Published in J Exp Med on November 01, 1977
T-cell-dependent B-cell stimulation is H-2 restricted and antigen dependent only at the resting B-cell level. Proc Natl Acad Sci U S A (1980) 3.08
Idiotype-anti-idiotype regulation. I. Immunization with a levan-binding myeloma protein leads to the appearance of auto-anti-(anti-idiotype) antibodies and to the activation of silent clones. J Exp Med (1981) 2.28
Specific T helper cells that activate B cells polyclonally. In vitro enrichment and cooperative function. J Exp Med (1980) 2.27
Studies on the clonal origin of multiple myeloma. Use of individually specific (idiotype) antibodies to trace the oncogenic event to its earliest point of expression in B-cell differentiation. J Exp Med (1979) 1.70
Ability of antigen-specific helper cells to effect a class-restricted increase in total Ig-secreting cells in spleens after immunization with the antigen. J Exp Med (1979) 1.65
Normal mice express idiotypes related to autoantibody idiotypes of lupus mice. Proc Natl Acad Sci U S A (1983) 1.50
Structural correlates of cross-reactive and individual idiotypic determinants on murine antibodies to alpha-(1 leads to 3) dextran. J Exp Med (1980) 1.46
Isolation of hybridomas expressing a specific heavy chain variable region gene segment by using a screening technique that detects mRNA sequences in whole cell lysates. Proc Natl Acad Sci U S A (1984) 1.30
Shared idiotypes among monoclonal antibodies specific for different immunodominant sugars of lipopolysaccharide of different Gram-negative bacteria. Proc Natl Acad Sci U S A (1982) 1.24
Idiotypic determinants on T-cell subpopulations. J Exp Med (1979) 1.08
Anti-immunoglobulin antibodies. I. Expression of cross-reactive idiotypes and Ir gene control of the response to IgG2a of the b allotype. J Exp Med (1980) 1.08
Idiotype connectance in the immune system. I. Expression of a cross-reactive idiotype on induced anti-p-azophenylarsonate antibodies and on endogenous antibodies not specific for arsonate. J Exp Med (1983) 1.03
Genetic control of a shared idiotype among antibodies directed to distinct specificities. J Exp Med (1980) 1.01
Autoregulation of immune responses via idiotype network interactions. Microbiol Rev (1980) 1.01
Shared idiotopes among monoclonal antibodies specific for A/PR/8/34 (H1N1) and X-31(H3N2) influenza viruses. Proc Natl Acad Sci U S A (1984) 1.00
Expression of an idiotype (Id-460) during in vivo anti-dinitrophenyl antibody responses. III. Detection of Id-460 in normal serum that does not bind dinitrophenyl. J Exp Med (1981) 0.99
Mitogen-reactive B cell subpopulations selectively express different sets of V regions. J Exp Med (1982) 0.92
Non-dinitrophenyl-binding immunoglobulin that bears a dominant idiotype (Id460) associated with antidinitrophenyl antibody is specific for an antigen on Pasteurella pneumotropica. J Exp Med (1984) 0.91
Ubiquitous nonimmunoglobulin p-azobenzenearsonate-binding molecules from lymphoid cells. J Exp Med (1982) 0.90
Idiotypic repertoire of anti-hen eggwhite lysozyme antibodies probed with hybridomas. Selection after immunization of an IdX marker common to antibodies of distinct epitope specificity. J Exp Med (1981) 0.88
Immune networks. Frequencies of antibody- and idiotype-producing B cell clones in various steady states. J Exp Med (1981) 0.86
Fine specificity and idiotypic expression of monoclonal antibodies directed against poly(Tyr,Glu)-poly(DLAla)--poly(Lys) and its ordered analogue (Tyr-Tyr-Glu-Glu)-poly(DLAla)--poly(Lys). Immunology (1983) 0.78
The relationship between variable region determinants and antigen specificity on mitogen reactive B cell subsets. J Exp Med (1982) 0.77
Towards a network theory of the immune system. Ann Immunol (Paris) (1974) 16.43
A plaque assay for all cells secreting Ig of a given type or class. Eur J Immunol (1976) 9.11
Induction of T and B cell immunity by anti-idiotypic antibody. Eur J Immunol (1975) 4.79
Induction of immunoglobulin and antibody synthesis in vitro by lipopolysaccharides. Eur J Immunol (1972) 4.64
Genetics of a new IgVH (T15 idiotype) marker in the mouse regulating natural antibody to phosphorylcholine. J Exp Med (1974) 3.64
Clonal growth and maturation to immunoglobulin secretion in vitro of every growth-inducible B lymphocyte. Cell (1977) 3.23
The inheritance of individual antigenic specificities of rabbit antibodies to streptococcal carbohydrates. J Exp Med (1971) 3.17
