Published in Nucleic Acids Res on August 25, 1982
Three trans-acting regulatory proteins of herpes simplex virus modulate immediate-early gene expression in a pathway involving positive and negative feedback regulation. J Virol (1985) 5.63
A synthetic heat-shock promoter element confers heat-inducibility on the herpes simplex virus thymidine kinase gene. EMBO J (1982) 5.19
The repeated GC-rich motifs upstream from the TATA box are important elements of the SV40 early promoter. Nucleic Acids Res (1983) 4.93
Sequences upstream from the T-A-T-A box are required in vivo and in vitro for efficient transcription from the adenovirus serotype 2 major late promoter. Proc Natl Acad Sci U S A (1982) 4.30
The DNA sequence of the H-2kb gene: evidence for gene conversion as a mechanism for the generation of polymorphism in histocompatibilty antigens. EMBO J (1983) 3.95
The human beta-globin promoter; nuclear protein factors and erythroid specific induction of transcription. EMBO J (1988) 3.16
Alternative transcription and splicing of the human porphobilinogen deaminase gene result either in tissue-specific or in housekeeping expression. Proc Natl Acad Sci U S A (1988) 3.11
The adenovirus-2 early EIIa transcription unit possesses two overlapping promoters with different sequence requirements for EIa-dependent stimulation. EMBO J (1985) 2.89
Specific interaction between a transcription factor and the upstream element of the adenovirus-2 major late promoter. EMBO J (1985) 2.83
Functional analysis of a herpes simplex virus type 1 promoter: identification of far-upstream regulatory sequences. Nucleic Acids Res (1983) 2.78
Sequences controlling in vitro transcription of SV40 promoters. EMBO J (1983) 2.65
Linker scanning mutagenesis of the 5'-flanking region of the mouse beta-major-globin gene: sequence requirements for transcription in erythroid and nonerythroid cells. Mol Cell Biol (1985) 2.54
Stimulation of in vitro transcription by the upstream element of the adenovirus-2 major late promoter involves a specific factor. Nucleic Acids Res (1984) 2.31
The adenovirus-2 EIIa early gene promoter: sequences required for efficient in vitro and in vivo transcription. Nucleic Acids Res (1983) 2.28
Immediate-early mRNA-2 of herpes simplex viruses types 1 and 2 is unspliced: conserved sequences around the 5' and 3' termini correspond to transcription regulatory signals. Nucleic Acids Res (1983) 2.01
Homologous upstream sequences near Epstein-Barr virus promoters. Proc Natl Acad Sci U S A (1983) 1.98
Identification of two factors required for transcription of the ovalbumin gene. Mol Cell Biol (1986) 1.96
The nucleotide sequence of the murine I-E beta b immune response gene: evidence for gene conversion events in class II genes of the major histocompatibility complex. EMBO J (1984) 1.87
Tissue restricted and stage specific transcription is maintained within 411 nucleotides flanking the 5' end of the chicken alpha-skeletal actin gene. Nucleic Acids Res (1986) 1.83
Transient expression of a mouse alpha-fetoprotein minigene: deletion analyses of promoter function. Mol Cell Biol (1983) 1.74
Structural organization of the P25 gene of Bombyx mori and comparative analysis of its 5' flanking DNA with that of the fibroin gene. Nucleic Acids Res (1985) 1.68
Generation and functional analyses for base-substitution mutants of the adenovirus 2 major late promoter. Nucleic Acids Res (1984) 1.68
Control of transcription initiation in vitro requires binding of a transcription factor to the distal promoter of the ovalbumin gene. Mol Cell Biol (1986) 1.61
Sequences in the polyomavirus DNA regulatory region involved in viral DNA replication and early gene expression. J Virol (1985) 1.60
Transactivation of a late herpes simplex virus promoter. Mol Cell Biol (1984) 1.53
Positive control of the herpes simplex virus thymidine kinase gene requires upstream DNA sequences. J Virol (1983) 1.50
