Borrelia burgdorferi erp proteins are immunogenic in mammals infected by tick bite, and their synthesis is inducible in cultured bacteria.

PubWeight™: 2.67‹?› | Rank: Top 1%

🔗 View Article (PMC 108251)

Published in Infect Immun on June 01, 1998

Authors

B Stevenson1, J L Bono, T G Schwan, P Rosa

Author Affiliations

1: Laboratory of Microbial Structure and Function, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840, USA. lkspic00@pop.uky.edu

Articles citing this

Clonal polymorphism of Borrelia burgdorferi strain B31 MI: implications for mutagenesis in an infectious strain background. Infect Immun (2002) 3.65

Profiling of temperature-induced changes in Borrelia burgdorferi gene expression by using whole genome arrays. Infect Immun (2003) 3.19

Efficient targeted mutagenesis in Borrelia burgdorferi. J Bacteriol (2000) 2.89

Differential binding of host complement inhibitor factor H by Borrelia burgdorferi Erp surface proteins: a possible mechanism underlying the expansive host range of Lyme disease spirochetes. Infect Immun (2002) 2.44

Bacterial genome adaptation to niches: divergence of the potential virulence genes in three Burkholderia species of different survival strategies. BMC Genomics (2005) 2.34

Spirochaetal lipoproteins and pathogenesis. Microbiology (2000) 2.30

Essential protective role attributed to the surface lipoproteins of Borrelia burgdorferi against innate defences. Mol Microbiol (2008) 2.23

Identification, characterization, and expression of three new members of the Borrelia burgdorferi Mlp (2.9) lipoprotein gene family. Infect Immun (1999) 2.18

A genome-wide proteome array reveals a limited set of immunogens in natural infections of humans and white-footed mice with Borrelia burgdorferi. Infect Immun (2008) 2.15

Further characterization of complement regulator-acquiring surface proteins of Borrelia burgdorferi. Infect Immun (2001) 2.02

RpoS is not central to the general stress response in Borrelia burgdorferi but does control expression of one or more essential virulence determinants. Infect Immun (2004) 1.94

Outer membrane proteins of pathogenic spirochetes. FEMS Microbiol Rev (2004) 1.87

Comprehensive analysis of the factor h binding capabilities of borrelia species associated with lyme disease: delineation of two distinct classes of factor h binding proteins. Infect Immun (2003) 1.86

Vector interactions and molecular adaptations of lyme disease and relapsing fever spirochetes associated with transmission by ticks. Emerg Infect Dis (2002) 1.86

Borrelia burgdorferi population dynamics and prototype gene expression during infection of immunocompetent and immunodeficient mice. Infect Immun (2003) 1.82

Borrelia burgdorferi population kinetics and selected gene expression at the host-vector interface. Infect Immun (2002) 1.76

Mutation and recombination in the upstream homology box-flanked ospE-related genes of the Lyme disease spirochetes result in the development of new antigenic variants during infection. Infect Immun (2000) 1.75

Regulation of OspE-related, OspF-related, and Elp lipoproteins of Borrelia burgdorferi strain 297 by mammalian host-specific signals. Infect Immun (2001) 1.73

Changes in temporal and spatial patterns of outer surface lipoprotein expression generate population heterogeneity and antigenic diversity in the Lyme disease spirochete, Borrelia burgdorferi. Infect Immun (2002) 1.65

Borrelia burgdorferi gene expression in vivo and spirochete pathogenicity. Infect Immun (2000) 1.53

Borrelia burgdorferi in tick cell culture modulates expression of outer surface proteins A and C in response to temperature. J Clin Microbiol (1999) 1.49

Borrelia burgdorferi proteins whose expression is similarly affected by culture temperature and pH. Infect Immun (2001) 1.49

Serologic proteome analysis of Borrelia burgdorferi membrane-associated proteins. Infect Immun (2006) 1.48

Analysis of mechanisms associated with loss of infectivity of clonal populations of Borrelia burgdorferi B31MI. Infect Immun (2001) 1.41

OspE-related, OspF-related, and Elp lipoproteins are immunogenic in baboons experimentally infected with Borrelia burgdorferi and in human lyme disease patients. J Clin Microbiol (2002) 1.41

