Published in Proc Natl Acad Sci U S A on April 01, 1979
Mechanisms for the incorporation of proteins in membranes and organelles. J Cell Biol (1982) 9.67
Translocation of proteins across the endoplasmic reticulum III. Signal recognition protein (SRP) causes signal sequence-dependent and site-specific arrest of chain elongation that is released by microsomal membranes. J Cell Biol (1981) 8.36
Translocation of proteins across the endoplasmic reticulum. I. Signal recognition protein (SRP) binds to in-vitro-assembled polysomes synthesizing secretory protein. J Cell Biol (1981) 7.40
Purification of a membrane-associated protein complex required for protein translocation across the endoplasmic reticulum. Proc Natl Acad Sci U S A (1980) 7.17
Protein translocation across the endoplasmic reticulum. II. Isolation and characterization of the signal recognition particle receptor. J Cell Biol (1982) 5.20
Translocation of proteins across the endoplasmic reticulum. II. Signal recognition protein (SRP) mediates the selective binding to microsomal membranes of in-vitro-assembled polysomes synthesizing secretory protein. J Cell Biol (1981) 4.80
Multiple genes are required for proper insertion of secretory proteins into the endoplasmic reticulum in yeast. J Cell Biol (1989) 4.13
Protein translocation across the endoplasmic reticulum. I. Detection in the microsomal membrane of a receptor for the signal recognition particle. J Cell Biol (1982) 4.10
Sorting of an apical plasma membrane glycoprotein occurs before it reaches the cell surface in cultured epithelial cells. J Cell Biol (1984) 3.48
A membrane component essential for vectorial translocation of nascent proteins across the endoplasmic reticulum: requirements for its extraction and reassociation with the membrane. J Cell Biol (1980) 3.09
pH-induced alterations in the fusogenic spike protein of Semliki Forest virus. J Cell Biol (1985) 2.98
Differential extractability of influenza virus hemagglutinin during intracellular transport in polarized epithelial cells and nonpolar fibroblasts. J Cell Biol (1989) 2.75
Identification and characterization of a membrane component essential for the translocation of nascent proteins across the membrane of the endoplasmic reticulum. J Cell Biol (1980) 2.63
The preS1 protein of hepatitis B virus is acylated at its amino terminus with myristic acid. J Virol (1987) 2.49
Formation of a functional ribosome-membrane junction during translocation requires the participation of a GTP-binding protein. J Cell Biol (1986) 2.44
Direct probing of the interaction between the signal sequence of nascent preprolactin and the signal recognition particle by specific cross-linking. J Cell Biol (1987) 2.21
Kinetics of endosome acidification detected by mutant and wild-type Semliki Forest virus. EMBO J (1986) 2.02
Co-translational protein targeting catalyzed by the Escherichia coli signal recognition particle and its receptor. EMBO J (1997) 1.99
The signal recognition particle receptor is a complex that contains two distinct polypeptide chains. J Cell Biol (1986) 1.95
The budding mechanism of spikeless vesicular stomatitis virus particles. EMBO J (1986) 1.81
Constitutive apical secretion of an 80-kD sulfated glycoprotein complex in the polarized epithelial Madin-Darby canine kidney cell line. J Cell Biol (1987) 1.79
Characterization of secretory protein translocation: ribosome-membrane interaction in endoplasmic reticulum. J Cell Biol (1986) 1.70
Characterization of molecules involved in protein translocation using a specific antibody. J Cell Biol (1982) 1.58
The influenza hemagglutinin precursor as an acid-sensitive probe of the biosynthetic pathway. EMBO J (1987) 1.54
Conformational studies of the synthetic precursor-specific region of preproparathyroid hormone. Proc Natl Acad Sci U S A (1980) 1.38
Functional substitution of the signal recognition particle 54-kDa subunit by its Escherichia coli homolog. Proc Natl Acad Sci U S A (1993) 1.38
