Synergism in the activation of human CD8 T cells by cross-linking the T-cell receptor complex with the CD8 differentiation antigen.

PubWeight™: 2.10‹?› | Rank: Top 2%

🔗 View Article (PMC 386915)

Published in Proc Natl Acad Sci U S A on November 01, 1986

Authors

F Emmrich, U Strittmatter, K Eichmann

Articles citing this

Thymic selection of CD8+ single positive cells with a class II major histocompatibility complex-restricted receptor. J Exp Med (1994) 4.91

Short related sequences in the cytoplasmic domains of CD4 and CD8 mediate binding to the amino-terminal domain of the p56lck tyrosine protein kinase. Mol Cell Biol (1990) 2.06

Coclustering of CD4 (L3T4) molecule with the T-cell receptor is induced by specific direct interaction of helper T cells and antigen-presenting cells. Proc Natl Acad Sci U S A (1987) 2.04

VLA-4 mediates CD3-dependent CD4+ T cell activation via the CS1 alternatively spliced domain of fibronectin. J Exp Med (1990) 1.95

Src-homology 3 domain of protein kinase p59fyn mediates binding to phosphatidylinositol 3-kinase in T cells. Proc Natl Acad Sci U S A (1993) 1.62

Development of the CD4 and CD8 lineage of T cells: instruction versus selection. EMBO J (1991) 1.59

Recognition by CD8 on cytotoxic T lymphocytes is ablated by several substitutions in the class I alpha 3 domain: CD8 and the T-cell receptor recognize the same class I molecule. Proc Natl Acad Sci U S A (1990) 1.59

A second subunit of CD8 is expressed in human T cells. EMBO J (1988) 1.55

Possible orientational constraints determine secretory signals induced by aggregation of IgE receptors on mast cells. EMBO J (1988) 1.50

Species-restricted interactions between CD8 and the alpha 3 domain of class I influence the magnitude of the xenogeneic response. J Exp Med (1989) 1.35

Phosphatidylinositol (PI) 3-kinase and PI 4-kinase binding to the CD4-p56lck complex: the p56lck SH3 domain binds to PI 3-kinase but not PI 4-kinase. Mol Cell Biol (1993) 1.34

Quantitative contribution of CD4 and CD8 to T cell antigen receptor serial triggering. J Exp Med (1997) 1.26

The Lyt-2 molecule recognizes residues in the class I alpha 3 domain in allogeneic cytotoxic T cell responses. J Exp Med (1988) 1.26

Direct evidence for binding of CD8 to HLA class I antigens. J Exp Med (1989) 1.24

Activation of T lymphocytes by immobilized monoclonal antibodies to CD3. Regulatory influences of monoclonal antibodies to additional T cell surface determinants. J Clin Invest (1988) 1.18

Reactivity of V beta 17a+ CD8+ T cell hybrids. Analysis using a new CD8+ T cell fusion partner. J Exp Med (1989) 1.17

Costimulatory signals for human T-cell activation induce nuclear translocation of pp19/cofilin. Proc Natl Acad Sci U S A (1994) 1.13

Molecular dynamics in the membranes of helper T cells. Proc Natl Acad Sci U S A (1988) 1.12

Coaggregation of the T-cell receptor with CD4 and other T-cell surface molecules enhances T-cell activation. Proc Natl Acad Sci U S A (1987) 1.12

Association of CD8 with p56lck is required for early T cell signalling events. EMBO J (1991) 1.10

The T-cell antigen CD5 acts as a receptor and substrate for the protein-tyrosine kinase p56lck. Mol Cell Biol (1994) 1.06

A secreted form of the human lymphocyte cell surface molecule CD8 arises from alternative splicing. Proc Natl Acad Sci U S A (1989) 1.05

The role of charge and multiple faces of the CD8 alpha/alpha homodimer in binding to major histocompatibility complex class I molecules: support for a bivalent model. Proc Natl Acad Sci U S A (1994) 1.05

CD4 and CD8 molecules can physically associate with the same T-cell receptor. Proc Natl Acad Sci U S A (1989) 1.04

Mutations in CD8 that affect interactions with HLA class I and monoclonal anti-CD8 antibodies. J Exp Med (1991) 1.00

