Published in Proc Natl Acad Sci U S A on September 01, 1990
Sequence requirement for peptide recognition by rat brain p21ras protein farnesyltransferase. Proc Natl Acad Sci U S A (1991) 2.27
Rap1a null mice have altered myeloid cell functions suggesting distinct roles for the closely related Rap1a and 1b proteins. J Immunol (2007) 1.56
The small Mr Ras-like GTPase Rap1 and the phospholipase C pathway act to regulate phagocytosis in Dictyostelium discoideum. Mol Biol Cell (1999) 1.23
Identification of small GTP-binding rab proteins in human platelets: thrombin-induced phosphorylation of rab3B, rab6, and rab8 proteins. Proc Natl Acad Sci U S A (1993) 1.13
Biology of the Rap proteins, members of the ras superfamily of GTP-binding proteins. Biochem J (1993) 1.06
Phosphorylation of a Ras-related GTP-binding protein, Rap-1b, by a neuronal Ca2+/calmodulin-dependent protein kinase, CaM kinase Gr. Proc Natl Acad Sci U S A (1991) 1.00
Protein prenylcysteine analog inhibits agonist-receptor-mediated signal transduction in human platelets. Proc Natl Acad Sci U S A (1993) 0.94
Prenyl group identification of rap2 proteins: a ras superfamily member other than ras that is farnesylated. Biochem J (1993) 0.91
The high-risk human papillomavirus type 16 E6 counters the GAP function of E6TP1 toward small Rap G proteins. J Virol (2003) 0.89
Glycoprotein IIb-IIIa and the translocation of Rap2B to the platelet cytoskeleton. Proc Natl Acad Sci U S A (1994) 0.86
Rap1 and Rap2 antagonistically control endothelial barrier resistance. PLoS One (2013) 0.83
Rap2B promotes proliferation, migration, and invasion of human breast cancer through calcium-related ERK1/2 signaling pathway. Sci Rep (2015) 0.82
Association of the low molecular weight GTP-binding protein rap2B with the cytoskeleton during platelet aggregation. Proc Natl Acad Sci U S A (1993) 0.81
Rap2B promotes migration and invasion of human suprarenal epithelioma. Tumour Biol (2014) 0.80
Microinjection of Rap2B protein or RNA induces rearrangement of pigment granules in Xenopus oocytes. Biochem J (1993) 0.78
Structure, functional regulation and signaling properties of Rap2B. Oncol Lett (2016) 0.75
p53 target gene Rap2B regulates the cytoskeleton and inhibits cell spreading. J Cancer Res Clin Oncol (2015) 0.75
Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature (1970) 1528.65
DNA sequencing with chain-terminating inhibitors. Proc Natl Acad Sci U S A (1977) 790.54
Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc Natl Acad Sci U S A (1979) 365.71
Use of bacteriophage T7 RNA polymerase to direct selective high-level expression of cloned genes. J Mol Biol (1986) 55.34
ras genes. Annu Rev Biochem (1987) 22.59
All ras proteins are polyisoprenylated but only some are palmitoylated. Cell (1989) 9.68
At least six nucleotides preceding the AUG initiator codon enhance translation in mammalian cells. J Mol Biol (1987) 9.21
A ras-related gene with transformation suppressor activity. Cell (1989) 5.81
Biological and biochemical properties of human rasH genes mutated at codon 61. Cell (1986) 5.05
Posttranslational modification of the Ha-ras oncogene protein: evidence for a third class of protein carboxyl methyltransferases. Proc Natl Acad Sci U S A (1988) 4.04
Genetic and pharmacological suppression of oncogenic mutations in ras genes of yeast and humans. Science (1989) 3.90
Post-translational processing of p21ras is two-step and involves carboxyl-methylation and carboxy-terminal proteolysis. EMBO J (1989) 3.51
Human cDNAs rap1 and rap2 homologous to the Drosophila gene Dras3 encode proteins closely related to ras in the 'effector' region. Oncogene (1988) 2.94
Specific binding of [alpha-32P]GTP to cytosolic and membrane-bound proteins of human platelets correlates with the activation of phospholipase C. Proc Natl Acad Sci U S A (1987) 1.99
Purification of the major GTP-binding proteins from human placental membranes. J Biol Chem (1986) 1.94
