Rank |
Title |
Journal |
Year |
PubWeight™‹?› |
1
|
The human LDL receptor: a cysteine-rich protein with multiple Alu sequences in its mRNA.
|
Cell
|
1984
|
12.54
|
2
|
Receptor-mediated endocytosis: concepts emerging from the LDL receptor system.
|
Annu Rev Cell Biol
|
1985
|
11.53
|
3
|
Cloning, structure, and expression of the mitochondrial cytochrome P-450 sterol 26-hydroxylase, a bile acid biosynthetic enzyme.
|
J Biol Chem
|
1989
|
11.06
|
4
|
Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells.
|
Genes Dev
|
1997
|
8.51
|
5
|
The LDL receptor gene: a mosaic of exons shared with different proteins.
|
Science
|
1985
|
5.49
|
6
|
Human genes involved in cholesterol metabolism: chromosomal mapping of the loci for the low density lipoprotein receptor and 3-hydroxy-3-methylglutaryl-coenzyme A reductase with cDNA probes.
|
Proc Natl Acad Sci U S A
|
1985
|
5.33
|
7
|
Infectious clones and vectors derived from adeno-associated virus (AAV) serotypes other than AAV type 2.
|
J Virol
|
1998
|
4.71
|
8
|
Mutation in LDL receptor: Alu-Alu recombination deletes exons encoding transmembrane and cytoplasmic domains.
|
Science
|
1985
|
4.51
|
9
|
Domain map of the LDL receptor: sequence homology with the epidermal growth factor precursor.
|
Cell
|
1984
|
4.21
|
10
|
The hypoxia-responsive transcription factor EPAS1 is essential for catecholamine homeostasis and protection against heart failure during embryonic development.
|
Genes Dev
|
1998
|
4.11
|
11
|
The low density lipoprotein receptor. Identification of amino acids in cytoplasmic domain required for rapid endocytosis.
|
J Biol Chem
|
1987
|
3.84
|
12
|
Expression cloning of a diphtheria toxin receptor: identity with a heparin-binding EGF-like growth factor precursor.
|
Cell
|
1992
|
3.81
|
13
|
The J.D. mutation in familial hypercholesterolemia: amino acid substitution in cytoplasmic domain impedes internalization of LDL receptors.
|
Cell
|
1986
|
3.44
|
14
|
The LDL receptor locus in familial hypercholesterolemia: mutational analysis of a membrane protein.
|
Annu Rev Genet
|
1990
|
3.40
|
15
|
Duplication of seven exons in LDL receptor gene caused by Alu-Alu recombination in a subject with familial hypercholesterolemia.
|
Cell
|
1987
|
3.31
|
16
|
Internalization-defective LDL receptors produced by genes with nonsense and frameshift mutations that truncate the cytoplasmic domain.
|
Cell
|
1985
|
3.13
|
17
|
Nucleotide sequence of the yeast alcohol dehydrogenase II gene.
|
J Biol Chem
|
1983
|
2.82
|
18
|
Deletion in cysteine-rich region of LDL receptor impedes transport to cell surface in WHHL rabbit.
|
Science
|
1986
|
2.76
|
19
|
Acid-dependent ligand dissociation and recycling of LDL receptor mediated by growth factor homology region.
|
Nature
|
1987
|
2.74
|
20
|
Mutations in the bile acid biosynthetic enzyme sterol 27-hydroxylase underlie cerebrotendinous xanthomatosis.
|
J Biol Chem
|
1991
|
2.70
|
21
|
Alu-Alu recombination deletes splice acceptor sites and produces secreted low density lipoprotein receptor in a subject with familial hypercholesterolemia.
|
J Biol Chem
|
1987
|
2.67
|
22
|
Nucleotide sequence of 3-hydroxy-3-methyl-glutaryl coenzyme A reductase, a glycoprotein of endoplasmic reticulum.
|
Nature
|
1984
|
2.66
|
23
|
Transduction by adeno-associated virus vectors in the rabbit airway: efficiency, persistence, and readministration.
|
J Virol
|
1997
|
2.65
|
24
|
Reasoned action and social reaction: willingness and intention as independent predictors of health risk.
|
J Pers Soc Psychol
|
1998
|
2.55
|
25
|
DNA sequences of two yeast promoter-up mutants.
