Published in Am J Physiol on November 01, 1986
On the mechanism of isoprenaline- and forskolin-induced depolarization of single guinea-pig ventricular myocytes. J Physiol (1988) 1.32
Effect of catecholamines on intracellular pH in sheep cardiac Purkinje fibres. J Physiol (1992) 0.80
Analysis of the hyperpolarizing effect of catecholamines on canine cardiac Purkinje fibres. Br J Pharmacol (1989) 0.75
Membrane capacity of the cardiac Purkinje fibre. J Physiol (1966) 3.65
A mutant of TTX-resistant cardiac sodium channels with TTX-sensitive properties. Science (1992) 3.47
Transmembrane Na+ and Ca2+ electrochemical gradients in cardiac muscle and their relationship to force development. J Gen Physiol (1982) 3.20
A structural model of the tetrodotoxin and saxitoxin binding site of the Na+ channel. Biophys J (1994) 2.64
Binding and degradation of 125I-insulin by rat hepatocytes. J Biol Chem (1975) 2.46
Activities of potassium and sodium ions in rabbit heart muscle. J Gen Physiol (1975) 2.38
The positive dynamic current and its inactivation properties in cardiac Purkinje fibres. J Physiol (1973) 2.23
Increase in intracellular sodium ion activity during stimulation in mammalian cardiac muscle. Circ Res (1982) 2.14
Retention and degradation of 125I-insulin by perfused livers from diabetic rats. J Clin Invest (1976) 2.04
Nonlinear relation between Vmax and INa in canine cardiac Purkinje cells. Circ Res (1988) 1.78
KcsA crystal structure as framework for a molecular model of the Na(+) channel pore. Biochemistry (2000) 1.76
Sodium channel selectivity filter regulates antiarrhythmic drug binding. Proc Natl Acad Sci U S A (1997) 1.61
Strength-duration curves in cardiac Purkinje fibres: effects of liminal length and charge distribution. J Physiol (1972) 1.60
Voltage dependence and time dependence of contraction in sheep cardiac Purkinje fibers. Circ Res (1971) 1.56
Slow inward current and contraction of sheep cardiac Purkinje fibers. J Gen Physiol (1975) 1.52
Predominant interactions between mu-conotoxin Arg-13 and the skeletal muscle Na+ channel localized by mutant cycle analysis. Biochemistry (1998) 1.50
Sodium current in voltage clamped internally perfused canine cardiac Purkinje cells. Biophys J (1987) 1.47
Kinetic analysis of single sodium channels from canine cardiac Purkinje cells. J Gen Physiol (1990) 1.44
A mu-conotoxin-insensitive Na+ channel mutant: possible localization of a binding site at the outer vestibule. Biophys J (1995) 1.42
Membrane response to current pulses in spheroidal aggregates of embryonic heart cells. J Gen Physiol (1975) 1.42
Influence of changes in external potassium and chloride ions on membrane potential and intracellular potassium ion activity in rabbit ventricular muscle. J Physiol (1976) 1.41
Isolation and characterization of proinsulin C-peptide from bovine pancreas. J Biol Chem (1971) 1.41
Relationships between voltage and tension in sheep cardiac Purkinje fibers. J Gen Physiol (1975) 1.38
Mechanism of cAMP-dependent modulation of cardiac sodium channel current kinetics. Circ Res (1993) 1.38
Differences in saxitoxin and tetrodotoxin binding revealed by mutagenesis of the Na+ channel outer vestibule. Biophys J (1998) 1.35
New studies of the excitatory sodium currents in heart muscle. Circ Res (1985) 1.35
Phosphorylation restores activity of L-type calcium channels after rundown in inside-out patches from rabbit cardiac cells. J Physiol (1992) 1.33
Characteristics of L- and T-type Ca2+ currents in canine cardiac Purkinje cells. Am J Physiol (1989) 1.33
Ultra-slow inactivation in mu1 Na+ channels is produced by a structural rearrangement of the outer vestibule. Biophys J (1999) 1.33
Delayed afterdepolarizations in heart muscle: mechanisms and relevance. Pharmacol Rev (1988) 1.31
Sodium current in isolated human ventricular myocytes. Am J Physiol (1993) 1.31