Idiotype suppression. I. Influence of the dose and of the effector functions of anti-idiotypic antibody on the production of an idiotype. Eur J Immunol (1974) 2.90
Similar idiotypic specificities in immunoglobulin fractions with different antibody functions or even without detectable antibody function. Proc Natl Acad Sci U S A (1971) 2.73
Frequencies of mitogen-reactive B cells in the mouse. I. Distribution in different lymphoid organs from different inbred strains of mice at different ages. J Exp Med (1977) 2.68
Idiotype suppression. II. Amplification of a suppressor T cell with anti-idiotypic activity. Eur J Immunol (1975) 2.59
Idiotypic identity of antibodies to streptococcal carbohydrate in inbred mice. Eur J Immunol (1972) 2.52
Idiotype expression and the inheritance of mouse antibody clones. J Exp Med (1973) 2.45
Idiotypic analysis of lymphocytes in vitro. I. Specificity and heterogeneity of B and T lymphocytes reactive with anti-idiotypic antibody. J Exp Med (1976) 2.05
Inheritance of antibody specificity. I. Anti-(4-hydroxy-3-nitrophenyl)acetyl of the mouse primary response. J Exp Med (1974) 1.82
Strain differences in the fine specificity of mouse anti-hapten antibodies. Eur J Immunol (1973) 1.69
On the structure of the T-cell receptor for antigen. Cold Spring Harb Symp Quant Biol (1977) 1.60
A plaque assay for all cells secreting Ig of a given type or class. Eur J Immunol (1976) 9.11
Routine versus clinically driven laboratory monitoring of HIV antiretroviral therapy in Africa (DART): a randomised non-inferiority trial. Lancet (2009) 7.96
Establishment of mouse cell lines which constitutively secrete large quantities of interleukin 2, 3, 4 or 5, using modified cDNA expression vectors. Eur J Immunol (1988) 6.51
Complete replacement of serum by albumin, transferrin, and soybean lipid in cultures of lipopolysaccharide-reactive B lymphocytes. J Exp Med (1978) 5.45
The mitogenic effect of lipopolysaccharide on bone marrow-derived mouse lymphocytes. Lipid A as the mitogenic part of the molecule. J Exp Med (1973) 4.74
Expression and function of idiotypes of lymphocytes. Adv Immunol (1978) 4.16
Monoclonal antibodies specific for the outer surface protein A (OspA) of Borrelia burgdorferi prevent Lyme borreliosis in severe combined immunodeficiency (scid) mice. Proc Natl Acad Sci U S A (1990) 4.15
Two distinct factors are required for induction of T-cell growth. Nature (1980) 4.13
The SCID but not the RAG-2 gene product is required for S mu-S epsilon heavy chain class switching. Immunity (1996) 4.02
Alternative metabolic states in murine macrophages reflected by the nitric oxide synthase/arginase balance: competitive regulation by CD4+ T cells correlates with Th1/Th2 phenotype. J Immunol (1998) 3.98
Continued RAG expression in late stages of B cell development and no apparent re-induction after immunization. Nature (1999) 3.86
Th1/Th2-regulated expression of arginase isoforms in murine macrophages and dendritic cells. J Immunol (1999) 3.68
The lipoprotein of the outer membrane of Escherichia coli: a B-lymphocyte mitogen. J Exp Med (1975) 3.55
Thymus-independent B-cell induction and paralysis. Adv Immunol (1975) 3.27
The role of mitogenic lectins in T-cell triggering. Nature (1979) 3.26
Clonal growth and maturation to immunoglobulin secretion in vitro of every growth-inducible B lymphocyte. Cell (1977) 3.23
Reciprocal regulation of the nitric oxide synthase/arginase balance in mouse bone marrow-derived macrophages by TH1 and TH2 cytokines. Eur J Immunol (1995) 3.17
The inheritance of individual antigenic specificities of rabbit antibodies to streptococcal carbohydrates. J Exp Med (1971) 3.17
A critical role of lambda 5 protein in B cell development. Cell (1992) 3.09
T-cell-dependent B-cell stimulation is H-2 restricted and antigen dependent only at the resting B-cell level. Proc Natl Acad Sci U S A (1980) 3.08
Second generation immune networks. Immunol Today (1991) 2.97
Editorial: Immune activation of B cells: evidence for 'one nonspecific triggering signal' not delivered by the Ig receptors. Scand J Immunol (1974) 2.93
Idiotype suppression. I. Influence of the dose and of the effector functions of anti-idiotypic antibody on the production of an idiotype. Eur J Immunol (1974) 2.90
Murine macrophages secrete interferon gamma upon combined stimulation with interleukin (IL)-12 and IL-18: A novel pathway of autocrine macrophage activation. J Exp Med (1998) 2.89
B lymphocyte lineage-restricted expression of mb-1, a gene with CD3-like structural properties. EMBO J (1988) 2.88
