Published in Mol Cell Biol on July 01, 2003
Mitogen-activated protein kinases in innate immunity. Nat Rev Immunol (2013) 3.23
Functions of NF-kappaB1 and NF-kappaB2 in immune cell biology. Biochem J (2004) 3.01
Lipopolysaccharide activation of the TPL-2/MEK/extracellular signal-regulated kinase mitogen-activated protein kinase cascade is regulated by IkappaB kinase-induced proteolysis of NF-kappaB1 p105. Mol Cell Biol (2004) 1.86
Mutational activation of the MAP3K8 protooncogene in lung cancer. Genes Chromosomes Cancer (2004) 1.42
Prostaglandin E receptor type 4-associated protein interacts directly with NF-kappaB1 and attenuates macrophage activation. J Biol Chem (2008) 1.29
ABIN-2 forms a ternary complex with TPL-2 and NF-kappa B1 p105 and is essential for TPL-2 protein stability. Mol Cell Biol (2004) 1.28
The 20S proteasome processes NF-kappaB1 p105 into p50 in a translation-independent manner. EMBO J (2006) 1.27
The Nfkb1 and Nfkb2 proteins p105 and p100 function as the core of high-molecular-weight heterogeneous complexes. Mol Cell (2009) 1.26
A serine/threonine kinase, Cot/Tpl2, modulates bacterial DNA-induced IL-12 production and Th cell differentiation. J Clin Invest (2004) 1.24
Regulation and function of TPL-2, an IκB kinase-regulated MAP kinase kinase kinase. Cell Res (2010) 1.20
The specificity of innate immune responses is enforced by repression of interferon response elements by NF-κB p50. Sci Signal (2011) 1.18
p38γ and p38δ kinases regulate the Toll-like receptor 4 (TLR4)-induced cytokine production by controlling ERK1/2 protein kinase pathway activation. Proc Natl Acad Sci U S A (2012) 1.08
Quantitative proteomics analysis of macrophage rafts reveals compartmentalized activation of the proteasome and of proteasome-mediated ERK activation in response to lipopolysaccharide. Mol Cell Proteomics (2008) 1.07
Coordinate regulation of TPL-2 and NF-κB signaling in macrophages by NF-κB1 p105. Mol Cell Biol (2012) 1.02
Phosphorylation of TPL-2 on serine 400 is essential for lipopolysaccharide activation of extracellular signal-regulated kinase in macrophages. Mol Cell Biol (2007) 1.01
NF-kappa B1 p105 regulates T cell homeostasis and prevents chronic inflammation. J Immunol (2009) 1.00
TPL2 kinase is a suppressor of lung carcinogenesis. Proc Natl Acad Sci U S A (2013) 0.99
TPL2 mediates autoimmune inflammation through activation of the TAK1 axis of IL-17 signaling. J Exp Med (2014) 0.96
IκB kinase 2 regulates TPL-2 activation of extracellular signal-regulated kinases 1 and 2 by direct phosphorylation of TPL-2 serine 400. Mol Cell Biol (2012) 0.95
Phosphorylation at Thr-290 regulates Tpl2 binding to NF-kappaB1/p105 and Tpl2 activation and degradation by lipopolysaccharide. Proc Natl Acad Sci U S A (2005) 0.94
Cot/tpl2 (MAP3K8) mediates myeloperoxidase activity and hypernociception following peripheral inflammation. J Biol Chem (2010) 0.93
Loss of tumor progression locus 2 (tpl2) enhances tumorigenesis and inflammation in two-stage skin carcinogenesis. Oncogene (2010) 0.92
IRAK1BP1 inhibits inflammation by promoting nuclear translocation of NF-kappaB p50. Proc Natl Acad Sci U S A (2010) 0.89
The protein kinase TPL2 is essential for ERK1/ERK2 activation and cytokine gene expression in airway epithelial cells exposed to pathogen-associated molecular patterns (PAMPs). PLoS One (2013) 0.89
Retracted GCK is essential to systemic inflammation and pattern recognition receptor signaling to JNK and p38. Proc Natl Acad Sci U S A (2009) 0.87
The Regulation of NF-κB Subunits by Phosphorylation. Cells (2016) 0.86
IκB kinase-induced interaction of TPL-2 kinase with 14-3-3 is essential for Toll-like receptor activation of ERK-1 and -2 MAP kinases. Proc Natl Acad Sci U S A (2014) 0.85
NF-κB1 inhibits TLR-induced IFN-β production in macrophages through TPL-2-dependent ERK activation. J Immunol (2011) 0.85
TPL2/COT/MAP3K8 (TPL2) activation promotes androgen depletion-independent (ADI) prostate cancer growth. PLoS One (2011) 0.85
Deregulation of Tpl2 and NF-kappaB signaling and induction of macrophage apoptosis by the anti-depressant drug lithium. Cell Signal (2008) 0.84