Open sodium channel properties of single canine cardiac Purkinje cells. Biophys J (1987) 1.30
mu-conotoxin GIIIA interactions with the voltage-gated Na(+) channel predict a clockwise arrangement of the domains. J Gen Physiol (2000) 1.30
Is there a second external lidocaine binding site on mammalian cardiac cells? Am J Physiol (1989) 1.29
Sarcolemmal evaginations with knob-like or stalked projections in Purkinje fibers of the sheep's heart. J Ultrastruct Res (1969) 1.27
Changes in intracellular Ca2+ activity with stimulation in sheep cardiac Purkinje strands. Am J Physiol (1982) 1.26
Isolation and characterization of single canine cardiac purkinje cells. Circ Res (1983) 1.24
Divalent cation competition with [3H]saxitoxin binding to tetrodotoxin-resistant and -sensitive sodium channels. A two-site structural model of ion/toxin interaction. J Gen Physiol (1993) 1.23
Surgical treatment of recurrent primary malignant tumor of the left atrium. J Thorac Cardiovasc Surg (1979) 1.23
Heart: excitation-contraction coupling. Annu Rev Physiol (1977) 1.22
High potassium and low sodium contractures in sheep cardiac muscle. J Gen Physiol (1971) 1.19
Mode of uptake and degradation of 125I-labelled insulin by isolated hepatocytes and H4 hepatoma cells. Can J Biochem (1979) 1.19
Effect of diameter on membrane capacity and conductance of sheep cardiac Purkinje fibers. J Gen Physiol (1975) 1.18
Relationship between membrane voltage and tension in voltage-clamped cardiac purkinje fibres. Nature (1968) 1.18
The voltage clamp and cardiac electrophysiology. Circ Res (1975) 1.17
The selectivity filter of the voltage-gated sodium channel is involved in channel activation. J Biol Chem (2001) 1.16
Functional expression of the rat heart I Na+ channel isoform. Demonstration of properties characteristic of native cardiac Na+ channels. FEBS Lett (1990) 1.15
Gating currents associated with Na channels in canine cardiac Purkinje cells. J Gen Physiol (1990) 1.15
Characterization of the sodium current in single human atrial myocytes. Circ Res (1992) 1.15
Two phosphatase sites on the Ca2+ channel affecting different kinetic functions. J Physiol (1993) 1.14
Relation between intracellular sodium and twitch tension in sheep cardiac Purkinje strands exposed to cardiac glycosides. Circ Res (1983) 1.13
Electrophysiology of Cl secretion in canine trachea. J Membr Biol (1983) 1.12
Role of outer ring carboxylates of the rat skeletal muscle sodium channel pore in proton block. J Physiol (2002) 1.12
The effects of membrane potential, extracellular potassium, and tetrodotoxin on the intracellular sodium ion activity of sheep cardiac muscle. Circ Res (1984) 1.11
Na,K pump stimulation by intracellular Na in isolated, intact sheep cardiac Purkinje fibers. J Gen Physiol (1988) 1.10
The relation of Vmax to INa, GNa, and h infinity in a model of the cardiac Purkinje fiber. Biophys J (1979) 1.09
An analysis of lidocaine block of sodium current in isolated human atrial and ventricular myocytes. J Mol Cell Cardiol (1995) 1.09
Membrane ionic conductances during rest and activity in guinea pig atrial muscle. Am J Physiol (1967) 1.08
ST-segment potentials and mapping. Theory and experiments. Circulation (1976) 1.08
Low conductance sodium channels in canine cardiac Purkinje cells. Biophys J (1987) 1.06
A critical residue for isoform difference in tetrodotoxin affinity is a molecular determinant of the external access path for local anesthetics in the cardiac sodium channel. Proc Natl Acad Sci U S A (2000) 1.05
Intracellular potassium and sodium activities of chick ventricular muscle during embryonic development. J Physiol (1980) 1.04
Post-repolarization block of cloned sodium channels by saxitoxin: the contribution of pore-region amino acids. Biophys J (1994) 1.03
Effects of quinidine on action potentials and ionic currents in isolated canine ventricular myocytes. Circ Res (1988) 1.03