Analysis of the neuroligin 3 and 4 genes in autism and other neuropsychiatric patients. Mol Psychiatry (2005) 2.78
T cell-dependent activation of resting B cells: requirement for both nonspecific unrestricted and antigen-specific Ia-restricted soluble factors. Proc Natl Acad Sci U S A (1981) 2.74
Frequencies of mitogen-reactive B cells in the mouse. I. Distribution in different lymphoid organs from different inbred strains of mice at different ages. J Exp Med (1977) 2.68
Studies on T lymphocyte activation. I. Requirements for the mitogen-dependent production of T cell growth factors. Eur J Immunol (1979) 2.59
Idiotype suppression. II. Amplification of a suppressor T cell with anti-idiotypic activity. Eur J Immunol (1975) 2.59
Antigen receptors of T helper cells. Contemp Top Immunobiol (1977) 2.54
Idiotypic identity of antibodies to streptococcal carbohydrate in inbred mice. Eur J Immunol (1972) 2.52
IL-2 receptor alpha chain (CD25, TAC) expression defines a crucial stage in pre-B cell development. Int Immunol (1994) 2.51
Recognition of idiotypes in lymphocyte interactions. II. Antigen-independent cooperation between T and B lymphocytes that possess similar and complementary idiotypes. Eur J Immunol (1978) 2.47
Extrathymic origin of intestinal intraepithelial lymphocytes bearing T-cell antigen receptor gamma delta. Proc Natl Acad Sci U S A (1991) 2.46
Idiotype expression and the inheritance of mouse antibody clones. J Exp Med (1973) 2.45
Lambda 5, a new light-chain-related locus selectively expressed in pre-B lymphocytes. Nature (1987) 2.43
Down-regulation of RAG1 and RAG2 gene expression in preB cells after functional immunoglobulin heavy chain rearrangement. Immunity (1995) 2.40
A second gene, VpreB in the lambda 5 locus of the mouse, which appears to be selectively expressed in pre-B lymphocytes. EMBO J (1987) 2.39
Long-term in vivo reconstitution of T-cell development by Pax5-deficient B-cell progenitors. Nature (1999) 2.36
Inhibition of mitogenic stimulation of mouse lymphocytes by anti-mouse immunoglobulin antibodies. I. Mode of action. Eur J Immunol (1974) 2.33
Specific T helper cells that activate B cells polyclonally. In vitro enrichment and cooperative function. J Exp Med (1980) 2.27
Molecular and cellular origins of B lymphocyte diversity. Cell (1991) 2.25
B-lymphocyte subpopulations in the mouse. Organ distribution and ontogeny of immunoglobulin-synthesizing and of mitogen-sensitive cells. Transplant Rev (1975) 2.25
Long-term proliferating early pre B cell lines and clones with the potential to develop to surface Ig-positive, mitogen reactive B cells in vitro and in vivo. EMBO J (1991) 2.25
Localization of gamma/delta T cells to the intestinal epithelium is independent of normal microbial colonization. J Exp Med (1990) 2.23
Selective triggering of B cell subpopulations by mitogens. Eur J Immunol (1974) 2.22
The proteins encoded by the VpreB and lambda 5 pre-B cell-specific genes can associate with each other and with mu heavy chain. J Exp Med (1990) 2.22
Functional analysis of B cell heterogeneity. Transplant Rev (1975) 2.17
High frequency of natural autoantibodies in normal newborn mice. J Immunol (1985) 2.17
Lyme borreliosis in the severe combined immunodeficiency (scid) mouse manifests predominantly in the joints, heart, and liver. Am J Pathol (1990) 2.15
The chemokine SDF-1, stromal cell-derived factor 1, attracts early stage B cell precursors via the chemokine receptor CXCR4. Eur J Immunol (1997) 2.14
Synthesis, surface deposition and secretion of immunoglobulin M in bone marrow-derived lymphocytes before and after mitogenic stimulation. Transplant Rev (1973) 2.14
Studies on T lymphocyte activation II. The target cells for concanavalin A-induced growth factors. Eur J Immunol (1979) 2.10
Synergism in the activation of human CD8 T cells by cross-linking the T-cell receptor complex with the CD8 differentiation antigen. Proc Natl Acad Sci U S A (1986) 2.10
A giant protease with potential to substitute for some functions of the proteasome. Science (1999) 2.08
Restoration of early thymocyte differentiation in T-cell receptor beta-chain-deficient mutant mice by transmembrane signaling through CD3 epsilon. Proc Natl Acad Sci U S A (1993) 2.06
Idiotypic analysis of lymphocytes in vitro. I. Specificity and heterogeneity of B and T lymphocytes reactive with anti-idiotypic antibody. J Exp Med (1976) 2.05
Recognition of idiotypes in lymphocyte interactions. I. Idiotypic selectivity in the cooperation between T and B lymphocytes. Eur J Immunol (1978) 2.05