Comparative analysis and immunological characterization of the Borrelia Bdr protein family. Infect Immun (1999) 1.40

Molecular and evolutionary characterization of the cp32/18 family of supercoiled plasmids in Borrelia burgdorferi 297. Infect Immun (2000) 1.38

Lyme arthritis resolution with antiserum to a 37-kilodalton Borrelia burgdorferi protein. Infect Immun (2000) 1.36

Analysis of promoter elements involved in the transcriptional initiation of RpoS-dependent Borrelia burgdorferi genes. J Bacteriol (2004) 1.35

Intra- and interbacterial genetic exchange of Lyme disease spirochete erp genes generates sequence identity amidst diversity. J Mol Evol (2003) 1.34

Linear and circular plasmid content in Borrelia burgdorferi clinical isolates. Infect Immun (2003) 1.33

Temporal analysis of Borrelia burgdorferi Erp protein expression throughout the mammal-tick infectious cycle. Infect Immun (2003) 1.29

Distribution of twelve linear extrachromosomal DNAs in natural isolates of Lyme disease spirochetes. J Bacteriol (2000) 1.28

Borrelia burgdorferi infection-associated surface proteins ErpP, ErpA, and ErpC bind human plasminogen. Infect Immun (2008) 1.27

Molecular characterization of Borrelia burgdorferi erp promoter/operator elements. J Bacteriol (2004) 1.26

Cloning and molecular characterization of plasmid-encoded antigens of Borrelia burgdorferi. Infect Immun (1999) 1.26

Demonstration of the genetic stability and temporal expression of select members of the lyme disease spirochete OspF protein family during infection in mice. Infect Immun (2001) 1.25

Distinct regulatory pathways control expression of Borrelia burgdorferi infection-associated OspC and Erp surface proteins. Infect Immun (2001) 1.21

Borrelia burgdorferi RevA antigen binds host fibronectin. Infect Immun (2009) 1.21

Influence of cultivation media on genetic regulatory patterns in Borrelia burgdorferi. Infect Immun (2001) 1.20

LuxS-mediated quorum sensing in Borrelia burgdorferi, the lyme disease spirochete. Infect Immun (2002) 1.17

The role of Borrelia burgdorferi outer surface proteins. FEMS Immunol Med Microbiol (2012) 1.16

Stability of erp loci during Borrelia burgdorferi infection: recombination is not required for chronic infection of immunocompetent mice. Infect Immun (1999) 1.15

Borrelia burgdorferi bba74 is expressed exclusively during tick feeding and is regulated by both arthropod- and mammalian host-specific signals. J Bacteriol (2009) 1.14

A second allele of eppA in Borrelia burgdorferi strain B31 is located on the previously undetected circular plasmid cp9-2. J Bacteriol (2000) 1.13

Expression and immunological analysis of the plasmid-borne mlp genes of Borrelia burgdorferi strain B31. Infect Immun (2000) 1.13

Borrelia burgdorferi RevA antigen is a surface-exposed outer membrane protein whose expression is regulated in response to environmental temperature and pH. Infect Immun (2001) 1.13

Selective binding of Borrelia burgdorferi OspE paralogs to factor H and serum proteins from diverse animals: possible expansion of the role of OspE in Lyme disease pathogenesis. Infect Immun (2006) 1.11

The relapsing fever spirochete Borrelia hermsii contains multiple, antigen-encoding circular plasmids that are homologous to the cp32 plasmids of Lyme disease spirochetes. Infect Immun (2000) 1.10

Temporal expression analysis of the Borrelia burgdorferi paralogous gene family 54 genes BBA64, BBA65, and BBA66 during persistent infection in mice. Infect Immun (2007) 1.07

Complement regulator-acquiring surface proteins of Borrelia burgdorferi: Structure, function and regulation of gene expression. Ticks Tick Borne Dis (2012) 1.05

Characterization of Borrelia burgdorferi BlyA and BlyB proteins: a prophage-encoded holin-like system. J Bacteriol (2000) 1.05

Borrelia burgdorferi B31 Erp proteins that are dominant immunoblot antigens of animals infected with isolate B31 are recognized by only a subset of human lyme disease patient sera. J Clin Microbiol (2000) 1.04

Evolving models of Lyme disease spirochete gene regulation. Wien Klin Wochenschr (2006) 1.02

