Published in Nucleic Acids Res on March 25, 1988
TRANSFAC: transcriptional regulation, from patterns to profiles. Nucleic Acids Res (2003) 29.26
TRANSFAC and its module TRANSCompel: transcriptional gene regulation in eukaryotes. Nucleic Acids Res (2006) 22.20
MatInd and MatInspector: new fast and versatile tools for detection of consensus matches in nucleotide sequence data. Nucleic Acids Res (1995) 21.22
TRANSFAC: an integrated system for gene expression regulation. Nucleic Acids Res (2000) 15.70
The TRANSFAC system on gene expression regulation. Nucleic Acids Res (2001) 13.63
TRANSFAC: a database on transcription factors and their DNA binding sites. Nucleic Acids Res (1996) 13.50
The European Bioinformatics Institute (EBI) databases. Nucleic Acids Res (1996) 7.19
TRANSFAC, TRRD and COMPEL: towards a federated database system on transcriptional regulation. Nucleic Acids Res (1997) 6.20
A sensitive method for the determination of protein-DNA binding specificities. Nucleic Acids Res (1990) 5.42
Whole genome PCR: application to the identification of sequences bound by gene regulatory proteins. Nucleic Acids Res (1989) 4.07
CCAAT/enhancer binding protein gene promoter: binding of nuclear factors during differentiation of 3T3-L1 preadipocytes. Proc Natl Acad Sci U S A (1991) 3.98
Molecular biology of the lignin-degrading basidiomycete Phanerochaete chrysosporium. Microbiol Rev (1993) 3.66
The GLI gene encodes a nuclear protein which binds specific sequences in the human genome. Mol Cell Biol (1990) 3.64
Two tissue-specific factors bind the erythroid promoter of the human porphobilinogen deaminase gene. Nucleic Acids Res (1989) 3.56
Target Detection Assay (TDA): a versatile procedure to determine DNA binding sites as demonstrated on SP1 protein. Nucleic Acids Res (1990) 3.08
Computer-assisted prediction, classification, and delimitation of protein binding sites in nucleic acids. Nucleic Acids Res (1993) 3.06
A novel, inducible and T cell-specific enhancer located at the 3' end of the T cell receptor alpha locus. EMBO J (1989) 2.64
The GLI-Kruppel family of human genes. Mol Cell Biol (1988) 2.52
Status of the transcription factors database (TFD). Nucleic Acids Res (1993) 2.49
Cloning of the gene encoding the yeast protein BTF1Y, which can substitute for the human TATA box-binding factor. Proc Natl Acad Sci U S A (1989) 2.30
Associations between restriction site polymorphism and enzyme activity variation for esterase 6 in Drosophila melanogaster. Genetics (1990) 1.99
Structure of the rat osteocalcin gene and regulation of vitamin D-dependent expression. Proc Natl Acad Sci U S A (1989) 1.98
Transcriptional activation of human papillomavirus 16 by nuclear factor I, AP1, steroid receptors and a possibly novel transcription factor, PVF: a model for the composition of genital papillomavirus enhancers. Nucleic Acids Res (1990) 1.81
An enhancer located in a CpG-island 3' to the TCR/CD3-epsilon gene confers T lymphocyte-specificity to its promoter. EMBO J (1989) 1.72
The EMBL Nucleotide Sequence Database. Nucleic Acids Res (1997) 1.71
Identification of a novel constitutive enhancer element and an associated binding protein: implications for human papillomavirus type 11 enhancer regulation. J Virol (1989) 1.52
The structure of the gene coding for the mouse cell adhesion molecule uvomorulin. Nucleic Acids Res (1991) 1.34
Replication-dependent activation of the adenovirus major late promoter is mediated by the increased binding of a transcription factor to sequences in the first intron. J Virol (1989) 1.34
Regulatory elements responsible for inducible expression of the granulocyte colony-stimulating factor gene in macrophages. Mol Cell Biol (1990) 1.29
Thymidylate synthase gene expression is stimulated by some (but not all) introns. Nucleic Acids Res (1989) 1.28
Distamycins inhibit the binding of OTF-1 and NFE-1 transfactors to their conserved DNA elements. Nucleic Acids Res (1989) 1.28
