Published in Nat Rev Mol Cell Biol on November 01, 2001
Cells lying on a bed of microneedles: an approach to isolate mechanical force. Proc Natl Acad Sci U S A (2003) 11.53
Environmental sensing through focal adhesions. Nat Rev Mol Cell Biol (2009) 9.56
A tense situation: forcing tumour progression. Nat Rev Cancer (2009) 7.80
Functional atlas of the integrin adhesome. Nat Cell Biol (2007) 6.89
The relationship between force and focal complex development. J Cell Biol (2002) 6.26
A functional genomic analysis of cell morphology using RNA interference. J Biol (2003) 5.99
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Vinculin controls focal adhesion formation by direct interactions with talin and actin. J Cell Biol (2007) 4.28
Paxillin comes of age. J Cell Sci (2008) 3.57
Cell spreading and focal adhesion dynamics are regulated by spacing of integrin ligands. Biophys J (2007) 3.57
Focal adhesion size controls tension-dependent recruitment of alpha-smooth muscle actin to stress fibers. J Cell Biol (2006) 3.37
Synergistic control of cell adhesion by integrins and syndecans. Nat Rev Mol Cell Biol (2007) 3.21
Calculation of forces at focal adhesions from elastic substrate data: the effect of localized force and the need for regularization. Biophys J (2002) 3.21
Matrix density-induced mechanoregulation of breast cell phenotype, signaling and gene expression through a FAK-ERK linkage. Oncogene (2009) 3.17
Anisotropy of cell adhesive microenvironment governs cell internal organization and orientation of polarity. Proc Natl Acad Sci U S A (2006) 3.15
Single pilus motor forces exceed 100 pN. Proc Natl Acad Sci U S A (2002) 2.93
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Assembly of fibronectin extracellular matrix. Annu Rev Cell Dev Biol (2010) 2.86
FAK deficiency in cells contributing to the basal lamina results in cortical abnormalities resembling congenital muscular dystrophies. Neuron (2003) 2.86
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Integrin beta1-focal adhesion kinase signaling directs the proliferation of metastatic cancer cells disseminated in the lungs. Proc Natl Acad Sci U S A (2009) 2.75
Integrin-mediated adhesion orients the spindle parallel to the substratum in an EB1- and myosin X-dependent manner. EMBO J (2007) 2.73
Targeting and activation of Rac1 are mediated by the exchange factor beta-Pix. J Cell Biol (2006) 2.58
Cell adhesion strengthening: contributions of adhesive area, integrin binding, and focal adhesion assembly. Mol Biol Cell (2005) 2.51
Force-induced unfolding of fibronectin in the extracellular matrix of living cells. PLoS Biol (2007) 2.49
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Nanometer analysis of cell spreading on matrix-coated surfaces reveals two distinct cell states and STEPs. Biophys J (2004) 2.46
Focal adhesions as mechanosensors: a physical mechanism. Proc Natl Acad Sci U S A (2005) 2.43
Cell organization in soft media due to active mechanosensing. Proc Natl Acad Sci U S A (2003) 2.41
Integrin-alpha9 is required for fibronectin matrix assembly during lymphatic valve morphogenesis. Dev Cell (2009) 2.41
Cell fate regulation by coupling mechanical cycles to biochemical signaling pathways. Curr Opin Cell Biol (2009) 2.33
Extracellular matrix in the trabecular meshwork. Exp Eye Res (2008) 2.29
Force probing surfaces of living cells to molecular resolution. Nat Chem Biol (2009) 2.28
Proteomic analysis of integrin-associated complexes identifies RCC2 as a dual regulator of Rac1 and Arf6. Sci Signal (2009) 2.26
Nanoscale cues regulate the structure and function of macroscopic cardiac tissue constructs. Proc Natl Acad Sci U S A (2009) 2.25
Vinculin regulates the recruitment and release of core focal adhesion proteins in a force-dependent manner. Curr Biol (2013) 2.20
