Published in Nature on January 24, 1985
The first 30 years of p53: growing ever more complex. Nat Rev Cancer (2009) 8.00
Activating mutations for transformation by p53 produce a gene product that forms an hsc70-p53 complex with an altered half-life. Mol Cell Biol (1988) 6.44
Activating mutations in p53 produce a common conformational effect. A monoclonal antibody specific for the mutant form. EMBO J (1990) 6.34
Induction of apoptosis by wild-type p53 in a human colon tumor-derived cell line. Proc Natl Acad Sci U S A (1992) 5.94
When mutants gain new powers: news from the mutant p53 field. Nat Rev Cancer (2009) 5.86
Transcriptional activation by wild-type but not transforming mutants of the p53 anti-oncogene. Science (1990) 5.47
Wild-type p53 can inhibit oncogene-mediated focus formation. Proc Natl Acad Sci U S A (1989) 5.40
p53 functions as a cell cycle control protein in osteosarcomas. Mol Cell Biol (1990) 5.20
Mutation is required to activate the p53 gene for cooperation with the ras oncogene and transformation. J Virol (1989) 4.63
Characterization of the human p53 gene. Mol Cell Biol (1986) 4.33
Mutant p53: one name, many proteins. Genes Dev (2012) 4.33
Rearrangement of the p53 gene in human osteogenic sarcomas. Proc Natl Acad Sci U S A (1987) 4.21
Association of adenovirus early-region 1A proteins with cellular polypeptides. Mol Cell Biol (1986) 4.14
Human papillomavirus type 16 DNA cooperates with activated ras in transforming primary cells. EMBO J (1987) 3.81
Monoclonal antibody analysis of p53 expression in normal and transformed cells. J Virol (1986) 3.72
Identification of a minimal transforming domain of p53: negative dominance through abrogation of sequence-specific DNA binding. Mol Cell Biol (1992) 3.37
Primary structure polymorphism at amino acid residue 72 of human p53. Mol Cell Biol (1987) 3.22
Negative growth regulation in a glioblastoma tumor cell line that conditionally expresses human wild-type p53. Proc Natl Acad Sci U S A (1990) 3.20
Human p53 cellular tumor antigen: cDNA sequence and expression in COS cells. EMBO J (1985) 3.18
Major deletions in the gene encoding the p53 tumor antigen cause lack of p53 expression in HL-60 cells. Proc Natl Acad Sci U S A (1985) 3.15
p53 cellular tumor antigen: analysis of mRNA levels in normal adult tissues, embryos, and tumors. Mol Cell Biol (1985) 3.13
Molecular cloning and in vitro expression of a cDNA clone for human cellular tumor antigen p53. Mol Cell Biol (1985) 3.09
Identification of the p53 protein domain involved in formation of the simian virus 40 large T-antigen-p53 protein complex. J Virol (1986) 3.04
Two regions of the adenovirus early region 1A proteins are required for transformation. J Virol (1988) 3.02
Stem cells: The promises and perils of p53. Nature (2009) 3.01
Immunological evidence for the association of p53 with a heat shock protein, hsc70, in p53-plus-ras-transformed cell lines. Mol Cell Biol (1987) 3.01
Mouse tumor model for neurofibromatosis type 1. Science (1999) 2.89
Behavior of myc and ras oncogenes in transformation of rat embryo fibroblasts. Mol Cell Biol (1986) 2.86
Expression of human HSP70 during the synthetic phase of the cell cycle. Proc Natl Acad Sci U S A (1986) 2.83
Human p53 is phosphorylated by p60-cdc2 and cyclin B-cdc2. Proc Natl Acad Sci U S A (1990) 2.77
Nuclear accumulation of p53 protein is mediated by several nuclear localization signals and plays a role in tumorigenesis. Mol Cell Biol (1990) 2.73
Adenovirus E1A coding sequences that enable ras and pmt oncogenes to transform cultured primary cells. Mol Cell Biol (1986) 2.70
Abnormal structure and expression of p53 gene in human hepatocellular carcinoma. Proc Natl Acad Sci U S A (1990) 2.59