Simultaneous coexpression of Borrelia burgdorferi Erp proteins occurs through a specific, erp locus-directed regulatory mechanism. J Bacteriol (2002) 1.01

Borrelia burgdorferi EbfC, a novel, chromosomally encoded protein, binds specific DNA sequences adjacent to erp loci on the spirochete's resident cp32 prophages. J Bacteriol (2006) 1.01

Lyme borreliosis spirochete Erp proteins, their known host ligands, and potential roles in mammalian infection. Int J Med Microbiol (2008) 1.00

Borrelia burgdorferi complement regulator-acquiring surface proteins (BbCRASPs): Expression patterns during the mammal-tick infection cycle. Int J Med Microbiol (2007) 0.99

Borrelia burgdorferi regulates expression of complement regulator-acquiring surface protein 1 during the mammal-tick infection cycle. Infect Immun (2005) 0.98

Borrelia burgdorferi and Treponema pallidum: a comparison of functional genomics, environmental adaptations, and pathogenic mechanisms. J Clin Invest (2001) 0.98

Transformation of the Lyme disease spirochete Borrelia burgdorferi with heterologous DNA. J Bacteriol (1998) 0.97

Borrelia burgdorferi enolase is a surface-exposed plasminogen binding protein. PLoS One (2011) 0.96

Transcriptional regulation of the Borrelia burgdorferi antigenically variable VlsE surface protein. J Bacteriol (2006) 0.96

Changes in bacterial growth rate govern expression of the Borrelia burgdorferi OspC and Erp infection-associated surface proteins. J Bacteriol (2012) 0.95

Borrelia burgdorferi-induced inflammation facilitates spirochete adaptation and variable major protein-like sequence locus recombination. J Immunol (2001) 0.95

BpaB, a novel protein encoded by the Lyme disease spirochete's cp32 prophages, binds to erp Operator 2 DNA. Nucleic Acids Res (2010) 0.92

The borrelial fibronectin-binding protein RevA is an early antigen of human Lyme disease. Clin Vaccine Immunol (2009) 0.91

EbfC (YbaB) is a new type of bacterial nucleoid-associated protein and a global regulator of gene expression in the Lyme disease spirochete. J Bacteriol (2012) 0.91

Analysis of the bmp gene family in Borrelia burgdorferi sensu lato. J Bacteriol (2000) 0.91

DNA-Binding proteins possibly involved in regulation of the post-logarithmic-phase expression of lipoprotein P35 in Borrelia burgdorferi. J Bacteriol (2000) 0.90

Complement factor H-related proteins CFHR2 and CFHR5 represent novel ligands for the infection-associated CRASP proteins of Borrelia burgdorferi. PLoS One (2010) 0.90

Functional characterization of Borrelia spielmanii outer surface proteins that interact with distinct members of the human factor H protein family and with plasminogen. Infect Immun (2009) 0.90

Recombinant BBK32 protein in serodiagnosis of early and late Lyme borreliosis. J Clin Microbiol (2002) 0.89

The OspE-related proteins inhibit complement deposition and enhance serum resistance of Borrelia burgdorferi, the lyme disease spirochete. Infect Immun (2011) 0.89

BpaB and EbfC DNA-binding proteins regulate production of the Lyme disease spirochete's infection-associated Erp surface proteins. J Bacteriol (2011) 0.88

Borrelia burgdorferi complement regulator-acquiring surface protein 2 (CspZ) as a serological marker of human Lyme disease. Clin Vaccine Immunol (2007) 0.88

Deletion of BBA64, BBA65, and BBA66 loci does not alter the infectivity of Borrelia burgdorferi in the murine model of Lyme disease. Infect Immun (2008) 0.86

Contribution of the infection-associated complement regulator-acquiring surface protein 4 (ErpC) to complement resistance of Borrelia burgdorferi. Clin Dev Immunol (2012) 0.86

Borrelia burgdorferi erp (ospE-related) gene sequences remain stable during mammalian infection. Infect Immun (2002) 0.84

Evidence that two ATP-dependent (Lon) proteases in Borrelia burgdorferi serve different functions. PLoS Pathog (2009) 0.82

