Published in J Biol Chem on September 05, 1987
The alternative aerobic ribonucleotide reductase of Escherichia coli, NrdEF, is a manganese-dependent enzyme that enables cell replication during periods of iron starvation. Mol Microbiol (2011) 2.03
Functional analysis of the small component of the 4-hydroxyphenylacetate 3-monooxygenase of Escherichia coli W: a prototype of a new Flavin:NAD(P)H reductase subfamily. J Bacteriol (2000) 1.63
Purification of the two-enzyme system catalyzing the oxidation of the D-proline residue of pristinamycin IIB during the last step of pristinamycin IIA biosynthesis. J Bacteriol (1995) 1.51
Characterization of 4-hydroxyphenylacetate 3-hydroxylase (HpaB) of Escherichia coli as a reduced flavin adenine dinucleotide-utilizing monooxygenase. Appl Environ Microbiol (2000) 1.47
Identification of the gene encoding the major NAD(P)H-flavin oxidoreductase of the bioluminescent bacterium Vibrio fischeri ATCC 7744. J Bacteriol (1994) 1.42
Vibrio harveyi NADPH-flavin oxidoreductase: cloning, sequencing and overexpression of the gene and purification and characterization of the cloned enzyme. J Bacteriol (1994) 1.32
Genetic and biochemical characterization of a 2,4,6-trichlorophenol degradation pathway in Ralstonia eutropha JMP134. J Bacteriol (2002) 1.28
Characterization of the flavin reductase gene (fre) of Escherichia coli and construction of a plasmid for overproduction of the enzyme. J Bacteriol (1991) 1.22
Cyanobacterial alkane biosynthesis further expands the catalytic repertoire of the ferritin-like 'di-iron-carboxylate' proteins. Curr Opin Chem Biol (2011) 1.19
Oxygen-sensitive ribonucleoside triphosphate reductase is present in anaerobic Escherichia coli. Proc Natl Acad Sci U S A (1989) 1.17
Characterization of chlorophenol 4-monooxygenase (TftD) and NADH:flavin adenine dinucleotide oxidoreductase (TftC) of Burkholderia cepacia AC1100. J Bacteriol (2003) 1.17
Nuclear localization of the Saccharomyces cerevisiae ribonucleotide reductase small subunit requires a karyopherin and a WD40 repeat protein. Proc Natl Acad Sci U S A (2006) 1.17
Reduction of Cob(III)alamin to Cob(II)alamin in Salmonella enterica serovar typhimurium LT2. J Bacteriol (2000) 1.10
Conversion of NfsB, a minor Escherichia coli nitroreductase, to a flavin reductase similar in biochemical properties to FRase I, the major flavin reductase in Vibrio fischeri, by a single amino acid substitution. J Bacteriol (1996) 1.05
Importance of the maintenance pathway in the regulation of the activity of Escherichia coli ribonucleotide reductase. Biochemistry (2008) 1.04
Complementarity of ensemble and single-molecule measures of protein motion: a relaxation dispersion NMR study of an enzyme complex. Proc Natl Acad Sci U S A (2006) 1.00
Purification, characterization, and overexpression of flavin reductase involved in dibenzothiophene desulfurization by Rhodococcus erythropolis D-1. Appl Environ Microbiol (2001) 0.99
The gene cluster for para-nitrophenol catabolism is responsible for 2-chloro-4-nitrophenol degradation in Burkholderia sp. strain SJ98. Appl Environ Microbiol (2014) 0.98
Structural insights into regioselectivity in the enzymatic chlorination of tryptophan. J Mol Biol (2009) 0.98
Determination of the in vivo stoichiometry of tyrosyl radical per betabeta' in Saccharomyces cerevisiae ribonucleotide reductase. Biochemistry (2006) 0.94
LuxG is a functioning flavin reductase for bacterial luminescence. J Bacteriol (2007) 0.93
The function of cytoplasmic flavin reductases in the reduction of azo dyes by bacteria. Appl Environ Microbiol (2000) 0.93
Unusual folded conformation of nicotinamide adenine dinucleotide bound to flavin reductase P. Protein Sci (1999) 0.93
