Published in Science on May 16, 1986
Immunization of Human Volunteers With P. Vivax Irradiated Sporozoites (SPZ-Irrad) | NCT01082341
CD8+ T cells (cytotoxic/suppressors) are required for protection in mice immunized with malaria sporozoites. Proc Natl Acad Sci U S A (1988) 4.67
alpha -galactosylceramide-activated Valpha 14 natural killer T cells mediate protection against murine malaria. Proc Natl Acad Sci U S A (2000) 2.30
Circumventing genetic restriction of protection against malaria with multigene DNA immunization: CD8+ cell-, interferon gamma-, and nitric oxide-dependent immunity. J Exp Med (1996) 2.15
Plasma IP-10, apoptotic and angiogenic factors associated with fatal cerebral malaria in India. Malar J (2008) 2.00
Induction of nitric oxide synthase protects against malaria in mice exposed to irradiated Plasmodium berghei infected mosquitoes: involvement of interferon gamma and CD8+ T cells. J Exp Med (1994) 1.83
Interleukin 12 induction of interferon gamma-dependent protection against malaria. Proc Natl Acad Sci U S A (1994) 1.77
Cytokines kill malaria parasites during infection crisis: extracellular complementary factors are essential. J Exp Med (1991) 1.69
Exploring the transcriptome of the malaria sporozoite stage. Proc Natl Acad Sci U S A (2001) 1.59
Synthetic peptide vaccine confers protection against murine malaria. J Exp Med (1987) 1.58
Transforming growth factor beta production is inversely correlated with severity of murine malaria infection. J Exp Med (1998) 1.57
Immunization with a recombinant C-terminal fragment of Plasmodium yoelii merozoite surface protein 1 protects mice against homologous but not heterologous P. yoelii sporozoite challenge. Infect Immun (1997) 1.57
The in vivo cytotoxic activity of CD8+ T cell clones correlates with their levels of expression of adhesion molecules. J Exp Med (1992) 1.56
Interleukin-12- and gamma interferon-dependent protection against malaria conferred by CpG oligodeoxynucleotide in mice. Infect Immun (2001) 1.55
CD4+ cytolytic T cell clone confers protection against murine malaria. J Exp Med (1990) 1.51
Susceptibility of different strains of mice to hepatic infection with Plasmodium berghei. Infect Immun (1994) 1.49
Incorporation of T and B epitopes of the circumsporozoite protein in a chemically defined synthetic vaccine against malaria. J Exp Med (1990) 1.46
Protection against malaria in Aotus monkeys immunized with a recombinant blood-stage antigen fused to a universal T-cell epitope: correlation of serum gamma interferon levels with protection. Infect Immun (1992) 1.45
Recombinant gamma interferon is a potent adjuvant for a malaria vaccine in mice. Clin Exp Immunol (1987) 1.42
Production by activated human T cells of interleukin 4 but not interferon-gamma is associated with elevated levels of serum antibodies to activating malaria antigens. Proc Natl Acad Sci U S A (1990) 1.40
Roles of CD4- and CD8-bearing T lymphocytes in the immune response to the erythrocytic stages of Plasmodium chabaudi. Infect Immun (1988) 1.38
Role of gamma interferon during infection with Plasmodium chabaudi chabaudi. Infect Immun (1990) 1.37
Expression in yeast of a Plasmodium vivax antigen of potential use in a human malaria vaccine. J Exp Med (1987) 1.35
The hypnozoite and relapse in primate malaria. Clin Microbiol Rev (1992) 1.34
T-cell immunity to peptide epitopes of liver-stage antigen 1 in an area of Papua New Guinea in which malaria is holoendemic. Infect Immun (1997) 1.27
Transformation of sporozoites into early exoerythrocytic malaria parasites does not require host cells. J Exp Med (2003) 1.26
A human Phase I/IIa malaria challenge trial of a polyprotein malaria vaccine. Vaccine (2011) 1.25
Correlation of memory T cell responses against TRAP with protection from clinical malaria, and CD4 CD25 high T cells with susceptibility in Kenyans. PLoS One (2008) 1.25
Gamma interferon controls Eimeria vermiformis primary infection in BALB/c mice. Infect Immun (1989) 1.21
Serum cytokine profiles in experimental human malaria. Relationship to protection and disease course after challenge. J Clin Invest (1992) 1.21