Poultry Body Temperature Contributes to Invasion Control through Reduced Expression of Salmonella Pathogenicity Island 1 Genes in Salmonella enterica Serovars Typhimurium and Enteritidis. Appl Environ Microbiol (2015) 0.81

Distribution of cp32 prophages among Lyme disease-causing spirochetes and natural diversity of their lipoprotein-encoding erp loci. Appl Environ Microbiol (2013) 0.80

Bpur, the Lyme disease spirochete's PUR domain protein: identification as a transcriptional modulator and characterization of nucleic acid interactions. J Biol Chem (2013) 0.80

Development of a Multiantigen Panel for Improved Detection of Borrelia burgdorferi Infection in Early Lyme Disease. J Clin Microbiol (2015) 0.80

Stability of Borrelia burgdorferi bdr loci in vitro and in vivo. Infect Immun (2000) 0.79

Intracellular Concentrations of Borrelia burgdorferi Cyclic Di-AMP Are Not Changed by Altered Expression of the CdaA Synthase. PLoS One (2015) 0.77

Salmonella enterica serovar Typhimurium utilizes the ClpPX and Lon proteases for optimal fitness in the ceca of chickens. Poult Sci (2016) 0.75

Multifunctional and Redundant Roles of Borrelia burgdorferi Outer Surface Proteins in Tissue Adhesion, Colonization, and Complement Evasion. Front Immunol (2016) 0.75

RNA-Seq-based analysis of changes in Borrelia burgdorferi gene expression linked to pathogenicity. Parasit Vectors (2015) 0.75

Articles cited by this

Lyme disease-a tick-borne spirochetosis? Science (1982) 27.50

Genomic sequence of a Lyme disease spirochaete, Borrelia burgdorferi. Nature (1997) 19.08

Coordinate regulation and sensory transduction in the control of bacterial virulence. Science (1989) 10.59

Induction of an outer surface protein on Borrelia burgdorferi during tick feeding. Proc Natl Acad Sci U S A (1995) 9.93

Changes in infectivity and plasmid profile of the Lyme disease spirochete, Borrelia burgdorferi, as a result of in vitro cultivation. Infect Immun (1988) 6.64

Variable major proteins of Borrellia hermsii. J Exp Med (1982) 5.62

Borrelia burgdorferi OspA is an arthropod-specific transmission-blocking Lyme disease vaccine. J Exp Med (1996) 5.46

Plasmid analysis of Borrelia burgdorferi, the Lyme disease agent. J Clin Microbiol (1988) 4.83

Temperature-related differential expression of antigens in the Lyme disease spirochete, Borrelia burgdorferi. Infect Immun (1995) 4.68

Expression of the temperature-inducible outer membrane proteins of yersiniae. Infect Immun (1985) 4.36

Role of the Yersinia pestis hemin storage (hms) locus in the transmission of plague by fleas. Science (1996) 3.65

Outer surface proteins E and F of Borrelia burgdorferi, the agent of Lyme disease. Infect Immun (1994) 3.59

Molecular analysis and expression of a Borrelia burgdorferi gene encoding a 22 kDa protein (pC) in Escherichia coli. Mol Microbiol (1992) 3.45

Borrelia burgdorferi genes selectively expressed in the infected host. Proc Natl Acad Sci U S A (1995) 3.42

Plasminogen is required for efficient dissemination of B. burgdorferi in ticks and for enhancement of spirochetemia in mice. Cell (1997) 3.25

Analysis of supercoiled circular plasmids in infectious and non-infectious Borrelia burgdorferi. Microb Pathog (1990) 3.24

Growth and migration of Borrelia burgdorferi in Ixodes ticks during blood feeding. Am J Trop Med Hyg (1995) 3.04

Molecular cloning and immunological characterization of a novel linear-plasmid-encoded gene, pG, of Borrelia burgdorferi expressed only in vivo. Infect Immun (1995) 3.00

Dissemination and salivary delivery of Lyme disease spirochetes in vector ticks (Acari: Ixodidae). J Med Entomol (1987) 3.00

Evidence for in vivo but not in vitro expression of a Borrelia burgdorferi outer surface protein F (OspF) homologue. Mol Microbiol (1995) 2.92

Reactivity of human Lyme borreliosis sera with a 39-kilodalton antigen specific to Borrelia burgdorferi. J Clin Microbiol (1990) 2.87

