative hexose transporter in the development of resistance to drugs. Mol Cell Biol (1991) 0.79
Optical imaging of tumors with copper-labeled rhodamine derivatives by targeting mitochondria. Theranostics (2012) 0.79
Immunohistochemical evidence that P-glycoprotein in non-small cell lung cancers is associated with shorter survival. Surg Today (1999) 0.79
Distribution and activity of doxorubicin combined with SDZ PSC 833 in mice with P388 and P388/DOX leukaemia. Br J Cancer (1996) 0.79
Sensitivity to TOP2 targeting chemotherapeutics is regulated by Oct1 and FILIP1L. PLoS One (2012) 0.79
Construction of a model cell line for the assay of MDR1 (multi drug resistance gene-1) substrates/inhibitors using HeLa cells. Pharmazie (2009) 0.78
Molecular chess? Hallmarks of anti-cancer drug resistance. BMC Cancer (2017) 0.78
Murine P-glycoprotein on stromal vessels mediates multidrug resistance in intracerebral human glioma xenografts. Br J Cancer (1997) 0.78
P-glycoprotein-mediated acquired multidrug resistance of human lung cancer cells in vivo. Br J Cancer (1996) 0.78
Alteration of canalicular transporters in a mouse model of total parenteral nutrition. J Pediatr Gastroenterol Nutr (2009) 0.78
The risk of clopidogrel resistance is associated with ABCB1 polymorphisms but not promoter methylation in a Chinese Han population. PLoS One (2017) 0.77
Induction of apoptosis and reversal of permeability glycoprotein-mediated multidrug resistance of MCF-7/ADM by ginsenoside Rh2. Int J Clin Exp Pathol (2015) 0.77
Molecular expression and functional activity of vitamin C specific transport system (SVCT2) in human breast cancer cells. Int J Pharm (2014) 0.77
L1210 cells selected for resistance to methoxymorpholinyl doxorubicin appear specifically resistant to this class of morpholinyl derivatives. Br J Cancer (1994) 0.77
Requirement for metabolic activation of acetylaminofluorene to induce multidrug gene expression. Environ Health Perspect (1994) 0.77
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Mammalian multidrug resistance gene: complete cDNA sequence indicates strong homology to bacterial transport proteins. Cell (1986) 5.51
Bipolar affective disorders linked to DNA markers on chromosome 11. Nature (1987) 4.64
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Genetic regulation of resistance to intracellular pathogens. Nature (1982) 4.45
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