Tyrosine phosphorylation of CD19 in pre-B and mature B cells. EMBO J (1993) 0.97

Human CD8 transgene regulation of HLA recognition by murine T cells. J Exp Med (1995) 0.96

Species specificity and augmentation of responses to class II major histocompatibility complex molecules in human CD4 transgenic mice. J Exp Med (1992) 0.95

Differentiation of Ia-reactive CD8+ murine T cells does not require Ia engagement. Implications for the role of CD4 and CD8 accessory molecules in T cell differentiation. J Exp Med (1988) 0.91

The role of CD4-Lck in T-cell receptor antagonism: evidence for negative signaling. Proc Natl Acad Sci U S A (1996) 0.89

Activation of human T lymphocytes: differential effects of CD3- and CD8-mediated signals. Proc Natl Acad Sci U S A (1988) 0.88

Expression of CD4 in transgenic mice alters the specificity of CD8 cells for allogeneic major histocompatibility complex. Proc Natl Acad Sci U S A (1991) 0.86

Allelic exclusion at DNA rearrangement level is required to prevent coexpression of two distinct T cell receptor beta genes. J Exp Med (1991) 0.84

Tyrosine kinase activity of CD4-associated p56lck may not be required for CD4-dependent T-cell activation. Proc Natl Acad Sci U S A (1993) 0.84

A CD8 polypeptide that is lost after passing the Golgi but before reaching the cell surface: a novel sorting mechanism. EMBO J (1988) 0.83

Functional consequences of anti-sense RNA-mediated inhibition of CD8 surface expression in a human T cell clone. J Exp Med (1988) 0.83

T-cell activation. I. Evidence for a functional linkage between class I MHC antigens and the Tc-Ti complex. Immunology (1989) 0.83

The CD4 molecule is not always required for the T cell response to bacterial enterotoxins. J Exp Med (1991) 0.82

Two distinct signals regulate induction of IL-2 responsiveness in CD8+ murine T cells. Immunology (1988) 0.80

Co-engagement of alpha(4)beta(1) integrin (VLA-4) and CD4 or CD8 is necessary to induce maximal Erk1/2 phosphorylation and cytokine production in human T cells. Hum Immunol (2010) 0.79

Articles cited by this

Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature (1970) 1528.65

A monoclonal antibody with selective reactivity with functionally mature human thymocytes and all peripheral human T cells. J Immunol (1979) 6.08

Clonal analysis of human cytotoxic T lymphocytes: T4+ and T8+ effector T cells recognize products of different major histocompatibility complex regions. Proc Natl Acad Sci U S A (1982) 5.85

Transmembrane signalling by the T cell antigen receptor. Perturbation of the T3-antigen receptor complex generates inositol phosphates and releases calcium ions from intracellular stores. J Exp Med (1985) 5.62

Requirement for the coexpression of T3 and the T cell antigen receptor on a malignant human T cell line. J Exp Med (1984) 5.26

Thymus-dependent membrane antigens in man: inhibition of cell-mediated lympholysis by monoclonal antibodies to TH2 antigen. Proc Natl Acad Sci U S A (1981) 4.38

Immunofluorescent studies of the development of pre-B cells, B lymphocytes and immunoglobulin isotype diversity in humans. Eur J Immunol (1977) 4.00

Activation of human T lymphocyte subsets: helper and suppressor/cytotoxic T cells recognize and respond to distinct histocompatibility antigens. J Immunol (1981) 3.69

Cross-linking of human T cell receptor proteins: association between the T cell idiotype beta subunit and the T3 glycoprotein heavy subunit. Cell (1985) 3.64

Comparison of T3-associated 49- and 43-kilodalton cell surface molecules on individual human T-cell clones: evidence for peptide variability in T-cell receptor structures. Proc Natl Acad Sci U S A (1983) 2.93

Perturbation of the T4 molecule transmits a negative signal to T cells. J Exp Med (1985) 2.66

Absence of the Lyt-2-,L3T4+ lineage of T cells in mice treated neonatally with anti-I-A correlates with absence of intrathymic I-A-bearing antigen-presenting cell function. J Exp Med (1985) 2.27

Identification of the receptor for antigen and major histocompatibility complex on human inducer T lymphocytes. Science (1983) 2.21