Human papillomavirus E6 proteins bind p53 in vivo and abrogate p53-mediated repression of transcription. EMBO J (1992) 2.45
High incidence of lung, bone, and lymphoid tumors in transgenic mice overexpressing mutant alleles of the p53 oncogene. Mol Cell Biol (1989) 2.45
The p53 tumour suppressor protein is phosphorylated at serine 389 by casein kinase II. EMBO J (1990) 2.38
p53 Research: the past thirty years and the next thirty years. Cold Spring Harb Perspect Biol (2010) 2.34
N-myc can cooperate with ras to transform normal cells in culture. Proc Natl Acad Sci U S A (1985) 2.33
Purification of complexes of nuclear oncogene p53 with rat and Escherichia coli heat shock proteins: in vitro dissociation of hsc70 and dnaK from murine p53 by ATP. Mol Cell Biol (1988) 2.25
Immunologically distinct p53 molecules generated by alternative splicing. Mol Cell Biol (1986) 2.20
The gene for human p53 cellular tumor antigen is located on chromosome 17 short arm (17p13). Proc Natl Acad Sci U S A (1986) 2.18
The 5' region of the p53 gene: evolutionary conservation and evidence for a negative regulatory element. EMBO J (1985) 2.17
p53 regulates a G2 checkpoint through cyclin B1. Proc Natl Acad Sci U S A (1999) 2.16
Molecular basis for heterogeneity of the human p53 protein. Mol Cell Biol (1986) 2.14
The 1993 Walter Hubert Lecture: the role of the p53 tumour-suppressor gene in tumorigenesis. Br J Cancer (1994) 2.14
Li-Fraumeni syndrome--a molecular and clinical review. Br J Cancer (1997) 2.14
Frequent mutation of the p53 gene in human esophageal cancer. Proc Natl Acad Sci U S A (1990) 2.07
Cell lines established by a temperature-sensitive simian virus 40 large-T-antigen gene are growth restricted at the nonpermissive temperature. Mol Cell Biol (1989) 2.04
Frequent mutations in the p53 tumor suppressor gene in human leukemia T-cell lines. Mol Cell Biol (1990) 2.03
Expression of cell-cycle-dependent genes in phytohemagglutinin-stimulated human lymphocytes. Proc Natl Acad Sci U S A (1985) 2.01
The large tumor antigen of simian virus 40 encodes at least two distinct transforming functions. J Virol (1989) 2.00
Oligomerization of oncoprotein p53. J Virol (1988) 1.98
p53 mutations increase resistance to ionizing radiation. Proc Natl Acad Sci U S A (1993) 1.93
Adenovirus serotype determines association and localization of the large E1B tumor antigen with cellular tumor antigen p53 in transformed cells. Mol Cell Biol (1985) 1.91
p53 nuclear protein accumulation correlates with mutations in the p53 gene, tumor grade, and stage in bladder cancer. Am J Pathol (1993) 1.85
Large T antigens of simian virus 40 and polyomavirus efficiently establish primary fibroblasts. J Virol (1986) 1.83
Inhibition of viral and cellular promoters by human wild-type p53. J Virol (1992) 1.83
Tumorigenicity of fibroblast lines expressing the adenovirus E1a, cellular p53, or normal c-myc genes. Mol Cell Biol (1986) 1.82
Wild-type p53 adopts a 'mutant'-like conformation when bound to DNA. EMBO J (1993) 1.78
p53 expression in colorectal tumors. Am J Pathol (1991) 1.77
Analysis of p53 mutants for transcriptional activity. Mol Cell Biol (1991) 1.73
Mapping of phosphomonoester and apparent phosphodiester bonds of the oncogene product p53 from simian virus 40-transformed 3T3 cells. Proc Natl Acad Sci U S A (1986) 1.72
Expression and complex formation of simian virus 40 large T antigen and mouse p53 in insect cells. J Virol (1988) 1.72
Deletion of 5'-coding sequences of the cellular p53 gene in mouse erythroleukemia: a novel mechanism of oncogene regulation. Mol Cell Biol (1987) 1.69