Two atypical L-cysteine-regulated NADPH-dependent oxidoreductases involved in redox maintenance, L-cystine and iron reduction, and metronidazole activation in the enteric protozoan Entamoeba histolytica. J Biol Chem (2010) 0.92
Gene cloning and molecular characterization of a two-enzyme system catalyzing the oxidative detoxification of beta-endosulfan. Appl Environ Microbiol (2002) 0.87
Decolorization of Textile Dyes and Degradation of Mono-Azo Dye Amaranth by Acinetobacter calcoaceticus NCIM 2890. Indian J Microbiol (2011) 0.84
Initial-rate kinetics of the flavin reductase reaction catalysed by human biliverdin-IXbeta reductase (BVR-B). Biochem J (2000) 0.84
Identification and characterization of the flavin:NADH reductase (PrnF) involved in a novel two-component arylamine oxygenase. J Bacteriol (2007) 0.83
Ribonucleotide reductase metallocofactor: assembly, maintenance and inhibition. Front Biol (Beijing) (2014) 0.81
The crystal structure of six-transmembrane epithelial antigen of the prostate 4 (Steap4), a ferri/cuprireductase, suggests a novel interdomain flavin-binding site. J Biol Chem (2013) 0.80
Characterization of SgcE6, the flavin reductase component supporting FAD-dependent halogenation and hydroxylation in the biosynthesis of the enediyne antitumor antibiotic C-1027. FEMS Microbiol Lett (2009) 0.80
A Two-Component para-Nitrophenol Monooxygenase Initiates a Novel 2-Chloro-4-Nitrophenol Catabolism Pathway in Rhodococcus imtechensis RKJ300. Appl Environ Microbiol (2015) 0.78
Structural basis of free reduced flavin generation by flavin reductase from Thermus thermophilus HB8. J Biol Chem (2011) 0.78
Studies on phytoremediation potentiality of Typhonium flagelliforme for the degradation of Brilliant Blue R. Planta (2010) 0.78
Reduction kinetics of a flavin oxidoreductase LuxG from Photobacterium leiognathi (TH1): half-sites reactivity. Biochemistry (2010) 0.77
Reduction of ribonucleotides. Annu Rev Biochem (1979) 6.33
Replication of polyoma DNA in isolated nuclei. I. Characterization of the system from mouse fibroblast 3T6 cells. J Mol Biol (1972) 4.47
RNA-linked short DNA fragments during polyoma replication. Proc Natl Acad Sci U S A (1973) 4.42
Ribonucleotide reductases. Annu Rev Biochem (1998) 4.09
The immotile-cilia syndrome. A congenital ciliary abnormality as an etiologic factor in chronic airway infections and male sterility. N Engl J Med (1977) 3.61
Defective gene product in dnaF mutant of Escherichia coli. Nat New Biol (1972) 3.32
Inhibition of ribonucleoside diphosphate reductase by hydroxyurea. Cancer Res (1968) 2.67
Iron and free radical in ribonucleotide reductase. Exchange of iron and Mössbauer spectroscopy of the protein B2 subunit of the Escherichia coli enzyme. J Biol Chem (1973) 2.59
Ribonucleotide reductase--a radical enzyme. Science (1983) 2.33
Effects of thymidine on deoxyribonucleoside triphosphate pools and deoxyribonucleic acid synthesis in Chinese hamster ovary cells. J Biol Chem (1973) 2.23
Discontinuous elongation of both strands at the replication forks in polyoma DNA replication. Nat New Biol (1973) 2.20
Replication of polyoma DNA in isolated nuclei. II. Evidence for semi-conservative replication. J Mol Biol (1972) 2.10
The involvement of the thioredoxin system in the reduction of methionine sulfoxide and sulfate. J Biol Chem (1970) 2.07
Initiator RNA in discontinuous polyoma DNA synthesis. Proc Natl Acad Sci U S A (1974) 1.98
Ribonucleoside diphosphate reductase. Purification of the two subunits, proteins B1 and B2. Eur J Biochem (1969) 1.84
Iron-sulfur cluster assembly: characterization of IscA and evidence for a specific and functional complex with ferredoxin. J Biol Chem (2001) 1.83
Changes of deoxyribonucleoside triphosphate pools induced by hydroxyurea and their relation to DNA synthesis. J Biol Chem (1986) 1.74
