Published in Biochem Pharmacol on July 01, 1988
Chelerythrine is a potent and specific inhibitor of protein kinase C. Biochem Biophys Res Commun (1990) 4.46
Binding properties of a selective tritiated vasopressin V2 receptor antagonist, [H]-SR 121463. Kidney Int (2000) 4.43
Arterial thrombosis, intrauterine death and "lupus" antiocoagulant: detection of immunoglobulin interfering with prostacyclin formation. Lancet (1981) 2.81
A role for phosphoinositide 3-kinase in bacterial invasion. Science (1996) 2.46
Identification and biological activity of the active metabolite of clopidogrel. Thromb Haemost (2000) 2.45
The cannabinoid CB1 receptor antagonist SR141716 increases Acrp30 mRNA expression in adipose tissue of obese fa/fa rats and in cultured adipocyte cells. Mol Pharmacol (2003) 2.12
The antiaggregating activity of clopidogrel is due to a metabolic activation by the hepatic cytochrome P450-1A. Thromb Haemost (1994) 2.05
Secretory phospholipase A2 generates the novel lipid mediator lysophosphatidic acid in membrane microvesicles shed from activated cells. Cell (1995) 1.99
The 100-kDa neurotensin receptor is gp95/sortilin, a non-G-protein-coupled receptor. J Biol Chem (1998) 1.84
Thromboxane synthetase inhibition as antithrombotic strategy. Lancet (1981) 1.82
Relationship between flavonoid structure and inhibition of phosphatidylinositol 3-kinase: a comparison with tyrosine kinase and protein kinase C inhibition. Biochem Pharmacol (1997) 1.64
Integrin-dependent translocation of phosphoinositide 3-kinase to the cytoskeleton of thrombin-activated platelets involves specific interactions of p85 alpha with actin filaments and focal adhesion kinase. J Cell Biol (1995) 1.57
Importance of hepatic metabolism in the antiaggregating activity of the thienopyridine clopidogrel. Biochem Pharmacol (1992) 1.56
Phosphatidic and lysophosphatidic acid production in phospholipase C-and thrombin-treated platelets. Possible involvement of a platelet lipase. Biochimie (1978) 1.56
A critical role for phosphoinositide 3-kinase upstream of Gab1 and SHP2 in the activation of ras and mitogen-activated protein kinases by epidermal growth factor. J Biol Chem (2000) 1.56
A genetic defect in phosphatidylcholine biosynthesis triggers apoptosis in Chinese hamster ovary cells. J Biol Chem (1996) 1.52
A simple and highly sensitive radioenzymatic assay for lysophosphatidic acid quantification. J Lipid Res (2000) 1.42
Interaction of pp60c-src, phospholipase C, inositol-lipid, and diacyglycerol kinases with the cytoskeletons of thrombin-stimulated platelets. J Biol Chem (1991) 1.37
An inherited bleeding disorder linked to a defective interaction between ADP and its receptor on platelets. Its influence on glycoprotein IIb-IIIa complex function. J Clin Invest (1995) 1.33
Biochemical and pharmacological properties of SR 49059, a new, potent, nonpeptide antagonist of rat and human vasopressin V1a receptors. J Clin Invest (1993) 1.28
Characterization of SR 121463A, a highly potent and selective, orally active vasopressin V2 receptor antagonist. J Clin Invest (1996) 1.28
Clopidogrel is more effective than aspirin as adjuvant treatment to prevent reocclusion after thrombolysis. Am J Physiol (1994) 1.27
Lysophosphatidic acid-induced Ca2+ mobilization in human A431 cells: structure-activity analysis. Biochem J (1995) 1.26
Lysophosphatidic acid as a phospholipid mediator: pathways of synthesis. FEBS Lett (1997) 1.25
Characterization of specific binding sites for [3H]-staurosporine on various protein kinases. Biochem Biophys Res Commun (1990) 1.24
Plasma 6-keto-PGF1 alpha levels after plasma exchange in thrombotic thrombocytopenic purpura. Lancet (1980) 1.19