Involvement of wild-type p53 in pre-B-cell differentiation in vitro. Proc Natl Acad Sci U S A (1991) 1.65
Phosphorylation of p53 in normal and simian virus 40-transformed NIH 3T3 cells. Mol Cell Biol (1988) 1.62
Inactivation of the cellular p53 gene is a common feature of Friend virus-induced erythroleukemia: relationship of inactivation to dominant transforming alleles. Mol Cell Biol (1990) 1.58
Widespread p53 overexpression in human malignant tumors. An immunohistochemical study using methacarn-fixed, embedded tissue. Am J Pathol (1992) 1.57
The tumor suppressor p53 is bound to RNA by a stable covalent linkage. Mol Cell Biol (1991) 1.56
Vimentin and p53 expression on epidermal growth factor receptor-positive, oestrogen receptor-negative breast carcinomas. Br J Cancer (1988) 1.55
Enhanced binding of a 95 kDa protein to p53 in cells undergoing p53-mediated growth arrest. EMBO J (1992) 1.49
Characterization of mutant p53-hsp72/73 protein-protein complexes by transient expression in monkey COS cells. Mol Cell Biol (1988) 1.48
In vitro expression of human p53 cDNA clones and characterization of the cloned human p53 gene. Mol Cell Biol (1985) 1.46
Modulation of cellular and viral promoters by mutant human p53 proteins found in tumor cells. J Virol (1992) 1.44
L-myc cooperates with ras to transform primary rat embryo fibroblasts. Mol Cell Biol (1988) 1.43
Synergism of v-myc and v-Ha-ras in the in vitro neoplastic progression of murine lymphoid cells. Mol Cell Biol (1986) 1.42
Gain-of-function mutations of the p53 gene induce lymphohematopoietic metastatic potential and tissue invasiveness. Am J Pathol (1994) 1.39
Mutant p53 tumor suppressor alleles release ras-induced cell cycle growth arrest. Mol Cell Biol (1991) 1.39
The p53-Bcl-2 connection. Cell Death Differ (2006) 1.39
Human p53 inhibits growth in Schizosaccharomyces pombe. Mol Cell Biol (1992) 1.38
Activated Ha-ras can cooperate with defective simian virus 40 in the transformation of nonestablished rat embryo fibroblasts. J Virol (1987) 1.36
Friend murine leukemia virus-immortalized myeloid cells are converted into tumorigenic cell lines by Abelson leukemia virus. Proc Natl Acad Sci U S A (1985) 1.34
Coordinate expression of the endogenous p53 gene in beta cells of transgenic mice expressing hybrid insulin-SV40 T antigen genes. EMBO J (1987) 1.32
Sequences from polyomavirus and simian virus 40 large T genes capable of immortalizing primary rat embryo fibroblasts. J Virol (1985) 1.31
Human p53 oncogene contains one promoter upstream of exon 1 and a second, stronger promoter within intron 1. Proc Natl Acad Sci U S A (1988) 1.27
neu/ERBB2 cooperates with p53-172H during mammary tumorigenesis in transgenic mice. Mol Cell Biol (1997) 1.27
Tight DNA binding and oligomerization are dispensable for the ability of p53 to transactivate target genes and suppress transformation. EMBO J (1993) 1.25
Expression of wild-type p53 is not compatible with continued growth of p53-negative tumor cells. Mol Cell Biol (1991) 1.25
Modulation of p53 protein expression during cellular transformation with simian virus 40. Mol Cell Biol (1987) 1.25
Inactivation of p53 gene in human and murine osteosarcoma cells. Br J Cancer (1992) 1.24
Two distinct regions of the murine p53 primary amino acid sequence are implicated in stable complex formation with simian virus 40 T antigen. J Virol (1988) 1.24
p53 in chronic myelogenous leukemia. Study of mechanisms of differential expression. J Exp Med (1988) 1.24
The p53 circuit board. Biochim Biophys Acta (2012) 1.24
p53 gene mRNA expression and chromosome 17p allele loss in breast cancer. Br J Cancer (1990) 1.24
