Published in Int J Cancer on October 15, 1978
Positional cloning of the mouse obese gene and its human homologue. Nature (1994) 38.85
Crystal structure at 3.5 A resolution of HIV-1 reverse transcriptase complexed with an inhibitor. Science (1992) 14.70
Weight-reducing effects of the plasma protein encoded by the obese gene. Science (1995) 13.05
Thymus-dependent areas in the lymphoid organs of neonatally thymectomized mice. J Exp Med (1966) 8.61
Abnormal splicing of the leptin receptor in diabetic mice. Nature (1996) 7.71
Vanilloid receptor-related osmotically activated channel (VR-OAC), a candidate vertebrate osmoreceptor. Cell (2000) 5.73
Leptin activation of Stat3 in the hypothalamus of wild-type and ob/ob mice but not db/db mice. Nat Genet (1996) 4.84
Leptin-specific patterns of gene expression in white adipose tissue. Genes Dev (2000) 4.57
Genetic and crystallographic studies of the 3',5'-exonucleolytic site of DNA polymerase I. Science (1988) 4.50
Selective deletion of leptin receptor in neurons leads to obesity. J Clin Invest (2001) 3.82
Physiological response to long-term peripheral and central leptin infusion in lean and obese mice. Proc Natl Acad Sci U S A (1997) 3.81
Peroxisome proliferator-activated receptor gamma target gene encoding a novel angiopoietin-related protein associated with adipose differentiation. Mol Cell Biol (2000) 3.60
Diagnostic criteria for schwannomatosis. Neurology (2005) 3.41
Mortality associated with Down's syndrome in the USA from 1983 to 1997: a population-based study. Lancet (2002) 3.35
Increased expression in adipocytes of ob RNA in mice with lesions of the hypothalamus and with mutations at the db locus. Proc Natl Acad Sci U S A (1995) 3.33
Polycythemia vera: stem-cell and probable clonal origin of the disease. N Engl J Med (1976) 3.18
Acute stimulation of glucose metabolism in mice by leptin treatment. Nature (1997) 3.12
Clonal origin of human tumors. Biochim Biophys Acta (1976) 3.07
Immunopathology of New Zealand black (NZB) mice. Transplantation (1965) 3.06
Cocrystal structure of an editing complex of Klenow fragment with DNA. Proc Natl Acad Sci U S A (1988) 3.02
Virus-assisted mapping of neural inputs to a feeding center in the hypothalamus. Science (2001) 2.98
Distinct transcriptional profiles of adipogenesis in vivo and in vitro. J Biol Chem (2001) 2.91
Chronic myelocytic leukemia: clonal origin in a stem cell common to the granulocyte, erythrocyte, platelet and monocyte/macrophage. Am J Med (1977) 2.82
Mortality in neurofibromatosis 1: an analysis using U.S. death certificates. Am J Hum Genet (2001) 2.78
Structure of the binding site for nonnucleoside inhibitors of the reverse transcriptase of human immunodeficiency virus type 1. Proc Natl Acad Sci U S A (1994) 2.71
Direct evidence for the presence of Epstein-Barr virus DNA and nuclear antigen in malignant epithelial cells from patients with poorly differentiated carcinoma of the nasopharynx. Proc Natl Acad Sci U S A (1974) 2.66
NF1 gene and neurofibromatosis 1. Am J Epidemiol (2000) 2.58
Anatomic localization of alternatively spliced leptin receptors (Ob-R) in mouse brain and other tissues. Proc Natl Acad Sci U S A (1997) 2.57
Human tumors studied with genetic markers. Birth Defects Orig Artic Ser (1976) 2.52
Insights into the pathogenesis of neurofibromatosis 1 vasculopathy. Clin Genet (2000) 2.49
Clonal origin of chronic myelocytic leukemia in man. Proc Natl Acad Sci U S A (1967) 2.48
Structural basis of asymmetry in the human immunodeficiency virus type 1 reverse transcriptase heterodimer. Proc Natl Acad Sci U S A (1994) 2.47
Primordial cell pool size and lineage relationships of five human cell types. Ann Hum Genet (1973) 2.21