A novel small molecular weight GTP-binding protein with the same putative effector domain as the ras proteins in bovine brain membranes. Purification, determination of primary structure, and characterization. J Biol Chem (1988) 1.73
A ras-related protein is phosphorylated and translocated by agonists that increase cAMP levels in human platelets. Proc Natl Acad Sci U S A (1989) 1.64
Nucleotide sequence of a human cDNA encoding a ras-related protein (rap1B). Nucleic Acids Res (1988) 1.54
Phosphorylation of smg p21, a ras p21-like GTP-binding protein, by cyclic AMP-dependent protein kinase in a cell-free system and in response to prostaglandin E1 in intact human platelets. J Biol Chem (1989) 1.27
Detection of 23-27 kDa GTP-binding proteins in platelets and other cells. Biochem J (1987) 1.20
ras p21 deletion mutants and monoclonal antibodies as tools for localization of regions relevant to p21 function. Proc Natl Acad Sci U S A (1986) 1.16
Phosphorylation by cyclic AMP-dependent protein kinase of a human platelet Mr 22,000 GTP-binding protein (smg p21) having the same putative effector domain as the ras gene products. Biochem Biophys Res Commun (1988) 1.13
Cloning, purification, and properties of Candida albicans thymidylate synthase. J Bacteriol (1989) 1.02
Agonist-induced phosphorylation of an immunologically ras-related protein in human erythroleukemia cells. Biochem Biophys Res Commun (1989) 0.97
Isolation and characterization of human blood platelet mRNA and construction of a cDNA library in lambda gt11. Confirmation of the platelet derivation by identification of GPIb coding mRNA and cloning of a GPIb coding cDNA insert. Thromb Haemost (1989) 0.95
Low Mr GTP-binding proteins in human platelets: cyclic AMP-dependent protein kinase phosphorylates m22KG(I) in membrane but not c21KG in cytosol. Biochem Biophys Res Commun (1989) 0.93
Identification of a platelet Mr 22,000 GTP-binding protein as the novel smg-21 gene product having the same putative effector domain as the ras gene products. Biochem Biophys Res Commun (1988) 0.89
Gn-proteins are distinct from ras p21 and other known low molecular mass GTP-binding proteins in the platelet. FEBS Lett (1988) 0.87
Rapid decrease of phosphatidylinositol 4,5-bisphosphate in thrombin-stimulated platelets. J Biol Chem (1982) 2.73
Small peptides as potent mimetics of the protein hormone erythropoietin. Science (1996) 2.70
Activation of a cytosolic ADP-ribosyltransferase by nitric oxide-generating agents. J Biol Chem (1989) 2.37
The rapid formation of inositol phosphates in human platelets by thrombin is inhibited by prostacyclin. J Biol Chem (1984) 2.28
An antagonist peptide-EPO receptor complex suggests that receptor dimerization is not sufficient for activation. Nat Struct Biol (1998) 2.24
Resistance of Crohn's disease T cells to multiple apoptotic signals is associated with a Bcl-2/Bax mucosal imbalance. J Immunol (1999) 2.11
The characterization of novel, dual ErbB-2/EGFR, tyrosine kinase inhibitors: potential therapy for cancer. Cancer Res (2001) 2.06
Phospholipase A2 activity specific for phosphatidic acid. A possible mechanism for the production of arachidonic acid in platelets. J Biol Chem (1981) 2.04
Nitric oxide-induced S-nitrosylation of glyceraldehyde-3-phosphate dehydrogenase inhibits enzymatic activity and increases endogenous ADP-ribosylation. J Biol Chem (1992) 2.03
Specific binding of [alpha-32P]GTP to cytosolic and membrane-bound proteins of human platelets correlates with the activation of phospholipase C. Proc Natl Acad Sci U S A (1987) 1.99
Interaction of the regulatory gene product with the operator site in the L-arabinose operon of Escherichia coli. J Mol Biol (1974) 1.97
Exogenous sn-1,2-diacylglycerols containing saturated fatty acids function as bioregulators of protein kinase C in human platelets. J Biol Chem (1985) 1.76
Stimulation of phosphatidic acid production in platelets precedes the formation of arachidonate and parallels the release of serotonin. Biochim Biophys Acta (1979) 1.75
1,2-Diacylglycerol and phorbol ester inhibit agonist-induced formation of inositol phosphates in human platelets: possible implications for negative feedback regulation of inositol phospholipid hydrolysis. Proc Natl Acad Sci U S A (1985) 1.73