Overproduction of protein p53 contributes to simian virus 40-mediated transformation. Mol Cell Biol (1986) 1.24
Identification of a germ-line mutation in the p53 gene in a patient with an intracranial ependymoma. Proc Natl Acad Sci U S A (1991) 1.23
Increased expression of p53 protein in human leukemia cells. Proc Natl Acad Sci U S A (1986) 1.21
The helix-loop-helix containing transcription factor USF binds to and transactivates the promoter of the p53 tumor suppressor gene. Nucleic Acids Res (1993) 1.19
Mutant p53 can substitute for human papillomavirus type 16 E6 in immortalization of human keratinocytes but does not have E6-associated trans-activation or transforming activity. J Virol (1992) 1.18
Mutations in p53 do not account for heritable breast cancer: a study in five affected families. Br J Cancer (1991) 1.17
Mdm2 promotes the rapid degradation of p53. Nature (1997) 21.26
Multiple point mutations affecting the simian virus 40 enhancer. Science (1983) 13.69
Simian virus 40 tandem repeated sequences as an element of the early promoter. Proc Natl Acad Sci U S A (1981) 13.67
Host-specific activation of transcription by tandem repeats from simian virus 40 and Moloney murine sarcoma virus. Proc Natl Acad Sci U S A (1982) 12.30
Enhancer elements. Cell (1983) 10.41
Pax7 is required for the specification of myogenic satellite cells. Cell (2000) 9.88
Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6. Nature (1991) 9.21
mdm2 expression is induced by wild type p53 activity. EMBO J (1993) 8.01
Characterization of enhancer elements in the long terminal repeat of Moloney murine sarcoma virus. J Virol (1984) 7.80
Specific interaction between enhancer-containing molecules and cellular components. Cell (1984) 6.96
Sequence of chicken ovalbumin mRNA. Nature (1978) 6.73
Activating mutations for transformation by p53 produce a gene product that forms an hsc70-p53 complex with an altered half-life. Mol Cell Biol (1988) 6.44
Conditional inhibition of transformation and of cell proliferation by a temperature-sensitive mutant of p53. Cell (1990) 6.37
Development of peripheral lymphoid organs and natural killer cells depends on the helix-loop-helix inhibitor Id2. Nature (1999) 6.23
Activation of SV40 genome by 72-base pair tandem repeats of Moloney sarcoma virus. Nature (1982) 6.02
Temporal control of gene expression in transgenic mice by a tetracycline-responsive promoter. Proc Natl Acad Sci U S A (1994) 5.71
New type of POU domain in germ line-specific protein Oct-4. Nature (1990) 5.65
Pax-6, a murine paired box gene, is expressed in the developing CNS. Development (1991) 5.49
Wild-type p53 can inhibit oncogene-mediated focus formation. Proc Natl Acad Sci U S A (1989) 5.40
Cre-mediated gene deletion in the mammary gland. Nucleic Acids Res (1997) 4.89
Bovine papilloma virus deoxyribonucleic acid: a novel eucaryotic cloning vector. Mol Cell Biol (1981) 4.75
The Pax4 gene is essential for differentiation of insulin-producing beta cells in the mammalian pancreas. Nature (1997) 4.69
Pax6 is required for the multipotent state of retinal progenitor cells. Cell (2001) 4.65
Pax6 is required for differentiation of glucagon-producing alpha-cells in mouse pancreas. Nature (1997) 4.58
Apaf1 (CED-4 homolog) regulates programmed cell death in mammalian development. Cell (1998) 4.53
A family of octamer-specific proteins present during mouse embryogenesis: evidence for germline-specific expression of an Oct factor. EMBO J (1989) 4.47
Oct-4: a germline-specific transcription factor mapping to the mouse t-complex. EMBO J (1990) 4.42
ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage. Genes Dev (2001) 4.06