Studies on gonococcus infection. XV. Identification of surface proteins of Neisseria gonorrhoeae correlated with leukocyte association. Infect Immun (1978) 2.62

Growth kinetics of the Lyme disease spirochete (Borrelia burgdorferi) in vector ticks (Ixodes dammini). Am J Trop Med Hyg (1990) 2.56

Partial destruction of Borrelia burgdorferi within ticks that engorged on OspE- or OspF-immunized mice. Infect Immun (1994) 2.42

Homology throughout the multiple 32-kilobase circular plasmids present in Lyme disease spirochetes. J Bacteriol (1997) 2.36

A family of genes located on four separate 32-kilobase circular plasmids in Borrelia burgdorferi B31. J Bacteriol (1996) 2.34

Antibody to a 39-kilodalton Borrelia burgdorferi antigen (P39) as a marker for infection in experimentally and naturally inoculated animals. J Clin Microbiol (1991) 2.32

Borrelia burgdorferi supercoiled plasmids encode multicopy tandem open reading frames and a lipoprotein gene family. J Bacteriol (1996) 2.14

Temporal pattern of Borrelia burgdorferi p21 expression in ticks and the mammalian host. J Clin Invest (1997) 2.13

Oligopeptide permease in Borrelia burgdorferi: putative peptide-binding components encoded by both chromosomal and plasmid loci. Microbiology (1998) 2.01

Correlation of plasmids with infectivity of Borrelia burgdorferi sensu stricto type strain B31. Infect Immun (1996) 2.01

The Borrelia burgdorferi circular plasmid cp26: conservation of plasmid structure and targeted inactivation of the ospC gene. Mol Microbiol (1997) 1.99

Adult Ixodes dammini on rabbits: a hypothesis for the development and transmission of Borrelia burgdorferi. J Infect Dis (1987) 1.91

Circular and linear plasmids of Lyme disease spirochetes have extensive homology: characterization of a repeated DNA element. J Bacteriol (1996) 1.87

Directed insertion of a selectable marker into a circular plasmid of Borrelia burgdorferi. J Bacteriol (1996) 1.78

Molecular and evolutionary analyses of a variable series of genes in Borrelia burgdorferi that are related to ospE and ospF, constitute a gene family, and share a common upstream homology box. J Bacteriol (1996) 1.69

Evidence of past recombination events among the genes encoding the Erp antigens of Borrelia burgdorferi. Microbiology (1998) 1.66

Colony formation and morphology in Borrelia burgdorferi. J Clin Microbiol (1987) 1.66

Expression of outer surface proteins A and C of Borrelia burgdorferi in Ixodes ricinus. J Clin Microbiol (1995) 1.60

Characterization of cp18, a naturally truncated member of the cp32 family of Borrelia burgdorferi plasmids. J Bacteriol (1997) 1.48

Membrane protein variations associated with in vitro passage of Borrelia burgdorferi. Infect Immun (1996) 1.37

Polymerase chain reaction with the 30-kb circular plasmid of Borrelia burgdorferi B31 as a target for detection of the Lyme borreliosis agents in cerebrospinal fluid. Res Microbiol (1993) 1.02

Long-term in vitro cultivation of Borrelia burgdorferi sensu lato strains: influence on plasmid patterns, genome stability and expression of proteins. Res Microbiol (1997) 0.99

Articles by these authors

A bacterial genome in flux: the twelve linear and nine circular extrachromosomal DNAs in an infectious isolate of the Lyme disease spirochete Borrelia burgdorferi. Mol Microbiol (2000) 7.60

Temperature-related differential expression of antigens in the Lyme disease spirochete, Borrelia burgdorferi. Infect Immun (1995) 4.68

Antigenic changes of Borrelia burgdorferi as a result of in vitro cultivation. J Infect Dis (1987) 3.66

Role of the Yersinia pestis hemin storage (hms) locus in the transmission of plague by fleas. Science (1996) 3.65

A specific and sensitive assay for the Lyme disease spirochete Borrelia burgdorferi using the polymerase chain reaction. J Infect Dis (1989) 3.53

Analysis of supercoiled circular plasmids in infectious and non-infectious Borrelia burgdorferi. Microb Pathog (1990) 3.24

