Published in J Cell Biol on July 01, 1986
Connexin43: a protein from rat heart homologous to a gap junction protein from liver. J Cell Biol (1987) 5.22
Hepatocyte gap junctions are permeable to the second messenger, inositol 1,4,5-trisphosphate, and to calcium ions. Proc Natl Acad Sci U S A (1989) 2.53
Hemi-gap-junction channels in solitary horizontal cells of the catfish retina. J Physiol (1992) 2.40
Intramolecular interactions mediate pH regulation of connexin43 channels. Biophys J (1996) 1.88
Role of connexin-based gap junction channels and hemichannels in ischemia-induced cell death in nervous tissue. Brain Res Brain Res Rev (2004) 1.54
A structural basis for the unequal sensitivity of the major cardiac and liver gap junctions to intracellular acidification: the carboxyl tail length. Biophys J (1993) 1.42
Defective ATP-dependent bile canalicular transport of organic anions in mutant (TR-) rats with conjugated hyperbilirubinemia. Proc Natl Acad Sci U S A (1990) 1.33
Expression of gap junction channels in communication-incompetent cells after stable transfection with cDNA encoding connexin 32. Proc Natl Acad Sci U S A (1990) 1.28
Proteoglycans and glycosaminoglycans induce gap junction synthesis and function in primary liver cultures. J Cell Biol (1987) 1.24
Coordinated intercellular calcium waves induced by noradrenaline in rat hepatocytes: dual control by gap junction permeability and agonist. EMBO J (1997) 1.08
Connexin32 gap junction channels in stably transfected cells. Equilibrium and kinetic properties. Biophys J (1991) 1.08
Voltage-dependent gap junction channels are formed by connexin32, the major gap junction protein of rat liver. Biophys J (1991) 1.04
Coordination of hormone-induced calcium signals in isolated rat hepatocyte couplets: demonstration with confocal microscopy. Mol Biol Cell (1992) 1.00
Novel paracrine signaling mechanism in the ocular ciliary epithelium. Proc Natl Acad Sci U S A (1998) 0.97
Hepatic ischemia-reperfusion injury: roles of Ca2+ and other intracellular mediators of impaired bile flow and hepatocyte damage. Dig Dis Sci (2006) 0.95
In situ regulation of cell-cell communication by the cAMP-dependent protein kinase and protein kinase C. Mol Cell Biochem (1993) 0.93
Ca(2+)-mobilizing hormones induce sequentially ordered Ca2+ signals in multicellular systems of rat hepatocytes. Biochem J (1994) 0.90
Effect of angiotensin II and ethanol on the expression of connexin 43 in WB rat liver epithelial cells. Biochem J (2001) 0.86
Periportal- and perivenous-enriched hepatocyte couplets: differences in canalicular activity and in response to oxidative stress. Biochem J (1993) 0.83
Thapsigargin inhibits a potassium conductance and stimulates calcium influx in the intact rat lens. J Physiol (1999) 0.79
Electrical coupling and innexin expression in the stomatogastric ganglion of the crab Cancer borealis. J Neurophysiol (2014) 0.78
High-yield preparation of isolated rat liver parenchymal cells: a biochemical and fine structural study. J Cell Biol (1969) 20.26
Hexagonal array of subunits in intercellular junctions of the mouse heart and liver. J Cell Biol (1967) 11.07
Molecular cloning of cDNA for rat liver gap junction protein. J Cell Biol (1986) 4.69
Structure of the junction between communicating cells. Nature (1980) 4.68
Permeability of cell junction depends on local cytoplasmic calcium activity. Nature (1975) 3.05
Gap junctions, electrotonic coupling, and intercellular communication. Neurosci Res Program Bull (1978) 2.65
Gap junctional conductance is a simple and sensitive function of intracellular pH. Science (1981) 2.64
Antibodies to gap-junctional protein selectively disrupt junctional communication in the early amphibian embryo. Nature (1984) 2.50
Physiology and pharmacology of gap junctions. Annu Rev Physiol (1985) 2.34
cAMP increases junctional conductance and stimulates phosphorylation of the 27-kDa principal gap junction polypeptide. Proc Natl Acad Sci U S A (1986) 2.20
Cell-to-cell channels with two independently regulated gates in series: analysis of junctional conductance modulation by membrane potential, calcium, and pH. J Membr Biol (1983) 2.19
Ionic communication between liver cells. J Cell Biol (1966) 2.04
Interaction of anaesthetics with electrical synapses. Nature (1980) 1.97
A protein homologous to the 27,000 dalton liver gap junction protein is present in a wide variety of species and tissues. Cell (1984) 1.96
