Published in EMBO J on May 01, 1987
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Pax-3, a novel murine DNA binding protein expressed during early neurogenesis. EMBO J (1991) 3.85
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Primary structure and developmental expression pattern of Hox 3.1, a member of the murine Hox 3 homeobox gene cluster. EMBO J (1988) 1.46
A murine even-skipped homologue, Evx 1, is expressed during early embryogenesis and neurogenesis in a biphasic manner. EMBO J (1990) 1.39
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The primary structure of the murine multifinger gene mKr2 and its specific expression in developing and adult neurons. EMBO J (1988) 1.07
Molecular mapping of signals in the Qa-2 antigen required for attachment of the phosphatidylinositol membrane anchor. Proc Natl Acad Sci U S A (1988) 1.05
Activated T cells transcribe an alternatively spliced mRNA encoding a soluble form of Qa-2 antigen. EMBO J (1990) 1.00
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Sequencing end-labeled DNA with base-specific chemical cleavages. Methods Enzymol (1980) 287.68
Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. Biochemistry (1979) 180.95
Efficient in vitro synthesis of biologically active RNA and RNA hybridization probes from plasmids containing a bacteriophage SP6 promoter. Nucleic Acids Res (1984) 86.56
High-efficiency cloning of full-length cDNA. Mol Cell Biol (1982) 22.81
MHC-restricted cytotoxic T cells: studies on the biological role of polymorphic major transplantation antigens determining T-cell restriction-specificity, function, and responsiveness. Adv Immunol (1979) 15.58
A pseudogene homologous to mouse transplantation antigens: transplantation antigens are encoded by eight exons that correlate with protein domains. Cell (1981) 5.43
Organization and evolution of the class I gene family in the major histocompatibility complex of the C57BL/10 mouse. Nature (1984) 4.22
The DNA sequence of the H-2kb gene: evidence for gene conversion as a mechanism for the generation of polymorphism in histocompatibilty antigens. EMBO J (1983) 3.95
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Mouse major histocompatibility class I gene expression begins at midsomite stage and is inducible in earlier-stage embryos by interferon. Proc Natl Acad Sci U S A (1985) 2.56
A potential donor gene for the bm1 gene conversion event in the C57BL mouse. Nature (1984) 2.18
Secretion of a transplantation-related antigen. Cell (1983) 2.12
A nonpolymorphic class I gene in the murine major histocompatibility complex. Cell (1984) 2.12
Pattern of serum protein gene expression in mouse visceral yolk sac and foetal liver. EMBO J (1984) 2.09
Expression of murine H-2Kb histocompatibility antigen in cells transformed with cloned H-2 genes. Nature (1982) 1.91
Interaction between major histocompatibility complex antigens and epidermal growth factor receptors on human cells. J Cell Biol (1984) 1.82
Molecular biology of the H-2 histocompatibility complex. Science (1986) 1.81
Tissue-specific expression of an unusual H-2 (class I)-related gene. Proc Natl Acad Sci U S A (1982) 1.76
Expression of class I genes in the major histocompatibility complex: identification of eight distinct mRNAs in DBA/2 mouse liver. Cell (1985) 1.57
The original function of MHC antigens as the general plasma membrane anchorage site of organogenesis-directing proteins. Immunol Rev (1977) 1.47
The major histocompatibility complex class I heavy chain as a structural subunit of the human cell membrane insulin receptor: implications for the range of biological functions of histocompatibility antigens. Proc Natl Acad Sci U S A (1986) 1.44
Secretion of a soluble class I molecule encoded by the Q10 gene of the C57BL/10 mouse. EMBO J (1985) 1.40
Asynchronous regulation of mouse H-2D and beta-2 microglobulin RNA transcripts. Immunogenetics (1985) 1.36
Duplicated gene pairs and alleles of class I genes in the Qa2 region of the murine major histocompatibility complex: a comparison. EMBO J (1985) 1.36