In vitro activity of CD4+ and CD8+ T lymphocytes from mice immunized with a synthetic malaria peptide. Proc Natl Acad Sci U S A (1991) 1.18
A Plasmodium falciparum candidate vaccine based on a six-antigen polyprotein encoded by recombinant poxviruses. Proc Natl Acad Sci U S A (2003) 1.18
Safety and enhanced immunogenicity of a hepatitis B core particle Plasmodium falciparum malaria vaccine formulated in adjuvant Montanide ISA 720 in a phase I trial. Infect Immun (2005) 1.17
Complete protection against Plasmodium yoelii by adoptive transfer of a CD8+ cytotoxic T-cell clone recognizing sporozoite surface protein 2. Infect Immun (1994) 1.14
Host-virus interactions during malaria infection in hepatitis B virus transgenic mice. J Exp Med (2000) 1.10
T lymphocyte interferon-gamma production induced by Plasmodium falciparum antigen is high in recently infected non-immune and low in immune subjects. Clin Exp Immunol (1990) 1.09
Phase I testing of a malaria vaccine composed of hepatitis B virus core particles expressing Plasmodium falciparum circumsporozoite epitopes. Infect Immun (2004) 1.07
Conserved protective mechanisms in radiation and genetically attenuated uis3(-) and uis4(-) Plasmodium sporozoites. PLoS One (2009) 1.04
Cytokine production and apoptosis among T cells from patients under treatment for Plasmodium falciparum malaria. Clin Exp Immunol (2002) 1.01
Class II-restricted protective immunity induced by malaria sporozoites. Infect Immun (2007) 1.00
Pre-erythrocytic-stage immune effector mechanisms in Plasmodium spp. infections. Philos Trans R Soc Lond B Biol Sci (1997) 1.00
A linear peptide containing minimal T- and B-cell epitopes of Plasmodium falciparum circumsporozoite protein elicits protection against transgenic sporozoite challenge. Infect Immun (2006) 1.00
Effector CD8+ T lymphocytes against liver stages of Plasmodium yoelii do not require gamma interferon for antiparasite activity. Infect Immun (2008) 0.99
C-reactive protein protects against preerythrocytic stages of malaria. Infect Immun (1989) 0.99
A modified hepatitis B virus core particle containing multiple epitopes of the Plasmodium falciparum circumsporozoite protein provides a highly immunogenic malaria vaccine in preclinical analyses in rodent and primate hosts. Infect Immun (2002) 0.97
DNA immunization by Plasmodium falciparum liver-stage antigen 3 induces protection against Plasmodium yoelii sporozoite challenge. Infect Immun (2001) 0.97
Analysis of immune responses against T- and B-cell epitopes from Plasmodium falciparum liver-stage antigen 1 in rodent malaria models and malaria-exposed human subjects in India. Infect Immun (2000) 0.96
Plasmodium-host interactions directly influence the threshold of memory CD8 T cells required for protective immunity. J Immunol (2011) 0.95
Inducing humoral and cellular responses to multiple sporozoite and liver-stage malaria antigens using exogenous plasmid DNA. Infect Immun (2013) 0.94
Recombinant gamma interferon causes neutrophil migration mediated by the release of a macrophage neutrophil chemotactic factor. Int J Exp Pathol (1990) 0.94
Memory CD8 T cells specific for plasmodia liver-stage antigens maintain protracted protection against malaria. Front Immunol (2012) 0.94
Phase I trial of an alhydrogel adjuvanted hepatitis B core virus-like particle containing epitopes of Plasmodium falciparum circumsporozoite protein. PLoS One (2008) 0.93
Mechanisms of protective immune responses induced by the Plasmodium falciparum circumsporozoite protein-based, self-assembling protein nanoparticle vaccine. Malar J (2013) 0.93
A retrospective evaluation of the role of T cells in the development of malaria vaccine. Exp Parasitol (2009) 0.92
Identification of non-CSP antigens bearing CD8 epitopes in mice immunized with irradiated sporozoites. Vaccine (2011) 0.92
Identification of targets of CD8⁺ T cell responses to malaria liver stages by genome-wide epitope profiling. PLoS Pathog (2013) 0.91
Gamma interferon-mediated inhibition of Eimeria vermiformis growth in cultured fibroblasts and epithelial cells. Infect Immun (1991) 0.91
