Published in J Exp Med on January 01, 1979
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Early development of the T cell repertoire. In vivo treatment of neonatal mice with anti-Ia antibodies interferes with differentiation of I-restricted T cells but not K/D-restricted T cells. J Exp Med (1983) 1.35
Conversion of immunity to suppression by in vivo administration of I-A subregion-specific antibodies. J Exp Med (1982) 1.19
Cells bearing Ia antigens in the murine thymus. An ultrastructural study. Am J Pathol (1983) 1.05
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A new I subregion (I-J) marked by a locus (Ia-4) controlling surface determinants on suppressor T lymphocytes. J Exp Med (1976) 6.11
A lymph node weight assay for the graft-versus-host activity of rat lymphoid cells. Transplantation (1970) 4.35
Evidence for the expression of Ia (H-2-associated) antigens on thymus-derived lymphocytes. J Exp Med (1974) 3.56
The involvement of LD- and SD-region differences in MLC and CML: a three-cell experiment. Transplant Proc (1973) 3.35
Bone-marrow transplantation (first of two parts). N Engl J Med (1975) 3.33
Specific binding of alloantigens to T cells activated in the mixed lymphocyte reaction. J Exp Med (1976) 2.04
Acquisition of murine major histocompatibility complex gene products by schistosomula of Schistosoma mansoni. J Exp Med (1978) 1.98
Reduction of syngeneic tumor growth by an anti-I-J-alloantiserum. Proc Natl Acad Sci U S A (1977) 1.93
Serological and functional evidence for further subdivision of the I regions of the H-2 gene complex. Cold Spring Harb Symp Quant Biol (1977) 1.91
Purification of the Thy-1 molecule, a major cell-surface glycoprotein of rat thymocytes. Biochem J (1975) 1.75
Antisera to human B-lymphocyte membrane glycoproteins block stimulation in mixed lymphocyte culture. Nature (1975) 1.64
Inhibition of stimulation in murine mixed lymphocyte cultures with an alloantiserum directed against a shared Ia determinant. J Immunol (1976) 1.46
Specific binding of K- and I-region products of the H-2 complex to activated thymus-derived (T) cells belonging to different Ly subclasses. J Exp Med (1976) 1.42
A cardinal role for I-region antigens (Ia) in immunological enhancement, and the clinical implications. Transplant Rev (1976) 1.35
Demonstration by MLR test of a previously unsuspected intra-H-2 crossover in the B10.HTT strain: implications concerning location of MLR determinants in the Ir region. Transplant Proc (1973) 1.33
The role of nonclassical Fc receptor-associated, Ag-B antigens (Ia) in rat allograft enhancement. J Exp Med (1976) 1.33
Selective expression of separate I-region loci in functionally different lymphocyte subpopulations. Cold Spring Harb Symp Quant Biol (1977) 1.14
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Ability of H-2 regions to induce graft-vs-host disease. J Immunol (1976) 1.05
In vitro analysis of allogeneic lymphocyte interaction. II. I-region control of the activity of a B-cell-derived H-2-restricted allogeneic effect factor and its receptor during B-cell activation. J Exp Med (1978) 0.98
Activation of T and B lymphocytes in vitro. V. Cellular locus, metabolism and genetics of induction, and production of the allogeneic effect factor. J Immunol (1977) 0.94
Expression of murine Ia antigens during embryonic development. J Immunol (1978) 0.94
Protection against homologous disease in hybrid mice by passive and active immunological enhancement-facilitation. Transplantation (1968) 0.92
Characteristics of disparate histocompatibility barriers in congenic strains of mice. I. Graft-versus-host reactions. Transplantation (1972) 0.88
Incompatible bone-marrow transplantation in lymphopenic immunologic deficiency. Circumvention of fatal graft-versus-host disease by immunologic enhancement. N Engl J Med (1971) 0.88
Suppression of the graft-versus-host reaction by passive immunization of donor against recipient antigens. Proc Soc Exp Biol Med (1970) 0.83
Prolongation of skin allograft survival and inhibition of graft versus host reaction in rodents treated with "middle molecules". Cell Immunol (1977) 0.79
The dominant role of Ia antibodies in the passive enhancement of H-2 incompatible skin grafts. Eur J Immunol (1975) 0.78
Activation of natural killer T cells by alpha-galactosylceramide treatment prevents the onset and recurrence of autoimmune Type 1 diabetes. Nat Med (2001) 3.56