|
Nature
|
1983
|
2.50
|
26
|
DNA-damaging agents greatly increase the transduction of nondividing cells by adeno-associated virus vectors.
|
J Virol
|
1994
|
2.50
|
27
|
Hemimethylation prevents DNA replication in E. coli.
|
Cell
|
1987
|
2.48
|
28
|
Direct and moderating effects of community context on the psychological well-being of African American women.
|
J Pers Soc Psychol
|
2000
|
2.47
|
29
|
Marked reduction in bile acid synthesis in cholesterol 7alpha-hydroxylase-deficient mice does not lead to diminished tissue cholesterol turnover or to hypercholesterolemia.
|
J Lipid Res
|
1998
|
2.46
|
30
|
Mutational analysis of the ligand binding domain of the low density lipoprotein receptor.
|
J Biol Chem
|
1988
|
2.43
|
31
|
Structure of the Saccharomyces cerevisiae HO gene and analysis of its upstream regulatory region.
|
Mol Cell Biol
|
1986
|
2.36
|
32
|
Male pseudohermaphroditism caused by mutations of testicular 17 beta-hydroxysteroid dehydrogenase 3.
|
Nat Genet
|
1994
|
2.35
|
33
|
The Lebanese allele at the low density lipoprotein receptor locus. Nonsense mutation produces truncated receptor that is retained in endoplasmic reticulum.
|
J Biol Chem
|
1987
|
2.29
|
34
|
Repeat transduction in the mouse lung by using adeno-associated virus vectors with different serotypes.
|
J Virol
|
2000
|
2.26
|
35
|
Persistent expression of human clotting factor IX from mouse liver after intravenous injection of adeno-associated virus vectors.
|
Proc Natl Acad Sci U S A
|
1997
|
2.22
|
36
|
cDNA cloning of cholesterol 24-hydroxylase, a mediator of cholesterol homeostasis in the brain.
|
Proc Natl Acad Sci U S A
|
1999
|
2.20
|
37
|
Molecular characterization of two mammalian bHLH-PAS domain proteins selectively expressed in the central nervous system.
|
Proc Natl Acad Sci U S A
|
1997
|
2.15
|
38
|
Characterization of transposable element-associated mutations that alter yeast alcohol dehydrogenase II expression.
|
Mol Cell Biol
|
1983
|
2.09
|
39
|
Deletions and single base pair changes in the yeast mating type locus that prevent homothallic mating type conversions.
|
Proc Natl Acad Sci U S A
|
1983
|
2.09
|
40
|
Exon-Alu recombination deletes 5 kilobases from the low density lipoprotein receptor gene, producing a null phenotype in familial hypercholesterolemia.
|
Proc Natl Acad Sci U S A
|
1986
|
2.04
|
41
|
42 bp element from LDL receptor gene confers end-product repression by sterols when inserted into viral TK promoter.
|
Cell
|
1987
|
2.03
|
42
|
Adeno-associated virus vector integration junctions.
|
J Virol
|
1997
|
2.03
|
43
|
The metabolism of aromatic compounds in higer plants. X. Properties of the cinnamic acid 4-hydroxylase of pea seedlings and some aspects of its metabolic and developmental control.
|
J Biol Chem
|
1971
|
2.02
|
44
|
Characterization of human sterol 27-hydroxylase. A mitochondrial cytochrome P-450 that catalyzes multiple oxidation reaction in bile acid biosynthesis.
|
J Biol Chem
|
1991
|
2.01
|
45
|
Cassette of eight exons shared by genes for LDL receptor and EGF precursor.
|
Science
|
1985
|
1.99
|
46
|
cDNA cloning of the bovine low density lipoprotein receptor: feedback regulation of a receptor mRNA.
|
Proc Natl Acad Sci U S A
|
1983
|
1.98
|
47
|
Deletion in the gene for the low-density-lipoprotein receptor in a majority of French Canadians with familial hypercholesterolemia.
|
N Engl J Med
|
1987
|
1.96
|
48
|
Deletion of exon encoding cysteine-rich repeat of low density lipoprotein receptor alters its binding specificity in a subject with familial hypercholesterolemia.
|
J Biol Chem
|
1986
|
1.94
|
49
|
Overexpression of low density lipoprotein (LDL) receptor eliminates LDL from plasma in transgenic mice.