Six3, a murine homologue of the sine oculis gene, demarcates the most anterior border of the developing neural plate and is expressed during eye development. Development (1995) 3.90
Splicing as a requirement for biogenesis of functional 16S mRNA of simian virus 40. Proc Natl Acad Sci U S A (1979) 3.89
Pax6 activity in the lens primordium is required for lens formation and for correct placement of a single retina in the eye. Genes Dev (2000) 3.85
Pax-3, a novel murine DNA binding protein expressed during early neurogenesis. EMBO J (1991) 3.85
Nucleotide sequence of the rat skeletal muscle actin gene. Nature (1982) 3.81
Generation of oscillations by the p53-Mdm2 feedback loop: a theoretical and experimental study. Proc Natl Acad Sci U S A (2000) 3.74
Homeotic transformations of murine vertebrae and concomitant alteration of Hox codes induced by retinoic acid. Cell (1991) 3.71
Waardenburg's syndrome patients have mutations in the human homologue of the Pax-3 paired box gene. Nature (1992) 3.63
Induction of WAF1/CIP1 by a p53-independent pathway. Cancer Res (1994) 3.54
Retinol-binding protein: the transport protein for vitamin A in human plasma. J Clin Invest (1968) 3.52
Interaction of c-Abl and p73alpha and their collaboration to induce apoptosis. Nature (1999) 3.50
Wild-type p53 can down-modulate the activity of various promoters. Proc Natl Acad Sci U S A (1991) 3.45
Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes. Cell Death Differ (2009) 3.44
Pax-2 controls multiple steps of urogenital development. Development (1995) 3.42
Induction of apoptosis in HeLa cells by trans-activation-deficient p53. Genes Dev (1995) 3.40
Two distinct mechanisms regulate the levels of a cellular tumor antigen, p53. Mol Cell Biol (1983) 3.39
Identification of a minimal transforming domain of p53: negative dominance through abrogation of sequence-specific DNA binding. Mol Cell Biol (1992) 3.37
BK viral enhancer element and a human cellular homolog. Science (1983) 3.36
The induction and suppression of prostaglandin H2 synthase (cyclooxygenase) in human monocytes. J Biol Chem (1990) 3.34
Influence of preoperative anxiety on hypotension after spinal anaesthesia in women undergoing Caesarean delivery. Br J Anaesth (2012) 3.29
DNA microarrays identification of primary and secondary target genes regulated by p53. Oncogene (2001) 3.28
p53 in growth control and neoplasia. Biochim Biophys Acta (1996) 3.19
Human p53 cellular tumor antigen: cDNA sequence and expression in COS cells. EMBO J (1985) 3.18
p53 cellular tumor antigen: analysis of mRNA levels in normal adult tissues, embryos, and tumors. Mol Cell Biol (1985) 3.13
A multigene family encoding several "finger" structures is present and differentially active in mammalian genomes. Cell (1987) 3.09
Wild type p53 can mediate sequence-specific transactivation of an internal promoter within the mdm2 gene. Oncogene (1993) 3.08
Prox1 function is crucial for mouse lens-fibre elongation. Nat Genet (1999) 3.01
A single gene and a pseudogene for the cellular tumour antigen p53. Nature (1984) 2.98
Developmental localization of the splicing alternatives of fibroblast growth factor receptor-2 (FGFR2). Dev Biol (1993) 2.96
Production of chimaeric mice containing embryonic stem (ES) cells carrying a homoeobox Hox 1.1 allele mutated by homologous recombination. Nature (1989) 2.94
Specific interaction between the p53 cellular tumour antigen and major heat shock proteins. Nature (1986) 2.94
Analysis of the gene coding for the murine cellular tumour antigen p53. EMBO J (1984) 2.94
Physical interaction with Yes-associated protein enhances p73 transcriptional activity. J Biol Chem (2001) 2.93
p53 activates the CD95 (APO-1/Fas) gene in response to DNA damage by anticancer drugs. J Exp Med (1998) 2.91