Purification and characterization of a DNA-binding heterodimer of 52 and 100 kDa from HeLa cells. Biochem J (1993) 1.27
TFClass: an expandable hierarchical classification of human transcription factors. Nucleic Acids Res (2012) 1.22
Human CD3-epsilon gene contains three miniexons and is transcribed from a non-TATA promoter. Proc Natl Acad Sci U S A (1988) 1.17
Structural diversity and nuclear protein binding sites in the long terminal repeats of feline leukemia virus. J Virol (1990) 1.17
Antisense oligonucleotides from the stage-specific myeloid zinc finger gene MZF-1 inhibit granulopoiesis in vitro. J Exp Med (1991) 1.17
Structure of the gene encoding VGF, a nervous system-specific mRNA that is rapidly and selectively induced by nerve growth factor in PC12 cells. Mol Cell Biol (1991) 1.16
The Xenopus ribosomal DNA 60- and 81-base-pair repeats are position-dependent enhancers that function at the establishment of the preinitiation complex: analysis in vivo and in an enhancer-responsive in vitro system. Mol Cell Biol (1989) 1.15
Regulation by transcription factors in bacteria: beyond description. FEMS Microbiol Rev (2009) 1.12
Structure of the two promoters of the human lck gene: differential accumulation of two classes of lck transcripts in T cells. Mol Cell Biol (1989) 1.10
Delineation of human papillomavirus type 18 enhancer binding proteins: the intracellular distribution of a novel octamer binding protein p92 is cell cycle regulated. Nucleic Acids Res (1991) 1.08
5' flanking sequence and structure of a gene encoding rat 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase. Proc Natl Acad Sci U S A (1989) 1.07
In vitro analysis of DNA-protein interactions by proximity ligation. Proc Natl Acad Sci U S A (2007) 1.07
Identification of a conserved sequence in the non-coding regions of many human genes. Nucleic Acids Res (1989) 1.05
The cooperative interaction between two motifs of an enhancer element of the chicken alpha A-crystallin gene, alpha CE1 and alpha CE2, confers lens-specific expression. Nucleic Acids Res (1992) 1.00
Similar effects of adenovirus E1A and glucocorticoid hormones on the expression of the metalloprotease stromelysin. Nucleic Acids Res (1988) 0.99
Structure and function of the enhancer 3' to the human A gamma globin gene. Nucleic Acids Res (1990) 0.99
Deletion analysis of the human CD2 gene locus control region in transgenic mice. Nucleic Acids Res (1991) 0.97
A GC-box motif upstream of the B19 parvovirus unique promoter is important for in vitro transcription. J Virol (1989) 0.97
Sequence analysis and organization of the Neodiprion abietis nucleopolyhedrovirus genome. J Virol (2006) 0.95
A set of viral DNA decamers enriched in transcription control signals. Nucleic Acids Res (1991) 0.94
Epithelial-specific keratin gene expression: identification of a 300 base-pair controlling segment. Nucleic Acids Res (1990) 0.92
Chicken beta B1-crystallin gene expression: presence of conserved functional polyomavirus enhancer-like and octamer binding-like promoter elements found in non-lens genes. Mol Cell Biol (1991) 0.91
Sequence conservation in avian CR1: an interspersed repetitive DNA family evolving under functional constraints. Proc Natl Acad Sci U S A (1991) 0.90
BAP, a rat liver protein that activates transcription through a promoter element with similarity to the USF/MLTF binding site. Nucleic Acids Res (1990) 0.88
Transcription initiation sites and structural organization of the extreme 5' region of the rat neural cell adhesion molecule gene. Mol Cell Biol (1990) 0.88
In vivo footprinting of the estrogen-inducible vitellogenin II gene from chicken. Nucleic Acids Res (1988) 0.88
Transcript heterogeneity of the human reduced folate carrier results from the use of multiple promoters and variable splicing of alternative upstream exons. Biochem J (1998) 0.86
Genomic footprinting: detection of putative regulatory proteins in the promoter region of the interferon alpha-1 gene in normal human tissues. Mol Cell Biol (1990) 0.84