A human NK and K cell subset shares with cytotoxic T cells expression of the antigen recognized by antibody OKT8. J Immunol (1983) 2.04

The T3 complex on human T lymphocytes involves four structurally distinct glycoproteins. J Biol Chem (1983) 1.94

The role of L3T4 in T cell activation: L3T4 may be both an Ia-binding protein and a receptor that transduces a negative signal. J Mol Cell Immunol (1986) 1.45

Requirements for T cell activation by OKT3 monoclonal antibody: role of modulation of T3 molecules and interleukin 1. J Immunol (1985) 1.39

Quantitative studies on T cell diversity. I. Determination of the precursor frequencies for two types of streptococcus A-specific helper cells in nonimmune, polyclonally activated splenic T cells. J Exp Med (1980) 1.39

Relationship between human T cell functional heterogeneity and human T cell surface molecules. Immunol Rev (1983) 1.24

Differential requirements for activation and growth of unprimed cytotoxic and helper T lymphocytes. Eur J Immunol (1983) 1.12

Blocking of human T lymphocyte functions by anti-Leu-2 and anti-Leu-3 antibodies: differential inhibition of proliferation and suppression. J Immunol (1983) 1.11

Monoclonal antibodies against differentiation antigens on human macrophages. Immunol Lett (1985) 0.86

Articles by these authors

Expression and function of idiotypes of lymphocytes. Adv Immunol (1978) 4.16

Monoclonal antibodies specific for the outer surface protein A (OspA) of Borrelia burgdorferi prevent Lyme borreliosis in severe combined immunodeficiency (scid) mice. Proc Natl Acad Sci U S A (1990) 4.15

Alternative metabolic states in murine macrophages reflected by the nitric oxide synthase/arginase balance: competitive regulation by CD4+ T cells correlates with Th1/Th2 phenotype. J Immunol (1998) 3.98

A recombinant 64 kilodalton protein of Mycobacterium bovis bacillus Calmette-Guerin specifically stimulates human T4 clones reactive to mycobacterial antigens. J Exp Med (1986) 3.92

Th1/Th2-regulated expression of arginase isoforms in murine macrophages and dendritic cells. J Immunol (1999) 3.68

Reciprocal regulation of the nitric oxide synthase/arginase balance in mouse bone marrow-derived macrophages by TH1 and TH2 cytokines. Eur J Immunol (1995) 3.17

The inheritance of individual antigenic specificities of rabbit antibodies to streptococcal carbohydrates. J Exp Med (1971) 3.17

Idiotype suppression. I. Influence of the dose and of the effector functions of anti-idiotypic antibody on the production of an idiotype. Eur J Immunol (1974) 2.90

Murine macrophages secrete interferon gamma upon combined stimulation with interleukin (IL)-12 and IL-18: A novel pathway of autocrine macrophage activation. J Exp Med (1998) 2.89

Idiotype suppression. II. Amplification of a suppressor T cell with anti-idiotypic activity. Eur J Immunol (1975) 2.59

Antigen receptors of T helper cells. Contemp Top Immunobiol (1977) 2.54

Idiotypic identity of antibodies to streptococcal carbohydrate in inbred mice. Eur J Immunol (1972) 2.52

Recognition of idiotypes in lymphocyte interactions. II. Antigen-independent cooperation between T and B lymphocytes that possess similar and complementary idiotypes. Eur J Immunol (1978) 2.47

Idiotype expression and the inheritance of mouse antibody clones. J Exp Med (1973) 2.45

Enumeration of T cells reactive with Mycobacterium tuberculosis organisms and specific for the recombinant mycobacterial 64-kDa protein. Eur J Immunol (1987) 2.45

Lyme borreliosis in the severe combined immunodeficiency (scid) mouse manifests predominantly in the joints, heart, and liver. Am J Pathol (1990) 2.15

A giant protease with potential to substitute for some functions of the proteasome. Science (1999) 2.08

Restoration of early thymocyte differentiation in T-cell receptor beta-chain-deficient mutant mice by transmembrane signaling through CD3 epsilon. Proc Natl Acad Sci U S A (1993) 2.06

Idiotypic analysis of lymphocytes in vitro. I. Specificity and heterogeneity of B and T lymphocytes reactive with anti-idiotypic antibody. J Exp Med (1976) 2.05

