Published in Blood on October 01, 1985
Identification of an alternatively spliced site in human plasma fibronectin that mediates cell type-specific adhesion. J Cell Biol (1986) 2.63
Characterization of a 140-kD avian cell surface antigen as a fibronectin-binding molecule. J Cell Biol (1986) 2.62
The membrane glycoprotein Ia-IIa (VLA-2) complex mediates the Mg++-dependent adhesion of platelets to collagen. J Cell Biol (1989) 2.44
Tyrosine-specific protein phosphorylation is regulated by glycoprotein IIb-IIIa in platelets. Proc Natl Acad Sci U S A (1989) 2.35
Full-length von Willebrand factor (vWF) cDNA encodes a highly repetitive protein considerably larger than the mature vWF subunit. EMBO J (1986) 2.35
Role of adhesive proteins in platelet tumor interaction in vitro and metastasis formation in vivo. J Clin Invest (1988) 2.23
A cell surface receptor complex for collagen type I recognizes the Arg-Gly-Asp sequence. J Cell Biol (1987) 2.04
Role of fibrinogen alpha and gamma chain sites in platelet aggregation. Proc Natl Acad Sci U S A (1992) 1.81
Platelet thrombospondin mediates attachment and spreading of human melanoma cells. J Cell Biol (1987) 1.81
Fibrinogen induces adhesion, spreading, and microfilament organization of human endothelial cells in vitro. J Cell Biol (1987) 1.59
RGD-dependent linkage between plant cell wall and plasma membrane: consequences for growth. J Cell Biol (1989) 1.51
Immunologic relationship between platelet membrane glycoprotein GPIIb/IIIa and cell surface molecules expressed by a variety of cells. Proc Natl Acad Sci U S A (1986) 1.48
An Arg-Gly-Asp-directed receptor on the surface of human melanoma cells exists in an divalent cation-dependent functional complex with the disialoganglioside GD2. J Cell Biol (1987) 1.44
Impaired platelet aggregation and sustained bleeding in mice lacking the fibrinogen motif bound by integrin alpha IIb beta 3. EMBO J (1996) 1.33
Fibrinogen-independent platelet adhesion and thrombus formation on subendothelium mediated by glycoprotein IIb-IIIa complex at high shear rate. J Clin Invest (1989) 1.33
Elastase-mediated fibrinogenolysis by chemoattractant-stimulated neutrophils occurs in the presence of physiologic concentrations of antiproteinases. J Exp Med (1987) 1.32
Investigation of the biological effects of anti-cell adhesive synthetic peptides that inhibit experimental metastasis of B16-F10 murine melanoma cells. J Clin Invest (1988) 1.18
Distinct determinants on collagen support alpha 2 beta 1 integrin-mediated platelet adhesion and platelet activation. Cell Regul (1991) 1.14
The relationship between platelet adhesion on surfaces and the structure versus the amount of adsorbed fibrinogen. Biomaterials (2009) 1.09
Adhesive properties of the beta 3 integrins: comparison of GP IIb-IIIa and the vitronectin receptor individually expressed in human melanoma cells. J Cell Biol (1991) 1.07
p42 mitogen-activated protein kinase and p90 ribosomal S6 kinase are selectively phosphorylated and activated during thrombin-induced platelet activation and aggregation. Mol Cell Biol (1994) 1.06
Adenosine diphosphate-induced aggregation of human platelets in flow through tubes. II. Effect of shear rate, donor sex, and ADP concentration. Biophys J (1989) 1.02
Von Willebrand factor promotes endothelial cell adhesion via an Arg-Gly-Asp-dependent mechanism. J Cell Biol (1989) 1.00
Identification of a multifunctional, cell-binding peptide sequence from the a1(NC1) of type IV collagen. J Cell Biol (1990) 0.96
Antimetastatic effects of synthetic polypeptides containing repeated structures of the cell adhesive Arg-Gly-Asp (RGD) and Tyr-Ile-Gly-Ser-Arg (YIGSR) sequences. Br J Cancer (1989) 0.93
A deletion in the gene for glycoprotein IIb associated with Glanzmann's thrombasthenia. J Clin Invest (1991) 0.93
Species differences in small molecule binding to alpha IIb beta 3 are the result of sequence differences in 2 loops of the alpha IIb beta propeller. Blood (2008) 0.92
Platelet-reactive sites in collagen. Collagens I and III possess different aggregatory sites. Biochem J (1987) 0.87
Differential structural requirements for fibrinogen binding to platelets and to endothelial cells. J Cell Biol (1989) 0.85
Evidence for novel binding sites on the platelet glycoprotein IIb and IIIa subunits and immobilized fibrinogen. Biochem J (1993) 0.82
RGDV peptide selectively inhibits platelet-dependent thrombus formation in vivo. Studies using a baboon model. J Clin Invest (1989) 0.82