Analysis of the human liver/bone/kidney alkaline phosphatase promoter in vivo and in vitro. Nucleic Acids Res (1990) 0.84
Enrichment of oligonucleotide sets with transcription control signals. II: Mammalian DNA. Nucleic Acids Res (1992) 0.84
Allele-specific transcription of the asthma-associated PHD finger protein 11 gene (PHF11) modulated by octamer-binding transcription factor 1 (Oct-1). J Allergy Clin Immunol (2011) 0.84
Isolation of high affinity cellular targets of the embryonal LTR binding protein, an undifferentiated embryonal carcinoma cell-specific repressor of Moloney leukemia virus. Nucleic Acids Res (1992) 0.84
Molecular structure of the human muscle-specific enolase gene (ENO3). Biochem J (1991) 0.81
Identification of direct target genes using joint sequence and expression likelihood with application to DAF-16. PLoS One (2008) 0.81
Identification and characterization of a novel enhancer for the rat neu promoter. Mol Cell Biol (1991) 0.81
Sequence-specific recognition of the HIV-1 long terminal repeat by distamycin: a DNAase I footprinting study. Biochem J (1994) 0.81
cDNA sequence and expression pattern of the putative pheromone carrier aphrodisin. Proc Natl Acad Sci U S A (1995) 0.81
Identification of a sequence-specific protein binding the 5'-transcribed spacer of rat ribosomal genes. Nucleic Acids Res (1991) 0.80
Identification of a DNA structural motif that includes the binding sites for Sp1, p53 and GA-binding protein. Nucleic Acids Res (1993) 0.80
Prediction of Cis-Regulatory Elements Controlling Genes Differentially Expressed by Retinal and Choroidal Vascular Endothelial Cells. J Ocul Biol Dis Infor (2008) 0.79
Modification of an adenovirus major late promoter-binding factor during poliovirus infection. J Virol (1989) 0.79
Human papillomavirus type 70 genome cloned from overlapping PCR products: complete nucleotide sequence and genomic organization. J Clin Microbiol (1996) 0.79
The promoter of the human parathyroid hormone gene contains a functional cyclic AMP-response element. Nucleic Acids Res (1990) 0.78
Identification of a face enhancer reveals direct regulation of LIM homeobox 8 (Lhx8) by wingless-int (WNT)/β-catenin signaling. J Biol Chem (2014) 0.78
A bipartite suppressor: conjunction of two distinct factor-binding sites is essential for down-regulation in rat epoxide hydrolase gene expression. Mol Cell Biol (1992) 0.78
Bioinformatic landscapes for plant transcription factor system research. Planta (2015) 0.77
Isolation and characterization of the genomic human CD7 gene: structural similarity with the murine Thy-1 gene. Proc Natl Acad Sci U S A (1991) 0.77
A novel downstream regulatory element of the mouse H-2Kb class I major histocompatibility gene. EMBO J (1992) 0.76
Sequences of acetyl CoA carboxylase promoter for tumour necrosis factor action. Mediators Inflamm (1993) 0.75
Methylation patterns in the human muscle-specific enolase gene (ENO3). Biochem J (1993) 0.75
Phorbol ester-inducible genes contain a common cis element recognized by a TPA-modulated trans-acting factor. Cell (1987) 20.61
Repetitive zinc-binding domains in the protein transcription factor IIIA from Xenopus oocytes. EMBO J (1985) 20.39
Multiple nuclear factors interact with the immunoglobulin enhancer sequences. Cell (1986) 20.08
The promoter-specific transcription factor Sp1 binds to upstream sequences in the SV40 early promoter. Cell (1983) 15.09
Purified transcription factor AP-1 interacts with TPA-inducible enhancer elements. Cell (1987) 14.62
A nuclear factor that binds to a conserved sequence motif in transcriptional control elements of immunoglobulin genes. Nature (1986) 14.34
Interaction of a gene-specific transcription factor with the adenovirus major late promoter upstream of the TATA box region. Cell (1985) 13.36
Purification and biochemical characterization of the promoter-specific transcription factor, Sp1. Science (1986) 12.58
