Published in J Biol Chem on August 15, 1986
Metabolism of the inositol phosphates produced upon receptor activation. Biochem J (1989) 2.64
The action of the protein kinase C inhibitor, staurosporine, on human platelets. Evidence against a regulatory role for protein kinase C in the formation of inositol trisphosphate by thrombin. Biochem J (1988) 1.95
Determination of mass changes in phosphatidylinositol 4,5-bisphosphate and evidence for agonist-stimulated metabolism of inositol 1,4,5-trisphosphate in airway smooth muscle. Biochem J (1991) 1.28
Lithium inhibits muscarinic-receptor-stimulated inositol tetrakisphosphate accumulation in rat cerebral cortex. Biochem J (1987) 1.24
Regulation of inositol 1,4,5-trisphosphate kinase activity after stimulation of human T cell antigen receptor. J Clin Invest (1987) 1.18
A diacylglycerol kinase inhibitor, R59022, potentiates secretion by and aggregation of thrombin-stimulated human platelets. Biochem J (1987) 1.14
Regulation of inositol 1,4,5-trisphosphate metabolism in insulin-secreting RINm5F cells. Biochem J (1988) 1.00
Role of protein kinase C in the regulation of histamine and bradykinin stimulated inositol polyphosphate turnover in adrenal chromaffin cells. Br J Pharmacol (1992) 0.94
Comparison of the effects of phorbol 12-myristate 13-acetate and prostaglandin E1 on calcium regulation in human platelets. Biochem J (1988) 0.88
Early signalling events implicated in leukotriene B4-induced activation of the NADPH oxidase in eosinophils: role of Ca2+, protein kinase C and phospholipases C and D. Biochem J (1995) 0.85
Metabolism of inositol 1,4,5-trisphosphate in permeabilized rat aortic smooth-muscle cells. Dependence on calcium concentration. Biochem J (1987) 0.83
Maturational regulation of inositol 1,4,5-trisphosphate metabolism in rabbit airway smooth muscle. J Clin Invest (1991) 0.81
Evaluation of the role of inositol trisphosphate in IgE-dependent exocytosis. Biochem J (1990) 0.81
Metabolism of the biologically active inositol phosphates Ins(1,4,5)P3 and Ins(1,3,4,5)P4 by ovarian follicles of Xenopus laevis. Biochem J (1990) 0.80
Subcellular localization of the enzymes that dephosphorylate myo-inositol polyphosphates in human platelets. Biochem J (1988) 0.80
Phospholipase C activation induced by noradrenaline in rat hippocampal slices is potentiated by GABA-receptor stimulation. EMBO J (1987) 0.77
Regulation of hormone-induced Ca2+ mobilization in the human platelets. Environ Health Perspect (1990) 0.75
4,4'-Di-isothiocyanatostilbene-2,2'-disulphonic acid ('DIDS') activates protein kinase C and Na+/H+ exchange in human platelets via alpha 2A-adrenergic receptors. Biochem J (1993) 0.75
Stimulation of protein kinase C redistribution and inhibition of leukotriene B4-induced inositol 1,4,5-trisphosphate generation in human neutrophils by lipoxin A4. Br J Pharmacol (1996) 0.75
Rapid decrease of phosphatidylinositol 4,5-bisphosphate in thrombin-stimulated platelets. J Biol Chem (1982) 2.73
Activation of a cytosolic ADP-ribosyltransferase by nitric oxide-generating agents. J Biol Chem (1989) 2.37
The rapid formation of inositol phosphates in human platelets by thrombin is inhibited by prostacyclin. J Biol Chem (1984) 2.28
Resistance of Crohn's disease T cells to multiple apoptotic signals is associated with a Bcl-2/Bax mucosal imbalance. J Immunol (1999) 2.11
Phospholipase A2 activity specific for phosphatidic acid. A possible mechanism for the production of arachidonic acid in platelets. J Biol Chem (1981) 2.04
Nitric oxide-induced S-nitrosylation of glyceraldehyde-3-phosphate dehydrogenase inhibits enzymatic activity and increases endogenous ADP-ribosylation. J Biol Chem (1992) 2.03
Specific binding of [alpha-32P]GTP to cytosolic and membrane-bound proteins of human platelets correlates with the activation of phospholipase C. Proc Natl Acad Sci U S A (1987) 1.99
Exogenous sn-1,2-diacylglycerols containing saturated fatty acids function as bioregulators of protein kinase C in human platelets. J Biol Chem (1985) 1.76
Stimulation of phosphatidic acid production in platelets precedes the formation of arachidonate and parallels the release of serotonin. Biochim Biophys Acta (1979) 1.75