Some electrical and pharmacological properties of gap junctions between adult ventricular myocytes. Am J Physiol (1985) 1.88
Gating of gap junction channels. Biophys J (1984) 1.70
Liver cells. Methods Enzymol (1979) 1.67
Differences between liver gap junction protein and lens MIP 26 from rat: implications for tissue specificity of gap junctions. Cell (1983) 1.65
Reduction of gap junctional conductance by microinjection of antibodies against the 27-kDa liver gap junction polypeptide. Proc Natl Acad Sci U S A (1985) 1.56
Dye transfer between cells of the embryonic chick lens becomes less sensitive to CO2 treatment with development. J Cell Biol (1982) 1.53
Gap junctional conductance: comparison of sensitivities to H and Ca ions. Proc Natl Acad Sci U S A (1982) 1.47
Loss and reappearance of gap junctions in regenerating liver. J Cell Biol (1978) 1.43
Cell membrane potential and resistance in liver. J Physiol (1978) 1.33
Voltage independence of an electrotonic synapse. Biophys J (1982) 1.28
Electrotonic coupling in internally perfused crayfish segmented axons. J Physiol (1981) 1.24
Intercellular communication in normal and regenerating rat liver: a quantitative analysis. J Cell Biol (1981) 1.24
Regulation of gap junctional conductance. Am J Physiol (1985) 1.09
Substituted benzyl acetates: a new class of compounds that reduce gap junctional conductance by cytoplasmic acidification. J Cell Biol (1984) 0.95
Lens cell-to-cell channel protein: I. Self-assembly into liposomes and permeability regulation by calmodulin. J Membr Biol (1985) 0.95
Ca2+ causes active contraction of bile canaliculi: direct evidence from microinjection studies. Proc Natl Acad Sci U S A (1984) 0.94
Dependence of gluconeogenesis, urea synthesis, and energy metabolism of hepatocytes on intracellular pH. J Biol Chem (1984) 0.90
Junction formation between cultured normal rat hepatocytes. An ultrastructural study on the presence of cholesterol and the structure of developing tight-junction strands. J Cell Sci (1983) 0.89
Metabolic inter-relationships of intracellular pH measured by double-barrelled micro-electrodes in perfused rat liver. J Physiol (1982) 0.84
Gap junctions: new tools, new answers, new questions. Neuron (1991) 4.93
Two hepatic cytoplasmic protein fractions, Y and Z, and their possible role in the hepatic uptake of bilirubin, sulfobromophthalein, and other anions. J Clin Invest (1969) 4.45
Ligandin: a hepatic protein which binds steroids, bilirubin, carcinogens and a number of exogenous organic anions. Nature (1971) 3.93
Equilibrium properties of a voltage-dependent junctional conductance. J Gen Physiol (1981) 3.91
Kinetic properties of a voltage-dependent junctional conductance. J Gen Physiol (1981) 3.33
Studies on the synthesis and degradation of proteins of the endoplasmic reticulum of rat liver. J Biol Chem (1969) 3.24
The identity of glutathione S-transferase B with ligandin, a major binding protein of liver. Proc Natl Acad Sci U S A (1974) 2.77
Gap junctional conductance is a simple and sensitive function of intracellular pH. Science (1981) 2.64
Hepatocyte proliferation in vitro: its dependence on the use of serum-free hormonally defined medium and substrata of extracellular matrix. Proc Natl Acad Sci U S A (1984) 2.64
Hepatocyte gap junctions are permeable to the second messenger, inositol 1,4,5-trisphosphate, and to calcium ions. Proc Natl Acad Sci U S A (1989) 2.53
P2X7 receptor-Pannexin1 complex: pharmacology and signaling. Am J Physiol Cell Physiol (2008) 2.49
Physiology and pharmacology of gap junctions. Annu Rev Physiol (1985) 2.34
Differential expression of three gap junction proteins in developing and mature brain tissues. Proc Natl Acad Sci U S A (1989) 2.34
cAMP increases junctional conductance and stimulates phosphorylation of the 27-kDa principal gap junction polypeptide. Proc Natl Acad Sci U S A (1986) 2.20
Chronic nonhemolytic unconjugated hyperbilirubinemia with glucuronyl transferase deficiency. Clinical, biochemical, pharmacologic and genetic evidence for heterogeneity. Am J Med (1969) 2.09
Gap junction channels: distinct voltage-sensitive and -insensitive conductance states. Biophys J (1994) 1.99
Gap junctions in the brain: where, what type, how many and why? Trends Neurosci (1993) 1.97