Characterization of Escherichia coli NrdH. A glutaredoxin-like protein with a thioredoxin-like activity profile. J Biol Chem (1997) 1.69
The tyrosine free radical in ribonucleotide reductase from Escherichia coli. J Biol Chem (1978) 1.68
Replication of polyoma DNA in isolated nuclei. 3. The nucleotide sequence at the RNA-DNA junction of nascent strands. J Mol Biol (1974) 1.64
Enzymatic synthesis of deoxyribonucleotides. X. Reduction of purine ribonucleotides; allosteric behavior and substrate specificity of the enzyme system from Escherichia coli B. J Biol Chem (1966) 1.64
Lack of dynein arms in immotile human spermatozoa. J Cell Biol (1975) 1.64
Deoxyribonucleotide pools and deoxyribonucleic acid synthesis in cultured mouse embryo cells. J Biol Chem (1970) 1.59
Role of effector binding in allosteric control of ribonucleoside diphosphate reductase. J Mol Biol (1969) 1.57
Nature of the free radical in ribonucleotide reductase from Escherichia coli. J Biol Chem (1977) 1.57
Electron spin resonance of the iron-containing protein B2 from ribonucleotide reductase. J Biol Chem (1972) 1.51
Escherichia coli ferredoxin NADP+ reductase: activation of E. coli anaerobic ribonucleotide reduction, cloning of the gene (fpr), and overexpression of the protein. J Bacteriol (1993) 1.49
Ribonucleoside diphosphate reductase. Formation of active and inactive complexes of proteins B1 and B2. J Mol Biol (1969) 1.47
Formation of Okazaki fragments in polyoma DNA synthesis caused by misincorporation of uracil. Cell (1978) 1.47
Ribonucleotide reductase in the archaeon Pyrococcus furiosus: a critical enzyme in the evolution of DNA genomes? Proc Natl Acad Sci U S A (1997) 1.43
Replication of polyoma DNA in isolated nuclei. V. Complementation of in vitro DNA replication. J Virol (1975) 1.39
Enzymic modification of a tyrosine residue to a stable free radical in ribonucleotide reductase. Proc Natl Acad Sci U S A (1983) 1.38
A second class I ribonucleotide reductase in Enterobacteriaceae: characterization of the Salmonella typhimurium enzyme. Proc Natl Acad Sci U S A (1994) 1.37
Reaction of the desulfoferrodoxin from Desulfoarculus baarsii with superoxide anion. Evidence for a superoxide reductase activity. J Biol Chem (2000) 1.37
From deoxynucleotides to DNA synthesis. Fed Proc (1978) 1.36
Flavodoxin is required for the activation of the anaerobic ribonucleotide reductase. Biochem Biophys Res Commun (1993) 1.34
Thioredoxin 2: cleavage with cyanogen bromide. Eur J Biochem (1967) 1.34
Inactivation of ribonucleotide reductase by nitric oxide. Biochem Biophys Res Commun (1991) 1.32
Supravital staining of human spermatozoa. Fertil Steril (1971) 1.31
Overproduction of the free radical of ribonucleotide reductase in hydroxyurea-resistant mouse fibroblast 3T6 cells. Proc Natl Acad Sci U S A (1981) 1.31
Iron and activated oxygen species in biology: the basic chemistry. Biometals (1999) 1.31
An iron-sulfur center and a free radical in the active anaerobic ribonucleotide reductase of Escherichia coli. J Biol Chem (1993) 1.29
Enzymatic synthesis of deoxyribonucleotides. IX. Allosteric effects in the reduction of pyrimidine ribonucleotides by the ribonucleoside diphosphate reductase system of Escherichia coli. J Biol Chem (1966) 1.27
Synthesis of polyoma DNA by isolated nuclei. Biochem Biophys Res Commun (1971) 1.26
A possible glycine radical in anaerobic ribonucleotide reductase from Escherichia coli: nucleotide sequence of the cloned nrdD gene. Proc Natl Acad Sci U S A (1993) 1.25
Control of deoxyribonucleotide synthesis in vitro and in vivo. Adv Enzyme Regul (1972) 1.24
The free radical of the anaerobic ribonucleotide reductase from Escherichia coli is at glycine 681. J Biol Chem (1996) 1.24
nrdD and nrdG genes are essential for strict anaerobic growth of Escherichia coli. Biochem Biophys Res Commun (1996) 1.24