Crystal structures of the Klenow fragment of DNA polymerase I complexed with deoxynucleoside triphosphate and pyrophosphate. Biochemistry (1993) 2.19
Population-based analyses of mortality in trisomy 13 and trisomy 18. Pediatrics (2003) 2.11
A patient with vertebral, cognitive and behavioural abnormalities and a de novo deletion of NRXN1alpha. J Med Genet (2007) 1.94
Autoimmune reactions and virus-like particles in germ-free NZB mice. Lancet (1967) 1.88
Drug safety in pregnant women and their babies: ignorance not bliss. Clin Pharmacol Ther (2007) 1.87
Linkage of functional and structural heterogeneity in proteins: dynamic hole burning in carboxymyoglobin. Science (1987) 1.87
Improving the prediction of complex diseases by testing for multiple disease-susceptibility genes. Am J Hum Genet (2003) 1.85
Lipoprotein lipase controls fatty acid entry into adipose tissue, but fat mass is preserved by endogenous synthesis in mice deficient in adipose tissue lipoprotein lipase. Proc Natl Acad Sci U S A (1997) 1.85
Increasing the specificity of diagnostic criteria for schwannomatosis. Neurology (2006) 1.85
Immunopathology and neoplasms in New Zealand black (NZB) and SJL-J mice. Prog Exp Tumor Res (1970) 1.84
Use of "unidentified bright objects" on MRI for diagnosis of neurofibromatosis 1 in children. Neurology (2000) 1.83
Agnogenic myeloid metaplasia: a clonal proliferation of hematopoietic stem cells with secondary myelofibrosis. Blood (1978) 1.83
On the use of population attributable fraction to determine sample size for case-control studies of gene-environment interaction. Epidemiology (2003) 1.82
Expression of the gene defect in X-linked agammaglobulinemia. N Engl J Med (1986) 1.80
Growth and antigenic properties of a biopsy-derived Burkitt's lymphoma in thymus-less (nude) mice. Int J Cancer (1973) 1.80
Leukaemic transformation of engrafted human marrow cells in vivo. Lancet (1971) 1.79
Use of the national institutes of health criteria for diagnosis of neurofibromatosis 1 in children. Pediatrics (2000) 1.79
Teratogenicity of recently introduced medications in human pregnancy. Obstet Gynecol (2002) 1.76
Assessment of algorithms for high throughput detection of genomic copy number variation in oligonucleotide microarray data. BMC Bioinformatics (2007) 1.75
The origin and development of human tumors studied with cell markers. N Engl J Med (1974) 1.73
Cellular promoters incorporated into the adenovirus genome: cell specificity of albumin and immunoglobulin expression. Mol Cell Biol (1986) 1.73
Cardiovascular malformations and other cardiovascular abnormalities in neurofibromatosis 1. Am J Med Genet (2000) 1.70
A reevaluation of risk of in utero exposure to lithium. JAMA (1994) 1.68
Submicroscopic deletions and duplications in individuals with intellectual disability detected by array-CGH. Am J Med Genet A (2005) 1.68
Evolving knowledge of the teratogenicity of medications in human pregnancy. Am J Med Genet C Semin Med Genet (2011) 1.68
Epidemiology and factor analysis of obesity, type II diabetes, hypertension, and dyslipidemia (syndrome X) on the Island of Kosrae, Federated States of Micronesia. Hum Hered (2001) 1.67
Association between benign and malignant peripheral nerve sheath tumors in NF1. Neurology (2005) 1.65
Transcriptional and post-transcriptional control of specific messenger RNAs in adult and embryonic liver. J Mol Biol (1984) 1.63
"Immunologic" oncogenesis. Blood (1967) 1.61
Improvement in stroke mortality in Canada and the United States, 1990 to 2002. Circulation (2006) 1.58
Chronic myelocytic leukemia. Origin of some lymphocytes from leukemic stem cells. J Clin Invest (1978) 1.55