Identification of a precursor in the biosynthesis of the p21 transforming protein of harvey murine sarcoma virus. J Virol (1982) 2.89
Regulation of mdm2 expression by p53: alternative promoters produce transcripts with nonidentical translation potential. Genes Dev (1994) 2.88
Rapid ATM-dependent phosphorylation of MDM2 precedes p53 accumulation in response to DNA damage. Proc Natl Acad Sci U S A (1999) 2.87
p53-independent upregulation of miR-34a during oncogene-induced senescence represses MYC. Cell Death Differ (2009) 2.80
Processing and expression of early SV40 mRNA: a role for RNA conformation in splicing. Cell (1979) 2.80
Pax6 controls radial glia differentiation in the cerebral cortex. Neuron (1998) 2.78
Expression of simian virus 40-rat preproinsulin recombinants in monkey kidney cells: use of preproinsulin RNA processing signals. Proc Natl Acad Sci U S A (1981) 2.76
Follicular cells of the thyroid gland require Pax8 gene function. Nat Genet (1998) 2.75
Post-transcriptional control of myc and p53 expression during differentiation of the embryonal carcinoma cell line F9. Nature (1985) 2.75
Differential affinities of simian virus 40 large tumor antigen for DNA. Proc Natl Acad Sci U S A (1980) 2.75
Overproduction of p53 antigen makes established cells highly tumorigenic. Nature (1985) 2.72
Pax2, a new murine paired-box-containing gene and its expression in the developing excretory system. Development (1990) 2.72
Murine developmental control genes. Science (1990) 2.71
Meth A fibrosarcoma cells express two transforming mutant p53 species. Oncogene (1988) 2.71
Cell type-specific transcriptional enhancement in vitro requires the presence of trans-acting factors. EMBO J (1985) 2.70
Distinct cis-essential modules direct the time-space pattern of the Pax6 gene activity. Dev Biol (1999) 2.70
Octamer binding proteins confer transcriptional activity in early mouse embryogenesis. EMBO J (1989) 2.70
Skeletal muscle actin mRNA. Characterization of the 3' untranslated region. Nucleic Acids Res (1981) 2.67
Non-visualization of the cavum septi pellucidi is not synonymous with agenesis of the corpus callosum. Ultrasound Obstet Gynecol (2012) 2.65
Critical role for Ser20 of human p53 in the negative regulation of p53 by Mdm2. EMBO J (1999) 2.64
Pax: a murine multigene family of paired box-containing genes. Genomics (1991) 2.60
Localization of gene for human p53 tumour antigen to band 17p13. Nature (1986) 2.56
Imidazole: a selective inhibitor of thromboxane synthetase. Prostaglandins (1977) 2.48
Diversity of germ-line immunoglobulin VH genes. Nature (1981) 2.47
All autophosphorylation sites of epidermal growth factor (EGF) receptor and HER2/neu are located in their carboxyl-terminal tails. Identification of a novel site in EGF receptor. J Biol Chem (1989) 2.46
Thromboxanes: selective biosynthesis and distinct biological properties. Science (1976) 2.46
Pax-3 is required for the development of limb muscles: a possible role for the migration of dermomyotomal muscle progenitor cells. Development (1994) 2.45
Activation of a cellular oncogene by DNA rearrangement: possible involvement of an IS-like element. Nature (1982) 2.45
Mutant p53 gain of function: differential effects of different p53 mutants on resistance of cultured cells to chemotherapy. Oncogene (1999) 2.43
Homeobox genes and connective tissue patterning. Development (1995) 2.43
Pax8, a murine paired box gene expressed in the developing excretory system and thyroid gland. Development (1990) 2.42
Cortical upper layer neurons derive from the subventricular zone as indicated by Svet1 gene expression. Development (2001) 2.37