Tissue-specific regulation of GTP-binding protein and muscarinic acetylcholine receptor levels during cardiac development.

Techniques used in the identification and analysis of function of pertussis toxin-sensitive guanine nucleotide binding proteins. Biochem J (1988) 1.86

Membrane localization of the pertussis toxin-sensitive G-protein subunits alpha i-2 and alpha i-3 and expression of a metallothionein-alpha i-2 fusion gene in LLC-PK1 cells. Proc Natl Acad Sci U S A (1990) 1.69

G alpha 16, a G protein alpha subunit specifically expressed in hematopoietic cells. Proc Natl Acad Sci U S A (1991) 1.51

Kinetics of M1 muscarinic receptor and G protein signaling to phospholipase C in living cells. J Gen Physiol (2010) 1.29

Isolation of the alpha subunits of GTP-binding regulatory proteins by affinity chromatography with immobilized beta gamma subunits. Proc Natl Acad Sci U S A (1989) 1.18

Distribution of G-proteins in rat liver plasma-membrane domains and endocytic pathways. Biochem J (1989) 1.01

GTP-binding proteins couple cardiac muscarinic receptors to a K channel. Nature (1985) 4.95

Antibodies directed against synthetic peptides distinguish between GTP-binding proteins in neutrophil and brain. J Biol Chem (1987) 2.99

Isozyme-selective stimulation of phospholipase C-beta 2 by G protein beta gamma-subunits. Nature (1992) 2.88

Human cDNA clones for four species of G alpha s signal transduction protein. Proc Natl Acad Sci U S A (1986) 2.38

Tailoring cAMP-signalling responses through isoform multiplicity. Trends Biochem Sci (1997) 2.25

Increased susceptibility to malaria during the early postpartum period. N Engl J Med (2000) 2.24

Disruption of the m1 receptor gene ablates muscarinic receptor-dependent M current regulation and seizure activity in mice. Proc Natl Acad Sci U S A (1997) 2.10

Variation of Plasmodium falciparum msp1 block 2 and msp2 allele prevalence and of infection complexity in two neighbouring Senegalese villages with different transmission conditions. Trans R Soc Trop Med Hyg (1999) 2.02

Use of specific antibodies to quantitate the guanine nucleotide-binding protein Go in brain. Proc Natl Acad Sci U S A (1986) 2.00

Epidemiological and virological influenza survey in Dakar, Senegal: 1996-1998. Am J Trop Med Hyg (2000) 1.96

Abolition of the expression of inhibitory guanine nucleotide regulatory protein Gi activity in diabetes. Nature (1987) 1.93

Plasmodium falciparum clinical malaria: lessons from longitudinal studies in Senegal. Parassitologia (1999) 1.86

Molecular properties of the muscarinic acetylcholine receptor. Annu Rev Neurosci (1987) 1.83

The inhibitory guanine nucleotide-binding protein (Ni) purified from bovine brain is a high affinity GTPase. J Biol Chem (1985) 1.83

The Rac-RhoGDI complex and the structural basis for the regulation of Rho proteins by RhoGDI. Nat Struct Biol (2000) 1.77

Delta-opioid-receptor-mediated inhibition of adenylate cyclase is transduced specifically by the guanine-nucleotide-binding protein Gi2. Biochem J (1990) 1.63

Antibodies to the GTP binding protein, Go, antagonize noradrenaline-induced calcium current inhibition in NG108-15 hybrid cells. Neuron (1989) 1.63

Rapid and efficient homing of human CD34(+)CD38(-/low)CXCR4(+) stem and progenitor cells to the bone marrow and spleen of NOD/SCID and NOD/SCID/B2m(null) mice. Blood (2001) 1.62

A novel N-terminal motif for palmitoylation of G-protein alpha subunits. Biochem J (1993) 1.57

Radiographic progression of hospital referred osteoarthritis of the hip. Ann Rheum Dis (1993) 1.57

Agonists that suppress M-current elicit phosphoinositide turnover and Ca2+ transients, but these events do not explain M-current suppression. Neuron (1988) 1.55

Antisera against a guanine nucleotide binding protein from retina cross-react with the beta subunit of the adenylyl cyclase-associated guanine nucleotide binding proteins, Ns and Ni. Proc Natl Acad Sci U S A (1985) 1.54

Specificity of the functional interactions of the beta-adrenergic receptor and rhodopsin with guanine nucleotide regulatory proteins reconstituted in phospholipid vesicles. J Biol Chem (1985) 1.52

In-vitro activity of pyronaridine and amodiaquine against African isolates (Senegal) of Plasmodium falciparum in comparison with standard antimalarial agents. J Antimicrob Chemother (1998) 1.51

Gi-mediated activation of the p21ras-mitogen-activated protein kinase pathway by alpha 2-adrenergic receptors expressed in fibroblasts. J Biol Chem (1993) 1.48

A bioluminescent assay for agonist activity at potentially any G-protein-coupled receptor. Anal Biochem (1997) 1.47