Recognition of idiotypes in lymphocyte interactions. I. Idiotypic selectivity in the cooperation between T and B lymphocytes. Eur J Immunol (1978) 2.05

Interleukin-6 in synovial fluid is closely associated with chronic synovitis in rheumatoid arthritis. Rheumatol Int (1993) 1.96

Arginase induction by suppressors of nitric oxide synthesis (IL-4, IL-10 and PGE2) in murine bone-marrow-derived macrophages. Biochem Biophys Res Commun (1995) 1.89

Absolute frequencies of lipopolysaccharide-reactive B cells producing A5A idiotype in unprimed, streptococcal A carbohydrate-primed, anti-A5A idiotype-sensitized and anti-A5A idiotype-suppressed A/J mice. J Exp Med (1977) 1.80

Rabbit antibodies to streptococcal carbohydrates. Influence of primary and secondary immunization and of possible genetic factors on the antibody response. J Exp Med (1969) 1.77

Relationships between relative binding affinity and electrophoretic behavior of rabbit antibodies to streptococcal carbohydrates. J Exp Med (1971) 1.72

Idiotypic analysis of lymphocytes in vitro. II. Genetic control of T-helper cell responsiveness to anti-idiotypic antibody. J Exp Med (1976) 1.71

Induction of rabbit antibody with molecular uniformity after immunization with group C streptococci. J Exp Med (1970) 1.71

Plasmid-encoded outer membrane protein YadA mediates specific binding of enteropathogenic yersiniae to various types of collagen. Infect Immun (1992) 1.68

Frequencies of CD4+ T cells reactive with Plasmodium chabaudi chabaudi: distinct response kinetics for cells with Th1 and Th2 characteristics during infection. Int Immunol (1989) 1.68

The product of the Herpesvirus saimiri open reading frame 1 (tip) interacts with T cell-specific kinase p56lck in transformed cells. J Biol Chem (1995) 1.65

Isolation and characterization of rheumatoid arthritis synovial fibroblasts from primary culture--primary culture cells markedly differ from fourth-passage cells. Arthritis Res (2000) 1.62

Amelioration of rat experimental arthritides by treatment with the alkaloid sinomenine. Int J Immunopharmacol (1996) 1.61

On the structure of the T-cell receptor for antigen. Cold Spring Harb Symp Quant Biol (1977) 1.60

Contribution of proteasome-mediated proteolysis to the hierarchy of epitopes presented by major histocompatibility complex class I molecules. Immunity (1995) 1.59

Apoptotic cell death in activated monocytes following incorporation of clodronate-liposomes. J Leukoc Biol (1996) 1.57

T cell receptor idiotypes are controlled by genes in the heavy chain linkage group and the major histocompatibility complex. Nature (1978) 1.51

Correlated expression of VH framework and VH idiotypic determinants on T helper cells and on functionally undefined T cells binding group A streptococcal carbohydrate. Eur J Immunol (1980) 1.50

Rabbit antibody light chains and gene evolution. Nature (1970) 1.48

Treatment of rheumatoid arthritis with an anti-CD4 monoclonal antibody. Arthritis Rheum (1991) 1.45

Effective activation of resting mouse T lymphocytes by cross-linking submitogenic concentrations of the T cell antigen receptor with either Lyt-2 or L3T4. Eur J Immunol (1987) 1.43

Outer membrane protein YadA of enteropathogenic yersiniae mediates specific binding to cellular but not plasma fibronectin. Infect Immun (1993) 1.41

Quantitative studies on T cell diversity. I. Determination of the precursor frequencies for two types of streptococcus A-specific helper cells in nonimmune, polyclonally activated splenic T cells. J Exp Med (1980) 1.39

Roles of CD4- and CD8-bearing T lymphocytes in the immune response to the erythrocytic stages of Plasmodium chabaudi. Infect Immun (1988) 1.38

Mendelian segregation of a mouse antibody idiotype. Eur J Immunol (1973) 1.37

The duration of nuclear residence of NFAT determines the pattern of cytokine expression in human SCID T cells. J Immunol (2000) 1.32

The emergence of antibodies with either identical or unrelated individual antigenic specificity during repeated immunizations with streptococcal vaccines. J Exp Med (1970) 1.30