Biogenesis of the platelet receptor for fibrinogen: evidence for separate precursors for glycoproteins IIb and IIIa. Proc Natl Acad Sci U S A (1986) 1.37
180-kD ribosome receptor is essential for both ribosome binding and protein translocation. J Cell Biol (1993) 1.14
Identification of signal sequence binding proteins integrated into the rough endoplasmic reticulum membrane. Biochem J (1987) 1.06
In vitro mutagenesis of trypsinogen: role of the amino terminus in intracellular protein targeting to secretory granules. J Cell Biol (1987) 1.02
The N-terminal region of the 37-kDa translocated fragment of Pseudomonas exotoxin A aborts translocation by promoting its own export after microsomal membrane insertion. Proc Natl Acad Sci U S A (1993) 1.00
Reconstitution of the fusogenic activity of vesicular stomatitis virus. EMBO J (1986) 0.95
An ATP-binding membrane protein is required for protein translocation across the endoplasmic reticulum membrane. Cell Regul (1991) 0.95
In vitro membrane assembly of a polytopic, transmembrane protein results in an enzymatically active conformation. J Cell Biol (1989) 0.94
Early events in the cellular formation of proparathyroid hormone. J Cell Biol (1980) 0.90
The Sec-dependent pathway. Res Microbiol (2013) 0.87
Molecular cloning of a cDNA encoding the glycoprotein of hen oviduct microsomal signal peptidase. Biochem J (1992) 0.85
The purification of M13 procoat, a membrane protein precursor. EMBO J (1982) 0.78
Profile of Peter Walter. Proc Natl Acad Sci U S A (2006) 0.75
Competitive Inhibition of the Endoplasmic Reticulum Signal Peptidase by Non-cleavable Mutant Preprotein Cargos. J Biol Chem (2015) 0.75
An efficient mRNA-dependent translation system from reticulocyte lysates. Eur J Biochem (1976) 46.42
Transfer of proteins across membranes. I. Presence of proteolytically processed and unprocessed nascent immunoglobulin light chains on membrane-bound ribosomes of murine myeloma. J Cell Biol (1975) 36.95
Transfer of proteins across membranes. II. Reconstitution of functional rough microsomes from heterologous components. J Cell Biol (1975) 15.47
Amino acid sequence for the peptide extension on the prolipoprotein of the Escherichia coli outer membrane. Proc Natl Acad Sci U S A (1977) 6.22
Ovalbumin: a secreted protein without a transient hydrophobic leader sequence. Proc Natl Acad Sci U S A (1978) 4.46
A signal sequence for the insertion of a transmembrane glycoprotein. Similarities to the signals of secretory proteins in primary structure and function. J Biol Chem (1978) 4.43
Proteins of rough microsomal membranes related to ribosome binding. I. Identification of ribophorins I and II, membrane proteins characteristics of rough microsomes. J Cell Biol (1978) 4.33
Nascent prehormones are intermediates in the biosynthesis of authentic bovine pituitary growth hormone and prolactin. Proc Natl Acad Sci U S A (1977) 4.14
Efficient cleavage and segregation of nascent presecretory proteins in a reticulocyte lysate supplemented with microsomal membranes. J Biol Chem (1978) 3.80
Post-translational cleavage of presecretory proteins with an extract of rough microsomes from dog pancreas containing signal peptidase activity. Proc Natl Acad Sci U S A (1977) 3.54
Detection of prokaryotic signal peptidase in an Escherichia coli membrane fraction: endoproteolytic cleavage of nascent f1 pre-coat protein. Proc Natl Acad Sci U S A (1978) 3.48
Protein transfer across microsomal membranes reassembled from separated membrane components. Nature (1978) 3.39
Cell-free synthesis of fish preproinsulin, and processing by heterologous mammalian microsomal membranes. Proc Natl Acad Sci U S A (1977) 3.27
Functional interaction of plant ribosomes with animal microsomal membranes. Biochem Biophys Res Commun (1977) 2.77