Paxillin dynamics measured during adhesion assembly and disassembly by correlation spectroscopy. Biophys J (2007) 2.16
RPTP-alpha acts as a transducer of mechanical force on alphav/beta3-integrin-cytoskeleton linkages. J Cell Biol (2003) 2.15
The fibronectin-binding integrins alpha5beta1 and alphavbeta3 differentially modulate RhoA-GTP loading, organization of cell matrix adhesions, and fibronectin fibrillogenesis. J Cell Biol (2002) 2.14
Fibronectin in tissue regeneration: timely disassembly of the scaffold is necessary to complete the build. Cell Mol Life Sci (2013) 2.14
The switchable integrin adhesome. J Cell Sci (2010) 2.12
Comparative dynamics of retrograde actin flow and focal adhesions: formation of nascent adhesions triggers transition from fast to slow flow. PLoS One (2008) 2.11
Decreased collagen production in chronologically aged skin: roles of age-dependent alteration in fibroblast function and defective mechanical stimulation. Am J Pathol (2006) 2.10
Magnetic microposts as an approach to apply forces to living cells. Proc Natl Acad Sci U S A (2007) 2.10
An inhibitory role for FAK in regulating proliferation: a link between limited adhesion and RhoA-ROCK signaling. J Cell Biol (2006) 2.08
FRET measurements of cell-traction forces and nano-scale clustering of adhesion ligands varied by substrate stiffness. Proc Natl Acad Sci U S A (2005) 2.07
Integrins control motile strategy through a Rho-cofilin pathway. J Cell Biol (2005) 2.04
Force-dependent integrin-cytoskeleton linkage formation requires downregulation of focal complex dynamics by Shp2. EMBO J (2003) 2.03
Stroma-derived three-dimensional matrices are necessary and sufficient to promote desmoplastic differentiation of normal fibroblasts. Am J Pathol (2005) 2.02
Beta1 integrins regulate mammary gland proliferation and maintain the integrity of mammary alveoli. EMBO J (2005) 1.94
Mechanical signaling through the cytoskeleton regulates cell proliferation by coordinated focal adhesion and Rho GTPase signaling. J Cell Sci (2011) 1.90
Structure and functional significance of mechanically unfolded fibronectin type III1 intermediates. Proc Natl Acad Sci U S A (2003) 1.86
Mammary epithelial-specific disruption of focal adhesion kinase retards tumor formation and metastasis in a transgenic mouse model of human breast cancer. Am J Pathol (2008) 1.82
Fibronectin fibrillogenesis regulates three-dimensional neovessel formation. Genes Dev (2008) 1.81
Fibroblasts and myofibroblasts in renal fibrosis. Int J Exp Pathol (2011) 1.76
Impact of order and disorder in RGD nanopatterns on cell adhesion. Nano Lett (2009) 1.75
Matrix elasticity, cytoskeletal forces and physics of the nucleus: how deeply do cells 'feel' outside and in? J Cell Sci (2010) 1.73
Alpha-smooth muscle actin is crucial for focal adhesion maturation in myofibroblasts. Mol Biol Cell (2003) 1.70
The forces behind cell movement. Int J Biol Sci (2007) 1.66
Cytoskeleton-plasma membrane-cell wall continuum in plants. Emerging links revisited. Plant Physiol (2003) 1.65
The actin cytoskeleton in endothelial cell phenotypes. Microvasc Res (2008) 1.65
Dynamic changes in the osteoclast cytoskeleton in response to growth factors and cell attachment are controlled by beta3 integrin. J Cell Biol (2003) 1.65
Direct comparison of the spread area, contractility, and migration of balb/c 3T3 fibroblasts adhered to fibronectin- and RGD-modified substrata. Biophys J (2004) 1.65
Dendritic fibroblasts in three-dimensional collagen matrices. Mol Biol Cell (2003) 1.61
Why integrin as a primary target for imaging and therapy. Theranostics (2011) 1.61
Assaying stem cell mechanobiology on microfabricated elastomeric substrates with geometrically modulated rigidity. Nat Protoc (2011) 1.60
Integrin α5β1 facilitates cancer cell invasion through enhanced contractile forces. J Cell Sci (2011) 1.59