Cellular mechanisms in the immune response to malaria in Plasmodium vinckei-infected mice. Infect Immun (1995) 0.90
CD8 T-cell-mediated protection against liver-stage malaria: lessons from a mouse model. Front Microbiol (2014) 0.89
Use of a tuberculin purified protein derivative--Asn-Ala-Asn-Pro conjugate in bacillus Calmette-Guérin primed mice overcomes H-2 restriction of the antibody response and avoids the need for adjuvants. Proc Natl Acad Sci U S A (1990) 0.88
A double-edged sword: the role of NKT cells in malaria and HIV infection and immunity. Semin Immunol (2009) 0.86
Immunogenicity of well-characterized synthetic Plasmodium falciparum multiple antigen peptide conjugates. Infect Immun (2001) 0.86
Protective value of elevated levels of gamma interferon in serum against exoerythrocytic stages of Plasmodium falciparum. J Clin Microbiol (1991) 0.85
Plasmodium cellular effector mechanisms and the hepatic microenvironment. Front Microbiol (2015) 0.84
Antigens for pre-erythrocytic malaria vaccines: building on success. Parasite Immunol (2009) 0.83
Interferon-γ, a valuable surrogate marker of Plasmodium falciparum pre-erythrocytic stages protective immunity. Malar J (2011) 0.83
Cytokine profiles amongst Sudanese patients with visceral leishmaniasis and malaria co-infections. BMC Immunol (2014) 0.83
Discovery of Novel Plasmodium falciparum Pre-Erythrocytic Antigens for Vaccine Development. PLoS One (2015) 0.82
LAP-like process as an immune mechanism downstream of IFN-γ in control of the human malaria Plasmodium vivax liver stage. Proc Natl Acad Sci U S A (2016) 0.81
Assessment in mice of a synthetic peptide-based vaccine against the sporozoite stage of the human malaria parasite, P. falciparum. Immunology (1988) 0.80
The TLR2 is activated by sporozoites and suppresses intrahepatic rodent malaria parasite development. Sci Rep (2015) 0.80
In vivo CD8+ T cell dynamics in the liver of Plasmodium yoelii immunized and infected mice. PLoS One (2013) 0.80
Protective immunity to liver-stage malaria. Clin Transl Immunology (2016) 0.78
Parasite exposure elicits a preferential T-cell response involved in protective immunity against Eimeria species in chickens primed by an internal-image anti-idiotypic antibody. Infect Immun (1989) 0.78
Interferons and interferon regulatory factors in malaria. Mediators Inflamm (2014) 0.77
IFN-γ protects hepatocytes against Plasmodium vivax infection via LAP-like degradation of sporozoites. Proc Natl Acad Sci U S A (2016) 0.76
Tomatine adjuvantation of protective immunity to a major pre-erythrocytic vaccine candidate of malaria is mediated via CD8+ T cell release of IFN-gamma. J Biomed Biotechnol (2010) 0.75
Transfected Plasmodium knowlesi produces bioactive host gamma interferon: a new perspective for modulating immune responses to malaria parasites. Infect Immun (2003) 0.75
A population of lymphocytes bearing a membrane receptor for antigen-antibody-complement complexes. I. Separation and characterization. J Exp Med (1970) 15.86
Receptors for complement of leukocytes. J Exp Med (1968) 11.57
Binding of sheep red blood cells to a large population of human lymphocytes. Nature (1971) 7.67
The role of membrane receptors for C3b and C3d in phagocytosis. J Exp Med (1977) 6.19
Phagocytosis of immune complexes by macrophages. Different roles of the macrophage receptor sites for complement (C3) and for immunoglobulin (IgG). J Exp Med (1972) 6.13
Protective immunity produced by the injection of x-irradiated sporozoites of plasmodium berghei. Nature (1967) 6.08
Gamma interferon, CD8+ T cells and antibodies required for immunity to malaria sporozoites. Nature (1988) 5.99
Inhibition of complement activation on the surface of cells after incorporation of decay-accelerating factor (DAF) into their membranes. J Exp Med (1984) 5.47
Enhanced binding of neuraminidase-treated sheep erythrocytes to human T lymphocytes. Blood (1973) 4.99
Complement receptor (CR1) deficiency in erythrocytes from patients with systemic lupus erythematosus. J Exp Med (1982) 4.96
