Flavodoxin is required for the activation of the anaerobic ribonucleotide reductase.

SoxR, a [2Fe-2S] transcription factor, is active only in its oxidized form. Proc Natl Acad Sci U S A (1996) 1.94

The deoxyxylulose phosphate pathway of isoprenoid biosynthesis: studies on the mechanisms of the reactions catalyzed by IspG and IspH protein. Proc Natl Acad Sci U S A (2003) 1.80

Mapping the interactions between flavodoxin and its physiological partners flavodoxin reductase and cobalamin-dependent methionine synthase. Proc Natl Acad Sci U S A (2001) 1.28

Iron-sulfur cluster interconversions in biotin synthase: dissociation and reassociation of iron during conversion of [2Fe-2S] to [4Fe-4S] clusters. Biochemistry (2000) 1.19

Flavodoxin mutants of Escherichia coli K-12. J Bacteriol (2000) 1.07

Interruption of the ferredoxin (flavodoxin) NADP+ oxidoreductase gene of Escherichia coli does not affect anaerobic growth but increases sensitivity to paraquat. J Bacteriol (1995) 1.07

Spectroscopic, steady-state kinetic, and mechanistic characterization of the radical SAM enzyme QueE, which catalyzes a complex cyclization reaction in the biosynthesis of 7-deazapurines. Biochemistry (2012) 1.05

Formate is the hydrogen donor for the anaerobic ribonucleotide reductase from Escherichia coli. Proc Natl Acad Sci U S A (1995) 0.99

Biochemical and Spectroscopic Characterization of a Radical S-Adenosyl-l-methionine Enzyme Involved in the Formation of a Peptide Thioether Cross-Link. Biochemistry (2016) 0.92

Dph3 is an electron donor for Dph1-Dph2 in the first step of eukaryotic diphthamide biosynthesis. J Am Chem Soc (2014) 0.92

Glycyl radical activating enzymes: structure, mechanism, and substrate interactions. Arch Biochem Biophys (2014) 0.88

Chemical and Biological Reduction of the Radical SAM Enzyme CPH4 Synthase. Biochemistry (2015) 0.88

A chemically competent thiosulfuranyl radical on the Escherichia coli class III ribonucleotide reductase. J Am Chem Soc (2014) 0.85

Conformational dynamics of Escherichia coli flavodoxins in apo- and holo-states by solution NMR spectroscopy. PLoS One (2014) 0.83

Bioactive peptide design using the Resonant Recognition Model. Nonlinear Biomed Phys (2007) 0.82

Pyruvate formate-lyase and its activation by pyruvate formate-lyase activating enzyme. J Biol Chem (2013) 0.81

Design and improvement of artificial redox modules by molecular fusion of flavodoxin and flavodoxin reductase from Escherichia coli. Sci Rep (2015) 0.79

Structural and phylogenetic analysis of Rhodobacter capsulatus NifF: uncovering general features of nitrogen-fixation (nif)-flavodoxins. Int J Mol Sci (2013) 0.79

Flavodoxin cofactor binding induces structural changes that are required for protein-protein interactions with NADP(+) oxidoreductase and pyruvate formate-lyase activating enzyme. Biochim Biophys Acta (2013) 0.78

A New Type of YumC-Like Ferredoxin (Flavodoxin) Reductase Is Involved in Ribonucleotide Reduction. MBio (2015) 0.78

Thermal inactivation of reduced ferredoxin (flavodoxin):NADP+ oxidoreductase from Escherichia coli. FEBS Lett (2002) 0.77

A megaplasmid-borne anaerobic ribonucleotide reductase in Alcaligenes eutrophus H16. J Bacteriol (1999) 0.77

Streptococcus pneumoniae TIGR4 Flavodoxin: Structural and Biophysical Characterization of a Novel Drug Target. PLoS One (2016) 0.75

Cbr1 is a Dph3 reductase required for the tRNA wobble uridine modification. Nat Chem Biol (2016) 0.75