Promoter sequences required for function of the human gamma globin gene in erythroid cells. EMBO J (1986) 1.47
The MES-1 murine enhancer element is closely associated with the heterogeneous 5' ends of two divergent transcription units. Mol Cell Biol (1986) 1.47
DNA sequences involved in transcriptional regulation of the mouse beta-globin promoter in murine erythroleukemia cells. Mol Cell Biol (1988) 1.45
A functional map of the nopaline synthase promoter. Nucleic Acids Res (1984) 1.42
Isolation of cellular DNA sequences that allow expression of adjacent genes. Proc Natl Acad Sci U S A (1983) 1.40
Human globin gene promoter sequences are sufficient for specific expression of a hybrid gene transfected into tissue culture cells. Mol Cell Biol (1987) 1.35
Transcription modulation in vitro of the fibroin gene exerted by a 200-base-pair region upstream from the "TATA" box. Proc Natl Acad Sci U S A (1983) 1.33
Modular structure of the beta-globin and the TK promoters. EMBO J (1984) 1.18
In monkey COS cells only the TATA box and the cap site region are required for faithful and efficient initiation of the fibroin gene transcription. Nucleic Acids Res (1984) 1.15
Sequence homologies within the 5' end region of the estrogen-controlled vitellogenin gene in Xenopus and chicken. EMBO J (1983) 1.14
Definition of the ovalbumin gene promoter by transfer of an ovalglobin fusion gene into cultured cells. Nucleic Acids Res (1983) 1.08
The structure of an unusual leghemoglobin gene from soybean. EMBO J (1983) 1.06
Functional, developmentally expressed genes for mouse U1a and U1b snRNAs contain both conserved and non-conserved transcription signals. Nucleic Acids Res (1986) 1.04
A directly repeated sequence in the beta-globin promoter regulates transcription in murine erythroleukemia cells. Mol Cell Biol (1990) 1.01
Stable transfer and expression of exogenous human globin genes in human erythroleukemia (K562) cells. Proc Natl Acad Sci U S A (1984) 0.95
The promoter and enhancer of the inactive chicken beta-globin gene contains precisely positioned nucleosomes. Nucleic Acids Res (1991) 0.90
Molecular cloning of a steroid-regulated 108K heat shock protein gene from hen oviduct. Nucleic Acids Res (1986) 0.82
Participation of the upstream region of the fibroin gene in the formation of transcription complex in vitro. Mol Cell Biol (1986) 0.80
A comparison of the promoter strengths of two eukaryotic genes in vitro reveals a region of DNA that can influence the rate of transcription in cis over long distances. Nucleic Acids Res (1983) 0.79
Specific transcription of preformed nucleoprotein complexes, containing the adenovirus major late promoter, with a chromatographic fraction containing RNA polymerase II. Proc Natl Acad Sci U S A (1985) 0.77
The genetics of hemoglobin A2 regulation in sickle cell anemia. Am J Hematol (2014) 0.75
Sequencing end-labeled DNA with base-specific chemical cleavages. Methods Enzymol (1980) 287.68
Mapping of RNA by a modification of the Berk-Sharp procedure: the 5' termini of 15 S beta-globin mRNA precursor and mature 10 s beta-globin mRNA have identical map coordinates. Nucleic Acids Res (1979) 31.23
In vivo sequence requirements of the SV40 early promotor region. Nature (1981) 25.00
Transcription maps of polyoma virus-specific RNA: analysis by two-dimensional nuclease S1 gel mapping. Methods Enzymol (1980) 24.43
The structure and evolution of the human beta-globin gene family. Cell (1980) 21.24
Expression of a beta-globin gene is enhanced by remote SV40 DNA sequences. Cell (1981) 20.72
Promoter sequences of eukaryotic protein-coding genes. Science (1980) 19.96
Transfer of purified herpes virus thymidine kinase gene to cultured mouse cells. Cell (1977) 18.95
The ovalbumin gene-sequence of putative control regions. Nucleic Acids Res (1980) 18.04
Identification of regulatory sequences in the prelude sequences of an H2A histone gene by the study of specific deletion mutants in vivo. Proc Natl Acad Sci U S A (1980) 16.88