|
Science
|
1988
|
1.91
|
50
|
Tissue distribution and ontogeny of steroid 5 alpha-reductase isozyme expression.
|
J Clin Invest
|
1993
|
1.88
|
51
|
Disruption of cholesterol 7alpha-hydroxylase gene in mice. I. Postnatal lethality reversed by bile acid and vitamin supplementation.
|
J Biol Chem
|
1996
|
1.87
|
52
|
Aerobic exercise, but not flexibility/resistance exercise, reduces serum IL-18, CRP, and IL-6 independent of beta-blockers, BMI, and psychosocial factors in older adults.
|
Brain Behav Immun
|
2006
|
1.86
|
53
|
cDNA cloning of mouse and human cholesterol 25-hydroxylases, polytopic membrane proteins that synthesize a potent oxysterol regulator of lipid metabolism.
|
J Biol Chem
|
1998
|
1.86
|
54
|
Deduced primary structure of the alpha subunit of the GTP-binding stimulatory protein of adenylate cyclase.
|
Proc Natl Acad Sci U S A
|
1986
|
1.86
|
55
|
The parturition defect in steroid 5alpha-reductase type 1 knockout mice is due to impaired cervical ripening.
|
Mol Endocrinol
|
1999
|
1.83
|
56
|
Climate change and the integrity of science.
|
Science
|
2010
|
1.80
|
57
|
Disruption of cholesterol 7alpha-hydroxylase gene in mice. II. Bile acid deficiency is overcome by induction of oxysterol 7alpha-hydroxylase.
|
J Biol Chem
|
1996
|
1.80
|
58
|
Cloning and regulation of cholesterol 7 alpha-hydroxylase, the rate-limiting enzyme in bile acid biosynthesis.
|
J Biol Chem
|
1990
|
1.79
|
59
|
Deletion of clustered O-linked carbohydrates does not impair function of low density lipoprotein receptor in transfected fibroblasts.
|
J Biol Chem
|
1986
|
1.79
|
60
|
Introduction of single base substitutions at homologous chromosomal sequences by adeno-associated virus vectors.
|
Mol Ther
|
2001
|
1.77
|
61
|
Disruption of the oxysterol 7alpha-hydroxylase gene in mice.
|
J Biol Chem
|
2000
|
1.76
|
62
|
Conservation of function between mammalian and plant steroid 5alpha-reductases.
|
Proc Natl Acad Sci U S A
|
1997
|
1.75
|
63
|
cDNA cloning and expression of the peptide-binding beta subunit of rat p21ras farnesyltransferase, the counterpart of yeast DPR1/RAM1.
|
Cell
|
1991
|
1.71
|
64
|
Deletion of steroid 5 alpha-reductase 2 gene in male pseudohermaphroditism.
|
Nature
|
1991
|
1.69
|
65
|
Identification of a new inborn error in bile acid synthesis: mutation of the oxysterol 7alpha-hydroxylase gene causes severe neonatal liver disease.
|
J Clin Invest
|
1998
|
1.68
|
66
|
Polymorphism and evolution of Alu sequences in the human low density lipoprotein receptor gene.
|
Proc Natl Acad Sci U S A
|
1985
|
1.63
|
67
|
Disruption of the sterol 27-hydroxylase gene in mice results in hepatomegaly and hypertriglyceridemia. Reversal by cholic acid feeding.
|
J Biol Chem
|
2000
|
1.60
|
68
|
Effects of gamma irradiation on the transduction of dividing and nondividing cells in brain and muscle of rats by adeno-associated virus vectors.
|
Hum Gene Ther
|
1996
|
1.60
|
69
|
Steroid 5 alpha-reductase 2 deficiency.
|
Endocr Rev
|
1993
|
1.60
|
70
|
Structural and biochemical properties of cloned and expressed human and rat steroid 5 alpha-reductases.
|
Proc Natl Acad Sci U S A
|
1990
|
1.57
|
71
|
Three direct repeats and a TATA-like sequence are required for regulated expression of the human low density lipoprotein receptor gene.
|
J Biol Chem
|
1987
|
1.56
|
72
|
Blood cholesterol screening influence of fasting state on cholesterol results and management decisions.