Transfer of proteins across membranes, Biosynthesis in vitro of pretrypsinogen and trypsinogen by cell fractions of canine pancreas. Eur J Biochem (1978) 2.62
Nascent chicken ovalbumin contains the functional equivalent of a signal sequence. J Cell Biol (1978) 1.88
Amino terminal sequence of the precursor of ovine beta-lactoglobulin. Biochem Biophys Res Commun (1978) 1.26
Transfer of proteins across membranes. I. Presence of proteolytically processed and unprocessed nascent immunoglobulin light chains on membrane-bound ribosomes of murine myeloma. J Cell Biol (1975) 36.95
Transfer of proteins across membranes. II. Reconstitution of functional rough microsomes from heterologous components. J Cell Biol (1975) 15.47
Functional and genomic analyses reveal an essential coordination between the unfolded protein response and ER-associated degradation. Cell (2000) 13.44
Intracellular protein topogenesis. Proc Natl Acad Sci U S A (1980) 13.40
Human oestrogen receptor cDNA: sequence, expression and homology to v-erb-A. Nature (1986) 11.35
Nuclei from rat liver: isolation method that combines purity with high yield. Science (1966) 10.35
Transcriptional induction of genes encoding endoplasmic reticulum resident proteins requires a transmembrane protein kinase. Cell (1993) 9.84
70K heat shock related proteins stimulate protein translocation into microsomes. Nature (1988) 9.60
Translocation of proteins across the endoplasmic reticulum III. Signal recognition protein (SRP) causes signal sequence-dependent and site-specific arrest of chain elongation that is released by microsomal membranes. J Cell Biol (1981) 8.36
A novel mechanism for regulating activity of a transcription factor that controls the unfolded protein response. Cell (1996) 8.17
Identification and characterization of a nuclear pore complex protein. Cell (1986) 7.93
Ribosome-membrane interaction. Nondestructive disassembly of rat liver rough microsomes into ribosomal and membranous components. J Cell Biol (1973) 7.92
The GTP-binding protein Ran/TC4 is required for protein import into the nucleus. Nature (1993) 7.80
Signal recognition particle contains a 7S RNA essential for protein translocation across the endoplasmic reticulum. Nature (1982) 7.80
The nuclear envelope lamina is reversibly depolymerized during mitosis. Cell (1980) 7.67
A novel ubiquitin-like modification modulates the partitioning of the Ran-GTPase-activating protein RanGAP1 between the cytosol and the nuclear pore complex. J Cell Biol (1996) 7.64
Translocation of proteins across the endoplasmic reticulum. I. Signal recognition protein (SRP) binds to in-vitro-assembled polysomes synthesizing secretory protein. J Cell Biol (1981) 7.40
Purification of a membrane-associated protein complex required for protein translocation across the endoplasmic reticulum. Proc Natl Acad Sci U S A (1980) 7.17
Protein import into nuclei: association and dissociation reactions involving transport substrate, transport factors, and nucleoporins. Cell (1995) 6.97
Preparation of microsomal membranes for cotranslational protein translocation. Methods Enzymol (1983) 6.94
Dissociation of mammalian polyribosomes into subunits by puromycin. Proc Natl Acad Sci U S A (1971) 6.77
Protein translocation across the endoplasmic reticulum. Cell (1984) 6.69
Immunocytochemical localization of the major polypeptides of the nuclear pore complex-lamina fraction. Interphase and mitotic distribution. J Cell Biol (1978) 6.29
The transmembrane kinase Ire1p is a site-specific endonuclease that initiates mRNA splicing in the unfolded protein response. Cell (1997) 6.26
In vitro synthesis and processing of a putative precursor for the small subunit of ribulose-1,5-bisphosphate carboxylase of Chlamydomonas reinhardtii. Proc Natl Acad Sci U S A (1977) 5.89
Controlled proteolysis of nascent polypeptides in rat liver cell fractions. II. Location of the polypeptides in rough microsomes. J Cell Biol (1970) 5.72