Analysis of transcriptional regulatory signals of the HSV thymidine kinase gene: identification of an upstream control region. Cell (1981) 12.73
Identification of DNA sequences required for transcription of the human alpha 1-globin gene in a new SV40 host-vector system. Cell (1981) 9.81
DNA sequence required for initiation of transcription in vitro from the major late promoter of adenovirus 2. Proc Natl Acad Sci U S A (1981) 9.08
Localization of DNA sequences necessary for transcription of the rabbit beta-globin gene in vitro. Cell (1981) 8.48
The nucleotide sequence of the human beta-globin gene. Cell (1980) 8.11
DNA sequences preceding the rabbit beta-globin gene are required for formation in mouse L cells of beta-globin RNA with the correct 5' terminus. Proc Natl Acad Sci U S A (1981) 5.26
DNA sequences necessary for transcription of the rabbit beta-globin gene in vivo. Nature (1982) 4.97
Ubiquitous and gene-specific regulatory 5' sequences in a sea urchin histone DNA clone coding for histone protein variants. Nucleic Acids Res (1980) 3.80
Beta + thalassemia: aberrant splicing results from a single point mutation in an intron. Cell (1981) 3.51
Structure and expression of a cloned beta o thalassaemic globin gene. Nucleic Acids Res (1981) 2.71
Eukaryotic promoters? Nature (1979) 1.98
Initial sequencing and analysis of the human genome. Nature (2001) 212.86
Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3. Nature (2001) 25.15
A physical map of the DNA regions flanking the rabbit beta-globin gene. Cell (1977) 12.96
The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells. Cell (1997) 12.68
A physical map of the human genome. Nature (2001) 12.39
The ABC transporter Bcrp1/ABCG2 is expressed in a wide variety of stem cells and is a molecular determinant of the side-population phenotype. Nat Med (2001) 11.94
Altered cytokine export and apoptosis in mice deficient in interleukin-1 beta converting enzyme. Science (1995) 11.38
Help for cytotoxic-T-cell responses is mediated by CD40 signalling. Nature (1998) 11.08
The DNA sequence of human chromosome 21. Nature (2000) 10.66
BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis. Mol Cell (2001) 9.33
The genome of the social amoeba Dictyostelium discoideum. Nature (2005) 9.18
Requirement of JNK for stress-induced activation of the cytochrome c-mediated death pathway. Science (2000) 8.56
Localization of DNA sequences necessary for transcription of the rabbit beta-globin gene in vitro. Cell (1981) 8.48
DNA methylation in the human gamma delta beta-globin locus in erythroid and nonerythroid tissues. Cell (1980) 8.41
Activating Smoothened mutations in sporadic basal-cell carcinoma. Nature (1998) 7.43
Protection of mice against the Lyme disease agent by immunizing with recombinant OspA. Science (1990) 7.33
Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice. Nature (1996) 7.27
Abrogation of TGFbeta signaling in T cells leads to spontaneous T cell differentiation and autoimmune disease. Immunity (2000) 6.97
Mice lacking alpha-synuclein display functional deficits in the nigrostriatal dopamine system. Neuron (2000) 6.92
CD40 and CD154 in cell-mediated immunity. Annu Rev Immunol (1998) 6.83
Reduced apoptosis and cytochrome c-mediated caspase activation in mice lacking caspase 9. Cell (1998) 6.79
Molecular basis of symbiosis between Rhizobium and legumes. Nature (1997) 6.66
DNA methylation and the regulation of globin gene expression. Cell (1983) 6.49
The rabbit beta-globin gene contains a large large insert in the coding sequence. Cell (1977) 6.45
Carbon monoxide has anti-inflammatory effects involving the mitogen-activated protein kinase pathway. Nat Med (2000) 6.32
A method for the recovery of DNA from agarose gels. Nucleic Acids Res (1978) 6.24
MspI, an isoschizomer of hpaII which cleaves both unmethylated and methylated hpaII sites. Nucleic Acids Res (1978) 6.01