NFκB1 is essential to prevent the development of multiorgan autoimmunity by limiting IL-6 production in follicular B cells. J Exp Med (2016) 0.81
Altered prostanoid signaling contributes to increased skin tumorigenesis in Tpl2 knockout mice. PLoS One (2013) 0.80
Mitogen-activated protein kinase-mediated licensing of interferon regulatory factor 3/7 reinforces the cell response to virus. J Biol Chem (2013) 0.80
Ubiquitin signaling in immune responses. Cell Res (2016) 0.80
Tumor progression locus 2 (Tpl2) kinase as a novel therapeutic target for cancer: double-sided effects of Tpl2 on cancer. Int J Mol Sci (2015) 0.79
Ebola virus VP35 induces high-level production of recombinant TPL-2-ABIN-2-NF-κB1 p105 complex in co-transfected HEK-293 cells. Biochem J (2013) 0.79
MAP3K8/TPL-2/COT is a potential predictive marker for MEK inhibitor treatment in high-grade serous ovarian carcinomas. Nat Commun (2015) 0.76
TLR and TNF-R1 activation of the MKK3/MKK6-p38α axis in macrophages is mediated by TPL-2 kinase. Biochem J (2016) 0.75
Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity. Annu Rev Immunol (2000) 20.70
Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells. Cell (1994) 9.73
Structure, regulation and function of NF-kappa B. Annu Rev Cell Biol (1994) 8.98
Targeted disruption of the p50 subunit of NF-kappa B leads to multifocal defects in immune responses. Cell (1995) 7.55
Requirement for Ras in Raf activation is overcome by targeting Raf to the plasma membrane. Nature (1994) 6.16
TNF-alpha induction by LPS is regulated posttranscriptionally via a Tpl2/ERK-dependent pathway. Cell (2000) 6.07
Positive and negative regulation of IkappaB kinase activity through IKKbeta subunit phosphorylation. Science (1999) 5.95
Structure of an IkappaBalpha/NF-kappaB complex. Cell (1998) 5.67
The crystal structure of the IkappaBalpha/NF-kappaB complex reveals mechanisms of NF-kappaB inactivation. Cell (1998) 4.71
Suppression of Raf-1 kinase activity and MAP kinase signalling by RKIP. Nature (1999) 3.99
High-throughput retroviral tagging to identify components of specific signaling pathways in cancer. Nat Genet (2002) 3.81
Intramolecular masking of the nuclear location signal and dimerization domain in the precursor for the p50 NF-kappa B subunit. Cell (1992) 3.73
Genome-wide retroviral insertional tagging of genes involved in cancer in Cdkn2a-deficient mice. Nat Genet (2002) 2.53
Activation of MEK-1 and SEK-1 by Tpl-2 proto-oncoprotein, a novel MAP kinase kinase kinase. EMBO J (1996) 2.38
Mechanism of suppression of the Raf/MEK/extracellular signal-regulated kinase pathway by the raf kinase inhibitor protein. Mol Cell Biol (2000) 2.27
S-acylation of LCK protein tyrosine kinase is essential for its signalling function in T lymphocytes. EMBO J (1997) 2.19
NF-kappaB1/p105 regulates lipopolysaccharide-stimulated MAP kinase signaling by governing the stability and function of the Tpl2 kinase. Mol Cell (2003) 2.08
TPL-2 kinase regulates the proteolysis of the NF-kappaB-inhibitory protein NF-kappaB1 p105. Nature (1999) 2.01
Tpl-2 acts in concert with Ras and Raf-1 to activate mitogen-activated protein kinase. Proc Natl Acad Sci U S A (1994) 2.00
Tumor progression locus 2 (Tpl-2) encodes a protein kinase involved in the progression of rodent T-cell lymphomas and in T-cell activation. Proc Natl Acad Sci U S A (1993) 1.95
NF-kappaB p105 is a target of IkappaB kinases and controls signal induction of Bcl-3-p50 complexes. EMBO J (1999) 1.87
Multiple mitogen-activated protein kinase signaling pathways connect the cot oncoprotein to the c-jun promoter and to cellular transformation. Mol Cell Biol (2000) 1.80
Chronic inflammation and susceptibility to bacterial infections in mice lacking the polypeptide (p)105 precursor (NF-kappaB1) but expressing p50. J Exp Med (1998) 1.79
betaTrCP-mediated proteolysis of NF-kappaB1 p105 requires phosphorylation of p105 serines 927 and 932. Mol Cell Biol (2003) 1.69
Direct phosphorylation of NF-kappaB1 p105 by the IkappaB kinase complex on serine 927 is essential for signal-induced p105 proteolysis. J Biol Chem (2001) 1.62