GCN4 protein, synthesized in vitro, binds HIS3 regulatory sequences: implications for general control of amino acid biosynthetic genes in yeast. Cell (1985) 11.63
Functional dissection of a eukaryotic transcriptional activator protein, GCN4 of yeast. Cell (1986) 11.42
Human oestrogen receptor cDNA: sequence, expression and homology to v-erb-A. Nature (1986) 11.35
Anatomy of herpes simplex virus (HSV) DNA. X. Mapping of viral genes by analysis of polypeptides and functions specified by HSV-1 X HSV-2 recombinants. J Virol (1978) 11.19
Two distinct transcription factors bind to the HSV thymidine kinase promoter in vitro. Cell (1985) 11.03
The c-erb-A gene encodes a thyroid hormone receptor. Nature (1987) 10.53
Specific DNA binding of GAL4, a positive regulatory protein of yeast. Cell (1985) 10.25
An RNA polymerase II transcription factor binds to an upstream element in the adenovirus major late promoter. Cell (1985) 10.06
Identification of a protein-binding site that mediates transcriptional response of the c-fos gene to serum factors. Cell (1986) 9.10
A lymphoid-specific protein binding to the octamer motif of immunoglobulin genes. Nature (1986) 8.64
Activation of the AIDS retrovirus promoter by the cellular transcription factor, Sp1. Science (1986) 8.01
Primary structure and expression of a functional human glucocorticoid receptor cDNA. Nature (1986) 7.81
Transcription factor AP-2 mediates induction by two different signal-transduction pathways: protein kinase C and cAMP. Cell (1987) 7.75
A Drosophila RNA polymerase II transcription factor contains a promoter-region-specific DNA-binding activity. Cell (1984) 7.69
Characterization of DNA sequences through which cadmium and glucocorticoid hormones induce human metallothionein-IIA gene. Nature (1984) 7.57
A single polypeptide possesses the binding and transcription activities of the adenovirus major late transcription factor. Mol Cell Biol (1986) 7.49
A Drosophila RNA polymerase II transcription factor binds to the regulatory site of an hsp 70 gene. Cell (1984) 7.23
The c-erb-A protein is a high-affinity receptor for thyroid hormone. Nature (1987) 7.06
Activation of transcription by two factors that bind promoter and enhancer sequences of the human metallothionein gene and SV40. Nature (1987) 6.76
A multiplicity of CCAAT box-binding proteins. Cell (1987) 6.37
Saturation mutagenesis of the yeast his3 regulatory site: requirements for transcriptional induction and for binding by GCN4 activator protein. Science (1986) 6.36
Two protein-binding sites in chromatin implicated in the activation of heat-shock genes. Nature (1984) 6.19
Sequence-specific binding of glucocorticoid receptor to MTV DNA at sites within and upstream of the transcribed region. Cell (1983) 6.01
Purification of nuclear factor I by DNA recognition site affinity chromatography. J Biol Chem (1986) 5.79
Primary structure of the Saccharomyces cerevisiae GAL4 gene. Mol Cell Biol (1984) 5.49
Binding of a nuclear factor to a regulatory sequence in the promoter of the mouse H-2Kb class I major histocompatibility gene. Mol Cell Biol (1987) 5.05
Topography of simian virus 40 A protein-DNA complexes: arrangement of pentanucleotide interaction sites at the origin of replication. J Virol (1983) 5.00
Bidirectional SV40 transcription mediated by tandem Sp1 binding interactions. Science (1985) 5.00
Viral and cellular fos proteins: a comparative analysis. Cell (1984) 4.89
Specific protein binding to far upstream activating sequences in polymerase II promoters. Proc Natl Acad Sci U S A (1985) 4.85
Mutually exclusive interaction of the CCAAT-binding factor and of a displacement protein with overlapping sequences of a histone gene promoter. Cell (1987) 4.78
Identification and purification of a polypeptide that binds to the c-fos serum response element. EMBO J (1987) 4.68
Role of an adenovirus E2 promoter binding factor in E1A-mediated coordinate gene control. Proc Natl Acad Sci U S A (1987) 4.68