|
J Gen Intern Med
|
2000
|
1.55
|
73
|
Design and packaging of adeno-associated virus gene targeting vectors.
|
J Virol
|
2000
|
1.54
|
74
|
Expression cloning and regulation of steroid 5 alpha-reductase, an enzyme essential for male sexual differentiation.
|
J Biol Chem
|
1989
|
1.52
|
75
|
The effectiveness of psychological interventions for the rehabilitation of low back pain: a randomized controlled trial evaluation.
|
Pain
|
1992
|
1.51
|
76
|
5 alpha-reduced androgens play a key role in murine parturition.
|
Mol Endocrinol
|
1996
|
1.50
|
77
|
Purification and characterization of a ribosome dissociation factor (eukaryotic initiation factor 6) from wheat germ.
|
J Biol Chem
|
1979
|
1.45
|
78
|
Simple method for determining isoniazid acetylator phenotype.
|
Br Med J
|
1970
|
1.40
|
79
|
Tissue distribution and kinetic characteristics of rat steroid 5 alpha-reductase isozymes. Evidence for distinct physiological functions.
|
J Biol Chem
|
1992
|
1.37
|
80
|
Molecular genetics of steroid 5 alpha-reductase 2 deficiency.
|
J Clin Invest
|
1992
|
1.36
|
81
|
Subcellular localization of 3-hydroxy-3-methylglutaryl coenzyme A reductase in Pisum sativum seedlings.
|
Arch Biochem Biophys
|
1975
|
1.34
|
82
|
Expression cloning and characterization of oxidative 17beta- and 3alpha-hydroxysteroid dehydrogenases from rat and human prostate.
|
J Biol Chem
|
1997
|
1.33
|
83
|
AvaII polymorphism in the human LDL receptor gene.
|
Nucleic Acids Res
|
1987
|
1.33
|
84
|
The cinnamic acid 4-hydroxylase of pea seedlings.
|
Arch Biochem Biophys
|
1967
|
1.32
|
85
|
Alternate pathways of bile acid synthesis in the cholesterol 7alpha-hydroxylase knockout mouse are not upregulated by either cholesterol or cholestyramine feeding.
|
J Lipid Res
|
2001
|
1.30
|
86
|
Job-related stress, social support, and burnout among classroom teachers.
|
J Appl Psychol
|
1987
|
1.26
|
87
|
Gene transfer into murine hematopoietic stem cells with helper-free foamy virus vectors.
|
Blood
|
2001
|
1.25
|
88
|
Cyp7b, a novel brain cytochrome P450, catalyzes the synthesis of neurosteroids 7alpha-hydroxy dehydroepiandrosterone and 7alpha-hydroxy pregnenolone.
|
Proc Natl Acad Sci U S A
|
1997
|
1.25
|
89
|
Packaging cells based on inducible gene amplification for the production of adeno-associated virus vectors.
|
J Virol
|
1998
|
1.25
|
90
|
High-fidelity correction of mutations at multiple chromosomal positions by adeno-associated virus vectors.
|
J Virol
|
1999
|
1.24
|
91
|
Brief report: the molecular basis of steroid 5 alpha-reductase deficiency in a large Dominican kindred.
|
N Engl J Med
|
1992
|
1.23
|
92
|
Expression cloning of an oxysterol 7alpha-hydroxylase selective for 24-hydroxycholesterol.
|
J Biol Chem
|
2000
|
1.20
|
93
|
The hypocholesterolemic agent LY295427 reverses suppression of sterol regulatory element-binding protein processing mediated by oxysterols.
|
J Biol Chem
|
2001
|
1.19
|
94
|
Transport-deficient mutations in the low density lipoprotein receptor. Alterations in the cysteine-rich and cysteine-poor regions of the protein block intracellular transport.
|
J Biol Chem
|
1988
|
1.19
|
95
|
Genetic and pharmacological evidence for more than one human steroid 5 alpha-reductase.
|
J Clin Invest
|
1992
|
1.15
|
96
|
Fetal death in mice lacking 5alpha-reductase type 1 caused by estrogen excess.
|
Mol Endocrinol
|
1997
|
1.15
|
97
|
mRNA for low density lipoprotein receptor in brain and spinal cord of immature and mature rabbits.