Expression and T cell recognition of hybrid antigens with amino-terminal domains encoded by Qa-2 region of major histocompatibility complex and carboxyl termini of transplantation antigens. J Exp Med (1985) 1.23
Structure and expression of genes encoding murine Qa-2 class I antigens. Proc Natl Acad Sci U S A (1985) 1.22
Influence of the mouse major histocompatibility complex, H-2, on liver adenylate cyclase activity and on glucagon binding to liver cell membranes. Biochemistry (1980) 1.20
Qa gene expression: biosynthesis and secretion of Qa-2 molecules in activated T cells. Proc Natl Acad Sci U S A (1986) 1.15
Multiple mechanisms regulate the expression of murine immune response genes. Cell (1985) 1.00
Demonstration of H-2 antigens on preimplantation mouse embryos using conventional antisera and monoclonal antibody. J Exp Zool (1984) 0.94
Abnormal cellular localization of thyroglobulin mRNA associated with hereditary congenital goiter and thyroglobulin deficiency. Proc Natl Acad Sci U S A (1978) 0.87
Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3. Nature (2001) 25.15
A physical map of the DNA regions flanking the rabbit beta-globin gene. Cell (1977) 12.96
The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells. Cell (1997) 12.68
Altered cytokine export and apoptosis in mice deficient in interleukin-1 beta converting enzyme. Science (1995) 11.38
Help for cytotoxic-T-cell responses is mediated by CD40 signalling. Nature (1998) 11.08
PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum. Development (1996) 9.58
BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis. Mol Cell (2001) 9.33
Requirement of JNK for stress-induced activation of the cytochrome c-mediated death pathway. Science (2000) 8.56
Localization of DNA sequences necessary for transcription of the rabbit beta-globin gene in vitro. Cell (1981) 8.48
DNA methylation in the human gamma delta beta-globin locus in erythroid and nonerythroid tissues. Cell (1980) 8.41
Out of Eden: stem cells and their niches. Science (2000) 8.31
Protection of mice against the Lyme disease agent by immunizing with recombinant OspA. Science (1990) 7.33
Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice. Nature (1996) 7.27
Bone morphogenetic protein-4 is required for mesoderm formation and patterning in the mouse. Genes Dev (1995) 7.13
Abrogation of TGFbeta signaling in T cells leads to spontaneous T cell differentiation and autoimmune disease. Immunity (2000) 6.97
CD40 and CD154 in cell-mediated immunity. Annu Rev Immunol (1998) 6.83
Reduced apoptosis and cytochrome c-mediated caspase activation in mice lacking caspase 9. Cell (1998) 6.79
DNA methylation and the regulation of globin gene expression. Cell (1983) 6.49
The rabbit beta-globin gene contains a large large insert in the coding sequence. Cell (1977) 6.45
Mouse small eye results from mutations in a paired-like homeobox-containing gene. Nature (1992) 6.32
Carbon monoxide has anti-inflammatory effects involving the mitogen-activated protein kinase pathway. Nat Med (2000) 6.32
A method for the recovery of DNA from agarose gels. Nucleic Acids Res (1978) 6.24
MspI, an isoschizomer of hpaII which cleaves both unmethylated and methylated hpaII sites. Nucleic Acids Res (1978) 6.01
Isolation of beta-globin-related genes from a human cosmid library. Gene (1981) 5.97
Conditional vascular cell adhesion molecule 1 deletion in mice: impaired lymphocyte migration to bone marrow. J Exp Med (2001) 5.97
The construction of cosmid libraries which can be used to transform eukaryotic cells. Nucleic Acids Res (1982) 5.66
ICOS co-stimulatory receptor is essential for T-cell activation and function. Nature (2001) 5.32
Analysis of the beta-delta-globin gene loci in normal and Hb Lepore DNA: direct determination of gene linkage and intergene distance. Cell (1978) 5.30
Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene. Nature (1997) 5.29
Bmp4 is required for the generation of primordial germ cells in the mouse embryo. Genes Dev (1999) 5.19