Platelet membrane glycoproteins implicated in ristocetin-induced aggregation. Studies of the proteins on platelets from patients with Bernard-Soulier syndrome and von Willebrand's disease. J Clin Invest (1976) 1.67
Purification and cDNA sequence of an inducible nitric oxide synthase from a human tumor cell line. Biochemistry (1993) 1.66
A ras-related protein is phosphorylated and translocated by agonists that increase cAMP levels in human platelets. Proc Natl Acad Sci U S A (1989) 1.64
Phospholipase A2 and phospholipase C activities of platelets. Differential substrate specificity, Ca2+ requirement, pH dependence, and cellular localization. J Biol Chem (1980) 1.60
Pertussis toxin inhibits chemotactic peptide-stimulated generation of inositol phosphates and lysosomal enzyme secretion in human leukemic (HL-60) cells. Proc Natl Acad Sci U S A (1985) 1.59
Cyclic adenosine 3',5'-monophosphate and prostacyclin inhibit membrane phospholipase activity in platelets. Biochem Biophys Res Commun (1977) 1.56
Nitric oxide-induced S-glutathionylation and inactivation of glyceraldehyde-3-phosphate dehydrogenase. J Biol Chem (1999) 1.56
The platelet collagen receptor glycoprotein VI is a member of the immunoglobulin superfamily closely related to FcalphaR and the natural killer receptors. J Biol Chem (1999) 1.55
Characterization of the platelet membrane glycoprotein abnormalities in Bernard-Soulier syndrome and comparison with normal by surface-labeling techniques and high-resolution two-dimensional gel electrophoresis. J Clin Invest (1982) 1.50
The initial action of thrombin on platelets. Conversion of phosphatidylinositol to phosphatidic acid preceding the production of arachidonic acid. J Biol Chem (1981) 1.46
Stimulation by acetylcholine of phosphatidylinositol labelling. Subcellular distribution in rat cerebral-cortex slices. Biochem J (1972) 1.45
A role for Gi in control of thrombin receptor-phospholipase C coupling in human platelets. J Biol Chem (1988) 1.44
Platelet activation and signal transduction by convulxin, a C-type lectin from Crotalus durissus terrificus (tropical rattlesnake) venom via the p62/GPVI collagen receptor. J Biol Chem (1997) 1.40
Formation of lysophosphatidylinositol in platelets stimulated with thrombin or ionophore A23187. J Biol Chem (1982) 1.40
Platelet glycoprotein Ia* is the processed form of multimerin--isolation and determination of N-terminal sequences of stored and released forms. Thromb Haemost (1998) 1.39
European Working Group on Clinical Cell Analysis: Consensus protocol for the flow cytometric characterisation of platelet function. Thromb Haemost (1998) 1.37
Phorbol 12,13-dibutyrate and 1-oleyl-2-acetyldiacylglycerol stimulate inositol trisphosphate dephosphorylation in human platelets. J Biol Chem (1986) 1.37
The phosphatidylinositol cycle and the regulation of arachidonic acid production. Nature (1981) 1.37
Relationship between glycocalicin and glycoprotein Ib of human platelets. Proc Natl Acad Sci U S A (1981) 1.36
Collagen stimulates [3H]inositol trisphosphate formation in indomethacin-treated human platelets. Biochem J (1985) 1.35
Snake venoms and hemostasis. J Thromb Haemost (2005) 1.32
Surface expression and functional characterization of alpha-granule factor V in human platelets: effects of ionophore A23187, thrombin, collagen, and convulxin. Blood (2000) 1.30
Association of p21ras with phosphatidylinositol 3-kinase. Proc Natl Acad Sci U S A (1991) 1.30
Cyclic AMP-dependent activation of Rap1b. J Biol Chem (1995) 1.29
Platelet-activating factor stimulates metabolism of phosphoinositides in horse platelets: possible relationship to Ca2+ mobilization during stimulation. Proc Natl Acad Sci U S A (1983) 1.25
Deficiency of intact thrombospondin and membrane glycoprotein Ia in platelets with defective collagen-induced aggregation and spontaneous loss of disorder. Blood (1988) 1.24