1,2-Diacylglycerol and phorbol ester inhibit agonist-induced formation of inositol phosphates in human platelets: possible implications for negative feedback regulation of inositol phospholipid hydrolysis. Proc Natl Acad Sci U S A (1985) 1.73
Phospholipase A2 and phospholipase C activities of platelets. Differential substrate specificity, Ca2+ requirement, pH dependence, and cellular localization. J Biol Chem (1980) 1.60
Pertussis toxin inhibits chemotactic peptide-stimulated generation of inositol phosphates and lysosomal enzyme secretion in human leukemic (HL-60) cells. Proc Natl Acad Sci U S A (1985) 1.59
Cyclic adenosine 3',5'-monophosphate and prostacyclin inhibit membrane phospholipase activity in platelets. Biochem Biophys Res Commun (1977) 1.56
Nitric oxide-induced S-glutathionylation and inactivation of glyceraldehyde-3-phosphate dehydrogenase. J Biol Chem (1999) 1.56
The initial action of thrombin on platelets. Conversion of phosphatidylinositol to phosphatidic acid preceding the production of arachidonic acid. J Biol Chem (1981) 1.46
Stimulation by acetylcholine of phosphatidylinositol labelling. Subcellular distribution in rat cerebral-cortex slices. Biochem J (1972) 1.45
A role for Gi in control of thrombin receptor-phospholipase C coupling in human platelets. J Biol Chem (1988) 1.44
Formation of lysophosphatidylinositol in platelets stimulated with thrombin or ionophore A23187. J Biol Chem (1982) 1.40
The phosphatidylinositol cycle and the regulation of arachidonic acid production. Nature (1981) 1.37
Collagen stimulates [3H]inositol trisphosphate formation in indomethacin-treated human platelets. Biochem J (1985) 1.35
Association of p21ras with phosphatidylinositol 3-kinase. Proc Natl Acad Sci U S A (1991) 1.30
Cyclic AMP-dependent activation of Rap1b. J Biol Chem (1995) 1.29
Platelet-activating factor stimulates metabolism of phosphoinositides in horse platelets: possible relationship to Ca2+ mobilization during stimulation. Proc Natl Acad Sci U S A (1983) 1.25
Thrombin stimulates the production of a novel polyphosphoinositide in human platelets. J Biol Chem (1990) 1.23
Evidence for multiple metabolic pools of phosphatidylinositol in stimulated platelets. J Biol Chem (1982) 1.23
The alpha 1C-adrenergic receptor: characterization of signal transduction pathways and mammalian tissue heterogeneity. Mol Pharmacol (1991) 1.22
Gangliosides and acetylcholinesterase in isolated membranes of the rat-brain cortex. Biochim Biophys Acta (1967) 1.20
Phosphatidylinositol metabolism in cells receiving extracellular stimulation. FEBS Lett (1973) 1.19
myo-Inositol 1,4,5-trisphosphate stimulates protein phosphorylation in saponin-permeabilized human platelets. Proc Natl Acad Sci U S A (1984) 1.18
Intracellular activation of protein kinase C and regulation of the surface transferrin receptor by diacylglycerol is a spontaneously reversible process that is associated with rapid formation of phosphatidic acid. Proc Natl Acad Sci U S A (1986) 1.16
1,2-Diacylglycerols do not potentiate the action of phospholipases A2 and C in human platelets. Biochem Biophys Res Commun (1984) 1.15
Structure and function of rap proteins in human platelets. Thromb Haemost (1994) 1.14
Thrombolamban, the 22-kDa platelet substrate of cyclic AMP-dependent protein kinase, is immunologically homologous with the Ras family of GTP-binding proteins. Proc Natl Acad Sci U S A (1990) 1.14
Hepatocytes and macrophages express an identical cytokine inducible nitric oxide synthase gene. Biochem Biophys Res Commun (1993) 1.14
A role for cyclooxygenase products in the formation of phosphatidic acid in stimulated human platelets. Differential mechanisms of action of thrombin and collagen. J Biol Chem (1983) 1.14
Inhibition of caspase-3 by S-nitrosation and oxidation caused by nitric oxide. Biochem Biophys Res Commun (1997) 1.14
RAP2B: a RAS-related GTP-binding protein from platelets. Proc Natl Acad Sci U S A (1990) 1.14
Production of cyclic inositol phosphate in stimulated tissues. Nat New Biol (1972) 1.13
The diglyceride kinase of rat cerebral cortex. Biochem J (1971) 1.11