Ribosome pausing and stacking during translation of a eukaryotic mRNA. EMBO J (1988) 5.61
Membrane assembly in vitro: synthesis, glycosylation, and asymmetric insertion of a transmembrane protein. Proc Natl Acad Sci U S A (1977) 5.51
Mitochondrial transmission during mating in Saccharomyces cerevisiae is determined by mitochondrial fusion and fission and the intramitochondrial segregation of mitochondrial DNA. Mol Biol Cell (1997) 5.47
Oligomerization and phosphorylation of the Ire1p kinase during intracellular signaling from the endoplasmic reticulum to the nucleus. EMBO J (1996) 5.46
Mechanism of protein translocation across the endoplasmic reticulum membrane. Annu Rev Cell Biol (1986) 5.28
Crystallographic analysis of the recognition of a nuclear localization signal by the nuclear import factor karyopherin alpha. Cell (1998) 5.27
Import of proteins into mitochondria: precursor forms of the extramitochondrially made F1-ATPase subunits in yeast. Proc Natl Acad Sci U S A (1979) 5.21
Protein translocation across the endoplasmic reticulum. II. Isolation and characterization of the signal recognition particle receptor. J Cell Biol (1982) 5.20
Homology in amino-terminal sequence of precursors to pancreatic secretory proteins. Proc Natl Acad Sci U S A (1975) 5.15
Controlled proteolysis of nascent polypeptides in rat liver cell fractions. I. Location of the polypeptides within ribosomes. J Cell Biol (1970) 5.08
Intracellular signaling from the endoplasmic reticulum to the nucleus: the unfolded protein response in yeast and mammals. Curr Opin Cell Biol (2001) 5.08
cDNA sequencing of nuclear lamins A and C reveals primary and secondary structural homology to intermediate filament proteins. Proc Natl Acad Sci U S A (1986) 5.07
Identification of a protein complex that is required for nuclear protein import and mediates docking of import substrate to distinct nucleoporins. Proc Natl Acad Sci U S A (1995) 5.04
Structure of the 80S ribosome from Saccharomyces cerevisiae--tRNA-ribosome and subunit-subunit interactions. Cell (2001) 5.01
tRNA ligase is required for regulated mRNA splicing in the unfolded protein response. Cell (1996) 4.93
The ubiquitin-like protein Smt3p is activated for conjugation to other proteins by an Aos1p/Uba2p heterodimer. EMBO J (1997) 4.80
Translocation of proteins across the endoplasmic reticulum. II. Signal recognition protein (SRP) mediates the selective binding to microsomal membranes of in-vitro-assembled polysomes synthesizing secretory protein. J Cell Biol (1981) 4.80
Studies on free and membrane-bound ribosomes in rat liver. I. Distribution as related to total cellular RNA. J Mol Biol (1967) 4.71
A modified procedure for the isolation of a pore complex-lamina fraction from rat liver nuclei. J Cell Biol (1976) 4.64
In vitro protein translocation across the yeast endoplasmic reticulum: ATP-dependent posttranslational translocation of the prepro-alpha-factor. Cell (1986) 4.59
Cloning of the human estrogen receptor cDNA. Proc Natl Acad Sci U S A (1985) 4.58
The peptide repeat domain of nucleoporin Nup98 functions as a docking site in transport across the nuclear pore complex. Cell (1995) 4.55
Translocation of proteins across membranes: the signal hypothesis and beyond. Symp Soc Exp Biol (1979) 4.54
Cell-free translation of messenger RNA in a wheat germ system. Methods Enzymol (1983) 4.52
Nup358, a cytoplasmically exposed nucleoporin with peptide repeats, Ran-GTP binding sites, zinc fingers, a cyclophilin A homologous domain, and a leucine-rich region. J Biol Chem (1995) 4.50
Purification of a Ran-interacting protein that is required for protein import into the nucleus. Proc Natl Acad Sci U S A (1994) 4.49
The chicken oestrogen receptor sequence: homology with v-erbA and the human oestrogen and glucocorticoid receptors. EMBO J (1986) 4.47
The signal recognition particle. Annu Rev Biochem (2001) 4.47