The insulin receptor tyrosyl kinase phosphorylates holomeric forms of the guanine nucleotide regulatory proteins Gi and Go. FEBS Lett (1987) 1.46

The GTP-binding regulatory proteins of neuroblastoma x glioma, NG108-15, and glioma, C6, cells. Immunochemical evidence of a pertussis toxin substrate that is neither Ni nor No. FEBS Lett (1986) 1.45

Stimulation of phospholipase C by guanine-nucleotide-binding protein beta gamma subunits. Eur J Biochem (1992) 1.43

Muscarinic M-current inhibition via G alpha q/11 and alpha-adrenoceptor inhibition of Ca2+ current via G alpha o in rat sympathetic neurones. J Physiol (1994) 1.42

Gq- and ras-dependent pathways mediate hypertrophy of neonatal rat ventricular myocytes following alpha 1-adrenergic stimulation. J Biol Chem (1994) 1.41

Guanine-nucleotide-binding proteins expressed in rat white adipose tissue. Identification of both mRNAs and proteins corresponding to Gi1, Gi2 and Gi3. Biochem J (1989) 1.37

Hormonal regulation of Gi2 alpha-subunit phosphorylation in intact hepatocytes. Biochem J (1990) 1.37

Increase of Gi alpha in human hearts with dilated but not ischemic cardiomyopathy. Circulation (1990) 1.36

Antibiotics for prophylaxis of Plasmodium falciparum infections: in vitro activity of doxycycline against Senegalese isolates. Am J Trop Med Hyg (2000) 1.35

CXCR4 and CD4 mediate a rapid CD95-independent cell death in CD4(+) T cells. Proc Natl Acad Sci U S A (1998) 1.35

In vitro activities of benflumetol against 158 Senegalese isolates of Plasmodium falciparum in comparison with those of standard antimalarial drugs. Antimicrob Agents Chemother (1999) 1.35

Bradykinin excites rat sympathetic neurons by inhibition of M current through a mechanism involving B2 receptors and G alpha q/11. Neuron (1995) 1.35

Immunochemical evidence for a novel pertussis toxin substrate in human neutrophils. J Biol Chem (1986) 1.33

Prostaglandin E1-mediated, cyclic AMP-independent, down-regulation of Gs alpha in neuroblastoma x glioma hybrid cells. J Biol Chem (1990) 1.33

Radiographic patterns and associations of osteoarthritis of the hip. Ann Rheum Dis (1992) 1.32

GTP-binding proteins in brain and neutrophil are tethered to the plasma membrane via their amino termini. Biochem Biophys Res Commun (1987) 1.30

The alpha subunit of Gq contributes to muscarinic inhibition of the M-type potassium current in sympathetic neurons. J Neurosci (1998) 1.30

Antibodies against the carboxyl-terminal 5-kDa peptide of the alpha subunit of transducin crossreact with the 40-kDa but not the 39-kDa guanine nucleotide binding protein from brain. Proc Natl Acad Sci U S A (1985) 1.30

Ligand regulation of green fluorescent protein-tagged forms of the human beta(1)- and beta(2)-adrenoceptors; comparisons with the unmodified receptors. Br J Pharmacol (2000) 1.30

Elucidating the role of muscarinic receptors in psychosis. Life Sci (2001) 1.29

Down-regulation of Gi sub-types by prolonged incubation of adipocytes with an A1 adenosine receptor agonist. J Biol Chem (1990) 1.29

Development of opiate receptors and GTP-binding regulatory proteins in neonatal rat brain. J Biol Chem (1987) 1.29

Human cDNA clones for an alpha subunit of Gi signal-transduction protein. Proc Natl Acad Sci U S A (1987) 1.28

Multisite phosphorylation of the alpha subunit of transducin by the insulin receptor kinase and protein kinase C. Proc Natl Acad Sci U S A (1986) 1.28

Similar feeding preferences of Anopheles gambiae and A. arabiensis in Senegal. Trans R Soc Trop Med Hyg (1998) 1.28

Antiparkinsonian agent piribedil displays antagonist properties at native, rat, and cloned, human alpha(2)-adrenoceptors: cellular and functional characterization. J Pharmacol Exp Ther (2001) 1.28

Functional reconstitution of the alpha 2-adrenergic receptor with guanine nucleotide regulatory proteins in phospholipid vesicles. J Biol Chem (1986) 1.27

Antibodies which recognize the C-terminus of the inhibitory guanine-nucleotide-binding protein (Gi) demonstrate that opioid peptides and foetal-calf serum stimulate the high-affinity GTPase activity of two separate pertussis-toxin substrates. Biochem J (1988) 1.27

Clinical implications of guanine nucleotide-binding proteins as receptor-effector couplers. N Engl J Med (1985) 1.27

Agonist activation of transfected human M1 muscarinic acetylcholine receptors in CHO cells results in down-regulation of both the receptor and the alpha subunit of the G-protein Gq. Biochem J (1993) 1.27