In vitro functional evidence of neuronal cannabinoid CB1 receptors in human ileum. Br J Pharmacol (1998) 1.18
The antiaggregating and antithrombotic activity of ticlopidine is potentiated by aspirin in the rat. Thromb Haemost (1996) 1.17
Sphingomyelinases and Niemann-Pick disease. J Clin Chem Clin Biochem (1986) 1.16
Potential involvement of adipocyte insulin resistance in obesity-associated up-regulation of adipocyte lysophospholipase D/autotaxin expression. Diabetologia (2005) 1.15
Biosynthetic labelling of platelet activating factor from radioactive acetate by stimulated platelets. Nature (1981) 1.15
Lipid products of phosphoinositide 3-kinase interact with Rac1 GTPase and stimulate GDP dissociation. J Biol Chem (1998) 1.15
Purification and characterization of the human SR 31747A-binding protein. A nuclear membrane protein related to yeast sterol isomerase. J Biol Chem (1997) 1.13
A thromboxane synthetase inhibitor reorients endoperoxide metabolism in whole blood towards prostacyclin and prostaglandin E2. Thromb Res (1982) 1.12
Biochemical and pharmacological activities of SR 142948A, a new potent neurotensin receptor antagonist. J Pharmacol Exp Ther (1997) 1.12
Flavonoids and the inhibition of PKC and PI 3-kinase. Gen Pharmacol (1999) 1.12
Studies on ether phospholipids. II. Comparative composition of various tissues from human, rat and guinea pig. Biochim Biophys Acta (1984) 1.11
Phosphatidylinositol 3,4,5-trisphosphate-dependent stimulation of phospholipase C-gamma2 is an early key event in FcgammaRIIA-mediated activation of human platelets. J Biol Chem (1998) 1.10
Lysophosphatidic acid synthesis and release. Prostaglandins Other Lipid Mediat (2001) 1.09
Hepatic lipase induces the formation of pre-beta 1 high density lipoprotein (HDL) from triacylglycerol-rich HDL2. A study comparing liver perfusion to in vitro incubation with lipases. J Biol Chem (1994) 1.09
Platelet membrane phospholipid asymmetry: from the characterization of a scramblase activity to the identification of an essential protein mutated in Scott syndrome. J Thromb Haemost (2011) 1.08
Effects of lysophosphatidic acid on proliferation and cytosolic Ca++ of human adult vascular smooth muscle cells in culture. Thromb Res (1999) 1.07
Relationship between phosphoinositide kinase activities and protein tyrosine phosphorylation in plasma membranes from A431 cells. Biochem J (1990) 1.06
Involvement of platelet glycoprotein IIb-IIIa (alpha IIb-beta 3 integrin) in thrombin-induced synthesis of phosphatidylinositol 3',4'-bisphosphate. J Biol Chem (1991) 1.06
Human platelet aggregation induced by 1-alkyl-lysophosphatidic acid and its analogs: a new group of phospholipid mediators? Biochem Biophys Res Commun (1982) 1.05
An epidermal growth factor receptor/Gab1 signaling pathway is required for activation of phosphoinositide 3-kinase by lysophosphatidic acid. J Biol Chem (1999) 1.05
Production of phosphatidylinositol 3,4,5-trisphosphate and phosphatidic acid in platelet rafts: evidence for a critical role of cholesterol-enriched domains in human platelet activation. Biochemistry (2001) 1.05
Characterization and properties of a phosphatidylinositol phosphodiesterase (phospholipase C) from platelet cytosol. FEBS Lett (1979) 1.04
The reaction of nitrogen monoxide and of nitrite with deoxyhaemocyanin and methaemocyanin of Helix pomatia. Eur J Biochem (1979) 1.04
Phosphatidylinositol 3-kinase inhibitors block aortic smooth muscle cell proliferation in mid-late G1 phase: effect on cyclin-dependent kinase 2 and the inhibitory protein p27KIP1. Biochem Biophys Res Commun (1998) 1.03
Tyrosine phosphorylation and relocation of SHIP are integrin-mediated in thrombin-stimulated human blood platelets. J Biol Chem (1997) 1.00