Arginine-glycine-aspartic acid- and fibrinogen gamma-chain carboxyterminal peptides inhibit platelet adherence to arterial subendothelium at high wall shear rates. An effect dissociable from interference with adhesive protein binding. J Clin Invest (1990) 0.82
Influence of tuftsin-like synthetic peptides derived from C-reactive protein (CRP) on platelet behaviour. Immunology (1988) 0.81
Requirements for the Ca2+-independent component in the initial intercellular adhesion of C2 myoblasts. J Cell Biol (1988) 0.80
Platelet response to aggregated C-reactive protein: fibrinogen-dependent and independent signals. Immunology (1988) 0.78
A robust vitronectin-derived peptide for the scalable long-term expansion and neuronal differentiation of human pluripotent stem cell (hPSC)-derived neural progenitor cells (hNPCs). Acta Biomater (2016) 0.75
Taking cell-matrix adhesions to the third dimension. Science (2001) 15.21
Transmembrane crosstalk between the extracellular matrix--cytoskeleton crosstalk. Nat Rev Mol Cell Biol (2001) 10.74
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Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems. Proc Natl Acad Sci U S A (1999) 7.88
Cell surface interactions with extracellular materials. Annu Rev Biochem (1983) 6.76
Integrin function: molecular hierarchies of cytoskeletal and signaling molecules. J Cell Biol (1995) 6.74
Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN. Science (1998) 6.62
Synergistic roles for receptor occupancy and aggregation in integrin transmembrane function. Science (1995) 6.45
Ultrastructure and function of growth cones and axons of cultured nerve cells. J Cell Biol (1971) 5.90
Microfilaments and cell locomotion. J Cell Biol (1971) 4.89
Molecular diversity of cell-matrix adhesions. J Cell Sci (1999) 4.33
Axon growth: roles of microfilaments and microtubules. Proc Natl Acad Sci U S A (1970) 4.33
Cell surface protein partially restores morphology, adhesiveness, and contact inhibition of movement to transformed fibroblasts. Proc Natl Acad Sci U S A (1976) 4.32
Integrins can collaborate with growth factors for phosphorylation of receptor tyrosine kinases and MAP kinase activation: roles of integrin aggregation and occupancy of receptors. J Cell Biol (1996) 4.21
Dynamics and segregation of cell-matrix adhesions in cultured fibroblasts. Nat Cell Biol (2000) 3.99
Levels of translatable mRNAs for cell surface protein, collagen precursors, and two membrane proteins are altered in Rous sarcoma virus-transformed chick embryo fibroblasts. Proc Natl Acad Sci U S A (1977) 3.80
Analysis of fibronectin receptor function with monoclonal antibodies: roles in cell adhesion, migration, matrix assembly, and cytoskeletal organization. J Cell Biol (1989) 3.77
Development of cell surface linkage complexes in cultured fibroblasts. J Cell Biol (1985) 3.59
The zinc-finger protein slug causes desmosome dissociation, an initial and necessary step for growth factor-induced epithelial-mesenchymal transition. J Cell Biol (1997) 3.52
Antiphospholipid antibodies: anticardiolipin and the lupus anticoagulant in systemic lupus erythematosus (SLE) and in non-SLE disorders. Prevalence and clinical significance. Ann Intern Med (1990) 3.35
Isolation of a major cell surface glycoprotein from fibroblasts. Proc Natl Acad Sci U S A (1974) 3.30
Dualistic nature of adhesive protein function: fibronectin and its biologically active peptide fragments can autoinhibit fibronectin function. J Cell Biol (1984) 3.18
Integrin dynamics and matrix assembly: tensin-dependent translocation of alpha(5)beta(1) integrins promotes early fibronectin fibrillogenesis. J Cell Biol (2000) 3.13
Role of carbohydrates in protein secretion and turnover: effects of tunicamycin on the major cell surface glycoprotein of chick embryo fibroblasts. Cell (1978) 3.12
The major cell surface glycoprotein of chick embryo fibroblasts is an agglutinin. Proc Natl Acad Sci U S A (1975) 3.06
The short amino acid sequence Pro-His-Ser-Arg-Asn in human fibronectin enhances cell-adhesive function. J Biol Chem (1994) 3.06
Microfilament bundles and cell shape are related to adhesiveness to substratum and are dissociable from growth control in cultured fibroblasts. Cell (1977) 2.99
A synthetic peptide from fibronectin inhibits experimental metastasis of murine melanoma cells. Science (1986) 2.91
Fibroblast cellular and plasma fibronectins are similar but not identical. J Cell Biol (1979) 2.70
Site-directed mutagenesis of the cell-binding domain of human fibronectin: separable, synergistic sites mediate adhesive function. Cell (1988) 2.70
