Published in J Clin Invest on February 01, 1979
Synthesis of prostacyclin from platelet-derived endoperoxides by cultured human endothelial cells. J Clin Invest (1980) 2.06
Eighth Gaddum Memorial Lecture. University of London Institute of Education, December 1980. Biological importance of prostacyclin. Br J Pharmacol (1982) 2.01
Elevated thromboxane levels in the rat during endotoxic shock: protective effects of imidazole, 13-azaprostanoic acid, or essential fatty acid deficiency. J Clin Invest (1980) 1.91
Erythrocyte-neutrophil interactions: formation of leukotriene B4 by transcellular biosynthesis. Proc Natl Acad Sci U S A (1986) 1.08
Unidirectional transfer of prostaglandin endoperoxides between platelets and endothelial cells. J Clin Invest (1984) 1.05
Triene prostaglandins: prostaglandin D3 and icosapentaenoic acid as potential antithrombotic substances. Proc Natl Acad Sci U S A (1979) 1.02
Non-steroid anti-inflammatory drugs, prostaglandins, and cancer. Cell Biosci (2013) 0.99
Interaction between lymphocytes and platelets in the synthesis of prostacyclin. J Clin Invest (1987) 0.86
In vivo platelet aggregation in the rat: dependence on extracellular divalent cation and inhibition by nonsteroidal anti-inflammatory drugs. Br J Pharmacol (1984) 0.84
Effects of thromboxane synthase inhibition on vascular responsiveness in the in vivo rat mesentery. J Clin Invest (1985) 0.84
Prostaglandin I2 (prostacyclin). Can Med Assoc J (1980) 0.82
Effects of dazoxiben, an inhibitor of thromboxane synthetase, on forearm vasoconstriction in response to cold stimulation, and on human blood vessel prostacyclin production. Br J Clin Pharmacol (1983) 0.81
Prostanoid synthesis by aortic rings in human blood: selective increase of prostacyclin mediated by a serum factor. Br J Pharmacol (1984) 0.79
Dazoxiben: a pharmacological tool or clinical candidate? Br J Clin Pharmacol (1983) 0.79
Inhibition and subsequent enhancement of platelet responsiveness by prostacyclin in the rabbit. Relationship to platelet adenosine 3',5'-cyclic monophosphate. J Clin Invest (1985) 0.78
Arachidonic acid-derived signaling lipids and functions in impaired healing. Wound Repair Regen (2015) 0.77
Possible role of prostaglandins in the regulation of coronary blood flow. Basic Res Cardiol (1981) 0.77
Introduction: thromboxane in biological systems and the possible impact of its inhibition. Br J Clin Pharmacol (1983) 0.76
The effects of dazoxiben, an inhibitor of thromboxane synthetase, on cold-induced forearm vasoconstriction and platelet behaviour in different individuals. Br J Clin Pharmacol (1985) 0.75
Effects of thromboxane synthetase inhibition on arachidonate metabolism and platelet behaviour. Br J Clin Pharmacol (1983) 0.75
The Jeremiah Metzger lecture. Participation of eicosanoids in the syndromes of myocardial ischemia. Trans Am Clin Climatol Assoc (1990) 0.75
Arterial walls generate from prostaglandin endoperoxides a substance (prostaglandin X) which relaxes strips of mesenteric and coeliac ateries and inhibits platelet aggregation. Prostaglandins (1976) 4.54
Human arterial and venous tissues generate prostacyclin (prostaglandin x), a potent inhibitor of platelet aggregation. Lancet (1977) 4.11
Synthesis of prostaglandin I2 (prostacyclin) by cultured human and bovine endothelial cells. Proc Natl Acad Sci U S A (1977) 3.74
Differential formation of prostacyclin (PGX or PGI2) by layers of the arterial wall. An explanation for the anti-thrombotic properties of vascular endothelium. Thromb Res (1977) 3.28
Prostacyclin (PGX) is the endogenous metabolite responsible for relaxation of coronary arteries induced by arachindonic acid. Prostaglandins (1977) 2.67
Unstable metabolites of arachidonic acid and their role in haemostasis and thrombosis. Br Med Bull (1978) 2.51
Imidazole: a selective inhibitor of thromboxane synthetase. Prostaglandins (1977) 2.48
Thromboxanes: selective biosynthesis and distinct biological properties. Science (1976) 2.46
A lipid peroxide inhibits the enzyme in blood vessel microsomes that generates from prostaglandin endoperoxides the substance (prostaglandin X) which prevents platelet aggregation. Prostaglandins (1976) 2.28