|
Proc Natl Acad Sci U S A
|
1987
|
1.14
|
98
|
Characterization of Chinese hamster ovary cell lines expressing human steroid 5 alpha-reductase isozymes.
|
J Biol Chem
|
1993
|
1.14
|
99
|
Identification and characterization of a mouse oxysterol 7alpha-hydroxylase cDNA.
|
J Biol Chem
|
1997
|
1.14
|
100
|
The bile acid synthetic gene 3beta-hydroxy-Delta(5)-C(27)-steroid oxidoreductase is mutated in progressive intrahepatic cholestasis.
|
J Clin Invest
|
2000
|
1.13
|
101
|
Regulation of microsomal 3-hydroxy-3-methylglutaryl coenzyme A reductase from pea seedlings: rapid posttranslational phytochrome-mediated decrease in activity and in vivo regulation by isoprenoid products.
|
Arch Biochem Biophys
|
1979
|
1.13
|
102
|
Social support and immune function among spouses of cancer patients.
|
J Pers Soc Psychol
|
1990
|
1.11
|
103
|
5alpha-reductase type 2 mutations are present in some boys with isolated hypospadias.
|
J Urol
|
1999
|
1.11
|
104
|
Social support and outcome of alcoholism treatment: an exploratory analysis.
|
Am J Drug Alcohol Abuse
|
1992
|
1.11
|
105
|
Feed-forward control of prostate growth: dihydrotestosterone induces expression of its own biosynthetic enzyme, steroid 5 alpha-reductase.
|
Proc Natl Acad Sci U S A
|
1991
|
1.09
|
106
|
Efficacy of electroacupuncture and TENS in the rehabilitation of chronic low back pain patients.
|
Pain
|
1986
|
1.09
|
107
|
Multiple crm- mutations in familial hypercholesterolemia. Evidence for 13 alleles, including four deletions.
|
J Clin Invest
|
1988
|
1.08
|
108
|
Natural mutagenesis study of the human steroid 5 alpha-reductase 2 isozyme.
|
Biochemistry
|
1994
|
1.08
|
109
|
Helper-free foamy virus vectors.
|
Hum Gene Ther
|
1998
|
1.07
|
110
|
Unexpected virilization in male mice lacking steroid 5 alpha-reductase enzymes.
|
Endocrinology
|
2001
|
1.06
|
111
|
Mechanism of action of the wheat germ ribosome dissociation factor: interaction with the 60 S subunit.
|
Arch Biochem Biophys
|
1980
|
1.05
|
112
|
On the turnover of brain cholesterol in patients with Alzheimer's disease. Abnormal induction of the cholesterol-catabolic enzyme CYP46 in glial cells.
|
Neurosci Lett
|
2001
|
1.05
|
113
|
Transduction of hematopoietic cells by foamy virus vectors.
|
Blood
|
1996
|
1.05
|
114
|
Cloning of the human cholesterol 7 alpha-hydroxylase gene (CYP7) and localization to chromosome 8q11-q12.
|
Genomics
|
1992
|
1.04
|
115
|
Enniatin production by Fusarium sambucinum: primary, secondary, and unitary metabolism.
|
J Gen Microbiol
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1975
|
1.03
|
116
|
Chromatin structure of two genomic sites for targeted transgene integration in induced pluripotent stem cells and hematopoietic stem cells.
|
Gene Ther
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2012
|
1.02
|
117
|
Cell type specific expression of steroid 5 alpha-reductase 2.
|
J Urol
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1994
|
1.02
|
118
|
Properties of microsomal 3-hydroxy-3-methylglutaryl coenzyme A reductase from Pisum sativum seedlings.
|
Arch Biochem Biophys
|
1975
|
1.02
|
119
|
Four-amino acid segment in steroid 5 alpha-reductase 1 confers sensitivity to finasteride, a competitive inhibitor.
|
J Biol Chem
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1992
|
1.02
|
120
|
Increased expression of early growth response-1 messenger ribonucleic acid in prostatic adenocarcinoma.
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J Urol
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1996
|
1.01
|
121
|
Two 7 alpha-hydroxylase enzymes in bile acid biosynthesis.
|
Curr Opin Lipidol
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1998
|
1.01
|
122
|
Rapid determination of isonicotinic acid hydrazide in whole blood with 2,4,6-trinitrobenzenesulphonic acid.