Cloning of the human estrogen receptor cDNA. Proc Natl Acad Sci U S A (1985) 4.58
The chicken oestrogen receptor sequence: homology with v-erbA and the human oestrogen and glucocorticoid receptors. EMBO J (1986) 4.47
Purification and characterization of a heat-shock element binding protein from yeast. EMBO J (1987) 4.43
Sequence-specific interactions of nuclear factors with the insulin gene enhancer. Cell (1986) 4.42
Factors involved in control of tissue-specific expression of albumin gene. Cell (1987) 4.39
A conserved family of nuclear proteins containing structural elements of the finger protein encoded by Krüppel, a Drosophila segmentation gene. Cell (1986) 4.39
Yeast HAP1 activator binds to two upstream activation sites of different sequence. Cell (1987) 4.37
Cloning of human mineralocorticoid receptor complementary DNA: structural and functional kinship with the glucocorticoid receptor. Science (1987) 4.32
Xenopus 5S gene transcription factor, TFIIIA: characterization of a cDNA clone and measurement of RNA levels throughout development. Cell (1984) 4.32
Multiple functional domains in the adenovirus E1A gene. Cell (1987) 4.22
Interaction of cell-type-specific nuclear proteins with immunoglobulin VH promoter region sequences. Nature (1986) 4.21
Sequence homology of the yeast regulatory protein ADR1 with Xenopus transcription factor TFIIIA. Nature (1986) 4.12
Sequences required for in vitro transcriptional activation of a Drosophila hsp 70 gene. Cell (1985) 4.11
Six distinct nuclear factors interact with the 75-base-pair repeat of the Moloney murine leukemia virus enhancer. Mol Cell Biol (1987) 4.02
Multiple cis- and trans-acting elements mediate the transcriptional response to phorbol esters. Nature (1987) 3.94
Activating protein factor binds in vitro to upstream control sequences in heat shock gene chromatin. Nature (1984) 3.92
Genomic sequencing reveals a positive correlation between the kinetics of strand-specific DNA demethylation of the overlapping estradiol/glucocorticoid-receptor binding sites and the rate of avian vitellogenin mRNA synthesis. Proc Natl Acad Sci U S A (1986) 3.92
Nucleoprotein complexes that regulate gene expression in adipocyte differentiation: direct participation of c-fos. Cell (1987) 3.89
Direct evidence that p40x of human T-cell leukemia virus type I is a trans-acting transcriptional activator. EMBO J (1986) 3.86
Identification of silencer binding proteins from yeast: possible roles in SIR control and DNA replication. EMBO J (1987) 3.86
Interaction of a common factor with conserved promoter and enhancer sequences in histone H2B, immunoglobulin, and U2 small nuclear RNA (snRNA) genes. Proc Natl Acad Sci U S A (1986) 3.81
A common positive trans-acting factor binds to enhancer sequences in the promoters of mouse H-2 and beta 2-microglobulin genes. Proc Natl Acad Sci U S A (1987) 3.80
Steroid-dependent interaction of transcription factors with the inducible promoter of mouse mammary tumor virus in vivo. Cell (1987) 3.74
MAT alpha 1 protein, a yeast transcription activator, binds synergistically with a second protein to a set of cell-type-specific genes. Cell (1987) 3.74
A general upstream binding factor for genes of the yeast translational apparatus. EMBO J (1985) 3.72
GCN4 protein, a positive transcription factor in yeast, binds general control promoters at all 5' TGACTC 3' sequences. Proc Natl Acad Sci U S A (1986) 3.68
Mutation of the c-fos gene dyad symmetry element inhibits serum inducibility of transcription in vivo and the nuclear regulatory factor binding in vitro. Mol Cell Biol (1987) 3.53
c-fos sequence necessary for basal expression and induction by epidermal growth factor, 12-O-tetradecanoyl phorbol-13-acetate and the calcium ionophore. Mol Cell Biol (1987) 3.52
Heat-inducible human factor that binds to a human hsp70 promoter. Mol Cell Biol (1987) 3.52