Organization and sequences of the variable, joining and constant region genes of the human T-cell receptor alpha-chain. Nature (1985) 3.08
Interleukin 4 reverses T cell proliferative unresponsiveness and prevents the onset of diabetes in nonobese diabetic mice. J Exp Med (1993) 2.47
Genetic and functional analysis of the Ia antigens: their possible role in regulating the immune response. Transplant Rev (1976) 2.15
Complete nucleotide sequence of a gene encoding a functional human class I histocompatibility antigen (HLA-CW3). EMBO J (1984) 1.92
B cell dependence on and response to accessory signals in murine lupus strains. J Exp Med (1983) 1.79
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IL-4 prevents insulitis and insulin-dependent diabetes mellitus in nonobese diabetic mice by potentiation of regulatory T helper-2 cell function. J Immunol (1997) 1.48
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Defective thymic T cell activation by concanavalin A and anti-CD3 in autoimmune nonobese diabetic mice. Evidence for thymic T cell anergy that correlates with the onset of insulitis. J Immunol (1991) 1.45
Treatment of murine lupus with cDNA encoding IFN-gammaR/Fc. J Clin Invest (2000) 1.40
Distinct antibody specificities to a 64-kD islet cell antigen in type 1 diabetes as revealed by trypsin treatment. J Exp Med (1990) 1.36
Development of methods for the quantitative in vitro analysis of androgen-dependent and autonomous Shionogi carcinoma 115 cells. Cell (1977) 1.31
In vitro analysis of allogeneic lymphocyte interaction. I. Characterization and cellular origin of an Ia-positive helper factor-allogeneic effect factor. J Exp Med (1977) 1.26
p38 mitogen-activated protein kinase mediates signal integration of TCR/CD28 costimulation in primary murine T cells. J Immunol (1999) 1.25
Evidence that a peptide spanning the B-C junction of proinsulin is an early Autoantigen epitope in the pathogenesis of type 1 diabetes. J Immunol (2001) 1.23
TCR and CD28 are coupled via ZAP-70 to the activation of the Vav/Rac-1-/PAK-1/p38 MAPK signaling pathway. J Immunol (1999) 1.18
Differential expression of CC chemokines and the CCR5 receptor in the pancreas is associated with progression to type I diabetes. J Immunol (2000) 1.16
Estimation of light-chain gene reiteration of mouse immunoglobulin by DNA-RNA hybridization. Proc Natl Acad Sci U S A (1973) 1.16
Thymic T cell anergy in autoimmune nonobese diabetic mice is mediated by deficient T cell receptor regulation of the pathway of p21ras activation. J Exp Med (1993) 1.15
Immune dysfunction in diabetes-prone BB rats. Interleukin 2 production and other mitogen-induced responses are suppressed by activated macrophages. J Exp Med (1984) 1.10
Altered thymic and peripheral T-lymphocyte repertoire preceding onset of diabetes in NOD mice. Diabetes (1991) 1.09
B-cell-tropic interleukins in murine systemic lupus erythematosus (SLE) 1. Immunol Rev (1984) 1.09
TGF-beta1 somatic gene therapy prevents autoimmune disease in nonobese diabetic mice. J Immunol (1998) 1.06
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Class I histocompatibility antigens and insulin receptors: evidence for interactions. Proc Natl Acad Sci U S A (1986) 1.05
Photoaffinity labeling demonstrates binding between Ia molecules and nominal antigen on antigen-presenting cells. Proc Natl Acad Sci U S A (1986) 1.04
Regulation of fas ligand expression during activation-induced cell death in T cells by p38 mitogen-activated protein kinase and c-Jun NH2-terminal kinase. J Exp Med (2000) 1.03
Persistence of serum antibodies to 64,000-Mr islet cell protein after onset of type I diabetes. Diabetes (1990) 1.03
Detection of pancreatic islet 64,000 M(r) autoantigens in insulin-dependent diabetes distinct from glutamate decarboxylase. J Clin Invest (1993) 1.03
The identification of actin as a major lymphocyte component. J Immunol (1979) 1.01
Processing and presentation of insulin. I. Analysis of immunogenic peptides and processing requirements for insulin A loop-specific T cells. J Immunol (1987) 1.00
The phosphodiesterase inhibitors pentoxifylline and rolipram suppress macrophage activation and nitric oxide production in vitro and in vivo. Clin Immunol (2001) 0.99