Superoxide formation and macrophage resistance to nitric oxide-mediated apoptosis. J Biol Chem (1997) 1.11
Properties and distribution of phosphatidylinositol-specific phospholipase C in human and horse platelets. Biochim Biophys Acta (1983) 1.10
Thrombin induces serotonin secretion and aggregation independently of inositol phospholipids hydrolysis and protein phosphorylation in human platelets permeabilized with saponin. J Biol Chem (1985) 1.09
Nitric oxide-induced apoptosis in RAW 264.7 macrophages is antagonized by protein kinase C- and protein kinase A-activating compounds. Mol Pharmacol (1995) 1.09
Erythropoietin induces p21ras activation and p120GAP tyrosine phosphorylation in human erythroleukemia cells. J Biol Chem (1992) 1.08
Ionophore A-23187- and thrombin-induced platelet aggregation: independence from cycloxygenase products. Proc Natl Acad Sci U S A (1978) 1.08
Macrophages resistant to endogenously generated nitric oxide-mediated apoptosis are hypersensitive to exogenously added nitric oxide donors: dichotomous apoptotic response independent of caspase 3 and reversal by the mitogen-activated protein kinase kinase (MEK) inhibitor PD 098059. Proc Natl Acad Sci U S A (1998) 1.07
Ca2+ mobilization primes protein kinase C in human platelets. Ca2+ and phorbol esters stimulate platelet aggregation and secretion synergistically through protein kinase C. Biochem J (1988) 1.07
Shape change induced in human platelets by platelet-activating factor. Correlation with the formation of phosphatidic acid and phosphorylation of a 40,000-dalton protein. J Biol Chem (1983) 1.07
Decanoyl lysophosphatidic acid induces platelet aggregation through an extracellular action. Evidence against a second messenger role for lysophosphatidic acid. Biochem J (1985) 1.07
Phosphatidylinositol-specific phospholipase-C of platelets: association with 1,2-diacyglycerol-kinase and inhibition by cyclic-AMP. Biochem Biophys Res Commun (1979) 1.06
Treatment of human platelets with trypsin, thrombin, or collagen inhibits the pertussis toxin-induced ADP-ribosylation of a 41-kDa protein. Proc Natl Acad Sci U S A (1986) 1.06
Rap1-B is phosphorylated by protein kinase A in intact human platelets. Biochem Biophys Res Commun (1990) 1.05
Degradation of phosphatidylinositol-4,5-bisphosphate is insensitive to CA2+ mobilization in stimulated platelets. Biochem Biophys Res Commun (1982) 1.05
Platelet-activating factor stimulates the phosphatidylinositol cycle. Appearance of phosphatidic acid is associated with the release of serotonin in horse platelets. J Biol Chem (1982) 1.05
Thrombin and phorbol ester stimulate inositol 1,3,4,5-tetrakisphosphate 3-phosphomonoesterase in human platelets. J Biol Chem (1990) 1.02
Prostacyclin inhibition of phosphatidic acid synthesis in human platelets is not mediated by protein kinase C. Biochem Biophys Res Commun (1984) 1.01
Phosphorylation of a Ras-related GTP-binding protein, Rap-1b, by a neuronal Ca2+/calmodulin-dependent protein kinase, CaM kinase Gr. Proc Natl Acad Sci U S A (1991) 1.00
Mutational analysis of the cAMP-dependent protein kinase-mediated phosphorylation site of Rap1b. J Biol Chem (1993) 1.00
Role of rap1B and p21ras GTPase-activating protein in the regulation of phospholipase C-gamma 1 in human platelets. Proc Natl Acad Sci U S A (1992) 1.00
Properties of a novel nitric oxide-stimulated ADP-ribosyltransferase. Arch Biochem Biophys (1990) 0.99
Platelet cytosolic 44-kDa protein is a substrate of cholera toxin-induced ADP-ribosylation and is not recognized by antisera against the alpha subunit of the stimulatory guanine nucleotide-binding regulatory protein. Proc Natl Acad Sci U S A (1988) 0.99
Leupeptin selectively inhibits human platelet responses induced by thrombin and trypsin; a role for proteolytic activation of phospholipase C. Biochem Biophys Res Commun (1985) 0.99
Adrenergic stimulation of phosphatidylinositol labelling in rat vas deferens. Biochim Biophys Acta (1974) 0.98
Agonist-induced phosphorylation of an immunologically ras-related protein in human erythroleukemia cells. Biochem Biophys Res Commun (1989) 0.97
Inositol 1,4,5-trisphosphate induces aggregation and release of 5-hydroxytryptamine from saponin-permeabilized human platelets. J Biol Chem (1986) 0.97