Monovalent fragments (Fab) of monoclonal antibodies to a sporozoite surface antigen (Pb44) protect mice against malarial infection. J Exp Med (1980) 4.81
TRAP is necessary for gliding motility and infectivity of plasmodium sporozoites. Cell (1997) 4.65
Genetic selection of a Plasmodium-refractory strain of the malaria vector Anopheles gambiae. Science (1986) 4.40
Multiple immunoglobulin heavy-chain gene transcripts in Abelson murine leukemia virus-transformed lymphoid cell lines. Mol Cell Biol (1982) 4.26
Cloned cytotoxic T cells recognize an epitope in the circumsporozoite protein and protect against malaria. Nature (1989) 4.08
The hepatitis delta (delta) virus possesses a circular RNA. Nature (1986) 4.00
A new complement function: solubilization of antigen-antibody aggregates. Proc Natl Acad Sci U S A (1975) 3.97
The evolution of primate malaria parasites based on the gene encoding cytochrome b from the linear mitochondrial genome. Proc Natl Acad Sci U S A (1998) 3.93
Migration of Plasmodium sporozoites through cells before infection. Science (2001) 3.89
Hybridoma produces protective antibodies directed against the sporozoite stage of malaria parasite. Science (1980) 3.71
Ca++-dependent binding of antigen-19 S antibody complexes to macrophages. J Immunol (1969) 3.70
Release of decay-accelerating factor (DAF) from the cell membrane by phosphatidylinositol-specific phospholipase C (PIPLC). Selective modification of a complement regulatory protein. J Exp Med (1986) 3.68
Studies on the mechanism of solubilization of immune precipitates by serum. J Exp Med (1976) 3.68
Complement receptor is an inhibitor of the complement cascade. J Exp Med (1981) 3.65
Cloning of decay-accelerating factor suggests novel use of splicing to generate two proteins. Nature (1987) 3.62
Unique role of the complement receptor CR1 in the degradation of C3b associated with immune complexes. J Exp Med (1982) 3.42
Functional analysis of bacteriophage f1 intergenic region. Virology (1981) 3.37
Distribution of decay-accelerating factor in the peripheral blood of normal individuals and patients with paroxysmal nocturnal hemoglobinuria. J Exp Med (1985) 3.33
Circumsporozoite proteins of human malaria parasites Plasmodium falciparum and Plasmodium vivax. J Exp Med (1982) 3.26
Rationale for development of a synthetic vaccine against Plasmodium falciparum malaria. Science (1985) 3.24
Chloroquine-resistant Plasmodium falciparum from East Africa: cultivation and drug sensitivity of the Tanzanian I/CDC strain from an American tourist. Lancet (1979) 3.22
Theta-bearing and complement-receptor lymphocytes are distinct populations of cells. Science (1971) 3.16
Circumsporozoite proteins of malaria parasites contain a single immunodominant region with two or more identical epitopes. J Exp Med (1983) 3.07
Human C4-binding protein. II. Role in proteolysis of C4b by C3b-inactivator. J Exp Med (1978) 2.98
Genetic studies with heteroduplex DNA of bacteriophage fl. Asymmetric segregation, base correction and implications for the mechanism of genetic recombination. J Mol Biol (1975) 2.95
Antibodies to sporozoites: their frequent occurrence in individuals living in an area of hyperendemic malaria. Science (1979) 2.91
Experimental mosquito-transmission of Plasmodium knowlesi to man and monkey. Am J Trop Med Hyg (1968) 2.89
Plasma concentration of LH, FSH, prolactin, progesterone and estradiol-17beta throughout the 4-day estrous cycle of the rat. Endocrinology (1974) 2.87
Identification of the complement decay-accelerating factor (DAF) on epithelium and glandular cells and in body fluids. J Exp Med (1987) 2.86
Inhibition of neuronal maturation in primary hippocampal neurons from tau deficient mice. J Cell Sci (2001) 2.82
Cloned HBV DNA causes hepatitis in chimpanzees. Nature (1982) 2.80
The basolateral domain of the hepatocyte plasma membrane bears receptors for the circumsporozoite protein of Plasmodium falciparum sporozoites. Cell (1992) 2.78
Monoclonal antibodies to circumsporozoite proteins identify the species of malaria parasite in infected mosquitoes. Nature (1982) 2.76
