Published in Prostaglandins on September 01, 1976
Triene prostaglandins: prostacyclin and thromboxane biosynthesis and unique biological properties. Proc Natl Acad Sci U S A (1979) 2.07
Eighth Gaddum Memorial Lecture. University of London Institute of Education, December 1980. Biological importance of prostacyclin. Br J Pharmacol (1982) 2.01
Application of imidazole as a selective inhibitor thromboxane synthetase in human platelets. Proc Natl Acad Sci U S A (1977) 1.56
Cardiac and renal prostaglandin I2. Biosynthesis and biological effects in isolated perfused rabbit tissues. J Clin Invest (1978) 1.48
Platelet and blood vessel arachidonate metabolism and interactions. J Clin Invest (1979) 1.44
Arachidonate metabolism in vascular disorders. J Clin Invest (1983) 1.43
Recirculation of prostacyclin (PGI2) in the dog. Br J Pharmacol (1978) 1.06
Coronary vasoconstrictor and vasodilator actions of arachidonic acid in the isolated perfused heart of the rat. Br J Pharmacol (1982) 0.91
Adrenoreceptor blockade in angiotensin-induced hypertension: effect on rat coronary arteries and myocardium. Am J Pathol (1982) 0.87
Factors affecting prostacyclin formation by the rat pregnant myometrium. Br J Pharmacol (1980) 0.84
The prostanoids in hemostasis and thrombosis: a review. Am J Pathol (1980) 0.83
Cardiovascular risks and benefits of perioperative nonsteroidal anti-inflammatory drug treatment. Drugs (1992) 0.80
Corneal reepithelialization and anti-inflammatory agents. Trans Am Ophthalmol Soc (1982) 0.78
Selective inhibitory actions of sodium-p-benzyl-4-[1-oxo-2-(4-chlorobenzyl)-3-phenyl propyl] phenyl phosphonate (N-0161) and indomethacin on the biosynthesis of prostaglandins and thromboxanes from arachidonic acid. Br J Pharmacol (1977) 0.78
Prostaglandin X, the vascular metabolite of arachidonic acid responsible for relaxation of bovine coronary artery strips [proceedings]. Br J Pharmacol (1977) 0.78
Myocardial synthesis of prostaglandin-like substances and coronary reactions to cardiostimulation and to hypoxia. Br J Pharmacol (1979) 0.78
A controlled trial of teaching critical appraisal of the clinical literature to medical students. JAMA (1987) 14.20
Arachidonic acid metabolism. Annu Rev Biochem (1986) 6.56
Thrombolysis in Myocardial Infarction (TIMI) Trial, Phase I: A comparison between intravenous tissue plasminogen activator and intravenous streptokinase. Clinical findings through hospital discharge. Circulation (1987) 5.73
Circadian variation in the frequency of onset of acute myocardial infarction. N Engl J Med (1985) 5.09
Identification of a (CUG)n triplet repeat RNA-binding protein and its expression in myotonic dystrophy. Nucleic Acids Res (1996) 4.75
Identification of a genetic locus for familial atrial fibrillation. N Engl J Med (1997) 4.66
Second dose of measles, mumps, and rubella vaccine: questionnaire survey of health professionals. BMJ (2001) 4.50
Determining optimal therapy--randomized trials in individual patients. N Engl J Med (1986) 4.49
Identification of a gene responsible for familial Wolff-Parkinson-White syndrome. N Engl J Med (2001) 4.46
Mutations in the gene for cardiac myosin-binding protein C and late-onset familial hypertrophic cardiomyopathy. N Engl J Med (1998) 4.29
Synthesis of the yeast cell wall and its regulation. Annu Rev Biochem (1982) 4.26
Do sick newborn infants benefit from participation in a randomized clinical trial? J Pediatr (1999) 3.98
Nitric oxide activates cyclooxygenase enzymes. Proc Natl Acad Sci U S A (1993) 3.93
Comparison of percutaneous and surgical tracheostomies. Chest (1996) 3.56
WD-repeat proteins: structure characteristics, biological function, and their involvement in human diseases. Cell Mol Life Sci (2001) 3.38
A clinician's guide for conducting randomized trials in individual patients. CMAJ (1988) 3.35
The induction and suppression of prostaglandin H2 synthase (cyclooxygenase) in human monocytes. J Biol Chem (1990) 3.34
Tissue Doppler imaging consistently detects myocardial abnormalities in patients with hypertrophic cardiomyopathy and provides a novel means for an early diagnosis before and independently of hypertrophy. Circulation (2001) 3.33
Verifying quality and safety in health informatics services. BMJ (2001) 3.31
Angiotensin II blockade reverses myocardial fibrosis in a transgenic mouse model of human hypertrophic cardiomyopathy. Circulation (2001) 3.21
Mutations in the lactose operon caused by bacteriophage Mu. J Mol Biol (1972) 3.17
Regulation of fibroblast cyclooxygenase synthesis by interleukin-1. J Biol Chem (1988) 3.06
The impact of blinding on the results of a randomized, placebo-controlled multiple sclerosis clinical trial. Neurology (1994) 2.95
Ipsilateral breast tumor recurrence postlumpectomy is predictive of subsequent mortality: results from a randomized trial. Investigators of the Ontario Clinical Oncology Group. Int J Radiat Oncol Biol Phys (1994) 2.86