Polycythemia vera. The in vitro response of normal and abnormal stem cell lines to erythropoietin. J Clin Invest (1978) 1.53
Evaluation of clinical diagnostic criteria for neurofibromatosis 2. Neurology (2002) 1.53
Comparison of the 15q deletions in Prader-Willi and Angelman syndromes: specific regions, extent of deletions, parental origin, and clinical consequences. Am J Med Genet (1990) 1.53
Malignant changes in New Zealand black mice. Clin Exp Immunol (1967) 1.52
Ordered water molecules as key allosteric mediators in a cooperative dimeric hemoglobin. Proc Natl Acad Sci U S A (1996) 1.51
Update on new developments in the study of human teratogens. Teratology (2002) 1.49
Excited state lifetimes in cytochromes measured from Raman scattering data: evidence for iron-porphyrin interactions. Proc Natl Acad Sci U S A (1977) 1.48
The thymus autoimmunity and malignancy in New Zealand black mice. Natl Cancer Inst Monogr (1966) 1.46
Race-ethnicity differences in folic acid intake in women of childbearing age in the United States after folic acid fortification: findings from the National Health and Nutrition Examination Survey, 2001-2002. Am J Clin Nutr (2007) 1.46
Use of genetic markers to study cellular origin and development of tumors in human females. Adv Cancer Res (1972) 1.46
Transient Raman study of CO-haemoprotein photolysis: origin of the quantum yield. Nature (1980) 1.43
Immunoglobulin and glucose-6-phosphate dehydrogenase as markers of cellular origin in Burkitt lymphoma. J Exp Med (1973) 1.42
Workshop report: evaluation of genetic and epigenetic risks associated with assisted reproductive technologies and infertility. Fertil Steril (2007) 1.42
Marketing infection control. Nurs Times (1991) 1.41
Liver cysts in patients with autosomal dominant polycystic kidney disease. Am J Med (1980) 1.41
Autoimmunity and chromosomal aberrations. Am J Hum Genet (1966) 1.41
Evidence that essential thrombocythemia is a clonal disorder with origin in a multipotent stem cell. Blood (1981) 1.40
Descriptive analysis of tibial pseudarthrosis in patients with neurofibromatosis 1. Am J Med Genet (1999) 1.40
Evidence for a multistep pathogenesis of chronic myelogenous leukemia. Blood (1981) 1.39
The pathogenesis of myeloproliferative syndromes. Br J Haematol (1978) 1.39
Effect of visualization display colour on polyp conspicuity at virtual colonoscopy. Clin Radiol (2008) 1.39
Aplastic anaemia treated by marrow transplantation. Lancet (1972) 1.39
Evidence for a multistep pathogenesis of a myelodysplastic syndrome. Blood (1984) 1.38
Predictors of the risk of mortality in neurofibromatosis 2. Am J Hum Genet (2002) 1.37
The iron-proximal histidine linkage and protein control of oxygen binding in hemoglobin. A transient Raman study. J Biol Chem (1983) 1.35
del(20p) with manifestations of arteriohepatic dysplasia. Am J Med Genet (1986) 1.35
Donor origin of the in vitro haematopoietic microenvironment after marrow transplantation in man. Nature (1982) 1.35
Saethre-Chotzen syndrome: a broad and variable pattern of skeletal malformations. J Pediatr (1977) 1.35
Site-specific PEGylation of hemoglobin at Cys-93(beta): correlation between the colligative properties of the PEGylated protein and the length of the conjugated PEG chain. Bioconjug Chem (2003) 1.34
A new craniodigital syndrome with mental retardation. J Pediatr (1971) 1.32
Clonal development, stem-cell differentiation, and clinical remissions in acute nonlymphocytic leukemia. N Engl J Med (1987) 1.32
Consequences of neonatal thymectomy in New Zealand black mice. Clin Exp Immunol (1967) 1.32
Expression of ob gene in adipose cells. Regulation by insulin. J Biol Chem (1996) 1.31