Activation of CD4 cells by fibronectin and anti-CD3 antibody. A synergistic effect mediated by the VLA-5 fibronectin receptor complex. J Exp Med (1989) 2.69
Identification of an alternatively spliced site in human plasma fibronectin that mediates cell type-specific adhesion. J Cell Biol (1986) 2.63
Characterization of a 140-kD avian cell surface antigen as a fibronectin-binding molecule. J Cell Biol (1986) 2.62
Physical state of the extracellular matrix regulates the structure and molecular composition of cell-matrix adhesions. Mol Biol Cell (2000) 2.58
Identification of two distinct regions of the type III connecting segment of human plasma fibronectin that promote cell type-specific adhesion. J Biol Chem (1987) 2.52
Regulation of fibronectin receptor distribution. J Cell Biol (1992) 2.46
The interaction of plasma fibronectin with fibroblastic cells in suspension. J Biol Chem (1985) 2.44
The membrane glycoprotein Ia-IIa (VLA-2) complex mediates the Mg++-dependent adhesion of platelets to collagen. J Cell Biol (1989) 2.44
Mechanism of the decrease in the major cell surface protein of chick embryo fibroblasts after transformation. Cell (1977) 2.42
Alteration of collagen-dependent adhesion, motility, and morphogenesis by the expression of antisense alpha 2 integrin mRNA in mammary cells. J Cell Sci (1995) 2.39
Novel function for beta 1 integrins in keratinocyte cell-cell interactions. J Cell Biol (1990) 2.39
Identification of a 160,000 dalton platelet membrane protein that mediates the initial divalent cation-dependent adhesion of platelets to collagen. Cell (1986) 2.38
Fibronectin receptor exhibits high lateral mobility in embryonic locomoting cells but is immobile in focal contacts and fibrillar streaks in stationary cells. J Cell Biol (1988) 2.38
Altered integrin expression and the malignant phenotype: the contribution of multiple integrated integrin receptors. J Mammary Gland Biol Neoplasia (1998) 2.30
Single subunit chimeric integrins as mimics and inhibitors of endogenous integrin functions in receptor localization, cell spreading and migration, and matrix assembly. J Cell Biol (1994) 2.27
Characterization of fibronectin interactions with glycosaminoglycans and identification of active proteolytic fragments. J Biol Chem (1980) 2.24
Transforming growth factor beta stimulates the expression of fibronectin and of both subunits of the human fibronectin receptor by cultured human lung fibroblasts. J Biol Chem (1988) 2.23
Shc and FAK differentially regulate cell motility and directionality modulated by PTEN. J Cell Biol (1999) 2.21
Insulin-induced receptor loss in cultured human lymphocytes is due to accelerated receptor degradation. Proc Natl Acad Sci U S A (1981) 2.18
Tumor suppressor PTEN inhibition of cell invasion, migration, and growth: differential involvement of focal adhesion kinase and p130Cas. Cancer Res (1999) 2.17
Fibronectin, integrins, and growth control. J Cell Physiol (2001) 2.14
Domain structure of the carboxyl-terminal half of human plasma fibronectin. J Biol Chem (1983) 2.09
The minimal essential sequence for a major cell type-specific adhesion site (CS1) within the alternatively spliced type III connecting segment domain of fibronectin is leucine-aspartic acid-valine. J Biol Chem (1991) 2.08
Affinity chromatographic isolation of the melanoma adhesion receptor for the IIICS region of fibronectin and its identification as the integrin alpha 4 beta 1. J Biol Chem (1990) 2.08
PTEN interactions with focal adhesion kinase and suppression of the extracellular matrix-dependent phosphatidylinositol 3-kinase/Akt cell survival pathway. J Biol Chem (1999) 2.07
Immunological characterization of a major transformation-sensitive fibroblast cell surface glycoprotein. Localization, redistribution, and role in cell shape. J Cell Biol (1978) 2.05
A monoclonal antibody against human thrombospondin inhibits platelet aggregation. Proc Natl Acad Sci U S A (1985) 2.04
Full-length sequence, localization, and chromosomal mapping of ameloblastin. A novel tooth-specific gene. J Biol Chem (1996) 2.00
Direct detection of antigens in sodium dodecyl sulfate-polyacrylamide gels. Anal Biochem (1977) 1.98
VLA-4 mediates CD3-dependent CD4+ T cell activation via the CS1 alternatively spliced domain of fibronectin. J Exp Med (1990) 1.95
Evidence for role of glycoprotein carbohydrates in membrane transport: specific inhibition by tunicamycin. Proc Natl Acad Sci U S A (1979) 1.94