A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. Nat Genet (1995) 17.27

Reduction of ribonucleotides. Annu Rev Biochem (1979) 6.33

Replication of polyoma DNA in isolated nuclei. I. Characterization of the system from mouse fibroblast 3T6 cells. J Mol Biol (1972) 4.47

RNA-linked short DNA fragments during polyoma replication. Proc Natl Acad Sci U S A (1973) 4.42

The leucine-responsive regulatory protein, a global regulator of metabolism in Escherichia coli. Microbiol Rev (1994) 4.37

Ribonucleotide reductases. Annu Rev Biochem (1998) 4.09

How a protein binds B12: A 3.0 A X-ray structure of B12-binding domains of methionine synthase. Science (1994) 3.93

The immotile-cilia syndrome. A congenital ciliary abnormality as an etiologic factor in chronic airway infections and male sterility. N Engl J Med (1977) 3.61

Defective gene product in dnaF mutant of Escherichia coli. Nat New Biol (1972) 3.32

Mutation of a gene encoding a protein with extracellular matrix motifs in Usher syndrome type IIa. Science (1998) 2.84

The production of superoxide anion radicals in the reaction of reduced flavins and flavoproteins with molecular oxygen. Biochem Biophys Res Commun (1969) 2.72

Inhibition of ribonucleoside diphosphate reductase by hydroxyurea. Cancer Res (1968) 2.67

Iron and free radical in ribonucleotide reductase. Exchange of iron and Mössbauer spectroscopy of the protein B2 subunit of the Escherichia coli enzyme. J Biol Chem (1973) 2.59

Human beta-defensins. Cell Mol Life Sci (2006) 2.57

Human methylenetetrahydrofolate reductase: isolation of cDNA, mapping and mutation identification. Nat Genet (1994) 2.50

The structure and properties of methylenetetrahydrofolate reductase from Escherichia coli suggest how folate ameliorates human hyperhomocysteinemia. Nat Struct Biol (1999) 2.43

Structure-based perspectives on B12-dependent enzymes. Annu Rev Biochem (1997) 2.36

Ribonucleotide reductase--a radical enzyme. Science (1983) 2.33

Effects of thymidine on deoxyribonucleoside triphosphate pools and deoxyribonucleic acid synthesis in Chinese hamster ovary cells. J Biol Chem (1973) 2.23

Discontinuous elongation of both strands at the replication forks in polyoma DNA replication. Nat New Biol (1973) 2.20

Replication of polyoma DNA in isolated nuclei. II. Evidence for semi-conservative replication. J Mol Biol (1972) 2.10

The involvement of the thioredoxin system in the reduction of methionine sulfoxide and sulfate. J Biol Chem (1970) 2.07

Characterization of the regulon controlled by the leucine-responsive regulatory protein in Escherichia coli. J Bacteriol (1992) 2.05

Initiator RNA in discontinuous polyoma DNA synthesis. Proc Natl Acad Sci U S A (1974) 1.98

Effects of common polymorphisms on the properties of recombinant human methylenetetrahydrofolate reductase. Proc Natl Acad Sci U S A (2001) 1.91

Ribonucleoside diphosphate reductase. Purification of the two subunits, proteins B1 and B2. Eur J Biochem (1969) 1.84

Iron-sulfur cluster assembly: characterization of IscA and evidence for a specific and functional complex with ferredoxin. J Biol Chem (2001) 1.83

Regulation of the gltBDF operon of Escherichia coli: how is a leucine-insensitive operon regulated by the leucine-responsive regulatory protein? J Bacteriol (1993) 1.78

The reactivity of flavoproteins with sulfite. Possible relevance to the problem of oxygen reactivity. J Biol Chem (1969) 1.75

Changes of deoxyribonucleoside triphosphate pools induced by hydroxyurea and their relation to DNA synthesis. J Biol Chem (1986) 1.74