In vitro analysis of allogeneic lymphocyte interaction. II. I-region control of the activity of a B-cell-derived H-2-restricted allogeneic effect factor and its receptor during B-cell activation. J Exp Med (1978) 0.98
Antigen-induced B lymphocyte activation involves the p21ras and ras.GAP signaling pathway. J Exp Med (1993) 0.97
Factors influencing the development of visual loss in advanced diabetic retinopathy. Diabetic Retinopathy Study (DRS) Report No. 10. Invest Ophthalmol Vis Sci (1985) 0.97
Immunochemical evidence for three Ia loci in the I-region of the H-2 complex. J Exp Med (1977) 0.96
Evidence for two homologous, but nonidentical, Ia molecules determined by the I-EC subregion. J Exp Med (1979) 0.96
T cell autoreactivity to insulin in diabetic and related non-diabetic individuals. J Immunol (1988) 0.94
Expression of murine Ia antigens during embryonic development. J Immunol (1978) 0.94
T-cell anergy and altered T-cell receptor signaling: effects on autoimmune disease. Immunol Today (1998) 0.94
Sequence and gene transfer analyses of HLA-CwBL18 (HLA-C blank) and HLA-Cw5 genes. Implications for the control of expression and immunogenicity of HLA-C antigens. J Immunol (1989) 0.94
Generation and chromosome mapping of expressed sequence tags (ESTs) from a human infant thymus. Genome (1999) 0.92
Gene therapy of diabetes using a novel GLP-1/IgG1-Fc fusion construct normalizes glucose levels in db/db mice. Gene Ther (2006) 0.92
Neonatal activation of CD28 signaling overcomes T cell anergy and prevents autoimmune diabetes by an IL-4-dependent mechanism. J Clin Invest (1997) 0.91
Immunotherapy of spontaneous type 1 diabetes in nonobese diabetic mice by systemic interleukin-4 treatment employing adenovirus vector-mediated gene transfer. Gene Ther (2000) 0.91
Derivation of a monoclonal antibody that detects an Ia antigen encoded by 2 complementing I-subregions. J Immunol (1980) 0.91
Decreased renal ischemia-reperfusion injury by IL-16 inactivation. Kidney Int (2007) 0.90
In vivo expression of GLP-1/IgG-Fc fusion protein enhances beta-cell mass and protects against streptozotocin-induced diabetes. Gene Ther (2007) 0.90
Intramuscular administration of expression plasmids encoding interferon-gamma receptor/IgG1 or IL-4/IgG1 chimeric proteins protects from autoimmunity. J Gene Med (2000) 0.89
Immunologic and genetic studies of diabetes in the BB rat. Crit Rev Immunol (1989) 0.89
Cyclosporin A markedly enhances superantigen-induced peripheral T cell deletion and inhibits anergy induction. J Exp Med (1992) 0.88
Processing and presentation of insulin. II. Evidence for intracellular, plasma membrane-associated and extracellular degradation of human insulin by antigen-presenting B cells. J Immunol (1989) 0.88
Insulin-like growth factors prevent cytokine-mediated cell death in isolated islets of Langerhans from pre-diabetic non-obese diabetic mice. J Endocrinol (1999) 0.88
Promoter region of HLA-C genes: regulatory elements common to and different from those of HLA-A and HLA-B genes. Immunogenetics (1990) 0.88
Tyrosine kinase and CD45 tyrosine phosphatase activity mediate p21ras activation in B cells stimulated through the antigen receptor. J Immunol (1994) 0.87
HLA-C genes are transcribed in HLA-C blank individuals. Immunogenetics (1988) 0.87
Regulation of BCR- and PKC/Ca(2+)-mediated activation of the Raf1/MEK/MAPK pathway by protein-tyrosine kinase and -tyrosine phosphatase activities. Mol Immunol (1996) 0.87
Idiotypic analysis of anti-I-Ak monoclonal antibodies. I. Production and characterization of syngeneic anti-idiotypic mAb against an anti-I-Ak mAb. J Immunol (1984) 0.86
Biolistic-mediated interleukin 4 gene transfer prevents the onset of type 1 diabetes. Hum Gene Ther (2000) 0.86
Functional and genetic analysis of Ia antigens. Cold Spring Harb Symp Quant Biol (1977) 0.86
Assignment of mitochondrial NAD(+)-specific isocitrate dehydrogenase beta subunit gene (IDH3B) to human chromosome band 20p13 by in situ hybridization and radiation hybrid mapping. Cytogenet Cell Genet (1999) 0.86
ZAP-70 is essential for the T cell antigen receptor-induced plasma membrane targeting of SOS and Vav in T cells. J Biol Chem (2000) 0.86
Fas antigen and sphingomyelin-ceramide turnover-mediated signaling: role in life and death of T lymphocytes. Immunol Rev (1994) 0.86