Human peripheral blood gamma delta T cells respond to antigens of Plasmodium falciparum. Int Immunol (1992) 1.28

Quantitative studies on T cell diversity. II. Determination of the frequencies and Lyt phenotypes of two types of precursor cells for alloreactive cytotoxic T cells in polyclonally and specifically activated splenic T cells. J Exp Med (1981) 1.28

Cytomegalovirus infection in transplant recipients. The role of tumor necrosis factor. Transplantation (1994) 1.27

Receptors and signals in early thymic selection. Immunity (1995) 1.26

Idiotype suppression. III. Induction of unresponsiveness to sensitization with anti-idiotypic antibody: identification of the cell types tolerized in high zone and in low zone, suppressor cell-mediated, idiotype suppression. Eur J Immunol (1978) 1.24

Cross-linking of the T cell receptor complex with the subset-specific differentiation antigen stimulates interleukin 2 receptor expression in human CD4 and CD8 T cells. Eur J Immunol (1987) 1.23

Mass changes of inositol 1,3,4,5,6-pentakisphosphate and inositol hexakisphosphate during cell cycle progression in rat thymocytes. J Biol Chem (1993) 1.21

Influence of genetic factors on the magnitude and the heterogeneity of the immune response in the rabbit. J Exp Med (1971) 1.19

Regulation of thymocyte development through CD3. I. Timepoint of ligation of CD3 epsilon determines clonal deletion or induction of developmental program. J Exp Med (1993) 1.15

The proteolytic fragments generated by vertebrate proteasomes: structural relationships to major histocompatibility complex class I binding peptides. Proc Natl Acad Sci U S A (1996) 1.15

Intracellular Ca2+ pools in Jurkat T-lymphocytes. Biochem J (1993) 1.15

Genetics of the idotype of BALB/c myeloma S117: multiple chromosomal loci for Vh genes encoding specificity for group A streptococcal carbohydrate. J Exp Med (1976) 1.15

Allotype exclusion in uniform rabbit antibody to streptococcal carbohydrate. J Exp Med (1970) 1.14

A novel multispecific competitor fragment for quantitative PCR analysis of cytokine gene expression in rats. J Immunol Methods (1994) 1.14

First- and second-line anti-tuberculosis drug resistance in Northwest Ethiopia. Int J Tuberc Lung Dis (2012) 1.11

The response of CD4+ T cells to Plasmodium chabaudi chabaudi. Immunol Rev (1989) 1.11

T-cell receptor-mediated metabolism of inositol polyphosphates in Jurkat T-lymphocytes. Identification of a D-myo-inositol 1,2,3,4,6-pentakisphosphate-2-phosphomonoesterase activity, a D-myo-inositol 1,3,4,5,6-pentakisphosphate-1/3-phosphatase activity and a D/L-myo-inositol 1,2,4,5,6-pentakisphosphate-1/3-kinase activity. J Biol Chem (1991) 1.10

Immortalization of human T cell clones by Herpesvirus saimiri. Signal transduction analysis reveals functional CD3, CD4, and IL-2 receptors. J Immunol (1993) 1.10

Reduction of monocyte-macrophage activation markers upon anti-CD4 treatment. Decreased levels of IL-1, IL-6, neopterin and soluble CD14 in patients with rheumatoid arthritis. Clin Exp Immunol (1993) 1.08

Aged murine killer T-cell clones acquire specific cytotoxicity for P815 mastocytoma cells. Nature (1984) 1.08

Vaccination against the intracellular bacterium Listeria monocytogenes with a clonotypic antiserum. J Immunol (1985) 1.07

The specificity of proteasomes: impact on MHC class I processing and presentation of antigens. Immunol Rev (1999) 1.07

T cell subsets participating in the generation of cytotoxic T cells. Springer Semin Immunopathol (1980) 1.07

Biased T cell receptor V alpha region repertoire in the synovial fluid of rheumatoid arthritis patients. Eur J Immunol (1991) 1.07

T-cells in the pathogenesis of rheumatoid arthritis villains or accomplices? Biochim Biophys Acta (1997) 1.06

Human macrophage maturation and heterogeneity: analysis with a newly generated set of monoclonal antibodies to differentiation antigens. Blood (1986) 1.06