The novel inositol lipid phosphatidylinositol 3,4-bisphosphate is produced by human blood platelets upon thrombin stimulation. Biochem J (1990) 1.00
An interaction between apo C-III variants and protease inhibitors contributes to high triglyceride/low HDL levels in treated HIV patients. AIDS (2001) 0.99
ADP receptor induced activation of guanine nucleotide binding proteins in rat platelet membranes--an effect selectively blocked by the thienopyridine clopidogrel. Thromb Haemost (1992) 0.99
Biochemical characterization of plasma membranes and intracellular membranes isolated from human platelets using Percoll gradients. Biochim Biophys Acta (1986) 0.99
Ultraviolet-treated lipoproteins as a model system for the study of the biological effects of lipid peroxides on cultured cells. II. Uptake and cytotoxicity of ultraviolet-treated LDL on lymphoid cell lines. Biochim Biophys Acta (1990) 0.98
Cytidylyltransferase translocation onto endoplasmic reticulum and increased de novo synthesis without phosphatidylcholine accumulation in Krebs-II ascite cells. Biochim Biophys Acta (1991) 0.97
Role of tachykinins in castor oil diarrhoea in rats. Br J Pharmacol (1997) 0.97
Platelet activating factor (PAF-acether) promotes an early degradation of phosphatidylinositol-4,5-biphosphate in rabbit platelets. FEBS Lett (1983) 0.97
Isolation and characterization of plasma membranes from krebs II ascite cells using Percoll gradient. Biochim Biophys Acta (1982) 0.97
Peripheral biological activity of SR 27897: a new potent non-peptide antagonist of CCKA receptors. Eur J Pharmacol (1993) 0.97
Ticlopidine and clopidogrel (SR 25990C) selectively neutralize ADP inhibition of PGE1-activated platelet adenylate cyclase in rats and rabbits. Thromb Haemost (1991) 0.97
The integrin alpha IIb/beta 3 in human platelet signal transduction. Biochem Pharmacol (2000) 0.97
Differential activation by fMet-Leu-Phe and phorbol ester of a plasma membrane phosphatidylcholine-specific phospholipase D in human neutrophil. FEBS Lett (1989) 0.96
Phosphatidylcholine cycle and regulation of phosphatidylcholine biosynthesis by enzyme translocation. Biochim Biophys Acta (1994) 0.96
Endothelin action in rat liver. Receptors, free Ca2+ oscillations, and activation of glycogenolysis. J Clin Invest (1991) 0.96
Neurotensin is an antagonist of the human neurotensin NT2 receptor expressed in Chinese hamster ovary cells. Eur J Pharmacol (1998) 0.95
[CMP-aminoethylphosphonate: intermediary in the phosphonolipids of the rat liver]. Biochimie (1973) 0.95
Verbascoside isolated from Lantana camara, an inhibitor of protein kinase C. J Nat Prod (1992) 0.95
Functional assessment of neuronal cannabinoid receptors in the muscular layers of human ileum and colon. Dig Liver Dis (2002) 0.94
Characterization and localization of leptin receptors in the rat kidney. FEBS Lett (1997) 0.94
Binding of [3H]-2-methylthio ADP to rat platelets--effect of clopidogrel and ticlopidine. J Pharmacol Exp Ther (1994) 0.93
Familial bleeding tendency with partial platelet thromboxane synthetase deficiency: reorientation of cyclic endoperoxide metabolism. Br J Haematol (1981) 0.93
Structure-activity analysis of the effects of lysophosphatidic acid on platelet aggregation. Biochemistry (1999) 0.92
Identification and quantification of diacylglycerols in HDL and accessibility to lipase. J Lipid Res (1996) 0.92
Hepatic lipase promotes the uptake of HDL esterified cholesterol by the perfused rat liver: a study using reconstituted HDL particles of defined phospholipid composition. J Lipid Res (1994) 0.92
In vitro characterization of tachykinin NK2-receptors modulating motor responses of human colonic muscle strips. Br J Pharmacol (1998) 0.92