Published in Protein Eng on September 01, 1988
Enhanced visibility of hydrogen atoms by neutron crystallography on fully deuterated myoglobin. Proc Natl Acad Sci U S A (2000) 1.36
Aplysia limacina myoglobin cDNA cloning: an alternative mechanism of oxygen stabilization as studied by active-site mutagenesis. Biochem J (1996) 0.88
The structural basis for 14-3-3:phosphopeptide binding specificity. Cell (1997) 10.87
Molecular basis of agonism and antagonism in the oestrogen receptor. Nature (1997) 9.09
A unified polymerase mechanism for nonhomologous DNA and RNA polymerases. Science (1994) 7.98
Hydrogen bonding in globular proteins. Prog Biophys Mol Biol (1984) 6.58
Structural model of ATP-binding proteins associated with cystic fibrosis, multidrug resistance and bacterial transport. Nature (1990) 6.41
Hydrogen bonding and biological specificity analysed by protein engineering. Nature (1985) 6.20
AAA+ superfamily ATPases: common structure--diverse function. Genes Cells (2001) 5.83
The use of double mutants to detect structural changes in the active site of the tyrosyl-tRNA synthetase (Bacillus stearothermophilus). Cell (1984) 4.75
The ankyrin repeat: a diversity of interactions on a common structural framework. Trends Biochem Sci (1999) 4.14
Structural analysis of 14-3-3 phosphopeptide complexes identifies a dual role for the nuclear export signal of 14-3-3 in ligand binding. Mol Cell (1999) 4.02
The molecular basis of FHA domain:phosphopeptide binding specificity and implications for phospho-dependent signaling mechanisms. Mol Cell (2000) 3.64
Structure at 1.65 A of RhoA and its GTPase-activating protein in complex with a transition-state analogue. Nature (1997) 3.55
The stereochemical mechanism of the cooperative effects in hemoglobin revisited. Annu Rev Biophys Biomol Struct (1998) 3.47
E-MSD: an integrated data resource for bioinformatics. Nucleic Acids Res (2004) 3.43
The structure of 2Zn pig insulin crystals at 1.5 A resolution. Philos Trans R Soc Lond B Biol Sci (1988) 3.30
Glycosaminoglycans interact selectively with chemokines and modulate receptor binding and cellular responses. Biochemistry (1999) 3.07
PDBe: Protein Data Bank in Europe. Nucleic Acids Res (2011) 3.03
Structure of the ligand-binding domain of oestrogen receptor beta in the presence of a partial agonist and a full antagonist. EMBO J (1999) 2.81
Structure of a 14-3-3 protein and implications for coordination of multiple signalling pathways. Nature (1995) 2.68
Redesigning enzyme structure by site-directed mutagenesis: tyrosyl tRNA synthetase and ATP binding. Nature (1982) 2.63
Structural basis of asymmetry in the human immunodeficiency virus type 1 reverse transcriptase heterodimer. Proc Natl Acad Sci U S A (1994) 2.47
The structural basis of Arfaptin-mediated cross-talk between Rac and Arf signalling pathways. Nature (2001) 2.46
Site-directed mutagenesis as a probe of enzyme structure and catalysis: tyrosyl-tRNA synthetase cysteine-35 to glycine-35 mutation. Biochemistry (1983) 2.31
Income and the midlife peak in common mental disorder prevalence. Psychol Med (2010) 2.13
The structural basis of sequence-independent peptide binding by OppA protein. Science (1994) 2.05
Dissecting the role of a conserved motif (the second region of homology) in the AAA family of ATPases. Site-directed mutagenesis of the ATP-dependent protease FtsH. J Biol Chem (1999) 1.97
The solution structure of human epidermal growth factor. Nature (1987) 1.94
Structural insights into the mode of action of a pure antiestrogen. Structure (2001) 1.92
Crystal structure of a small G protein in complex with the GTPase-activating protein rhoGAP. Nature (1997) 1.90
Structure of the TPR domain of p67phox in complex with Rac.GTP. Mol Cell (2000) 1.77
Identification of a glycosaminoglycan binding surface on human interleukin-8. Biochemistry (1998) 1.71
The mechanism of autooxidation of myoglobin. J Biol Chem (1993) 1.71