Mechanism of thymus-independent immunocyte triggering. Mitogenic activation of B cells results in specific immune responses. J Exp Med (1974) 2.04
A B-cell mitogen from a pathogenic trypanosome is a eukaryotic proline racemase. Nat Med (2000) 2.01
Growth control of activated, synchronized murine B cells by the C3d fragment of human complement. Nature (1985) 1.98
Organization of the murine Ig-related lambda 5 gene transcribed selectively in pre-B lymphocytes. EMBO J (1987) 1.97
Influenza virus site recognized by a murine helper T cell specific for H1 strains. Localization to a nine amino acid sequence in the hemagglutinin molecule. J Exp Med (1983) 1.94
Live adult worms detected by ultrasonography in human Bancroftian filariasis. Am J Trop Med Hyg (1994) 1.90
Arginase induction by suppressors of nitric oxide synthesis (IL-4, IL-10 and PGE2) in murine bone-marrow-derived macrophages. Biochem Biophys Res Commun (1995) 1.89
Molecular basis of B-cell activation. I. Mitogenicity of native and substituted dextrans. Scand J Immunol (1974) 1.87
A subpopulation of B220+ cells in murine bone marrow does not express CD19 and contains natural killer cell progenitors. J Exp Med (1996) 1.86
Antigen-specific T-helper cells stimulate H-2-compatible and H-2-incompatible B-cell blasts polyclonally. J Exp Med (1980) 1.85
Genetic defect in responsiveness to the B cell mitogen lipopolysaccharide. Eur J Immunol (1977) 1.83
All T15 Id-positive antibodies (but not the majority of VHT15+ antibodies) are produced by peritoneal CD5+ B lymphocytes. Int Immunol (1990) 1.82
Para-aortic splanchnopleura from early mouse embryos contains B1a cell progenitors. Nature (1993) 1.82
The kinectics of proliferation and maturation of mitogen-activated bone marrow-derived lymphocytes. Eur J Immunol (1974) 1.81
Characterization of immature B cells by a novel monoclonal antibody, by turnover and by mitogen reactivity. Eur J Immunol (1998) 1.80
B cell mitogenic properties of thymus-independent antigens. Nat New Biol (1973) 1.80
Rabbit antibodies to streptococcal carbohydrates. Influence of primary and secondary immunization and of possible genetic factors on the antibody response. J Exp Med (1969) 1.77
H-2-unrestricted polyclonal maturation without replication of small B cells induced by antigen-activated T cell help factors. Eur J Immunol (1980) 1.77
The expression of Vpre-B/lambda 5 surrogate light chain in early bone marrow precursor B cells of normal and B cell-deficient mutant mice. Cell (1994) 1.75
Changes in the V(H) gene repertoire of developing precursor B lymphocytes in mouse bone marrow mediated by the pre-B cell receptor. Immunity (1997) 1.72
Relationships between relative binding affinity and electrophoretic behavior of rabbit antibodies to streptococcal carbohydrates. J Exp Med (1971) 1.72
Idiotypic analysis of lymphocytes in vitro. II. Genetic control of T-helper cell responsiveness to anti-idiotypic antibody. J Exp Med (1976) 1.71
Genetic control of B-cell responses. I. Selective unresponsiveness to lipopolysaccharide. Scand J Immunol (1975) 1.71
Induction of rabbit antibody with molecular uniformity after immunization with group C streptococci. J Exp Med (1970) 1.71
Frequencies of CD4+ T cells reactive with Plasmodium chabaudi chabaudi: distinct response kinetics for cells with Th1 and Th2 characteristics during infection. Int Immunol (1989) 1.68
Isolation of a cDNA copy of an RNA species expressed in murine pre-B cells. EMBO J (1986) 1.63
In vitro activation of mouse lymphocytes in serum-free medium: effect of T and B cell mitogens on proliferation and antibody synthesis. Eur J Immunol (1973) 1.62
IgM-producing tumors in the BALB-c mouse: a model for B-cell maturation. J Exp Med (1974) 1.61
Mutations affecting either generation or survival of cells influence the pool size of mature B cells. Immunity (1999) 1.61
On the structure of the T-cell receptor for antigen. Cold Spring Harb Symp Quant Biol (1977) 1.60
Contribution of proteasome-mediated proteolysis to the hierarchy of epitopes presented by major histocompatibility complex class I molecules. Immunity (1995) 1.59
Monoclonal antibodies specific for murine IgM I. Characterization of antigenic determinants on the four constant domains of the mu heavy chain. Eur J Immunol (1984) 1.58
Influence of immunoglobulin heavy- and light-chain expression on B-cell differentiation. Genes Dev (1994) 1.58
Differentiation of B cells: sequential appearance of responsiveness to polyclonal activators. Scand J Immunol (1974) 1.57