NAD(P)H:flavin oxidoreductase of Escherichia coli. A ferric iron reductase participating in the generation of the free radical of ribonucleotide reductase. J Biol Chem (1987) 1.73

Cobalamin-dependent methionine synthase. FASEB J (1990) 1.70

Characterization of Escherichia coli NrdH. A glutaredoxin-like protein with a thioredoxin-like activity profile. J Biol Chem (1997) 1.69

The tyrosine free radical in ribonucleotide reductase from Escherichia coli. J Biol Chem (1978) 1.68

Replication of polyoma DNA in isolated nuclei. 3. The nucleotide sequence at the RNA-DNA junction of nascent strands. J Mol Biol (1974) 1.64

Enzymatic synthesis of deoxyribonucleotides. X. Reduction of purine ribonucleotides; allosteric behavior and substrate specificity of the enzyme system from Escherichia coli B. J Biol Chem (1966) 1.64

Lack of dynein arms in immotile human spermatozoa. J Cell Biol (1975) 1.64

Mapping regulatory networks in microbial cells. Trends Microbiol (1999) 1.62

Deoxyribonucleotide pools and deoxyribonucleic acid synthesis in cultured mouse embryo cells. J Biol Chem (1970) 1.59

Nature of the free radical in ribonucleotide reductase from Escherichia coli. J Biol Chem (1977) 1.57

Role of effector binding in allosteric control of ribonucleoside diphosphate reductase. J Mol Biol (1969) 1.57

Electron spin resonance of the iron-containing protein B2 from ribonucleotide reductase. J Biol Chem (1972) 1.51

Escherichia coli ferredoxin NADP+ reductase: activation of E. coli anaerobic ribonucleotide reduction, cloning of the gene (fpr), and overexpression of the protein. J Bacteriol (1993) 1.49

The structure of the C-terminal domain of methionine synthase: presenting S-adenosylmethionine for reductive methylation of B12. Structure (1996) 1.49

Ribonucleoside diphosphate reductase. Formation of active and inactive complexes of proteins B1 and B2. J Mol Biol (1969) 1.47

Formation of Okazaki fragments in polyoma DNA synthesis caused by misincorporation of uracil. Cell (1978) 1.47

Cobalamin-dependent methionine synthase is a modular protein with distinct regions for binding homocysteine, methyltetrahydrofolate, cobalamin, and adenosylmethionine. Biochemistry (1997) 1.47

Retained appendicolith after laparoscopic appendectomy: the need for systematic double ligature of the appendiceal base. Surg Endosc (2004) 1.46

Ribonucleotide reductase in the archaeon Pyrococcus furiosus: a critical enzyme in the evolution of DNA genomes? Proc Natl Acad Sci U S A (1997) 1.43

Comparison of cobalamin-independent and cobalamin-dependent methionine synthases from Escherichia coli: two solutions to the same chemical problem. Biochemistry (1992) 1.42

Acyl-coenzyme A dehydrogenase from pig kidney. Purification and properties. Biochemistry (1979) 1.39

Adenosylmethionine as a source of 5'-deoxyadenosyl radicals. Curr Opin Chem Biol (2001) 1.39

Replication of polyoma DNA in isolated nuclei. V. Complementation of in vitro DNA replication. J Virol (1975) 1.39

Mechanism of reductive activation of cobalamin-dependent methionine synthase: an electron paramagnetic resonance spectroelectrochemical study. Biochemistry (1990) 1.39

Enzymic modification of a tyrosine residue to a stable free radical in ribonucleotide reductase. Proc Natl Acad Sci U S A (1983) 1.38

A second class I ribonucleotide reductase in Enterobacteriaceae: characterization of the Salmonella typhimurium enzyme. Proc Natl Acad Sci U S A (1994) 1.37

Reaction of the desulfoferrodoxin from Desulfoarculus baarsii with superoxide anion. Evidence for a superoxide reductase activity. J Biol Chem (2000) 1.37