Modulation of the classical pathway C3 convertase by plasma proteins C4 binding protein and C3b inactivator. Proc Natl Acad Sci U S A (1979) 2.73
Activity of multiple light chain genes in murine myeloma cells producing a single, functional light chain. Cell (1980) 2.68
CD8+ cytolytic T cell clones derived against the Plasmodium yoelii circumsporozoite protein protect against malaria. Int Immunol (1991) 2.67
Population dynamics of untreated Plasmodium falciparum malaria within the adult human host during the expansion phase of the infection. Parasitology (2002) 2.67
Demonstration of heat-shock protein 70 in the sporozoite stage of malaria parasites. Parasitol Res (1994) 2.65
Rationale for the development of an engineered sporozoite malaria vaccine. Adv Immunol (1989) 2.64
Malaria circumsporozoite protein binds to heparan sulfate proteoglycans associated with the surface membrane of hepatocytes. J Exp Med (1993) 2.60
Structure of the plasmodium knowlesi gene coding for the circumsporozoite protein. Cell (1983) 2.60
Human C4-binding protein. I. Isolation and characterization. J Exp Med (1978) 2.60
Signal for attachment of a phospholipid membrane anchor in decay accelerating factor. Science (1987) 2.59
Diagnostic pitfalls in sporadic transthyretin familial amyloid polyneuropathy (TTR-FAP). Neurology (2007) 2.59
Cell surface immunoglobulin. IV. Distribution among thymocytes, bone mrrow cells, and their derived populations. J Exp Med (1972) 2.50
Circumsporozoite protein is required for development of malaria sporozoites in mosquitoes. Nature (1997) 2.49
DNA cloning of Plasmodium falciparum circumsporozoite gene: amino acid sequence of repetitive epitope. Science (1984) 2.47
Human lymphocytes bear membrane receptors for C3b and C3d. J Clin Invest (1973) 2.46
Circumsporozoite proteins of malaria parasites. Cell (1985) 2.45
Priming with recombinant influenza virus followed by administration of recombinant vaccinia virus induces CD8+ T-cell-mediated protective immunity against malaria. Proc Natl Acad Sci U S A (1993) 2.44
Conservation of a gliding motility and cell invasion machinery in Apicomplexan parasites. J Cell Biol (1999) 2.43
Circumsporozoite protein of Plasmodium vivax: gene cloning and characterization of the immunodominant epitope. Science (1985) 2.41
Research toward malaria vaccines. Science (1986) 2.40
The indirect fluorescent antibody test for malaria. Am J Trop Med Hyg (1972) 2.37
Identification of Plasmodium vivax-like human malaria parasite. Lancet (1993) 2.37
Antihapten antibody specificity and L chain type. J Exp Med (1967) 2.33
Further studies on the Plasmodium berghei-Anopheles stephensi--rodent system of mammalian malaria. J Parasitol (1968) 2.32
Spinophilin regulates the formation and function of dendritic spines. Proc Natl Acad Sci U S A (2000) 2.32
Identification of the membrane receptor for the complement fragment C3d by means of a monoclonal antibody. J Exp Med (1983) 2.31
The purification and characterization of rat gamma interferon by use of two monoclonal antibodies. J Gen Virol (1986) 2.29
Tissue localization of lymphocytes bearing a membrane receptor for antigen-antibody-complement complexes. Proc Natl Acad Sci U S A (1970) 2.29
Complement-dependent release of immune complexes from the lymphocyte membrane. J Exp Med (1973) 2.27
Stage-specific surface antigens expressed during the morphogenesis of vertebrate forms of Trypanosoma cruzi. Exp Parasitol (1987) 2.25
Increased proportion of complement-receptor lymphocytes in the peripheral blood of patients with chronic lymphocytic leukemia. Blood (1972) 2.25
Requirements for the solubilization of immune aggregates by complement. The role of the classical pathway. J Clin Invest (1978) 2.24
Receptors for immune complexes on lymphocytes. Adv Immunol (1974) 2.23
Infectious hepatitis B virus from cloned DNA of known nucleotide sequence. Proc Natl Acad Sci U S A (1985) 2.20
Interferon-gamma inhibits the intrahepatocytic development of malaria parasites in vitro. J Immunol (1987) 2.19
Immunization of Aotus monkeys with recombinant proteins of an erythrocyte surface antigen of Plasmodium falciparum. Nature (1986) 2.19