Thrombin stimulates the production of a novel polyphosphoinositide in human platelets. J Biol Chem (1990) 1.23
Evidence for multiple metabolic pools of phosphatidylinositol in stimulated platelets. J Biol Chem (1982) 1.23
The alpha 1C-adrenergic receptor: characterization of signal transduction pathways and mammalian tissue heterogeneity. Mol Pharmacol (1991) 1.22
Isolation of the membrane glycoproteins of human blood platelets by lectin affinity chromatography. Biochim Biophys Acta (1977) 1.20
Absence of platelet membrane glycoproteins IIb/IIIa from monocytes. J Exp Med (1985) 1.20
Gangliosides and acetylcholinesterase in isolated membranes of the rat-brain cortex. Biochim Biophys Acta (1967) 1.20
Platelet chemokines and their receptors: what is their relevance to platelet storage and transfusion practice? Transfus Med (2001) 1.19
Structure and function of platelet membrane glycoproteins Ib and V. Effects of leukocyte elastase and other proteases on platelets response to von Willebrand factor and thrombin. Eur J Biochem (1985) 1.19
Phosphatidylinositol metabolism in cells receiving extracellular stimulation. FEBS Lett (1973) 1.19
myo-Inositol 1,4,5-trisphosphate stimulates protein phosphorylation in saponin-permeabilized human platelets. Proc Natl Acad Sci U S A (1984) 1.18
Intracellular activation of protein kinase C and regulation of the surface transferrin receptor by diacylglycerol is a spontaneously reversible process that is associated with rapid formation of phosphatidic acid. Proc Natl Acad Sci U S A (1986) 1.16
1,2-Diacylglycerols do not potentiate the action of phospholipases A2 and C in human platelets. Biochem Biophys Res Commun (1984) 1.15
Structure and function of rap proteins in human platelets. Thromb Haemost (1994) 1.14
Structural studies on the O-linked carbohydrate chains of human platelet glycocalicin. Eur J Biochem (1984) 1.14
Thrombolamban, the 22-kDa platelet substrate of cyclic AMP-dependent protein kinase, is immunologically homologous with the Ras family of GTP-binding proteins. Proc Natl Acad Sci U S A (1990) 1.14
A role for cyclooxygenase products in the formation of phosphatidic acid in stimulated human platelets. Differential mechanisms of action of thrombin and collagen. J Biol Chem (1983) 1.14
Hepatocytes and macrophages express an identical cytokine inducible nitric oxide synthase gene. Biochem Biophys Res Commun (1993) 1.14
Inhibition of caspase-3 by S-nitrosation and oxidation caused by nitric oxide. Biochem Biophys Res Commun (1997) 1.14
Glycoproteins of platelet membranes from Glanzmann's thrombasthenia. A comparison with normal using carbohydrate-specific or protein-specific labelling techniques and high-resolution two-dimensional gel electrophoresis. Eur J Biochem (1981) 1.13
Production of cyclic inositol phosphate in stimulated tissues. Nat New Biol (1972) 1.13
High resolution two-dimensional gel electrophoresis of the proteins and glycoproteins of human blood platelets and platelet membranes. Biochim Biophys Acta (1979) 1.12
The diglyceride kinase of rat cerebral cortex. Biochem J (1971) 1.11
Superoxide formation and macrophage resistance to nitric oxide-mediated apoptosis. J Biol Chem (1997) 1.11
Identification of a 13 amino acid peptide mimetic of erythropoietin and description of amino acids critical for the mimetic activity of EMP1. Biochemistry (1998) 1.10
Chemokine and chemokine receptor mRNA expression in human platelets. Cytokine (1995) 1.10
Properties and distribution of phosphatidylinositol-specific phospholipase C in human and horse platelets. Biochim Biophys Acta (1983) 1.10
Thrombin induces serotonin secretion and aggregation independently of inositol phospholipids hydrolysis and protein phosphorylation in human platelets permeabilized with saponin. J Biol Chem (1985) 1.09
Nitric oxide-induced apoptosis in RAW 264.7 macrophages is antagonized by protein kinase C- and protein kinase A-activating compounds. Mol Pharmacol (1995) 1.09
Erythropoietin induces p21ras activation and p120GAP tyrosine phosphorylation in human erythroleukemia cells. J Biol Chem (1992) 1.08