Alterations in muscarinic K+ channel response to acetylcholine and to G protein-mediated activation in atrial myocytes isolated from failing human hearts. Circulation (1994) 1.02
A structural motif for the voltage-gated potassium channel pore. Proc Natl Acad Sci U S A (1995) 1.02
Influence of extracellular K+ concentration on cable properties and excitability of sheep cardiac Purkinje fibers. Circ Res (1970) 1.02
Action potential and contraction of heart muscle. Am J Cardiol (1973) 1.02
Intra- and extracellular K+ and Na+ activities and resting membrane potential in sheep cardiac purkinje strands. Circ Res (1980) 1.01
Structural and gating changes of the sodium channel induced by mutation of a residue in the upper third of IVS6, creating an external access path for local anesthetics. Mol Pharmacol (2001) 1.00
The cloned cardiac Na channel alpha-subunit expressed in Xenopus oocytes show gating and blocking properties of native channels. J Membr Biol (1992) 1.00
The influence of intercellular clefts on the electrical properties of sheep cardiac Purkinje fibers. Biophys J (1979) 1.00
Specific neosaxitoxin interactions with the Na+ channel outer vestibule determined by mutant cycle analysis. Biophys J (2001) 1.00
Intracellular chloride activity in mammalian ventricular muscle. Am J Physiol (1981) 1.00
Fab fragments of digoxin-specific antibodies used to reverse ventricular fibrillation induced by digoxin ingestion in a child. Pediatrics (1982) 0.99
Dose-dependent modulation of the cardiac sodium channel by sea anemone toxin ATXII. Circ Res (1992) 0.99
Effect of formaldehyde and glutaraldehyde on electrical properties of cardiac Purkinje fibers. J Gen Physiol (1969) 0.99
Catecholamine effects on intracellular sodium activity and tension in dog heart. Am J Physiol (1982) 0.98
Regulation of intracellular sodium concentrations in rat diaphragm muscle. Science (1967) 0.98
Characterization of insulin-like actions of anti-insulin receptor antibodies. Effects on insulin binding, insulin degradation, and glycogen synthesis in isolated rat hepatocytes. J Biol Chem (1980) 0.98
Relationship between lipid fluidity and water permeability of bovine tracheal epithelial cell apical membranes. Biochemistry (1986) 0.98
Acetylcholine-sensitive muscarinic K+ channels in mammalian ventricular myocytes. Am J Physiol (1994) 0.98
Cardiac-specific external paths for lidocaine, defined by isoform-specific residues, accelerate recovery from use-dependent block. Circ Res (2001) 0.97
Electrochemical properties of hydrated cation-selective glass membrane. A model of K+ and Na+ transport. Biophys J (1974) 0.97
Modeling of the outer vestibule and selectivity filter of the L-type Ca2+ channel. Biochemistry (2001) 0.97
Adrenergic modulation of the transient outward current in isolated canine Purkinje cells. Circ Res (1988) 0.96
Beta-adrenergic and cholinergic modulation of inward rectifier K+ channel function and phosphorylation in guinea-pig ventricle. J Physiol (1995) 0.96
A real-time pressure algorithm. Comput Biol Med (1981) 0.95
The electrophysiology of acute myocardial ischemia. Annu Rev Med (1985) 0.95
External site for local anesthetic block of cardiac Na+ channels. J Mol Cell Cardiol (1991) 0.93
A cleft model for cardiac Purkinje strands. Biophys J (1981) 0.93
Validity of myocardial infarction models. Circulation (1975) 0.92
Modal behavior of the mu 1 Na+ channel and effects of coexpression of the beta 1-subunit. Biophys J (1996) 0.92
The cellular mechanism of active chloride secretion in vertebrate epithelia: studies in intestine and trachea. Philos Trans R Soc Lond B Biol Sci (1982) 0.92
Na/Ca exchange in the intact cardiac cell. J Gen Physiol (1985) 0.92
Effects of Ca2+/Mg2+ removal on aiNa, aiK, and tension in cardiac Purkinje fibers. Am J Physiol (1986) 0.92
Therapeutic uses of calcium-blocking agents:verapamil, nifedipine, and diltiazem. Compr Ther (1981) 0.91