Isolation of a circular plasmid region sufficient for autonomous replication and transformation of infectious Borrelia burgdorferi. Mol Microbiol (2001) 2.95

Effects of environmental pH on membrane proteins in Borrelia burgdorferi. Infect Immun (1999) 2.91

Efficient targeted mutagenesis in Borrelia burgdorferi. J Bacteriol (2000) 2.89

Reactivity of human Lyme borreliosis sera with a 39-kilodalton antigen specific to Borrelia burgdorferi. J Clin Microbiol (1990) 2.87

Polymerase chain reaction analyses identify two distinct classes of Borrelia burgdorferi. J Clin Microbiol (1991) 2.71

Secretogranins I and II: two tyrosine-sulfated secretory proteins common to a variety of cells secreting peptides by the regulated pathway. J Cell Biol (1985) 2.53

Rickettsia peacockii sp. nov., a new species infecting wood ticks, Dermacentor andersoni, in western Montana. Int J Syst Bacteriol (1997) 2.34

The primary structure of human secretogranin I (chromogranin B): comparison with chromogranin A reveals homologous terminal domains and a large intervening variable region. EMBO J (1987) 2.33

Antibody to a 39-kilodalton Borrelia burgdorferi antigen (P39) as a marker for infection in experimentally and naturally inoculated animals. J Clin Microbiol (1991) 2.32

Borrelia burgdorferi periplasmic flagella have both skeletal and motility functions. Proc Natl Acad Sci U S A (2000) 2.25

New method for plague surveillance using polymerase chain reaction to detect Yersinia pestis in fleas. J Clin Microbiol (1993) 2.04

Oligopeptide permease in Borrelia burgdorferi: putative peptide-binding components encoded by both chromosomal and plasmid loci. Microbiology (1998) 2.01

The Borrelia burgdorferi circular plasmid cp26: conservation of plasmid structure and targeted inactivation of the ospC gene. Mol Microbiol (1997) 1.99

Characterization of an endosymbiont infecting wood ticks, Dermacentor andersoni, as a member of the genus Francisella. Appl Environ Microbiol (1997) 1.82

Identification of a protein in several Borrelia species which is related to OspC of the Lyme disease spirochetes. J Clin Microbiol (1993) 1.80

Nucleotide sequence and analysis of the gene in Borrelia burgdorferi encoding the immunogenic P39 antigen. FEMS Microbiol Lett (1994) 1.77

Evaluation of the role of the Yersinia pestis plasminogen activator and other plasmid-encoded factors in temperature-dependent blockage of the flea. J Infect Dis (1998) 1.75

Immune capture and detection of Borrelia burgdorferi antigens in urine, blood, or tissues from infected ticks, mice, dogs, and humans. J Clin Microbiol (1991) 1.70

The granin (chromogranin/secretogranin) family. Trends Biochem Sci (1991) 1.67

Evidence of past recombination events among the genes encoding the Erp antigens of Borrelia burgdorferi. Microbiology (1998) 1.66

Linear chromosomes of Lyme disease agent spirochetes: genetic diversity and conservation of gene order. J Bacteriol (1995) 1.64

Archaeal-type lysyl-tRNA synthetase in the Lyme disease spirochete Borrelia burgdorferi. Proc Natl Acad Sci U S A (1997) 1.62

Homology between Borrelia burgdorferi OspC and members of the family of Borrelia hermsii variable major proteins. Gene (1994) 1.61

The primary structure of human secretogranin II, a widespread tyrosine-sulfated secretory granule protein that exhibits low pH- and calcium-induced aggregation. J Biol Chem (1989) 1.60

Tick-borne relapsing fever in the northwestern United States and southwestern Canada. Clin Infect Dis (1998) 1.59

Borrelia burgdorferi contains repeated DNA sequences that are species specific and plasmid associated. Infect Immun (1990) 1.57

Lethal effect of Rickettsia rickettsii on its tick vector (Dermacentor andersoni). Appl Environ Microbiol (1999) 1.57

Serodiagnosis of Louse-Borne relapsing fever with glycerophosphodiester phosphodiesterase (GlpQ) from Borrelia recurrentis. J Clin Microbiol (2000) 1.55

Altered stationary-phase response in a Borrelia burgdorferi rpoS mutant. J Bacteriol (2000) 1.49