The proto-oncogene Cot kinase participates in CD3/CD28 induction of NF-kappaB acting through the NF-kappaB-inducing kinase and IkappaB kinases. Immunity (1999) 1.61
Tpl-2 is an oncogenic kinase that is activated by carboxy-terminal truncation. Genes Dev (1997) 1.57
Proteolytic processing of NF-kappa B/I kappa B in human monocytes. ATP-dependent induction by pro-inflammatory mediators. J Biol Chem (1995) 1.37
Surface plasmon resonance and its use in biomolecular interaction analysis (BIA). Curr Opin Struct Biol (1995) 1.36
The human cot proto-oncogene encodes two protein serine/threonine kinases with different transforming activities by alternative initiation of translation. J Biol Chem (1993) 1.18
Genomic organization and expression of Tpl-2 in normal cells and Moloney murine leukemia virus-induced rat T-cell lymphomas: activation by provirus insertion. J Virol (1993) 1.14
The death domain of NF-kappa B1 p105 is essential for signal-induced p105 proteolysis. J Biol Chem (2002) 1.06
Expression cDNA cloning of a serine kinase transforming gene. Oncogene (1993) 1.00
The activity of a 70 kilodalton I kappa B molecule identical to the carboxyl terminus of the p105 NF-kappa B precursor is modulated by protein kinase A. Cell Growth Differ (1993) 0.96
The structural basis for 14-3-3:phosphopeptide binding specificity. Cell (1997) 10.87
A unified polymerase mechanism for nonhomologous DNA and RNA polymerases. Science (1994) 7.98
Aggregation of lipid rafts accompanies signaling via the T cell antigen receptor. J Cell Biol (1999) 4.71
Structure and mechanism of DNA topoisomerase II. Nature (1996) 4.56
The ankyrin repeat: a diversity of interactions on a common structural framework. Trends Biochem Sci (1999) 4.14
Structural analysis of 14-3-3 phosphopeptide complexes identifies a dual role for the nuclear export signal of 14-3-3 in ligand binding. Mol Cell (1999) 4.02
The molecular basis of FHA domain:phosphopeptide binding specificity and implications for phospho-dependent signaling mechanisms. Mol Cell (2000) 3.64
Structure at 1.65 A of RhoA and its GTPase-activating protein in complex with a transition-state analogue. Nature (1997) 3.55
CD40 regulates the processing of NF-kappaB2 p100 to p52. EMBO J (2002) 3.30
A genomewide scan for loci predisposing to type 2 diabetes in a U.K. population (the Diabetes UK Warren 2 Repository): analysis of 573 pedigrees provides independent replication of a susceptibility locus on chromosome 1q. Am J Hum Genet (2001) 3.26
The crystal structure of the L1 metallo-beta-lactamase from Stenotrophomonas maltophilia at 1.7 A resolution. J Mol Biol (1998) 3.24
The structure of simian virus 40 refined at 3.1 A resolution. Structure (1996) 2.96
The structure of unliganded reverse transcriptase from the human immunodeficiency virus type 1. Proc Natl Acad Sci U S A (1995) 2.95
Structure of a 14-3-3 protein and implications for coordination of multiple signalling pathways. Nature (1995) 2.68
H1 and H7 influenza haemagglutinin structures extend a structural classification of haemagglutinin subtypes. Virology (2004) 2.67
The role of lipid rafts in T cell antigen receptor (TCR) signalling. Semin Immunol (2000) 2.64
Glycaemic index methodology. Nutr Res Rev (2005) 2.47
Structural basis of asymmetry in the human immunodeficiency virus type 1 reverse transcriptase heterodimer. Proc Natl Acad Sci U S A (1994) 2.47
The structural basis of Arfaptin-mediated cross-talk between Rac and Arf signalling pathways. Nature (2001) 2.46
Activation of MEK-1 and SEK-1 by Tpl-2 proto-oncoprotein, a novel MAP kinase kinase kinase. EMBO J (1996) 2.38
Measured context-sensitive half-times of remifentanil and alfentanil. Anesthesiology (1995) 2.26
Immortalized B lymphocytes produce B-cell growth factor. Nature (1984) 2.23
S-acylation of LCK protein tyrosine kinase is essential for its signalling function in T lymphocytes. EMBO J (1997) 2.19
Kepler's optical phase curve of the exoplanet HAT-P-7b. Science (2009) 2.18
TPL-2 kinase regulates the proteolysis of the NF-kappaB-inhibitory protein NF-kappaB1 p105. Nature (1999) 2.01