Prostaglandins in human seminal plasma. Prostaglandins and related factors 46. J Biol Chem (1966) 1.91
Cyclic adenosine 3',5'-monophosphate inhibits the availability of arachidonate to prostaglandin synthetase in human platelet suspensions. J Clin Invest (1977) 1.63
Effect of aspirin on thrombin-induced adherence of platelets to cultured cells from the blood vessel wall. J Clin Invest (1978) 1.59
Application of imidazole as a selective inhibitor thromboxane synthetase in human platelets. Proc Natl Acad Sci U S A (1977) 1.56
Paradoxical endogenous synthesis of a coronary dilating substance from arachidonate. Prostaglandins (1976) 1.52
Cardiac and renal prostaglandin I2. Biosynthesis and biological effects in isolated perfused rabbit tissues. J Clin Invest (1978) 1.48
Thrombogenic effect of high-dose aspirin in rabbits. Relationship to inhibition of vessel wall synthesis of prostaglandin I2-like activity. J Clin Invest (1978) 1.43
Prostaglandins H1 and H2. Convenient biochemical synthesis and isolation. Further biological and spectroscopic characterization. Prostaglandins (1977) 1.40
Characterization of a novel metabolic pathway of arachidonate in coronary arteries which generates a potent endogenous coronary vasodilator. J Biol Chem (1977) 1.37
Preparation and purification of lipid hydroperoxides from arachidonic and gamma-linolenic acids. Lipids (1976) 1.33
Isomerization of prostaglandin H2 into prostaglandin D2 in the presence of serum albumin. Biochim Biophys Acta (1976) 1.25
Antithrombotic properties of vascular endothelium. Lancet (1977) 0.98
Synthesis of prostaglandin 6-keto F1alpha by cultured aortic smooth muscle cells and stimulation of its formation in a coupled system with platelet lysates. Prostaglandins (1978) 0.93
Participation of p53 cellular tumour antigen in transformation of normal embryonic cells. Nature (1985) 6.86
Arachidonic acid metabolism. Annu Rev Biochem (1986) 6.56
Nitric oxide activates cyclooxygenase enzymes. Proc Natl Acad Sci U S A (1993) 3.93
Retinol-binding protein: the transport protein for vitamin A in human plasma. J Clin Invest (1968) 3.52
The induction and suppression of prostaglandin H2 synthase (cyclooxygenase) in human monocytes. J Biol Chem (1990) 3.34
Influence of preoperative anxiety on hypotension after spinal anaesthesia in women undergoing Caesarean delivery. Br J Anaesth (2012) 3.29
Regulation of fibroblast cyclooxygenase synthesis by interleukin-1. J Biol Chem (1988) 3.06
Identification of an enzyme in platelet microsomes which generates thromboxane A2 from prostaglandin endoperoxides. Nature (1976) 2.83
Selective regulation of cellular cyclooxygenase by dexamethasone and endotoxin in mice. J Clin Invest (1990) 2.66
Endogenous glucocorticoids regulate an inducible cyclooxygenase enzyme. Proc Natl Acad Sci U S A (1992) 2.55
Bioactive cardiac substances: potent vasorelaxant activity in mammalian atria. Science (1983) 2.53
Imidazole: a selective inhibitor of thromboxane synthetase. Prostaglandins (1977) 2.48
Thromboxanes: selective biosynthesis and distinct biological properties. Science (1976) 2.46
Galectin-3: a novel antiapoptotic molecule with a functional BH1 (NWGR) domain of Bcl-2 family. Cancer Res (1997) 2.22
Physiological aspects of information processing in the basal ganglia of normal and parkinsonian primates. Trends Neurosci (1998) 2.17
Impact of community educational programmes on foreign body aspiration in Israel. Eur J Pediatr (1995) 2.09
Triene prostaglandins: prostacyclin and thromboxane biosynthesis and unique biological properties. Proc Natl Acad Sci U S A (1979) 2.07
Mechanism of tolerance development to organic nitrates. J Pharmacol Exp Ther (1973) 2.04
Galectin-3 induces endothelial cell morphogenesis and angiogenesis. Am J Pathol (2000) 1.97
Stimulation of prostaglandin biosynthesis by adenine nucleotides. Profile of prostaglandin release by perfused organs. Circ Res (1974) 1.97
Inhibition of spontaneous metastasis in a rat prostate cancer model by oral administration of modified citrus pectin. J Natl Cancer Inst (1995) 1.92