Phosphorylated aspartate in the structure of a response regulator protein. J Mol Biol (1999) 1.66
Crystal structure of GerE, the ultimate transcriptional regulator of spore formation in Bacillus subtilis. J Mol Biol (2001) 1.62
The structure of the cofactor-binding fragment of the LysR family member, CysB: a familiar fold with a surprising subunit arrangement. Structure (1997) 1.50
NF-kappaB1 p105 negatively regulates TPL-2 MEK kinase activity. Mol Cell Biol (2003) 1.49
An evolutionary link between sporulation and prophage induction in the structure of a repressor:anti-repressor complex. J Mol Biol (1998) 1.47
Locating interaction sites on proteins: the crystal structure of thermolysin soaked in 2% to 100% isopropanol. Proteins (1999) 1.46
A large increase in enzyme-substrate affinity by protein engineering. Nature (1984) 1.46
Oligomeric structure of the Bacillus subtilis cell division protein DivIVA determined by transmission electron microscopy. Mol Microbiol (2004) 1.45
Heller's myotomy with partial fundoplication. Br J Surg (1989) 1.41
Crystallographic and calorimetric analysis of peptide binding to OppA protein. J Mol Biol (1999) 1.35
Experimental and computational mapping of the binding surface of a crystalline protein. Protein Eng (2001) 1.35
Injuries incurred at "roller discos". Br Med J (Clin Res Ed) (1982) 1.33
Structure of the protein tyrosine kinase domain of C-terminal Src kinase (CSK) in complex with staurosporine. J Mol Biol (1999) 1.32
Structure and function of endoglucanase V. Nature (1993) 1.31
Structural factors governing azide and cyanide binding to mammalian metmyoglobins. J Biol Chem (1994) 1.31
The crystal structures of the oligopeptide-binding protein OppA complexed with tripeptide and tetrapeptide ligands. Structure (1995) 1.28
The x-ray crystal structure of phosphomannose isomerase from Candida albicans at 1.7 angstrom resolution. Nat Struct Biol (1996) 1.27
Crystallisation of the Bacillus subtilis sporulation inhibitor SinR, complexed with its antagonist, SinI. FEBS Lett (1996) 1.26
Stability of myoglobin: a model for the folding of heme proteins. Biochemistry (1994) 1.23
Effects of cigarette smoking upon clinical outcomes of assisted reproduction: a meta-analysis. Hum Reprod Update (2008) 1.23
Understanding the mechanism of ice binding by type III antifreeze proteins. J Mol Biol (2001) 1.22
Ezetimibe monotherapy for cholesterol lowering in 2,722 people: systematic review and meta-analysis of randomized controlled trials. J Intern Med (2008) 1.20
PhosphoSerine/threonine binding domains: you can't pSERious? Structure (2001) 1.20
Comparison of three different crystal forms shows HIV-1 reverse transcriptase displays an internal swivel motion. Structure (1994) 1.19
HOOK: a program for finding novel molecular architectures that satisfy the chemical and steric requirements of a macromolecule binding site. Proteins (1994) 1.17
The role of water in sequence-independent ligand binding by an oligopeptide transporter protein. Nat Struct Biol (1996) 1.15
Structural and functional architecture of the yeast cell-cycle transcription factor swi6. J Mol Biol (1998) 1.14
Characterization of the DNA-binding domains from the yeast cell-cycle transcription factors Mbp1 and Swi4. Biochemistry (2000) 1.14
Automated method for modeling seven-helix transmembrane receptors from experimental data. Biophys J (1995) 1.12
Reduction in CD4 binding affinity associated with removal of a single glycosylation site in the external glycoprotein of HIV-2. Virology (1991) 1.12
Application of high-throughput technologies to a structural proteomics-type analysis of Bacillus anthracis. Acta Crystallogr D Biol Crystallogr (2006) 1.11
X-ray structural analysis of the yeast cell cycle regulator Swi6 reveals variations of the ankyrin fold and has implications for Swi6 function. Nat Struct Biol (1999) 1.11