A cellular transcription factor E4F1 interacts with an E1a-inducible enhancer and mediates constitutive enhancer function in vitro. EMBO J (1987) 3.45
Detection of factors that interact with the human beta-interferon regulatory region in vivo by DNAase I footprinting. Cell (1986) 3.35
The E2 "gene" of bovine papillomavirus encodes an enhancer-binding protein. Proc Natl Acad Sci U S A (1987) 3.31
A GAL family of upstream activating sequences in yeast: roles in both induction and repression of transcription. EMBO J (1986) 3.29
The Saccharomyces and Drosophila heat shock transcription factors are identical in size and DNA binding properties. Cell (1987) 3.28
Cell-type specific protein binding to the enhancer of simian virus 40 in nuclear extracts. Nature (1986) 3.25
Specific interaction of cellular factors with the B enhancer of polyoma virus. EMBO J (1985) 3.23
Transcription factor Sp1 recognizes a DNA sequence in the mouse dihydrofolate reductase promoter. Nature (1986) 3.18
A multigene family encoding several "finger" structures is present and differentially active in mammalian genomes. Cell (1987) 3.09
Two different factors bind to the alpha-domain of the polyoma virus enhancer, one of which also interacts with the SV40 and c-fos enhancers. EMBO J (1987) 3.09
The TGGCA protein binds to the MMTV-LTR, the adenovirus origin of replication, and the BK virus enhancer. Nucleic Acids Res (1985) 2.93
Binding of transcription factors and creation of a large nucleoprotein complex on the human cytomegalovirus enhancer. Proc Natl Acad Sci U S A (1987) 2.89
Distinct factors bind to apparently homologous sequences in the immunoglobulin heavy-chain enhancer. Nature (1986) 2.86
Characterization of Drosophila transcription factors that activate the tandem promoters of the alcohol dehydrogenase gene. Cell (1985) 2.86
DNA-binding site of major regulatory protein alpha 4 specifically associated with promoter-regulatory domains of alpha genes of herpes simplex virus type 1. Proc Natl Acad Sci U S A (1986) 2.85
Specific interaction between a transcription factor and the upstream element of the adenovirus-2 major late promoter. EMBO J (1985) 2.83
Specific protein binding to the simian virus 40 enhancer in vitro. Mol Cell Biol (1986) 2.82
Identification of a factor in HeLa cells specific for an upstream transcriptional control sequence of an EIA-inducible adenovirus promoter and its relative abundance in infected and uninfected cells. Proc Natl Acad Sci U S A (1986) 2.81
Analysis of the Kluyveromyces lactis positive regulatory gene LAC9 reveals functional homology to, but sequence divergence from, the Saccharomyces cerevisiae GAL4 gene. Nucleic Acids Res (1986) 2.76
Purification of KBF1, a common factor binding to both H-2 and beta 2-microglobulin enhancers. EMBO J (1987) 2.71
Molecular cloning of complementary DNA encoding the avian receptor for vitamin D. Science (1987) 2.71
Xenopus cytoskeletal actin and human c-fos gene promoters share a conserved protein-binding site. EMBO J (1987) 2.69
Yeast regulatory gene PPR1. I. Nucleotide sequence, restriction map and codon usage. J Mol Biol (1984) 2.66
Contacts between hormone receptor and DNA double helix within a glucocorticoid regulatory element of mouse mammary tumor virus. Proc Natl Acad Sci U S A (1984) 2.64
Purification of the c-fos enhancer-binding protein. Mol Cell Biol (1987) 2.64
Nuclear factor 1 interacts with five DNA elements in the promoter region of the human cytomegalovirus major immediate early gene. EMBO J (1986) 2.62
Sequence and nuclear localization of the Saccharomyces cerevisiae HAP2 protein, a transcriptional activator. Mol Cell Biol (1987) 2.59
Sequence and structure of the serendipity locus of Drosophila melanogaster. A densely transcribed region including a blastoderm-specific gene. J Mol Biol (1985) 2.58
Conserved major histocompatibility complex class II boxes--X and Y--are transcriptional control elements and specifically bind nuclear proteins. Proc Natl Acad Sci U S A (1987) 2.55