Isolation of nuclear pore complexes in association with a lamina. Proc Natl Acad Sci U S A (1975) 4.46
A protein-conducting channel in the endoplasmic reticulum. Cell (1991) 4.45
Gene gating: a hypothesis. Proc Natl Acad Sci U S A (1985) 4.45
A signal sequence for the insertion of a transmembrane glycoprotein. Similarities to the signals of secretory proteins in primary structure and function. J Biol Chem (1978) 4.43
Identification and characterization of a yeast nucleolar protein that is similar to a rat liver nucleolar protein. J Cell Biol (1988) 4.42
Regulation of ribosome biogenesis by the rapamycin-sensitive TOR-signaling pathway in Saccharomyces cerevisiae. Mol Biol Cell (1999) 4.34
Model for signal sequence recognition from amino-acid sequence of 54K subunit of signal recognition particle. Nature (1989) 4.25
Nascent prehormones are intermediates in the biosynthesis of authentic bovine pituitary growth hormone and prolactin. Proc Natl Acad Sci U S A (1977) 4.14
Protein translocation across the endoplasmic reticulum. I. Detection in the microsomal membrane of a receptor for the signal recognition particle. J Cell Biol (1982) 4.10
Chicken ovalbumin contains an internal signal sequence. Nature (1979) 4.06
The two steps of nuclear import, targeting to the nuclear envelope and translocation through the nuclear pore, require different cytosolic factors. Cell (1992) 4.05
Immunoprecipitation of proteins from cell-free translations. Methods Enzymol (1983) 4.04
Isolation and characterization of a proteinaceous subnuclear fraction composed of nuclear matrix, peripheral lamina, and nuclear pore complexes from embryos of Drosophila melanogaster. J Cell Biol (1982) 4.03
A nuclear pore complex protein that contains zinc finger motifs, binds DNA, and faces the nucleoplasm. Cell (1993) 3.98
Alignment of conduits for the nascent polypeptide chain in the ribosome-Sec61 complex. Science (1997) 3.95
Nuclear pore complex contains a family of glycoproteins that includes p62: glycosylation through a previously unidentified cellular pathway. Proc Natl Acad Sci U S A (1987) 3.95
Efficient cleavage and segregation of nascent presecretory proteins in a reticulocyte lysate supplemented with microsomal membranes. J Biol Chem (1978) 3.80
A transmembrane form of the prion protein in neurodegenerative disease. Science (1998) 3.76
Ubc9p is the conjugating enzyme for the ubiquitin-like protein Smt3p. J Biol Chem (1997) 3.76
Mammalian karyopherin alpha 1 beta and alpha 2 beta heterodimers: alpha 1 or alpha 2 subunit binds nuclear localization signal and beta subunit interacts with peptide repeat-containing nucleoporins. Proc Natl Acad Sci U S A (1995) 3.73
Kap104p: a karyopherin involved in the nuclear transport of messenger RNA binding proteins. Science (1996) 3.70
A distinct nuclear import pathway used by ribosomal proteins. Cell (1997) 3.66
SUMO-1 modification and its role in targeting the Ran GTPase-activating protein, RanGAP1, to the nuclear pore complex. J Cell Biol (1998) 3.65
Nopp140 shuttles on tracks between nucleolus and cytoplasm. Cell (1992) 3.63
Biogenesis of peroxisomes: intracellular site of synthesis of catalase and uricase. Proc Natl Acad Sci U S A (1978) 3.63
Secretory protein translocation in a yeast cell-free system can occur posttranslationally and requires ATP hydrolysis. J Cell Biol (1986) 3.62
A new family of yeast nuclear pore complex proteins. J Cell Biol (1992) 3.60
An E. coli ribonucleoprotein containing 4.5S RNA resembles mammalian signal recognition particle. Science (1990) 3.55
Photocrosslinking of the signal sequence of nascent preprolactin to the 54-kilodalton polypeptide of the signal recognition particle. Proc Natl Acad Sci U S A (1986) 3.55
Post-translational cleavage of presecretory proteins with an extract of rough microsomes from dog pancreas containing signal peptidase activity. Proc Natl Acad Sci U S A (1977) 3.54