Studies of Y and Z, two hepatic cytoplasmic organic anion-binding proteins: effect of drugs, chemicals, hormones, and cholestasis. J Clin Invest (1971) 1.97
Functional analysis of human cardiac gap junction channel mutants. Proc Natl Acad Sci U S A (1991) 1.94
Human connexin43 gap junction channels. Regulation of unitary conductances by phosphorylation. Circ Res (1994) 1.92
Volatile anesthetics block intercellular communication between neonatal rat myocardial cells. Circ Res (1989) 1.90
Voltage dependence of junctional conductance in early amphibian embryos. Science (1979) 1.90
Functional properties of channels formed by the neuronal gap junction protein connexin36. J Neurosci (1999) 1.90
Some electrical and pharmacological properties of gap junctions between adult ventricular myocytes. Am J Physiol (1985) 1.88
Wnt-1 regulation of connexin43 in cardiac myocytes. J Clin Invest (2000) 1.87
Connective tissue biomatrix: its isolation and utilization for long-term cultures of normal rat hepatocytes. J Cell Biol (1980) 1.84
Molecular characterization and functional expression of the human cardiac gap junction channel. J Cell Biol (1990) 1.81
Gap junctions between cultured astrocytes: immunocytochemical, molecular, and electrophysiological analysis. J Neurosci (1991) 1.74
Biophysical properties of gap junctions between freshly dispersed pairs of mouse pancreatic beta cells. Biophys J (1991) 1.71
Immunological studies of Y protein. A major cytoplasmic organic anion-binding protein in rat liver. J Clin Invest (1972) 1.71
Single-channel events and gating behavior of the cardiac gap junction channel. Proc Natl Acad Sci U S A (1988) 1.70
Gating of gap junction channels. Biophys J (1984) 1.70
Quinine blocks specific gap junction channel subtypes. Proc Natl Acad Sci U S A (2001) 1.67
Connexin43 null mice reveal that astrocytes express multiple connexins. Brain Res Brain Res Rev (2000) 1.61
How to close a gap junction channel. Efficacies and potencies of uncoupling agents. Methods Mol Biol (2001) 1.61
Phylogenetic study of organic anion transfer from plasma into the liver. Nat New Biol (1971) 1.60
Isolated liver gap junctions: gating of transjunctional currents is similar to that in intact pairs of rat hepatocytes. Proc Natl Acad Sci U S A (1986) 1.57
Taurocholate transport by rat liver sinusoidal membrane vesicles: evidence of sodium cotransport. Hepatology (1982) 1.57
Reduction of gap junctional conductance by microinjection of antibodies against the 27-kDa liver gap junction polypeptide. Proc Natl Acad Sci U S A (1985) 1.56
Intercellular communication in spinal cord astrocytes: fine tuning between gap junctions and P2 nucleotide receptors in calcium wave propagation. J Neurosci (2000) 1.56
Regulation of protein turnover in mammalian tissues. Fed Proc (1968) 1.55
Familial intrahepatic cholestasis 1: studies of localization and function. Hepatology (2001) 1.54
Activation of a voltage-insensitive conductance by inward calcium current. Nature (1975) 1.53
The function of Gp170, the multidrug resistance gene product, in rat liver canalicular membrane vesicles. J Biol Chem (1989) 1.52
Rat liver canalicular membrane vesicles. Isolation and topological characterization. J Biol Chem (1983) 1.51
A meningococcal endocarditis in a patient with Sweet's syndrome. Int J Cardiol (2007) 1.50
Gap junctional conductance: comparison of sensitivities to H and Ca ions. Proc Natl Acad Sci U S A (1982) 1.47
Voltage dependence of macroscopic and unitary currents of gap junction channels formed by mouse connexin50 expressed in rat neuroblastoma cells. J Physiol (1999) 1.46
Phosphorylation shifts unitary conductance and modifies voltage dependent kinetics of human connexin43 gap junction channels. Biophys J (1992) 1.41
Deficiency of hepatic organic anion-binding protein as a possible cause of non-haemolytic unconjugated hyperbilirubinaemia in the newborn. Lancet (1969) 1.41
Gap junctions in vascular tissues. Evaluating the role of intercellular communication in the modulation of vasomotor tone. Circ Res (1996) 1.40
The binding of fatty acids to cytoplasmic proteins: binding to Z protein in liver and other tissues of the rat. Biochem Biophys Res Commun (1972) 1.38
Deficiency of hepatic organic anion-binding protein, impaired organic amnion uptake by liver and "physiologic" jaundice in newborn monkeys. N Engl J Med (1970) 1.38
Interactions of bilirubin and other ligands with ligandin. Biochemistry (1975) 1.38