Allotype-linked genetic control of a polymorphic VH framework framework determinant on mouse T-helper cell receptors. Nature (1980) 1.06

Regulation of thymocyte development through CD3: functional dissociation between p56lck and CD3 sigma in early thymic selection. Immunity (1995) 1.05

Sanglifehrin A, a novel cyclophilin-binding compound showing immunosuppressive activity with a new mechanism of action. J Immunol (2001) 1.05

Age-dependent levels of select immunological mediators in sera of healthy children. Clin Diagn Lab Immunol (1998) 1.05

Detection of multiple viral DNA species in synovial tissue and fluid of patients with early arthritis. Ann Rheum Dis (2000) 1.05

Regulation of thymocyte development through CD3. II. Expression of T cell receptor beta CD3 epsilon and maturation to the CD4+8+ stage are highly correlated in individual thymocytes. J Exp Med (1993) 1.04

Regulation of T cell receptor (TCR)-beta locus allelic exclusion and initiation of TCR-alpha locus rearrangement in immature thymocytes by signaling through the CD3 complex. Eur J Immunol (1995) 1.04

Interaction of enteropathogenic Yersinia enterocolitica with complex basement membranes and the extracellular matrix proteins collagen type IV, laminin-1 and -2, and nidogen/entactin. J Biol Chem (1994) 1.03

Preferential expression of a defined T-cell receptor beta-chain gene in hapten-specific cytotoxic T-cell clones. Nature (1986) 1.03

Activation of synovial fibroblasts in rheumatoid arthritis. Ann Rheum Dis (1995) 1.03

Depletion of gamma/delta T cells does not prevent or ameliorate, but rather aggravates, rat adjuvant arthritis. Arthritis Rheum (1996) 1.02

Vascular endothelial growth factor in pleural effusions of different origin. Eur Respir J (2005) 1.02

Complement activation, cytokines, and adhesion molecules in children undergoing cardiac surgery with or without cardiopulmonary bypass. Pediatr Cardiol (1999) 1.01

Quantitative studies on T cell diversity. III. Limiting dilution analysis of precursor cells for T helper cells reactive to xenogeneic erythrocytes. J Exp Med (1982) 1.01

Suppression and prevention of adjuvant arthritis in rats by a monoclonal antibody to the alpha/beta T cell receptor. Eur J Immunol (1990) 1.01

Cytotoxic T lymphocyte epitopes of HIV-1 Nef: Generation of multiple definitive major histocompatibility complex class I ligands by proteasomes. J Exp Med (2000) 1.01

Potential immunocompetence of proteolytic fragments produced by proteasomes before evolution of the vertebrate immune system. J Exp Med (1997) 1.00

Biochemical evidence of the physical association of the majority of CD3 delta chains with the accessory/co-receptor molecules CD4 and CD8 on nonactivated T lymphocytes. Eur J Immunol (1992) 0.99

Predominant utilization of V beta 8+ T cell receptor genes in the H-2Ld-restricted cytotoxic T cell response against the immediate-early protein pp89 of the murine cytomegalovirus. J Immunol (1989) 0.99

Long-term amelioration of rat adjuvant arthritis following systemic elimination of macrophages by clodronate-containing liposomes. Arthritis Rheum (1995) 0.99

Quantitative studies on T cell diversity. IV. Mathematical analysis of multiple limiting populations of effector and suppressor T cells. J Exp Med (1983) 0.99

Antigen receptors on major histocompatibility complex-restricted T lymphocytes. I. Preparation and characterization of syngeneic antisera against trinitrophenyl-activated T cell blasts and demonstration of their specificity for idiotypes on cytotoxic T lymphocytes. J Exp Med (1980) 0.98

Frequencies and regulation of trinitrophenyl-specific cytotoxic T precursor cells: immunization results in release from suppression. J Immunol (1983) 0.98

Expression of activation antigens on T cells in rheumatoid arthritis patients. Scand J Immunol (1990) 0.98

Characterization of cyclic adenosine diphosphate-ribose-induced Ca2+ release in T lymphocyte cell lines. J Immunol (1995) 0.98

In vitro generation of lymphoid precursors from embryonic stem cells. EMBO J (1994) 0.97