Conditional vascular cell adhesion molecule 1 deletion in mice: impaired lymphocyte migration to bone marrow. J Exp Med (2001) 5.97
Isolation of beta-globin-related genes from a human cosmid library. Gene (1981) 5.97
Bisulfite genomic sequencing: systematic investigation of critical experimental parameters. Nucleic Acids Res (2001) 5.89
The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog. Nature (1996) 5.69
The construction of cosmid libraries which can be used to transform eukaryotic cells. Nucleic Acids Res (1982) 5.66
Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells. Nature (1996) 5.45
ICOS co-stimulatory receptor is essential for T-cell activation and function. Nature (2001) 5.32
Analysis of the beta-delta-globin gene loci in normal and Hb Lepore DNA: direct determination of gene linkage and intergene distance. Cell (1978) 5.30
Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene. Nature (1997) 5.29
Activation of interferon-gamma inducing factor mediated by interleukin-1beta converting enzyme. Science (1997) 5.16
DNA sequences necessary for transcription of the rabbit beta-globin gene in vivo. Nature (1982) 4.97
Pseudoautosomal deletions encompassing a novel homeobox gene cause growth failure in idiopathic short stature and Turner syndrome. Nat Genet (1997) 4.95
DNA methylation at a CCGG sequence in the large intron of the rabbit beta-globin gene: tissue-specific variations. Nucleic Acids Res (1978) 4.77
The sequence GGCmCGG is resistant to MspI cleavage. Nucleic Acids Res (1983) 4.75
Nibrin, a novel DNA double-strand break repair protein, is mutated in Nijmegen breakage syndrome. Cell (1998) 4.72
Essential role of phosphoinositide metabolism in synaptic vesicle recycling. Cell (1999) 4.70
The Jnk1 and Jnk2 protein kinases are required for regional specific apoptosis during early brain development. Neuron (1999) 4.51
Mice deficient for the CD40 ligand. Immunity (1994) 4.45
DNA sequences required for regulated expression of beta-globin genes in murine erythroleukemia cells. Cell (1984) 4.42
Defective T cell differentiation in the absence of Jnk1. Science (1998) 4.40
Organization and evolution of the class I gene family in the major histocompatibility complex of the C57BL/10 mouse. Nature (1984) 4.22
Renal and neuronal abnormalities in mice lacking GDNF. Nature (1996) 4.06
Interleukin (IL)-6 directs the differentiation of IL-4-producing CD4+ T cells. J Exp Med (1997) 4.06
Positional cloning of the gene for X-linked retinitis pigmentosa 2. Nat Genet (1998) 4.01
Distinct roles in lymphoid organogenesis for lymphotoxins alpha and beta revealed in lymphotoxin beta-deficient mice. Immunity (1997) 3.99
The structure of a mutant H-2 gene suggests that the generation of polymorphism in H-2 genes may occur by gene conversion-like events. Nature (1983) 3.99
The DNA sequence of the H-2kb gene: evidence for gene conversion as a mechanism for the generation of polymorphism in histocompatibilty antigens. EMBO J (1983) 3.95
Comparison of cloned rabbit and mouse beta-globin genes showing strong evolutionary divergence of two homologous pairs of introns. Nature (1978) 3.86
Immune-mediated eradication of tumors through the blockade of transforming growth factor-beta signaling in T cells. Nat Med (2001) 3.74
Differentiation of CD4+ T cells to Th1 cells requires MAP kinase JNK2. Immunity (1998) 3.70
GDNF: a potent survival factor for motoneurons present in peripheral nerve and muscle. Science (1994) 3.63
Outer surface proteins E and F of Borrelia burgdorferi, the agent of Lyme disease. Infect Immun (1994) 3.59
Stat5 is required for IL-2-induced cell cycle progression of peripheral T cells. Immunity (1999) 3.53
Beta + thalassemia: aberrant splicing results from a single point mutation in an intron. Cell (1981) 3.51
Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes. Cell Death Differ (2009) 3.44
Borrelia burgdorferi genes selectively expressed in the infected host. Proc Natl Acad Sci U S A (1995) 3.42