Structural factors governing hemin dissociation from metmyoglobin. Biochemistry (1996) 1.10
GTPase-activating proteins and their complexes. Curr Opin Struct Biol (1998) 1.09
A retrospective analysis of conservative versus active management in severe open myelomeningocele. Z Kinderchir Grenzgeb (1979) 1.08
Analysis of C alpha geometry in protein structures. Proteins (1994) 1.08
Drug-like annotation and duplicate analysis of a 23-supplier chemical database totalling 2.7 million compounds. J Chem Inf Comput Sci (2004) 1.07
The trans-activation domain of the sporulation response regulator Spo0A revealed by X-ray crystallography. Mol Microbiol (2000) 1.07
Ligand-induced conformational change in penicillin acylase. J Mol Biol (1998) 1.07
Structure and mechanism of the oestrogen receptor. Biochem Soc Trans (2003) 1.07
Structure and molecular model refinement of Aspergillus oryzae (TAKA) alpha-amylase: an application of the simulated-annealing method. Acta Crystallogr B (1991) 1.06
The structure of the GTPase-activating domain from p50rhoGAP. Nature (1997) 1.03
The FHA domain in DNA repair and checkpoint signaling. Cold Spring Harb Symp Quant Biol (2000) 1.03
Domain swapping in the sporulation response regulator Spo0A. J Mol Biol (2000) 1.03
Probing histidine-substrate interactions in tyrosyl-tRNA synthetase using asparagine and glutamine replacements. Biochemistry (1985) 1.02
A structural biologist's view of the oestrogen receptor. J Steroid Biochem Mol Biol (2000) 1.02
Peptide binding in OppA, the crystal structures of the periplasmic oligopeptide binding protein in the unliganded form and in complex with lysyllysine. Biochemistry (1997) 1.01
Expression of HIV-1 gp120 and human soluble CD4 by recombinant baculoviruses and their interaction in vitro. AIDS Res Hum Retroviruses (1990) 1.00
Frailty in older inpatients: what physicians need to know. QJM (2012) 0.99
Insulin's structural behavior and its relation to activity. Biopolymers (1983) 0.99
Alteration of axial coordination by protein engineering in myoglobin. Bisimidazole ligation in the His64-->Val/Val68-->His double mutant. J Biol Chem (1995) 0.99
The solution structure of human transforming growth factor alpha. Eur J Biochem (1991) 0.99
Molecular structure of insulin: the insulin monomer and its assembly. Br Med Bull (1989) 0.98
Distal pocket polarity in ligand binding to myoglobin: structural and functional characterization of a threonine68(E11) mutant. Biochemistry (1991) 0.98
Rapid nondestructive analysis of threading dislocations in wurtzite materials using the scanning electron microscope. Phys Rev Lett (2012) 0.98
Structure of the Bacillus cell fate determinant SpoIIAA in phosphorylated and unphosphorylated forms. Structure (2001) 0.97
Quaternary re-arrangement analysed by spectral enhancement: the interaction of a sporulation repressor with its antagonist. J Mol Biol (1999) 0.96
Interactions among residues CD3, E7, E10, and E11 in myoglobins: attempts to simulate the ligand-binding properties of Aplysia myoglobin. Biochemistry (1995) 0.94
Walking speed in children and young adults with neuromuscular disease: comparison between two assessment methods. J Pediatr Orthop (2003) 0.94
Relating structure to thermodynamics: the crystal structures and binding affinity of eight OppA-peptide complexes. Protein Sci (1999) 0.94
Mechanism of hydrogen cyanide binding to myoglobin. Biochemistry (1996) 0.93
Seat belt injury to ileostomy. Br Med J (1978) 0.93
Application of the use of high-throughput technologies to the determination of protein structures of bacterial and viral pathogens. Acta Crystallogr D Biol Crystallogr (2006) 0.93
Investigating the high affinity and low sequence specificity of calmodulin binding to its targets. J Mol Biol (1994) 0.93
Characterising the geometric diversity of functional groups in chemical databases. J Comput Aided Mol Des (1995) 0.92