Cross-talk between the allosteric effector-binding sites in mouse ribonucleotide reductase. J Biol Chem (2000) 1.24
The iron center in ribonucleotide reductase from Escherichia coli. J Biol Chem (1980) 1.24
Purification of a thioredoxin system from yeast. J Biol Chem (1970) 1.23
NADPH-sulfite reductase from Escherichia coli. A flavin reductase participating in the generation of the free radical of ribonucleotide reductase. J Biol Chem (1993) 1.22
Characterization of the flavin reductase gene (fre) of Escherichia coli and construction of a plasmid for overproduction of the enzyme. J Bacteriol (1991) 1.22
Deoxyribonucleotide pools in mouse-fibroblast cell lines with altered ribonucleotide reductase. Eur J Biochem (1976) 1.21
SufA/IscA: reactivity studies of a class of scaffold proteins involved in [Fe-S] cluster assembly. J Biol Inorg Chem (2004) 1.21
Male and female infertility problems in the immotile-cilia syndrome. Eur J Respir Dis Suppl (1983) 1.19
4th FEBS Meeting's Plenary Lecture. The biosynthesis of deoxyribonucleotides. Eur J Biochem (1968) 1.19
The active form of the R2F protein of class Ib ribonucleotide reductase from Corynebacterium ammoniagenes is a diferric protein. J Biol Chem (2000) 1.19
The redox centers of ribonucleotide reductase of Escherichia coli. Adv Enzymol Relat Areas Mol Biol (1992) 1.19
The anaerobic ribonucleoside triphosphate reductase from Escherichia coli requires S-adenosylmethionine as a cofactor. Proc Natl Acad Sci U S A (1990) 1.18
Superoxide reductase from Desulfoarculus baarsii: reaction mechanism and role of glutamate 47 and lysine 48 in catalysis. Biochemistry (2001) 1.18
Primase initiates Okazaki pieces during polyoma DNA synthesis. Nature (1978) 1.17
Oxygen-sensitive ribonucleoside triphosphate reductase is present in anaerobic Escherichia coli. Proc Natl Acad Sci U S A (1989) 1.17
Spectrum and iron content of protein B2 from ribonucleoside diphosphate reductase. Eur J Biochem (1969) 1.17
The ribonucleotide reductase system of Lactococcus lactis. Characterization of an NrdEF enzyme and a new electron transport protein. J Biol Chem (1996) 1.16
Iron-sulfur center of biotin synthase and lipoate synthase. Biochemistry (2000) 1.16
Characterization of components of the anaerobic ribonucleotide reductase system from Escherichia coli. J Biol Chem (1992) 1.16
Thioredoxin. A localized conformational change accompanying reduction of the protein to the sulfhydryl form. Biochemistry (1967) 1.16
Activation of the anaerobic ribonucleotide reductase from Escherichia coli. The essential role of the iron-sulfur center for S-adenosylmethionine reduction. J Biol Chem (1997) 1.14
Replication of polyoma DNA in nuclear extracts and nucleoprotein complexes. J Mol Biol (1979) 1.14
Effect of dextran infusion on the adenosine diphosphate induced adhesiveness and the spreading capacity of human blood platelets. Thromb Diath Haemorrh (1966) 1.14
Generation of the glycyl radical of the anaerobic Escherichia coli ribonucleotide reductase requires a specific activating enzyme. J Biol Chem (1995) 1.12
Dynamics of the thymidine triphosphate pool during the cell cycle of synchronized 3T3 mouse fibroblasts. Mutat Res (1988) 1.12
Two-dimensional crystals of enzyme-effector complexes: ribonucleotide reductase at 18-A resolution. Biochemistry (1987) 1.12
Flagellar mutants in man: on the heterogeneity of the immotile-cilia syndrome. J Ultrastruct Res (1979) 1.11
Enzymatic regulation of the radical content of the small subunit of Escherichia coli ribonucleotide reductase involving reduction of its redox centers. J Biol Chem (1989) 1.10
Enzymatic synthesis of deoxyribonucleotides, 8. The effects of ATP and dATP in the CDP reductase system from E. coli. Proc Natl Acad Sci U S A (1965) 1.10