The human papillomavirus type 16 E2 transcription factor binds with low cooperativity to two flanking sites and represses the E6 promoter through displacement of Sp1 and TFIID. J Virol (1994) 2.01
Cholesterol depletion disrupts lipid rafts and modulates the activity of multiple signaling pathways in T lymphocytes. Eur J Immunol (2000) 2.00
Identification of native complexes containing the yeast coactivator/repressor proteins NGG1/ADA3 and ADA2. J Biol Chem (1997) 1.98
Crystal structure of a small G protein in complex with the GTPase-activating protein rhoGAP. Nature (1997) 1.90
Lipopolysaccharide activation of the TPL-2/MEK/extracellular signal-regulated kinase mitogen-activated protein kinase cascade is regulated by IkappaB kinase-induced proteolysis of NF-kappaB1 p105. Mol Cell Biol (2004) 1.86
Structure of the TPR domain of p67phox in complex with Rac.GTP. Mol Cell (2000) 1.77
The mechanism of autooxidation of myoglobin. J Biol Chem (1993) 1.71
Soluble factor requirements for the autostimulatory growth of B lymphoblasts immortalized by Epstein-Barr virus. J Exp Med (1984) 1.69
A review of the pharmacokinetics and pharmacodynamics of remifentanil. Anesth Analg (1999) 1.68
Avian and human receptor binding by hemagglutinins of influenza A viruses. Glycoconj J (2006) 1.66
An alternate method for synthesis of double-stranded DNA segments. J Biol Chem (1982) 1.63
Direct phosphorylation of NF-kappaB1 p105 by the IkappaB kinase complex on serine 927 is essential for signal-induced p105 proteolysis. J Biol Chem (2001) 1.62
Methicillin-resistant Staphylococcus aureus infections in 11 dogs. Vet Rec (1999) 1.61
Synthesis and properties of oligonucleotides containing 2'-deoxynebularine and 2'-deoxyxanthosine. Nucleic Acids Res (1986) 1.60
ACE-Asia intercomparison of a thermal-optical method for the determination of particle-phase organic and elemental carbon. Environ Sci Technol (2003) 1.59
Specific cleavage of the retinoblastoma protein by an ICE-like protease in apoptosis. EMBO J (1996) 1.58
Palmitoylation of multiple Src-family kinases at a homologous N-terminal motif. Biochem J (1994) 1.56
The use of propofol for its antiemetic effect: a survey of clinical practice in the United States. J Clin Anesth (2000) 1.56
Creatine ingestion favorably affects performance and muscle metabolism during maximal exercise in humans. Am J Physiol (1996) 1.56
The irritable bowel syndrome and psychiatric disorders in the community: is there a link? Am J Gastroenterol (2001) 1.56
Structure of a ternary complex of an allosteric lactate dehydrogenase from Bacillus stearothermophilus at 2.5 A resolution. J Mol Biol (1992) 1.54
Clinical evaluation of intraperitoneal Pseudomonas exotoxin immunoconjugate OVB3-PE in patients with ovarian cancer. J Clin Oncol (1991) 1.53
Survey of cancellation rate of hypertensive patients undergoing anaesthesia and elective surgery. Br J Anaesth (2001) 1.44
The merozoite surface protein 6 gene codes for a 36 kDa protein associated with the Plasmodium falciparum merozoite surface protein-1 complex. Mol Biochem Parasitol (2001) 1.43
Peri-operative silent myocardial ischaemia in patients undergoing lower limb joint replacement surgery: an indicator of postoperative morbidity or mortality? Anaesthesia (1999) 1.39
The Levels of Emotional Awareness Scale: a cognitive-developmental measure of emotion. J Pers Assess (1990) 1.38
Changes in gene expression in macrophages infected with Mycobacterium tuberculosis: a combined transcriptomic and proteomic approach. Immunology (2001) 1.37
The high molecular mass rhoptry protein, RhopH1, is encoded by members of the clag multigene family in Plasmodium falciparum and Plasmodium yoelii. Mol Biochem Parasitol (2001) 1.33
Structural basis for oseltamivir resistance of influenza viruses. Vaccine (2009) 1.31
Structural factors governing azide and cyanide binding to mammalian metmyoglobins. J Biol Chem (1994) 1.31
The 22 kDa component of the protein complex on the surface of Plasmodium falciparum merozoites is derived from a larger precursor, merozoite surface protein 7. Mol Biochem Parasitol (2001) 1.30