Ionophore A-23187- and thrombin-induced platelet aggregation: independence from cycloxygenase products. Proc Natl Acad Sci U S A (1978) 1.08
Ca2+ mobilization primes protein kinase C in human platelets. Ca2+ and phorbol esters stimulate platelet aggregation and secretion synergistically through protein kinase C. Biochem J (1988) 1.07
Macrophages resistant to endogenously generated nitric oxide-mediated apoptosis are hypersensitive to exogenously added nitric oxide donors: dichotomous apoptotic response independent of caspase 3 and reversal by the mitogen-activated protein kinase kinase (MEK) inhibitor PD 098059. Proc Natl Acad Sci U S A (1998) 1.07
Shape change induced in human platelets by platelet-activating factor. Correlation with the formation of phosphatidic acid and phosphorylation of a 40,000-dalton protein. J Biol Chem (1983) 1.07
Decanoyl lysophosphatidic acid induces platelet aggregation through an extracellular action. Evidence against a second messenger role for lysophosphatidic acid. Biochem J (1985) 1.07
The GPIb thrombin-binding site is essential for thrombin-induced platelet procoagulant activity. Blood (2000) 1.07
Phosphatidylinositol-specific phospholipase-C of platelets: association with 1,2-diacyglycerol-kinase and inhibition by cyclic-AMP. Biochem Biophys Res Commun (1979) 1.06
Treatment of human platelets with trypsin, thrombin, or collagen inhibits the pertussis toxin-induced ADP-ribosylation of a 41-kDa protein. Proc Natl Acad Sci U S A (1986) 1.06
Rap1-B is phosphorylated by protein kinase A in intact human platelets. Biochem Biophys Res Commun (1990) 1.05
Platelet-activating factor stimulates the phosphatidylinositol cycle. Appearance of phosphatidic acid is associated with the release of serotonin in horse platelets. J Biol Chem (1982) 1.05
Degradation of phosphatidylinositol-4,5-bisphosphate is insensitive to CA2+ mobilization in stimulated platelets. Biochem Biophys Res Commun (1982) 1.05
Human platelet glycoprotein Ia. One component is only expressed on the surface of activated platelets and may be a granule constituent. J Biol Chem (1989) 1.03
Thrombin and phorbol ester stimulate inositol 1,3,4,5-tetrakisphosphate 3-phosphomonoesterase in human platelets. J Biol Chem (1990) 1.02
Prostacyclin inhibition of phosphatidic acid synthesis in human platelets is not mediated by protein kinase C. Biochem Biophys Res Commun (1984) 1.01
Purification of the araC protein. Proc Natl Acad Sci U S A (1971) 1.01
Expression of platelet glycoprotein Ib alpha in HEL cells. J Biol Chem (1986) 1.00
Distribution of platelet glycoproteins and phosphoproteins in hydrophobic and hydrophilic phases in Triton X-114 phase partition. Biochim Biophys Acta (1984) 1.00
Phosphorylation of a Ras-related GTP-binding protein, Rap-1b, by a neuronal Ca2+/calmodulin-dependent protein kinase, CaM kinase Gr. Proc Natl Acad Sci U S A (1991) 1.00
Mutational analysis of the cAMP-dependent protein kinase-mediated phosphorylation site of Rap1b. J Biol Chem (1993) 1.00
Role of rap1B and p21ras GTPase-activating protein in the regulation of phospholipase C-gamma 1 in human platelets. Proc Natl Acad Sci U S A (1992) 1.00
Properties of a novel nitric oxide-stimulated ADP-ribosyltransferase. Arch Biochem Biophys (1990) 0.99
Platelet cytosolic 44-kDa protein is a substrate of cholera toxin-induced ADP-ribosylation and is not recognized by antisera against the alpha subunit of the stimulatory guanine nucleotide-binding regulatory protein. Proc Natl Acad Sci U S A (1988) 0.99
Leupeptin selectively inhibits human platelet responses induced by thrombin and trypsin; a role for proteolytic activation of phospholipase C. Biochem Biophys Res Commun (1985) 0.99
Monoclonal antibodies against platelet membrane glycoproteins. Characterization and effect on platelet function. Eur J Biochem (1983) 0.99
Cloning and characterization of the gene encoding the human platelet glycoprotein V. A member of the leucine-rich glycoprotein family cleaved during thrombin-induced platelet activation. J Biol Chem (1993) 0.98