Integrin alpha3beta1-dependent beta-catenin phosphorylation links epithelial Smad signaling to cell contacts. J Cell Biol (2009) 1.58
Impact of local versus global ligand density on cellular adhesion. Nano Lett (2011) 1.58
Cellular responses to substrate topography: role of myosin II and focal adhesion kinase. Biophys J (2006) 1.58
Galectin binding to Mgat5-modified N-glycans regulates fibronectin matrix remodeling in tumor cells. Mol Cell Biol (2006) 1.57
Disease-associated mutant alpha-actinin-4 reveals a mechanism for regulating its F-actin-binding affinity. Proc Natl Acad Sci U S A (2007) 1.53
Concerted regulation of focal adhesion dynamics by galectin-3 and tyrosine-phosphorylated caveolin-1. J Cell Biol (2008) 1.52
A role for the juxtamembrane cytoplasm in the molecular dynamics of focal adhesions. PLoS One (2009) 1.50
Revealing early steps of alpha2beta1 integrin-mediated adhesion to collagen type I by using single-cell force spectroscopy. Mol Biol Cell (2007) 1.49
Tyrosine phosphorylation of type Igamma phosphatidylinositol phosphate kinase by Src regulates an integrin-talin switch. J Cell Biol (2003) 1.49
Caveolin-1-dependent beta1 integrin endocytosis is a critical regulator of fibronectin turnover. J Cell Sci (2008) 1.49
Nanotopography influences adhesion, spreading, and self-renewal of human embryonic stem cells. ACS Nano (2012) 1.47
BRAF(V600E) and microenvironment in thyroid cancer: a functional link to drive cancer progression. Cancer Res (2011) 1.47
Perturbing integrin function inhibits microtubule growth from centrosomes, spindle assembly, and cytokinesis. J Cell Biol (2006) 1.46
Interaction of fascin and protein kinase Calpha: a novel intersection in cell adhesion and motility. EMBO J (2003) 1.45
Interdomain association in fibronectin: insight into cryptic sites and fibrillogenesis. EMBO J (2007) 1.45
The outgrowth of micrometastases is enabled by the formation of filopodium-like protrusions. Cancer Discov (2012) 1.45
The effect of actin disrupting agents on contact guidance of human embryonic stem cells. Biomaterials (2007) 1.45
Coherent angular motion in the establishment of multicellular architecture of glandular tissues. Proc Natl Acad Sci U S A (2012) 1.45
Two characteristic regimes in frequency-dependent dynamic reorientation of fibroblasts on cyclically stretched substrates. Biophys J (2008) 1.44
Limitation of cell adhesion by the elasticity of the extracellular matrix. Biophys J (2006) 1.44
Cellular stress failure in ventilator-injured lungs. Am J Respir Crit Care Med (2005) 1.44
FAK is required for axonal sorting by Schwann cells. J Cell Biol (2007) 1.43
Induction of cell polarization and migration by a gradient of nanoscale variations in adhesive ligand spacing. Nano Lett (2008) 1.43
A specific alpha5beta1-integrin conformation promotes directional integrin translocation and fibronectin matrix formation. J Cell Sci (2004) 1.42
Plasma and cellular fibronectin: distinct and independent functions during tissue repair. Fibrogenesis Tissue Repair (2011) 1.41
Epidermal growth factor receptor-dependent regulation of integrin-mediated signaling and cell cycle entry in epithelial cells. Mol Cell Biol (2004) 1.40
Force-induced adsorption and anisotropic growth of focal adhesions. Biophys J (2006) 1.40
Reversine increases the plasticity of lineage-committed mammalian cells. Proc Natl Acad Sci U S A (2007) 1.39
An integrin-linked machinery of cytoskeletal regulation that enables experimental tumor initiation and metastatic colonization. Cancer Cell (2013) 1.36
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PRL-3 promotes the motility, invasion, and metastasis of LoVo colon cancer cells through PRL-3-integrin beta1-ERK1/2 and-MMP2 signaling. Mol Cancer (2009) 1.35
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