ABIN-2 forms a ternary complex with TPL-2 and NF-kappa B1 p105 and is essential for TPL-2 protein stability. Mol Cell Biol (2004) 1.28
Human fructosamine-3-kinase: purification, sequencing, substrate specificity, and evidence of activity in vivo. Diabetes (2001) 1.25
Use of nude mouse xenografts as preclinical drug screens: in vivo activity of established chemotherapeutic agents against melanoma and ovarian carcinoma xenografts. Cancer Treat Rep (1987) 1.25
The effect of the interaction of propofol and alfentanil on recall, loss of consciousness, and the Bispectral Index. Anesth Analg (1998) 1.25
Human rhinovirus-14 protease 3C (3Cpro) binds specifically to the 5'-noncoding region of the viral RNA. Evidence that 3Cpro has different domains for the RNA binding and proteolytic activities. J Biol Chem (1993) 1.23
14-3-3 is phosphorylated by casein kinase I on residue 233. Phosphorylation at this site in vivo regulates Raf/14-3-3 interaction. J Biol Chem (1997) 1.22
A district epilepsy service, with community-based specialist liaison nurses and guidelines for shared care. Seizure (1994) 1.22
Effect of neomycin and ionophore A23189 on ATP levels and turnover of polyphosphoinositides in human erythrocytes. Can J Biochem (1977) 1.21
14-3-3 alpha and delta are the phosphorylated forms of raf-activating 14-3-3 beta and zeta. In vivo stoichiometric phosphorylation in brain at a Ser-Pro-Glu-Lys MOTIF. J Biol Chem (1995) 1.20
Crystal structure of the transcription elongation/anti-termination factor NusA from Mycobacterium tuberculosis at 1.7 A resolution. J Mol Biol (2001) 1.20
PhosphoSerine/threonine binding domains: you can't pSERious? Structure (2001) 1.20
Comparison of three different crystal forms shows HIV-1 reverse transcriptase displays an internal swivel motion. Structure (1994) 1.19
Structural and functional architecture of the yeast cell-cycle transcription factor swi6. J Mol Biol (1998) 1.14
Characterization of the DNA-binding domains from the yeast cell-cycle transcription factors Mbp1 and Swi4. Biochemistry (2000) 1.14
14-3-3 proteins: biological function and domain structure. Biochem Soc Trans (1995) 1.14
Metabolic response of type I and II muscle fibers during repeated bouts of maximal exercise in humans. Am J Physiol (1996) 1.13
The CD3-gamma and CD3-delta subunits of the T cell antigen receptor can be expressed within distinct functional TCR/CD3 complexes. EMBO J (1991) 1.12
Targeting effect compartment or central compartment concentration of propofol: what predicts loss of consciousness? Anesthesiology (1999) 1.11
Efficacy and safety of different techniques of paravertebral block for analgesia after thoracotomy: a systematic review and metaregression. Br J Anaesth (2009) 1.11
Low socioeconomic class is a risk factor for upper and lower gastrointestinal symptoms: a population based study in 15 000 Australian adults. Gut (2001) 1.11
CD5 is phosphorylated on tyrosine after stimulation of the T-cell antigen receptor complex. Proc Natl Acad Sci U S A (1992) 1.11
X-ray structural analysis of the yeast cell cycle regulator Swi6 reveals variations of the ankyrin fold and has implications for Swi6 function. Nat Struct Biol (1999) 1.11
Mesenteric arterial occlusion as a vascular emergency. Br J Surg (1969) 1.09
GTPase-activating proteins and their complexes. Curr Opin Struct Biol (1998) 1.09
Regulation of D-3 phosphoinositides during T cell activation via the T cell antigen receptor/CD3 complex and CD2 antigens. Eur J Immunol (1992) 1.09
Mechanism of inhibition of protein kinase C by 14-3-3 isoforms. 14-3-3 isoforms do not have phospholipase A2 activity. Biochem J (1994) 1.08
The clinical effectiveness and cost-effectiveness of genotyping for CYP2D6 for the management of women with breast cancer treated with tamoxifen: a systematic review. Health Technol Assess (2011) 1.08
Quality control in urodynamics: a review of urodynamic traces from one centre. BJU Int (2003) 1.05
Isoproterenol and aminophylline improve contractility of fatigued canine diaphragm. Am Rev Respir Dis (1984) 1.05