Characterization of cp18, a naturally truncated member of the cp32 family of Borrelia burgdorferi plasmids. J Bacteriol (1997) 1.48

Molecular and immunological analysis of a polymorphic periplasmic protein of Borrelia burgdorferi. J Clin Microbiol (1991) 1.48

Tyrosine sulfation: a post-translational modification of proteins destined for secretion? FEBS Lett (1984) 1.41

Genetics and regulation of chitobiose utilization in Borrelia burgdorferi. J Bacteriol (2001) 1.41

Population structure of the relapsing fever spirochete Borrelia hermsii as indicated by polymorphism of two multigene families that encode immunogenic outer surface lipoproteins. Infect Immun (1998) 1.40

DNA exchange and insertional inactivation in spirochetes. J Mol Microbiol Biotechnol (2000) 1.33

The major tyrosine-sulfated protein of the bovine anterior pituitary is a secretory protein present in gonadotrophs, thyrotrophs, mammotrophs, and corticotrophs. J Cell Biol (1985) 1.32

Transduction by phiBB-1, a bacteriophage of Borrelia burgdorferi. J Bacteriol (2001) 1.31

Recombinant capsular antigen (fraction 1) from Yersinia pestis induces a protective antibody response in BALB/c mice. Am J Trop Med Hyg (1990) 1.31

Telomere resolution in the Lyme disease spirochete. EMBO J (2001) 1.28

Amplification of Borrelia burgdorferi DNA in skin biopsies from patients with Lyme disease. J Clin Microbiol (1991) 1.26

Blockade of membrane transport and disassembly of the Golgi complex by expression of syntaxin 1A in neurosecretion-incompetent cells: prevention by rbSEC1. J Cell Sci (1999) 1.23

Alpha-[11C] methyl-L-tryptophan and glucose metabolism in patients with temporal lobe epilepsy. Neurology (2003) 1.19

Estimation of vector infectivity rates for plague by means of a standard curve-based competitive polymerase chain reaction method to quantify Yersinia pestis in fleas. Am J Trop Med Hyg (1998) 1.19

Identification and characterization of Lyme disease spirochetes, Borrelia burgdorferi sensu lato, isolated in Korea. J Clin Microbiol (1993) 1.18

Syntaxin 1A is delivered to the apical and basolateral domains of epithelial cells: the role of munc-18 proteins. J Cell Sci (2001) 1.17

A regulated secretory pathway in cultured hippocampal astrocytes. J Biol Chem (1999) 1.17

A second allele of eppA in Borrelia burgdorferi strain B31 is located on the previously undetected circular plasmid cp9-2. J Bacteriol (2000) 1.13

Expression and immunological analysis of the plasmid-borne mlp genes of Borrelia burgdorferi strain B31. Infect Immun (2000) 1.13

Identification of a Yersinia pestis-specific DNA probe with potential for use in plague surveillance. J Clin Microbiol (1988) 1.13

Characterization of circular plasmid dimers in Borrelia burgdorferi. J Bacteriol (1998) 1.12

Detection of Rickettsia rickettsii in saliva, hemolymph and triturated tissues of infected Dermacentor andersoni ticks by polymerase chain reaction. Mol Cell Probes (1992) 1.12

DNA typing of rickettsiae in naturally infected ticks using a polymerase chain reaction/restriction fragment length polymorphism system. Am J Trop Med Hyg (1994) 1.12

The relapsing fever spirochete Borrelia hermsii contains multiple, antigen-encoding circular plasmids that are homologous to the cp32 plasmids of Lyme disease spirochetes. Infect Immun (2000) 1.10

Interferon type I response in porcine reproductive and respiratory syndrome virus-infected MARC-145 cells. Arch Virol (2004) 1.10

Adhesion to and invasion of cultured tick (Acarina: Ixodidae) cells by Borrelia burgdorferi (Spirochaetales: Spirochaetaceae) and maintenance of infectivity. J Med Entomol (1993) 1.09

Purification of a sulfated secretory protein from the adenohypophysis. Immunochemical evidence that similar macromolecules are present in other glands. Eur J Cell Biol (1983) 1.08

Brain Regional alpha-[11C]methyl-L-tryptophan trapping in impulsive subjects with borderline personality disorder. Am J Psychiatry (2001) 1.06