Isolation of yeast histone genes H2A and H2B. Cell (1979) 5.17
Activation of interferon-gamma inducing factor mediated by interleukin-1beta converting enzyme. Science (1997) 5.16
Fibroblast growth factor 10 (FGF10) and branching morphogenesis in the embryonic mouse lung. Development (1997) 5.09
DNA sequences necessary for transcription of the rabbit beta-globin gene in vivo. Nature (1982) 4.97
Derivation of pluripotential embryonic stem cells from murine primordial germ cells in culture. Cell (1992) 4.85
DNA methylation at a CCGG sequence in the large intron of the rabbit beta-globin gene: tissue-specific variations. Nucleic Acids Res (1978) 4.77
The sequence GGCmCGG is resistant to MspI cleavage. Nucleic Acids Res (1983) 4.75
Essential role of phosphoinositide metabolism in synaptic vesicle recycling. Cell (1999) 4.70
The Jnk1 and Jnk2 protein kinases are required for regional specific apoptosis during early brain development. Neuron (1999) 4.51
Mice deficient for the CD40 ligand. Immunity (1994) 4.45
Defective T cell differentiation in the absence of Jnk1. Science (1998) 4.40
Organization and evolution of the class I gene family in the major histocompatibility complex of the C57BL/10 mouse. Nature (1984) 4.22
Interleukin (IL)-6 directs the differentiation of IL-4-producing CD4+ T cells. J Exp Med (1997) 4.06
Distinct roles in lymphoid organogenesis for lymphotoxins alpha and beta revealed in lymphotoxin beta-deficient mice. Immunity (1997) 3.99
The structure of a mutant H-2 gene suggests that the generation of polymorphism in H-2 genes may occur by gene conversion-like events. Nature (1983) 3.99
Intestinal tumorigenesis is suppressed in mice lacking the metalloproteinase matrilysin. Proc Natl Acad Sci U S A (1997) 3.96
The DNA sequence of the H-2kb gene: evidence for gene conversion as a mechanism for the generation of polymorphism in histocompatibilty antigens. EMBO J (1983) 3.95
Comparison of cloned rabbit and mouse beta-globin genes showing strong evolutionary divergence of two homologous pairs of introns. Nature (1978) 3.86
Immune-mediated eradication of tumors through the blockade of transforming growth factor-beta signaling in T cells. Nat Med (2001) 3.74
Differentiation of CD4+ T cells to Th1 cells requires MAP kinase JNK2. Immunity (1998) 3.70
Differential expression of multiple fork head related genes during gastrulation and axial pattern formation in the mouse embryo. Development (1993) 3.63
Outer surface proteins E and F of Borrelia burgdorferi, the agent of Lyme disease. Infect Immun (1994) 3.59
Altered wound healing in mice lacking a functional osteopontin gene (spp1). J Clin Invest (1998) 3.56
Bmp4 and Fgf10 play opposing roles during lung bud morphogenesis. Development (2000) 3.54
Beta + thalassemia: aberrant splicing results from a single point mutation in an intron. Cell (1981) 3.51
Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes. Cell Death Differ (2009) 3.44
Borrelia burgdorferi genes selectively expressed in the infected host. Proc Natl Acad Sci U S A (1995) 3.42
Male mice defective in the DNA mismatch repair gene PMS2 exhibit abnormal chromosome synapsis in meiosis. Cell (1995) 3.34
Sequence requirements for the transcription of the rabbit beta-globin gene in vivo: the -80 region. Nucleic Acids Res (1982) 3.11
Impairment of antigen-specific T-cell priming in mice lacking CD40 ligand. Nature (1995) 3.07
Effects on blood pressure and exploratory behaviour of mice lacking angiotensin II type-2 receptor. Nature (1995) 3.06
Distinct mesodermal signals, including BMPs from the septum transversum mesenchyme, are required in combination for hepatogenesis from the endoderm. Genes Dev (2001) 3.04
Roles of OspA, OspB, and flagellin in protective immunity to Lyme borreliosis in laboratory mice. Infect Immun (1992) 3.04
Elimination of Borrelia burgdorferi from vector ticks feeding on OspA-immunized mice. Proc Natl Acad Sci U S A (1992) 2.99