Metabolism of inositides and the activation of platelets. Life Sci (1983) 0.96
The role of phospholipase C in platelet responses. Life Sci (1983) 0.96
Rapid inactivation of cyclooxygenase activity after stimulation of intact platelets. Proc Natl Acad Sci U S A (1979) 0.96
Association of phosphorylated insulin-like growth factor-I receptor with the SH2 domains of phosphatidylinositol 3-kinase p85. J Biol Chem (1992) 0.96
Prostaglandin endoperoxide analogues stimulate phospholipase C and protein phosphorylation during platelet shape change. Blood (1985) 0.96
Neomycin inhibits inositol phosphate formation in human platelets stimulated by thrombin but not other agonists. FEBS Lett (1986) 0.95
Measurement of inositol phospholipid turnover in platelets. Methods Enzymol (1987) 0.95
Dual mechanisms of platelet hormone receptor desensitization. Differential importance between agonists of protein kinase C-dependent and -independent pathways. J Biol Chem (1989) 0.95
Insulin like growth factor-I induces limited association of phosphatidylinositol 3-kinase to its receptor. Endocrinology (1992) 0.94
Action of corticosteroids in regulation of prostaglandin biosynthesis in cultured fibroblasts. Proc Natl Acad Sci U S A (1978) 0.94
Preparation of 32P-labeled inositides and their degradation by soluble kidney enzymes. Biochim Biophys Acta (1975) 0.94
Phosphorylation of nitric oxide synthase by protein kinase A. Biochem Biophys Res Commun (1991) 0.94
Inflammatory mediators are perpetuated in macrophages resistant to apoptosis induced by hypoxia. Proc Natl Acad Sci U S A (1997) 0.93
Phosphatidylinositol 3-kinase is a target for protein tyrosine nitration. Biochem Biophys Res Commun (1998) 0.93
Identification of a novel RalGDS-related protein as a candidate effector for Ras and Rap1. J Biol Chem (1996) 0.93
cDNA sequence of a new ras-related gene (rap2b) isolated from human platelets with sequence homology to rap2. Nucleic Acids Res (1990) 0.92
Effect of pertussis toxin on the phosphodiesteratic cleavage of the polyphosphoinositides by guanosine 5'-O-thiotriphosphate and thrombin in permeabilized human platelets. Biochim Biophys Acta (1986) 0.92
Prenyl group identification of rap2 proteins: a ras superfamily member other than ras that is farnesylated. Biochem J (1993) 0.91
Nitric oxide: a signal for ADP-ribosylation of proteins. Life Sci (1994) 0.91
A novel pathway for the formation of phosphatidylinositol 3,4-bisphosphate. Phosphorylation of phosphatidylinositol 3-monophosphate by phosphatidylinositol-3-monophosphate 4-kinase. J Biol Chem (1990) 0.91
GTP and GDP will stimulate platelet cytosolic phospholipase C independently of Ca2+. Biochem Biophys Res Commun (1986) 0.90
Inhibition of ras-induced germinal vesicle breakdown in Xenopus oocytes by rap-1B. Biochem Biophys Res Commun (1991) 0.90
Action of Triton X-100 on lipids and proteolipids of nerve-ending membranes. Life Sci II (1968) 0.90
Rapid acylation and deacylation of arachidonic acid into phosphatidic acid of horse neutrophils. J Biol Chem (1980) 0.90
Lipids and proteolipids in isolated subcellular membranes of rat brain cortex. J Neurochem (1968) 0.90
Isoprenylation of rap2 proteins in platelets and human erythroleukemia cells. J Biol Chem (1991) 0.90
Receptor-stimulated phospholipase A2 activation is coupled to influx of external calcium and not to mobilization of intracellular calcium in C62B glioma cells. J Biol Chem (1989) 0.90
Prostacyclin inhibits platelet aggregation induced by phorbol ester or Ca2+ ionophore at steps distal to activation of protein kinase C and Ca2+-dependent protein kinases. Biochem J (1989) 0.90
Effect of adrenergic agonists on phosphatidylinositol labelling in heart and aorta. Biochim Biophys Acta (1976) 0.89
1,2-Didecanoylglycerol and phorbol 12,13-dibutyrate enhance anterior pituitary hormone secretion in vitro. Endocrinology (1985) 0.89
Properties of the exchange rate of guanine nucleotides to the novel rap-2B protein. Biochem Biophys Res Commun (1990) 0.89
Functional relationship between cyclic AMP-dependent protein phosphorylation and platelet inhibition. Biochem J (1990) 0.88