Regulation of T-helper-1 versus T-helper-2 activity and enhancement of tumor immunity by combined DNA-based vaccination and nonviral cytokine gene transfer. Gene Ther (2000) 0.86
Sequestration of CD4-associated Lck from the TCR complex may elicit T cell hyporesponsiveness in nonobese diabetic mice. J Immunol (1998) 0.86
Insulin dependent diabetes mellitus in the non-obese diabetic mouse: a disease mediated by T cell anergy? Life Sci (1994) 0.85
7S-K nuclear RNA from simian virus 40-transformed cells has sequence homology to the viral early promoter. Proc Natl Acad Sci U S A (1983) 0.85
CD28 co-stimulation restores T cell responsiveness in NOD mice by overcoming deficiencies in Rac-1/p38 mitogen-activated protein kinase signaling and IL-2 and IL-4 gene transcription. Int Immunol (2001) 0.84
Graft-vs-host reactions induce H-2 class II gene transcription in host kidney cells. Immunogenetics (1984) 0.84
The phosphodiesterase inhibitors pentoxifylline and rolipram prevent diabetes in NOD mice. Diabetes (1998) 0.84
Immunopathology and the gene therapy of lupus. Gene Ther (2003) 0.84
IL-12 plasmid-enhanced DNA vaccination against carcinoembryonic antigen (CEA) studied in immune-gene knockout mice. Gene Ther (2000) 0.83
An alpha-galactosylceramide C20:2 N-acyl variant enhances anti-inflammatory and regulatory T cell-independent responses that prevent type 1 diabetes. Clin Exp Immunol (2009) 0.83
IL-2 secretion is pertussis toxin sensitive in a T lymphocyte hybridoma. J Immunol (1989) 0.83
Immunochemical characterization of the Ly-8.2 murine lymphocyte alloantigen: possible relationship to actin. J Immunol (1979) 0.82
In vitro analysis of allogeneic lymphocyte interaction. III. Generation of a helper allogeneic effect factor (AEF) across an I-J subregion disparity. J Immunol (1979) 0.82
Failure in immune regulation begets IDDM in NOD mice. Diabetes Metab Rev (1998) 0.82
Isolation of messenger-like RNA from immunochemically separated polyribosomes. J Mol Biol (1972) 0.82
Production and in vitro refolding of a single-chain antibody specific for human plasma apolipoprotein A-I. J Biotechnol (2000) 0.82
T cell hybrids with specificity for islet cell antigens. J Immunol (1986) 0.82
p21ras and protein kinase C function in distinct and interdependent signaling pathways in C3H 10T1/2 fibroblasts. Mol Cell Biol (1993) 0.81
Stimulation of a shorter duration in the state of anergy by an invariant natural killer T cell agonist enhances its efficiency of protection from type 1 diabetes. Clin Exp Immunol (2011) 0.81
Idiotypic analysis of anti-I-Ak monoclonal antibodies. II. Detection of shared idiotopes on syngeneic BALB/c and allogeneic A.TH-derived anti-I-Ak mAb by BALB/c-derived anti-I-Ak anti-idiotypic mAb. J Immunol (1984) 0.81
Characterization of murine newborn inhibitory T lymphocytes: functional and phenotypic comparison with an adult T cell subset activated in vitro by alphafetoprotein. Eur J Immunol (1981) 0.81
Prevention of experimental allergic encephalomyelitis by intramuscular gene transfer with cytokine-encoding plasmid vectors. Hum Gene Ther (1999) 0.80
Structure-guided design of an invariant natural killer T cell agonist for optimum protection from type 1 diabetes in non-obese diabetic mice. Clin Exp Immunol (2011) 0.80
Influence of antigen processing on immune responsiveness. Immunol Today (1989) 0.79
Influence of the valency and hydrophobicity of an antigen on its efficiency of processing and presentation by antigen-specific B cells. Res Immunol (1989) 0.79
Genetic linkage of thymic T-cell proliferative unresponsiveness to mouse chromosome 11 in NOD mice. A possible role for chemokine genes. Diabetes (1995) 0.79
Major histocompatibility complex class II molecules function as a template for the processing of a partially processed insulin peptide into a T-cell epitope. Diabetes (1996) 0.79
Isolation of T-lymphocyte lines with specificity for islet cell antigens from spontaneously diabetic (insulin-dependent) rats. Diabetes (1984) 0.79
The biological and biochemical basis of allogeneic effect factor (AEF) activity: relationship to T cell alloreactivity. Immunobiology (1982) 0.79
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Beta 2-microglobulin induces a conformational change in an MHC class I H chain that occurs intracellularly and is maintained at the cell surface. J Immunol (1994) 0.79