Expression, purification, and characterization of inosine 5'-monophosphate dehydrogenase from Borrelia burgdorferi. J Biol Chem (1997) 1.06

Variable small protein (Vsp)-dependent and Vsp-independent pathways for glycosaminoglycan recognition by relapsing fever spirochaetes. Mol Microbiol (2000) 1.02

Investigation of bacterial diversity in the feces of cattle fed different diets. J Anim Sci (2013) 1.00

Tick-borne relapsing fever in British Columbia, Canada: first isolation of Borrelia hermsii. J Clin Microbiol (1998) 0.99

Use of DNA hybridizations probes for detection of the plague bacillus (Yersinia pestis) in fleas (Siphonaptera: Pulicidae and Ceratophyllidae). J Med Entomol (1989) 0.98

Distribution of chromogranin A and secretogranin I (chromogranin B) in neuroendocrine cells and tumors. Am J Pathol (1988) 0.98

Borrelia burgdorferi and Treponema pallidum: a comparison of functional genomics, environmental adaptations, and pathogenic mechanisms. J Clin Invest (2001) 0.98

Transformation of the Lyme disease spirochete Borrelia burgdorferi with heterologous DNA. J Bacteriol (1998) 0.97

Can protracted relapsing fever resemble Lyme disease? Med Hypotheses (1991) 0.97

Distribution of suspected tick vectors and reported cases of Rocky Mountain spotted fever in California. Am J Epidemiol (1976) 0.97

Characterization of adenohypophysial polypeptides by two-dimensional gel electrophoresis. I. L-[3H]leucine-labeled polypeptides. Mol Cell Endocrinol (1981) 0.96

Molecular organization of prolactin granules. III. Intracellular transport of sulfated glycosaminoglycans and glycoproteins of the bovine prolactin granule matrix. J Cell Biol (1980) 0.96

Boyhood behaviour problems as precursors of criminality: a fifteen-year follow-up study. J Child Psychol Psychiatry (1981) 0.96

Agonist-induced desensitization/resensitization of human G protein-coupled receptor 17: a functional cross-talk between purinergic and cysteinyl-leukotriene ligands. J Pharmacol Exp Ther (2011) 0.96

Ectoparasites (sucking lice, fleas and ticks) of small mammals in southeastern Kenya. Med Vet Entomol (2009) 0.95

Overall lack of regulated secretion in a PC12 variant cell clone. J Biol Chem (1996) 0.94

Clinical implications of delayed growth of the Lyme borreliosis spirochete, Borrelia burgdorferi. Acta Trop (1990) 0.94

Cystitis induced by infection with the Lyme disease spirochete, Borrelia burgdorferi, in mice. Am J Pathol (1992) 0.94

Percutaneous arterial closure in peripheral vascular disease: a prospective randomized evaluation of the Perclose device. J Vasc Surg (2003) 0.93

N-type Ca2+ channels are present in secretory granules and are transiently translocated to the plasma membrane during regulated exocytosis. J Biol Chem (1996) 0.93

Identification of gastroenteropancreatic neuroendocrine cells in normal and neoplastic human tissue with antibodies against synaptophysin, chromogranin A, secretogranin I (chromogranin B), and secretogranin II. Gastroenterology (1988) 0.91

Characterization of adenohypophysial polypeptides by two-dimensional gel electrophoresis. II. Sulfated and glycosylated polypeptides. Mol Cell Endocrinol (1981) 0.91

Lyme borreliosis: a relapsing fever-like disease? Scand J Infect Dis Suppl (1991) 0.88

Co-localization of secretogranins/chromogranins with thyrotropin and luteinizing hormone in secretory granules of cow anterior pituitary. J Histochem Cytochem (1990) 0.87

Platelet activation by a relapsing fever spirochaete results in enhanced bacterium-platelet interaction via integrin alphaIIbbeta3 activation. Mol Microbiol (2001) 0.87

Argyrophilic carcinoma of the male breast. A neuroendocrine tumor containing predominantly chromogranin B (secretogranin I). Am J Surg Pathol (1991) 0.87

Failure of intragastrically administered Yersinia pestis capsular antigen to protect mice against challenge with virulent plague: suppression of fraction 1-specific antibody response. Am J Trop Med Hyg (1992) 0.86