Mechanism of noradrenaline-induced heterologous desensitization of adenylate cyclase stimulation in rat heart muscle cells: increase in the level of inhibitory G-protein alpha-subunits. Eur J Pharmacol (1989) 1.26

A cohort study of Plasmodium falciparum diversity during the dry season in Ndiop, a Senegalese village with seasonal, mesoendemic malaria. Trans R Soc Trop Med Hyg (2000) 1.26

Immunological and molecular characterization of Go alpha-like proteins in the Drosophila central nervous system. J Biol Chem (1989) 1.25

Diabetes-induced alterations in the expression, functioning and phosphorylation state of the inhibitory guanine nucleotide regulatory protein Gi-2 in hepatocytes. Biochem J (1990) 1.25

A prospective trial evaluating a standard approach to reoperation for missed parathyroid adenoma. Ann Surg (1996) 1.23

Purification of heterotrimeric GTP-binding proteins from brain: identification of a novel form of Go. Biochemistry (1988) 1.22

The dually acylated NH2-terminal domain of gi1alpha is sufficient to target a green fluorescent protein reporter to caveolin-enriched plasma membrane domains. Palmitoylation of caveolin-1 is required for the recognition of dually acylated g-protein alpha subunits in vivo. J Biol Chem (1999) 1.22

Monitoring receptor oligomerization using time-resolved fluorescence resonance energy transfer and bioluminescence resonance energy transfer. The human delta -opioid receptor displays constitutive oligomerization at the cell surface, which is not regulated by receptor occupancy. J Biol Chem (2001) 1.22

The G protein alpha subunit has a key role in determining the specificity of coupling to, but not the activation of, G protein-gated inwardly rectifying K(+) channels. J Biol Chem (2000) 1.20

A pH-sensitive fluor, CypHer 5, used to monitor agonist-induced G protein-coupled receptor internalization in live cells. Biotechniques (2002) 1.20

A new functional Ras antagonist inhibits human pancreatic tumor growth in nude mice. Oncogene (1999) 1.19

Identification of two distinct isoforms of the guanine nucleotide binding protein G0 in neuroblastoma X glioma hybrid cells: independent regulation during cyclic AMP-induced differentiation. J Neurochem (1990) 1.18

PH domains and phospholipases--a meaningful relationship? Trends Biochem Sci (1994) 1.17

In vitro activities of ferrochloroquine against 55 Senegalese isolates of Plasmodium falciparum in comparison with those of standard antimalarial drugs. Trop Med Int Health (2002) 1.17

Site-directed mutagenesis of the m2 muscarinic acetylcholine receptor. Analysis of the role of N-glycosylation in receptor expression and function. J Biol Chem (1990) 1.17

Activation of protein kinase C induces rapid internalization and subsequent degradation of muscarinic acetylcholine receptors in neuroblastoma cells. J Biol Chem (1986) 1.16

Concurrent down-regulation of IP prostanoid receptors and the alpha-subunit of the stimulatory guanine-nucleotide-binding protein (Gs) during prolonged exposure of neuroblastoma x glioma cells to prostanoid agonists. Quantification and functional implications. Biochem J (1992) 1.15

Guanine nucleotide regulation of the pertussis and cholera toxin substrates of rat glioma C6 BU1 cells. Biochim Biophys Acta (1987) 1.15

Stimulation of phospholipase C-beta2 by the Rho GTPases Cdc42Hs and Rac1. EMBO J (1998) 1.14

TGFbeta1 represses proliferation of pancreatic carcinoma cells which correlates with Smad4-independent inhibition of ERK activation. Oncogene (2000) 1.14

Growth factor-dependent activation of the Ras-Raf-MEK-MAPK pathway in the human pancreatic carcinoma cell line PANC-1 carrying activated K-ras: implications for cell proliferation and cell migration. Oncogene (2000) 1.13

Differential effects of suramin on the coupling of receptors to individual species of pertussis-toxin-sensitive guanine-nucleotide-binding proteins. Biochem J (1988) 1.13

Receptor for the pain modulatory neuropeptides FF and AF is an orphan G protein-coupled receptor. J Biol Chem (2000) 1.13

Widespread distribution of Gq alpha/G11 alpha detected immunologically by an antipeptide antiserum directed against the predicted C-terminal decapeptide. FEBS Lett (1991) 1.12

Detection of the major pertussis toxin substrate of human leukocytes with antisera raised against synthetic peptides. FEBS Lett (1986) 1.12

Treatment of intact hepatocytes with either the phorbol ester TPA or glucagon elicits the phosphorylation and functional inactivation of the inhibitory guanine nucleotide regulatory protein Gi. FEBS Lett (1989) 1.12

Purification and immunochemical characterization of the major pertussis-toxin-sensitive guanine-nucleotide-binding protein of bovine-neutrophil membranes. Eur J Biochem (1987) 1.11