Atriopeptins as cardiac hormones. Hypertension (1985) 1.91
The interaction of thyroxine with human plasma prealbumin and with the prealbumin-retinol-binding protein complex. J Biol Chem (1969) 1.88
Purification and sequence analysis of bioactive atrial peptides (atriopeptins). Science (1984) 1.85
On the role of cell surface carbohydrates and their binding proteins (lectins) in tumor metastasis. Cancer Metastasis Rev (2001) 1.78
Exaggerated human vascular cell prostaglandin biosynthesis mediated by monocytes: role of monokines and interleukin 1. J Immunol (1985) 1.76
Atriopeptin: a cardiac hormone intimately involved in fluid, electrolyte, and blood-pressure homeostasis. N Engl J Med (1986) 1.71
Studies on the protein-protein and protein-ligand interactions involved in retinol transport in plasma. J Biol Chem (1970) 1.68
Temporal and pharmacological division of fibroblast cyclooxygenase expression into transcriptional and translational phases. Proc Natl Acad Sci U S A (1989) 1.67
Organic nitrates: relationship between biotransformation and rational angina pectoris therapy. J Pharmacol Exp Ther (1972) 1.67
Cyclic adenosine 3',5'-monophosphate inhibits the availability of arachidonate to prostaglandin synthetase in human platelet suspensions. J Clin Invest (1977) 1.63
Galectin-3 is a novel substrate for human matrix metalloproteinases-2 and -9. Biochemistry (1994) 1.63
Isolation and characterization of the complementary DNA for sheep seminal vesicle prostaglandin endoperoxide synthase (cyclooxygenase). J Biol Chem (1988) 1.61
Cell cycle arrest and inhibition of anoikis by galectin-3 in human breast epithelial cells. Cancer Res (1999) 1.60
On the role of galectin-3 in cancer apoptosis. Apoptosis (2005) 1.60
Endogenous nitric oxide enhances prostaglandin production in a model of renal inflammation. J Clin Invest (1994) 1.59
Sulfhydryl requirement for relaxation of vascular smooth muscle. J Pharmacol Exp Ther (1973) 1.57
Application of imidazole as a selective inhibitor thromboxane synthetase in human platelets. Proc Natl Acad Sci U S A (1977) 1.56
Prostaglandin endoperoxide and thromboxane generating systems and their selective inhibition. Prostaglandins (1976) 1.56
Down-regulation of galectin-3 suppresses tumorigenicity of human breast carcinoma cells. Clin Cancer Res (2001) 1.55
Paradoxical endogenous synthesis of a coronary dilating substance from arachidonate. Prostaglandins (1976) 1.52
Ser-Leu-Arg-Arg-atriopeptin III: the major circulating form of atrial peptide. Science (1985) 1.52
The NH2 terminus of galectin-3 governs cellular compartmentalization and functions in cancer cells. Cancer Res (1999) 1.51
Ventricular atriopeptin. Unmasking of messenger RNA and peptide synthesis by hypertrophy or dexamethasone. Hypertension (1987) 1.49
Unmasking of thromboxane A2 synthesis by ureteral obstruction in the rabbit kidney. Nature (1977) 1.48
Cardiac and renal prostaglandin I2. Biosynthesis and biological effects in isolated perfused rabbit tissues. J Clin Invest (1978) 1.48
Vasopressin-stimulated release of atriopeptin: endocrine antagonists in fluid homeostasis. Science (1985) 1.48
Coronary tone modulation: formation and actions of prostaglandins, endoperoxides, and thromboxanes. Science (1977) 1.47
Galectin-3 stimulates cell proliferation. Exp Cell Res (1998) 1.44
Specific regulation of peptide-induced renal prostaglandin synthesis. J Biol Chem (1979) 1.43
Exaggerated prostaglandin biosynthesis and its influence on renal resistance in the isolated hydronephrotic rabbit kidney. J Clin Invest (1977) 1.42
Altered organization of cell-substrate contacts and membrane-associated cytoskeleton in tumor cell variants exhibiting different metastatic capabilities. Cancer Res (1982) 1.41
Interactions between galectin-3 and Mac-2-binding protein mediate cell-cell adhesion. Cancer Res (1996) 1.41
Tumor cell autocrine motility factor is the neuroleukin/phosphohexose isomerase polypeptide. Cancer Res (1996) 1.39
Regulation of prostaglandin production by nitric oxide; an in vivo analysis. Br J Pharmacol (1995) 1.37