Organic anion-binding protein in rat liver: drug induction and its physiologic consequence. Proc Natl Acad Sci U S A (1969) 1.38
Permeability of gap junctions between embryonic cells of Fundulus: a reevaluation. Dev Biol (1978) 1.37
Transporters on demand: intrahepatic pools of canalicular ATP binding cassette transporters in rat liver. J Biol Chem (2000) 1.37
Defective ATP-dependent bile canalicular transport of organic anions in mutant (TR-) rats with conjugated hyperbilirubinemia. Proc Natl Acad Sci U S A (1990) 1.33
Reciprocal regulation of the junctional proteins claudin-1 and connexin43 by interleukin-1beta in primary human fetal astrocytes. J Neurosci (2000) 1.33
Inositol 1,4,5-trisphosphate and calcium regulate the calcium channel function of the hepatic inositol 1,4,5-trisphosphate receptor. J Biol Chem (1997) 1.33
Gap junction-mediated intercellular diffusion of Ca2+ in cultured human corporal smooth muscle cells. Am J Physiol (1992) 1.31
Phosphorylation of connexin43 and the regulation of neonatal rat cardiac myocyte gap junctions. J Mol Cell Cardiol (1997) 1.30
Gap junctional conductance and permeability are linearly related. Science (1986) 1.29
Rat liver canalicular membrane vesicles contain an ATP-dependent bile acid transport system. Proc Natl Acad Sci U S A (1991) 1.29
Involvement of gap junctions in tumorigenesis: transfection of tumor cells with connexin 32 cDNA retards growth in vivo. Proc Natl Acad Sci U S A (1991) 1.29
Expression of gap junction channels in communication-incompetent cells after stable transfection with cDNA encoding connexin 32. Proc Natl Acad Sci U S A (1990) 1.28
Role of ligandin in transfer of bilirubin from plasma into liver. Am J Physiol (1979) 1.27
Enzymatic conversion of bilirubin monoglucuronide to diglucuronide by rat liver plasma membranes. J Biol Chem (1977) 1.26
Gating characteristics of a steeply voltage-dependent gap junction channel in rat Schwann cells. J Gen Physiol (1993) 1.25
Evidence for secretory pathway localization of a voltage-dependent anion channel isoform. Proc Natl Acad Sci U S A (2000) 1.25
Proteoglycans and glycosaminoglycans induce gap junction synthesis and function in primary liver cultures. J Cell Biol (1987) 1.24
Properties of gap junction channels formed by Cx46 alone and in combination with Cx50. Biophys J (2000) 1.24
Taurocholate transport by rat liver canalicular membrane vesicles. Evidence for the presence of an Na+-independent transport system. J Clin Invest (1984) 1.24
IL-1beta differentially regulates calcium wave propagation between primary human fetal astrocytes via pathways involving P2 receptors and gap junction channels. Proc Natl Acad Sci U S A (1999) 1.23
Structural and functional studies of ligandin, a major renal organic anion-binding protein. J Clin Invest (1975) 1.23
Newly synthesized canalicular ABC transporters are directly targeted from the Golgi to the hepatocyte apical domain in rat liver. J Biol Chem (2000) 1.23
Properties of gap junction channels formed of connexin 45 endogenously expressed in human hepatoma (SKHep1) cells. Am J Physiol (1995) 1.22
Hormonally induced cell shape changes in cultured rat ovarian granulosa cells. J Cell Biol (1979) 1.21
The role of aquaporin-4 in the blood-brain barrier development and integrity: studies in animal and cell culture models. Neuroscience (2004) 1.21
Cytokine regulation of neuronal differentiation of hippocampal progenitor cells. Nature (1993) 1.18
Studies on subunit structure and evidence that ligandin is a heterodimer. J Biol Chem (1978) 1.16
Phosphorylation of connexin 32, a hepatocyte gap-junction protein, by cAMP-dependent protein kinase, protein kinase C and Ca2+/calmodulin-dependent protein kinase II. Eur J Biochem (1990) 1.16
Gap junction distribution is altered between cardiac myocytes infected with Trypanosoma cruzi. Circ Res (1992) 1.16
Inotropic agents modulate gap junctional conductance between cardiac myocytes. Am J Physiol (1988) 1.16
Inhibition of endothelial cell migration, intercellular communication, and vascular tube formation by thromboxane A(2). J Biol Chem (1999) 1.15
Modulation of cell junctions during differentiation of the chicken otocyst sensory epithelium. Dev Biol (1979) 1.14
Ligandin. Bilirubin binding and glutathione-S-transferase activity are independent processes. J Biol Chem (1978) 1.14