Neural tube, skeletal and body wall defects in mice lacking transcription factor AP-2. Nature (1996) 2.98
Regulation of IL-4 expression by the transcription factor JunB during T helper cell differentiation. EMBO J (1999) 2.96
Bone morphogenetic proteins (BMPs) as regulators of dorsal forebrain development. Development (1997) 2.93
Beta-globin gene inactivation by DNA translocation in gamma beta-thalassaemia. Nature (1984) 2.83
Shigella-induced apoptosis is dependent on caspase-1 which binds to IpaB. J Biol Chem (1998) 2.75
Sera from patients with chronic Lyme disease protect mice from Lyme borreliosis. J Infect Dis (1994) 2.72
Structure and expression of a cloned beta o thalassaemic globin gene. Nucleic Acids Res (1981) 2.71
Activation of the STAT signaling pathway can cause expression of caspase 1 and apoptosis. Mol Cell Biol (1997) 2.71
Phenotypic and physiologic characterization of transgenic mice expressing interleukin 4 in the lung: lymphocytic and eosinophilic inflammation without airway hyperreactivity. Proc Natl Acad Sci U S A (1996) 2.70
Retina- and ventral forebrain-specific Cre recombinase activity in transgenic mice. Genesis (2000) 2.70
Defective IL-12 production in mitogen-activated protein (MAP) kinase kinase 3 (Mkk3)-deficient mice. EMBO J (1999) 2.70
gamma-beta-Thalassaemia studies showing that deletion of the gamma- and delta-genes influences beta-globin gene expression in man. Nature (1980) 2.68
Development of mammary hyperplasia and neoplasia in MMTV-TGF alpha transgenic mice. Cell (1990) 2.63
BMP4 is essential for lens induction in the mouse embryo. Genes Dev (1998) 2.62
Cell interactions modulate embryonal carcinoma cell differentiation into parietal or visceral endoderm. Nature (1981) 2.62
Involvement of Sonic hedgehog (Shh) in mouse embryonic lung growth and morphogenesis. Development (1997) 2.61
Molecular mapping of Osp-A mediated immunity against Borrelia burgdorferi, the agent of Lyme disease. J Immunol (1991) 2.61
Domain interactions of H-2 class I antigens alter cytotoxic T-cell recognition sites. Nature (1984) 2.60
Involvement of Bone Morphogenetic Protein-4 (BMP-4) and Vgr-1 in morphogenesis and neurogenesis in the mouse. Development (1991) 2.60
Expression of interleukin 9 in the lungs of transgenic mice causes airway inflammation, mast cell hyperplasia, and bronchial hyperresponsiveness. J Exp Med (1998) 2.55
In situ hybridization analysis of TGF beta 3 RNA expression during mouse development: comparative studies with TGF beta 1 and beta 2. Development (1990) 2.53
Borrelia burgdorferi strain 25015: characterization of outer surface protein A and vaccination against infection. J Immunol (1992) 2.49
MKK7 is an essential component of the JNK signal transduction pathway activated by proinflammatory cytokines. Genes Dev (2001) 2.48
Nodal is a novel TGF-beta-like gene expressed in the mouse node during gastrulation. Nature (1993) 2.45
Developmental and spatial patterns of expression of the mouse homeobox gene, Hox 2.1. Development (1987) 2.44
Organogenesis and pattern formation in the mouse: RNA distribution patterns suggest a role for bone morphogenetic protein-2A (BMP-2A). Development (1990) 2.44
Transgenic mice demonstrate AP-1 (activator protein-1) transactivation is required for tumor promotion. Proc Natl Acad Sci U S A (1999) 2.43
Structure of the murine immune response I-A beta locus: sequence of the I-A beta gene and an adjacent beta-chain second domain exon. Cell (1983) 2.42
Partial destruction of Borrelia burgdorferi within ticks that engorged on OspE- or OspF-immunized mice. Infect Immun (1994) 2.42
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Bone morphogenetic protein 4 regulates the budding site and elongation of the mouse ureter. J Clin Invest (2000) 2.42
CD8 T cell clones from young nonobese diabetic (NOD) islets can transfer rapid onset of diabetes in NOD mice in the absence of CD4 cells. J Exp Med (1996) 2.42
Interferon-gamma expression by Th1 effector T cells mediated by the p38 MAP kinase signaling pathway. EMBO J (1998) 2.41