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Clin Chim Acta
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1970
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1.01
|
123
|
Plastid 3-hydroxy-3-methylglutaryl coenzyme A reductase has distinctive kinetic and regulatory features: properties of the enzyme and positive phytochrome control of activity in pea seedlings.
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Arch Biochem Biophys
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1982
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1.01
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124
|
Genetic analysis of intestinal cholesterol absorption in inbred mice.
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J Lipid Res
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2001
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1.00
|
125
|
Perceived parental social support and academic achievement: an attachment theory perspective.
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J Pers Soc Psychol
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1994
|
0.98
|
126
|
Transfer of contaminants in adeno-associated virus vector stocks can mimic transduction and lead to artifactual results.
|
Hum Gene Ther
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1997
|
0.97
|
127
|
TaqI polymorphism in the human LDL receptor gene.
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Nucleic Acids Res
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1987
|
0.95
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128
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17beta-Hydroxysteroid dehydrogenase 3 deficiency.
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Trends Endocrinol Metab
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2008
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0.95
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129
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Cholesterol biosynthesis and metabolism.
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Cardiovasc Drugs Ther
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1992
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0.95
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130
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Characterization and chromosomal mapping of a human steroid 5 alpha-reductase gene and pseudogene and mapping of the mouse homologue.
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Genomics
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1991
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0.95
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131
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Self-esteem, self-serving cognitions, and health risk behavior.
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J Pers
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2000
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0.93
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132
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The LDL receptor in familial hypercholesterolemia: use of human mutations to dissect a membrane protein.
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Cold Spring Harb Symp Quant Biol
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1986
|
0.92
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133
|
The effect of peers' alcohol consumption on parental influence: a cognitive mediational model.
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J Stud Alcohol Suppl
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1999
|
0.92
|
134
|
Cell-type-specific expression of rat steroid 5 alpha-reductase isozymes.
|
Proc Natl Acad Sci U S A
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1993
|
0.91
|
135
|
Expression and regulation of steroid 5 alpha-reductase 2 in prostate disease.
|
J Urol
|
1994
|
0.90
|
136
|
The effect of social support and the work environment upon burnout among nurses.
|
J Human Stress
|
1986
|
0.89
|
137
|
The exercise-induced enhancement of influenza immunity is mediated in part by improvements in psychosocial factors in older adults.
|
Brain Behav Immun
|
2005
|
0.89
|
138
|
Regulation of cytosolic HMG-CoA reductase activity in pea seedlings: contrasting responses to different hormones, and hormone-product interaction, suggest hormonal modulation of activity.
|
Biochem Biophys Res Commun
|
1982
|
0.89
|
139
|
Isoniazid acetylator phenotyping of Amharas in Ethiopia.
|
Afr J Med Sci
|
1973
|
0.88
|
140
|
Simplified isoniazid acetylator phenotyping.
|
Can Med Assoc J
|
1972
|
0.88
|
141
|
Structure of the rat gene encoding cholesterol 7 alpha-hydroxylase.
|
Biochemistry
|
1990
|
0.88
|
142
|
Regulation of low density lipoprotein receptor gene expression in human lymphocytes.
|
J Biol Chem
|
1989
|
0.88
|
143
|
Male and female isoenzymes of steroid 5alpha-reductase.
|
Rev Reprod
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1999
|
0.87
|
144
|
Social support and depression in men during alcoholism treatment.
|
J Subst Abuse
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1992
|
0.87
|
145
|
Reversible dissociation of wheat germ ribosomal subunits: cation-dependent equilibria and thermodynamic parameters.
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Biochemistry
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1980
|
0.86
|
146
|
Genetic analysis of cholesterol accumulation in inbred mice.
|
J Lipid Res
|
2001
|
0.86
|
147
|
Cloning and expression of recombinant, functional ricin B chain.
|
Proc Natl Acad Sci U S A
|
1987
|
0.84
|
148
|
Immunohistochemical localization of steroid 5 alpha-reductase 2 in the human male fetal reproductive tract and adult prostate.
|
J Clin Endocrinol Metab
|
1996
|
0.83
|
149
|
Treatment of canine leukocyte adhesion deficiency by foamy virus vectors expressing CD18 from a PGK promoter.
|
Gene Ther
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2011
|
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