Characterization of a novel metabolic pathway of arachidonate in coronary arteries which generates a potent endogenous coronary vasodilator. J Biol Chem (1977) 1.37
Dual inhibition of nitric oxide and prostaglandin production contributes to the antiinflammatory properties of nitric oxide synthase inhibitors. J Clin Invest (1995) 1.33
Mechanism of enhanced fibroblast arachidonic acid metabolism by mononuclear cell factor. J Clin Invest (1984) 1.33
Analysis of the fate of systemically administered liposomes and implications for their use in drug delivery. Cancer Res (1982) 1.32
Interaction of prostaglandins with blood plasma proteins. Comparative binding of prostaglandins A 2 , F 2 and E 2 to human plasma proteins. Biochem J (1972) 1.32
Prostaglandin synthesis inhibition and the action of vasopressin: studies in man and rat. Am J Physiol (1977) 1.32
Modulation of keratinocyte proliferation in vitro by endogenous prostaglandin synthesis. J Clin Invest (1986) 1.31
Hormone selective lipase activation in the isolated rabbit heart. Prostaglandins (1977) 1.30
Hormone interactions in the isolated rabbit heart. Synthesis and coronary vasomotor effects of prostaglandins, angiotensin, and bradykinin. Circ Res (1975) 1.30
Differential biosynthesis of prostaglandins by hydronephrotic rabbit and cat kidneys. J Pharmacol Exp Ther (1981) 1.30
Atriopeptin-immunoreactive neurons in the brain: presence in cardiovascular regulatory areas. Science (1985) 1.29
Metastasis of human colon cancer is altered by modifying expression of the beta-galactoside-binding protein galectin 3. Gastroenterology (1998) 1.28
Identification of a cyclooxygenase-related gene and its potential role in prostaglandin formation. Biochem Biophys Res Commun (1989) 1.28
Paradoxical conservation of cardiac and renal arachidonate content in essential fatty acid deficiency. J Biol Chem (1985) 1.27
Calcium-dependent norepinephrine release from presynaptic nerve endings in vitro. Proc Natl Acad Sci U S A (1972) 1.27
Metabolic and cellular alterations underlying the exaggerated renal prostaglandin and thromboxane synthesis in ureter obstruction in rabbits. Inflammatory response involving fibroblasts and mononuclear cells. J Clin Invest (1983) 1.26
Regional localization of prostacyclin and thromboxane synthesis in dog stomach and intestinal tract. J Pharmacol Exp Ther (1979) 1.26
Expression of an endogenous galactose-binding lectin correlates with neoplastic progression in the colon. Cancer (1995) 1.25
Blood vessel-hormone interactions: angiotensin, bradykinin, and prostaglandins. Am J Physiol (1977) 1.25
Selective incorporation of 14C-arachidonic acid into the phospholipids of intact tissues and subsequent metabolism to 14C-prostaglandins. Prostaglandins (1976) 1.24
Radioimmunoassay of human plasma retinol-binding protein. J Clin Invest (1970) 1.24
Novel, selective delta6 or delta5 fatty acid desaturase inhibitors as antiinflammatory agents in mice. J Pharmacol Exp Ther (1998) 1.24
Design of liposomes to improve delivery of macrophage-augmenting agents to alveolar macrophages. Cancer Res (1980) 1.23
Relationship of prostaglandin secretion by rabbit alveolar macrophages to phagocytosis and lysosomal enzyme release. Biochem J (1979) 1.23
Lectin-like activities associated with human and murine neoplastic cells. Cancer Res (1981) 1.23
Speech sounds learned by sleeping newborns. Nature (2002) 1.23
Effects of endogenously produced leukotrienes, thromboxane, and prostaglandins on coronary vascular resistance in rabbit myocardial infarction. J Clin Invest (1985) 1.22
The biotransformation of nitroglycerin. Biochem Pharmacol (1965) 1.22
Effects of natural complex carbohydrate (citrus pectin) on murine melanoma cell properties related to galectin-3 functions. Glycoconj J (1994) 1.21
The autocrine motility factor receptor gene encodes a novel type of seven transmembrane protein. FEBS Lett (1999) 1.21
Pomegranate juice supplementation to atherosclerotic mice reduces macrophage lipid peroxidation, cellular cholesterol accumulation and development of atherosclerosis. J Nutr (2001) 1.20