From deoxynucleotides to DNA synthesis. Fed Proc (1978) 1.36

Identification of the zinc ligands in cobalamin-independent methionine synthase (MetE) from Escherichia coli. Biochemistry (1999) 1.35

Thioredoxin 2: cleavage with cyanogen bromide. Eur J Biochem (1967) 1.34

Inactivation of ribonucleotide reductase by nitric oxide. Biochem Biophys Res Commun (1991) 1.32

Supravital staining of human spermatozoa. Fertil Steril (1971) 1.31

Overproduction of the free radical of ribonucleotide reductase in hydroxyurea-resistant mouse fibroblast 3T6 cells. Proc Natl Acad Sci U S A (1981) 1.31

Iron and activated oxygen species in biology: the basic chemistry. Biometals (1999) 1.31

An iron-sulfur center and a free radical in the active anaerobic ribonucleotide reductase of Escherichia coli. J Biol Chem (1993) 1.29

Genetic heterogeneity of Usher syndrome: analysis of 151 families with Usher type I. Am J Hum Genet (2000) 1.29

Mapping the interactions between flavodoxin and its physiological partners flavodoxin reductase and cobalamin-dependent methionine synthase. Proc Natl Acad Sci U S A (2001) 1.28

Enzymatic synthesis of deoxyribonucleotides. IX. Allosteric effects in the reduction of pyrimidine ribonucleotides by the ribonucleoside diphosphate reductase system of Escherichia coli. J Biol Chem (1966) 1.27

Cobalamin-independent methionine synthase from Escherichia coli: a zinc metalloenzyme. Biochemistry (1996) 1.26

Synthesis of polyoma DNA by isolated nuclei. Biochem Biophys Res Commun (1971) 1.26

Assignment of enzymatic function to specific protein regions of cobalamin-dependent methionine synthase from Escherichia coli. Biochemistry (1993) 1.26

A possible glycine radical in anaerobic ribonucleotide reductase from Escherichia coli: nucleotide sequence of the cloned nrdD gene. Proc Natl Acad Sci U S A (1993) 1.25

The lrp gene product regulates expression of lysU in Escherichia coli K-12. J Bacteriol (1992) 1.25

Methodology employed for anaerobic spectrophotometric titrations and for computer-assisted data analysis. Methods Enzymol (1979) 1.25

Control of deoxyribonucleotide synthesis in vitro and in vivo. Adv Enzyme Regul (1972) 1.24

The free radical of the anaerobic ribonucleotide reductase from Escherichia coli is at glycine 681. J Biol Chem (1996) 1.24

nrdD and nrdG genes are essential for strict anaerobic growth of Escherichia coli. Biochem Biophys Res Commun (1996) 1.24

Cross-talk between the allosteric effector-binding sites in mouse ribonucleotide reductase. J Biol Chem (2000) 1.24

The iron center in ribonucleotide reductase from Escherichia coli. J Biol Chem (1980) 1.24

Purification of a thioredoxin system from yeast. J Biol Chem (1970) 1.23

NADPH-sulfite reductase from Escherichia coli. A flavin reductase participating in the generation of the free radical of ribonucleotide reductase. J Biol Chem (1993) 1.22

Characterization of the flavin reductase gene (fre) of Escherichia coli and construction of a plasmid for overproduction of the enzyme. J Bacteriol (1991) 1.22

Mutations in the B12-binding region of methionine synthase: how the protein controls methylcobalamin reactivity. Biochemistry (1996) 1.21

Deoxyribonucleotide pools in mouse-fibroblast cell lines with altered ribonucleotide reductase. Eur J Biochem (1976) 1.21

SufA/IscA: reactivity studies of a class of scaffold proteins involved in [Fe-S] cluster assembly. J Biol Inorg Chem (2004) 1.21

Cloning and sequence analysis of the Escherichia coli metH gene encoding cobalamin-dependent methionine synthase and isolation of a tryptic fragment containing the cobalamin-binding domain. J Biol Chem (1989) 1.21