Male mice defective in the DNA mismatch repair gene PMS2 exhibit abnormal chromosome synapsis in meiosis. Cell (1995) 3.34
FGF and Shh signals control dopaminergic and serotonergic cell fate in the anterior neural plate. Cell (1998) 3.33
Impairment of antigen-specific T-cell priming in mice lacking CD40 ligand. Nature (1995) 3.07
Defective lymphoid development in mice lacking Jak3. Science (1995) 3.04
Roles of OspA, OspB, and flagellin in protective immunity to Lyme borreliosis in laboratory mice. Infect Immun (1992) 3.04
Topical ketorolac tromethamine 0.5% ophthalmic solution in ocular inflammation after cataract surgery. Ophthalmology (2001) 3.01
Elimination of Borrelia burgdorferi from vector ticks feeding on OspA-immunized mice. Proc Natl Acad Sci U S A (1992) 2.99
Neural tube, skeletal and body wall defects in mice lacking transcription factor AP-2. Nature (1996) 2.98
Regulation of IL-4 expression by the transcription factor JunB during T helper cell differentiation. EMBO J (1999) 2.96
Characterization of a multicomponent receptor for GDNF. Nature (1996) 2.92
Drinks like a fish: zebra fish (Danio rerio) as a behavior genetic model to study alcohol effects. Pharmacol Biochem Behav (2000) 2.83
Beta-globin gene inactivation by DNA translocation in gamma beta-thalassaemia. Nature (1984) 2.83
Shigella-induced apoptosis is dependent on caspase-1 which binds to IpaB. J Biol Chem (1998) 2.75
Sera from patients with chronic Lyme disease protect mice from Lyme borreliosis. J Infect Dis (1994) 2.72
Structure and expression of a cloned beta o thalassaemic globin gene. Nucleic Acids Res (1981) 2.71
Activation of the STAT signaling pathway can cause expression of caspase 1 and apoptosis. Mol Cell Biol (1997) 2.71
Phenotypic and physiologic characterization of transgenic mice expressing interleukin 4 in the lung: lymphocytic and eosinophilic inflammation without airway hyperreactivity. Proc Natl Acad Sci U S A (1996) 2.70
Defective IL-12 production in mitogen-activated protein (MAP) kinase kinase 3 (Mkk3)-deficient mice. EMBO J (1999) 2.70
gamma-beta-Thalassaemia studies showing that deletion of the gamma- and delta-genes influences beta-globin gene expression in man. Nature (1980) 2.68
THE FILTRATION RATE, EFFECTIVE RENAL BLOOD FLOW, TUBULAR EXCRETORY MASS AND PHENOL RED CLEARANCE IN SPECIFIC TOXEMIA OF PREGANANCY. J Clin Invest (1942) 2.65
Molecular mapping of Osp-A mediated immunity against Borrelia burgdorferi, the agent of Lyme disease. J Immunol (1991) 2.61
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Expression of interleukin 9 in the lungs of transgenic mice causes airway inflammation, mast cell hyperplasia, and bronchial hyperresponsiveness. J Exp Med (1998) 2.55
X-linked spastic paraplegia (SPG1), MASA syndrome and X-linked hydrocephalus result from mutations in the L1 gene. Nat Genet (1994) 2.53
Borrelia burgdorferi strain 25015: characterization of outer surface protein A and vaccination against infection. J Immunol (1992) 2.49
An L-type calcium-channel gene mutated in incomplete X-linked congenital stationary night blindness. Nat Genet (1998) 2.48
MKK7 is an essential component of the JNK signal transduction pathway activated by proinflammatory cytokines. Genes Dev (2001) 2.48
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Partial destruction of Borrelia burgdorferi within ticks that engorged on OspE- or OspF-immunized mice. Infect Immun (1994) 2.42
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CD8 T cell clones from young nonobese diabetic (NOD) islets can transfer rapid onset of diabetes in NOD mice in the absence of CD4 cells. J Exp Med (1996) 2.42
Interferon-gamma expression by Th1 effector T cells mediated by the p38 MAP kinase signaling pathway. EMBO J (1998) 2.41
Expression in rat fibroblasts of a human transforming growth factor-alpha cDNA results in transformation. Cell (1986) 2.41