Allergen-induced increase in bronchial responsiveness to histamine: relationship to the late asthmatic response and change in airway caliber. J Allergy Clin Immunol (1982) 2.84
The molecular genetic basis for hypertrophic cardiomyopathy. J Mol Cell Cardiol (2001) 2.83
Identification of an enzyme in platelet microsomes which generates thromboxane A2 from prostaglandin endoperoxides. Nature (1976) 2.83
A comparison between heparin and low-dose aspirin as adjunctive therapy with tissue plasminogen activator for acute myocardial infarction. Heparin-Aspirin Reperfusion Trial (HART) Investigators. N Engl J Med (1990) 2.73
A standard heparin nomogram for the management of heparin therapy. Arch Intern Med (1991) 2.69
It's time for a change to a troponin standard. Circulation (2000) 2.69
Selective regulation of cellular cyclooxygenase by dexamethasone and endotoxin in mice. J Clin Invest (1990) 2.66
The impact of socioeconomic status on health functioning as assessed by the SF-36 questionnaire: the Whitehall II Study. Am J Public Health (1997) 2.65
Reliability of a Standardized Mini-Mental State Examination compared with the traditional Mini-Mental State Examination. Am J Psychiatry (1991) 2.61
Desmin mutation responsible for idiopathic dilated cardiomyopathy. Circulation (1999) 2.59
Endogenous glucocorticoids regulate an inducible cyclooxygenase enzyme. Proc Natl Acad Sci U S A (1992) 2.55
Bioactive cardiac substances: potent vasorelaxant activity in mammalian atria. Science (1983) 2.53
Imidazole: a selective inhibitor of thromboxane synthetase. Prostaglandins (1977) 2.48
Impairment of endothelium-dependent arterial relaxation by lysolecithin in modified low-density lipoproteins. Nature (1990) 2.46
Thromboxanes: selective biosynthesis and distinct biological properties. Science (1976) 2.46
Angiotensin-converting enzyme polymorphism in hypertrophic cardiomyopathy and sudden cardiac death. Lancet (1993) 2.38
Echocardiography-guided ethanol septal reduction for hypertrophic obstructive cardiomyopathy. Circulation (1998) 2.37
APOE modifies the association between Aβ load and cognition in cognitively normal older adults. Neurology (2011) 2.35
Influence of coronary collateral vessels on myocardial infarct size in humans. Results of phase I thrombolysis in myocardial infarction (TIMI) trial. The TIMI Investigators. Circulation (1991) 2.33
Novel PRKAG2 mutation responsible for the genetic syndrome of ventricular preexcitation and conduction system disease with childhood onset and absence of cardiac hypertrophy. Circulation (2001) 2.25
Simvastatin induces regression of cardiac hypertrophy and fibrosis and improves cardiac function in a transgenic rabbit model of human hypertrophic cardiomyopathy. Circulation (2001) 2.23
Novel proteins with binding specificity for DNA CTG repeats and RNA CUG repeats: implications for myotonic dystrophy. Hum Mol Genet (1996) 2.23
A transgenic rabbit model for human hypertrophic cardiomyopathy. J Clin Invest (1999) 2.19
Electrocardiographic and clinical criteria for recognition of acute myocardial infarction based on analysis of 3,697 patients. Am J Cardiol (1983) 2.18
Allergic Rhinitis and its Impact on Asthma (ARIA): achievements in 10 years and future needs. J Allergy Clin Immunol (2012) 2.17
Development and implementation of guidelines for family practice: lessons from The Netherlands. J Fam Pract (1995) 2.11
Diagnostic marker cooperative study for the diagnosis of myocardial infarction. Circulation (1999) 2.09
Triene prostaglandins: prostacyclin and thromboxane biosynthesis and unique biological properties. Proc Natl Acad Sci U S A (1979) 2.07
Identification of patients most likely to benefit from implantable cardioverter-defibrillator therapy: the Canadian Implantable Defibrillator Study. Circulation (2000) 2.05
Mechanism of tolerance development to organic nitrates. J Pharmacol Exp Ther (1973) 2.04
Short and long term prognosis of acute myocardial infarction since introduction of thrombolysis. BMJ (1993) 2.03
Comparison of immediate invasive, delayed invasive, and conservative strategies after tissue-type plasminogen activator. Results of the Thrombolysis in Myocardial Infarction (TIMI) Phase II-A trial. Circulation (1990) 2.01
Stimulation of prostaglandin biosynthesis by adenine nucleotides. Profile of prostaglandin release by perfused organs. Circ Res (1974) 1.97
Isolation and sequence analysis of a full-length cDNA for human M creatine kinase. Biochem Biophys Res Commun (1986) 1.96
Atriopeptins as cardiac hormones. Hypertension (1985) 1.91
Direct evidence that oxygen-derived free radicals contribute to postischemic myocardial dysfunction in the intact dog. Proc Natl Acad Sci U S A (1989) 1.90
Integrated patient records: another move towards quality for patients? Qual Health Care (1993) 1.88