Isolation and characterization of a heparin-binding domain from the amino terminus of platelet thrombospondin. J Biol Chem (1984) 1.94
Characterization of a major fibroblast cell surface glycoprotein. Biochemistry (1977) 1.92
Requirement for the synergy site for cell adhesion to fibronectin depends on the activation state of integrin alpha 5 beta 1. J Biol Chem (1995) 1.91
The platelet glycoprotein thrombospondin binds specifically to sulfated glycolipids. J Biol Chem (1985) 1.90
Tumor suppressor PTEN inhibits integrin- and growth factor-mediated mitogen-activated protein (MAP) kinase signaling pathways. J Cell Biol (1998) 1.85
Neural crest cell migration: requirements for exogenous fibronectin and high cell density. J Cell Biol (1983) 1.84
Isolation and biological characterization of active fragments of the adhesive glycoprotein fibronectin. Cell (1979) 1.83
Decreased expression of integrin adhesive protein receptors in adenocarcinoma of the breast. Am J Pathol (1990) 1.82
The impact of heparin concentration and activated clotting time monitoring on blood conservation. A prospective, randomized evaluation in patients undergoing cardiac operation. J Thorac Cardiovasc Surg (1995) 1.80
Re-expression of the alpha 2 beta 1 integrin abrogates the malignant phenotype of breast carcinoma cells. Proc Natl Acad Sci U S A (1995) 1.80
Characterization of a membrane-associated glycoprotein complex implicated in cell adhesion to fibronectin. J Cell Biochem (1985) 1.79
Effects of transformation on fibronectin gene expression using cloned fibronectin cDNA. J Biol Chem (1981) 1.79
Identification of a tetrapeptide recognition sequence for the alpha 2 beta 1 integrin in collagen. J Biol Chem (1991) 1.79
Transmembrane signal transduction by integrin cytoplasmic domains expressed in single-subunit chimeras. J Biol Chem (1994) 1.79
Cell adhesion and migration in the early vertebrate embryo: location and possible role of the putative fibronectin receptor complex. J Cell Biol (1986) 1.78
Inhibition of binding of fibronectin to matrix assembly sites by anti-integrin (alpha 5 beta 1) antibodies. J Cell Biol (1990) 1.75
Fibronectin and integrins in invasion and metastasis. Cancer Metastasis Rev (1995) 1.75
Cell surface receptors for extracellular matrix components. Biochim Biophys Acta (1990) 1.73
p190-B, a new member of the Rho GAP family, and Rho are induced to cluster after integrin cross-linking. J Biol Chem (1995) 1.70
Electron microscopy and structural model of human fibronectin receptor. EMBO J (1988) 1.69
Differences in domain structures between plasma and cellular fibronectins. J Biol Chem (1981) 1.66
Vinexin: a novel vinculin-binding protein with multiple SH3 domains enhances actin cytoskeletal organization. J Cell Biol (1999) 1.65
Isolation of genomic DNA clones spanning the entire fibronectin gene. Proc Natl Acad Sci U S A (1983) 1.65
Regulation of fibronectin receptor distribution by transformation, exogenous fibronectin, and synthetic peptides. J Cell Biol (1986) 1.62
Mapping of epitopes for monoclonal antibodies against human platelet thrombospondin with electron microscopy and high sensitivity amino acid sequencing. J Cell Biol (1985) 1.62
Biosynthesis and glycosylation of the insulin receptor. Evidence for a single polypeptide precursor of the two major subunits. J Biol Chem (1983) 1.62
Attachment, spreading and locomotion of avian neural crest cells are mediated by multiple adhesion sites on fibronectin molecules. EMBO J (1988) 1.62
Synthetic peptides competitively inhibit both direct binding to fibroblasts and functional biological assays for the purified cell-binding domain of fibronectin. J Biol Chem (1985) 1.60
Identification of a novel integrin binding site in fibronectin. Differential utilization by beta 3 integrins. J Biol Chem (1994) 1.60
Monoclonal antibody characterization of two distant sites required for function of the central cell-binding domain of fibronectin in cell adhesion, cell migration, and matrix assembly. J Cell Biol (1991) 1.59
The synthesis, turnover, and artificial restoration of a major cell surface glycoprotein. Cell (1975) 1.58
The interaction of fibronectin fragments with fibroblastic cells. J Biol Chem (1985) 1.58
The CS5 peptide is a second site in the IIICS region of fibronectin recognized by the integrin alpha 4 beta 1. Inhibition of alpha 4 beta 1 function by RGD peptide homologues. J Biol Chem (1991) 1.54
A two-domain mechanism for group A streptococcal adherence through protein F to the extracellular matrix. EMBO J (1996) 1.54