Does breastfeeding at six months predict cognitive development? Aust N Z J Public Health (1998) 1.87
Randomized clinical trial of breast irradiation following lumpectomy and axillary dissection for node-negative breast cancer: an update. Ontario Clinical Oncology Group. J Natl Cancer Inst (1996) 1.86
Purification and sequence analysis of bioactive atrial peptides (atriopeptins). Science (1984) 1.85
Depression and risk of sudden cardiac death after acute myocardial infarction: testing for the confounding effects of fatigue. Psychosom Med (2000) 1.80
Familial colloid cyst of the third ventricle: case report and review of associated conditions. Neurosurgery (1996) 1.79
An improved basis for enzymatic estimation of infarct size. Circulation (1975) 1.77
Exaggerated human vascular cell prostaglandin biosynthesis mediated by monocytes: role of monokines and interleukin 1. J Immunol (1985) 1.76
The influence of location and extent of myocardial infarction on long-term ventricular dysrhythmia and mortality. Circulation (1979) 1.75
ABC of child abuse. Child sexual abuse--II. BMJ (1989) 1.72
Tissue Doppler imaging consistently detects myocardial contraction and relaxation abnormalities, irrespective of cardiac hypertrophy, in a transgenic rabbit model of human hypertrophic cardiomyopathy. Circulation (2000) 1.72
Atriopeptin: a cardiac hormone intimately involved in fluid, electrolyte, and blood-pressure homeostasis. N Engl J Med (1986) 1.71
Severity of coronary artery calcification by electron beam computed tomography predicts silent myocardial ischemia. Circulation (2000) 1.70
Magnetic resonance spectroscopy, β-amyloid load, and cognition in a population-based sample of cognitively normal older adults. Neurology (2011) 1.70
Disability, distress and unemployment in neurology outpatients with symptoms 'unexplained by organic disease'. J Neurol Neurosurg Psychiatry (2011) 1.69
Electrocardiographic diagnosis of myocardial infarction in the presence of complete left bundle branch block. Am Heart J (1988) 1.69
Post-myocardial infarction mortality in patients with ventricular premature depolarizations. Canadian Amiodarone Myocardial Infarction Arrhythmia Trial Pilot Study. Circulation (1991) 1.68
Postprandial plasma bile acid responses in normal weight and obese subjects. Ann Clin Biochem (2010) 1.67
Effects of nifedipine on myocardial perfusion and ischemic injury in dogs. Circ Res (1978) 1.67
Temporal and pharmacological division of fibroblast cyclooxygenase expression into transcriptional and translational phases. Proc Natl Acad Sci U S A (1989) 1.67
Organic nitrates: relationship between biotransformation and rational angina pectoris therapy. J Pharmacol Exp Ther (1972) 1.67
The struggle to diagnose UTI in children under two in primary care. Fam Pract (1997) 1.65
Deleterious effects of methylprednisolone in patients with myocardial infarction. Circulation (1976) 1.65
Cyclic adenosine 3',5'-monophosphate inhibits the availability of arachidonate to prostaglandin synthetase in human platelet suspensions. J Clin Invest (1977) 1.63
Early diagnosis of acute myocardial infarction based on assay for subforms of creatine kinase-MB. Circulation (1990) 1.61
Depression and substance use in minority middle-school students. Am J Public Health (2001) 1.61
Isolation and characterization of the complementary DNA for sheep seminal vesicle prostaglandin endoperoxide synthase (cyclooxygenase). J Biol Chem (1988) 1.61
Endogenous nitric oxide enhances prostaglandin production in a model of renal inflammation. J Clin Invest (1994) 1.59
Optimal delivery of aerosols from metered dose inhalers. Chest (1981) 1.59
Unexplained extra visits to general practitioners before the diagnosis of first urinary tract infection: a case-control study. Arch Dis Child (2002) 1.58
Fibrinolytic variables in patients with recurrent venous thrombosis: a prospective cohort study. Thromb Haemost (2001) 1.58
Sulfhydryl requirement for relaxation of vascular smooth muscle. J Pharmacol Exp Ther (1973) 1.57
Application of imidazole as a selective inhibitor thromboxane synthetase in human platelets. Proc Natl Acad Sci U S A (1977) 1.56
Prostaglandin endoperoxide and thromboxane generating systems and their selective inhibition. Prostaglandins (1976) 1.56
Integrated record keeping as an essential aspect of a primary care led health service. BMJ (1998) 1.55
Enhancement of recovery of myocardial function by oxygen free-radical scavengers after reversible regional ischemia. Circulation (1985) 1.54
Serial plasma catecholamine response early in the course of clinical acute myocardial infarction: relationship to infarct extent and mortality. Am Heart J (1981) 1.54
Ten down under: implementing ICD-10 in Australia. J AHIMA (2000) 1.54
Autonomous expression of c-myc in BC3H1 cells partially inhibits but does not prevent myogenic differentiation. Mol Cell Biol (1987) 1.52