Published in Nature on September 21, 1978
Cells lying on a bed of microneedles: an approach to isolate mechanical force. Proc Natl Acad Sci U S A (2003) 11.53
Fibronectins: multifunctional modular glycoproteins. J Cell Biol (1982) 8.05
Role of collagenous matrices in the adhesion and growth of cells. J Cell Biol (1981) 5.60
Purification of fibronectin from human plasma by affinity chromatography under non-denaturing conditions. Biochem J (1979) 4.46
Receptors for cold-insoluble globulin (plasma fibronectin) on human monocytes. J Exp Med (1981) 3.93
Immunoelectron microscopic studies of the sites of cell-substratum and cell-cell contacts in cultured fibroblasts. J Cell Biol (1982) 3.92
Purification and characterization of the soluble hemagglutinin (cholera lectin)( produced by Vibrio cholerae. Infect Immun (1982) 3.50
A monoclonal antibody detaches embryonic skeletal muscle from extracellular matrices. J Cell Biol (1982) 3.23
Human fibronectin: cell specific alternative mRNA splicing generates polypeptide chains differing in the number of internal repeats. Nucleic Acids Res (1984) 3.12
Isolation of a cell surface receptor protein for laminin from murine fibrosarcoma cells. J Cell Biol (1983) 3.02
Matrix control of protein diffusion in biological membranes. Proc Natl Acad Sci U S A (1981) 2.96
Treponema pallidum receptor binding proteins interact with fibronectin. J Exp Med (1983) 2.90
Vibrio cholerae hemagglutinin/lectin/protease hydrolyzes fibronectin and ovomucin: F.M. Burnet revisited. Proc Natl Acad Sci U S A (1983) 2.90
Fibroblast cellular and plasma fibronectins are similar but not identical. J Cell Biol (1979) 2.70
Fibroblast receptor for cell-substratum adhesion: studies on the interaction of baby hamster kidney cells with latex beads coated by cold insoluble globulin (plasma fibronectin). J Cell Biol (1980) 2.59
Modeling dynamic reciprocity: engineering three-dimensional culture models of breast architecture, function, and neoplastic transformation. Semin Cancer Biol (2005) 2.53
Neutrophil-mediated endothelial injury in vitro mechanisms of cell detachment. J Clin Invest (1981) 2.50
Membrane insertion at the leading edge of motile fibroblasts. Proc Natl Acad Sci U S A (1983) 2.45
Cell surface heparan sulfate mediates some adhesive responses to glycosaminoglycan-binding matrices, including fibronectin. J Cell Biol (1983) 2.35
Production of fibronectin by the human alveolar macrophage: mechanism for the recruitment of fibroblasts to sites of tissue injury in interstitial lung diseases. Proc Natl Acad Sci U S A (1981) 2.34
Fibronectin mediates Treponema pallidum cytadherence through recognition of fibronectin cell-binding domain. J Exp Med (1985) 2.32
Induction of fibroblast chemotaxis by fibronectin. Localization of the chemotactic region to a 140,000-molecular weight non-gelatin-binding fragment. J Exp Med (1981) 2.10
Laminin, fibronectin, and collagen in synaptic and extrasynaptic portions of muscle fiber basement membrane. J Cell Biol (1982) 2.10
Membrane glycoproteins involved in cell--substratum adhesion. Proc Natl Acad Sci U S A (1981) 2.08
Lymphocyte locomotion and attachment on two-dimensional surfaces and in three-dimensional matrices. J Cell Biol (1982) 2.07
Presence of the organ-specific 'microsomal' autoantigen on the surface of human thyroid cells in culture: its involvement in complement-mediated cytotoxicity. Clin Exp Immunol (1981) 2.04
Isolation of a fibronectin-binding protein from Staphylococcus aureus. Infect Immun (1982) 2.02
Binding of human fibronectin to group A, C, and G streptococci. Infect Immun (1983) 2.01
Monovalent ionophores inhibit secretion of procollagen and fibronectin from cultured human fibroblasts. Proc Natl Acad Sci U S A (1979) 1.99
In vivo co-distribution of fibronectin and actin fibers in granulation tissue: immunofluorescence and electron microscope studies of the fibronexus at the myofibroblast surface. J Cell Biol (1984) 1.99
Cell surface molecules and fibronectin-mediated cell adhesion: effect of proteolytic digestion of membrane proteins. J Cell Biol (1982) 1.90
Connective tissue biomatrix: its isolation and utilization for long-term cultures of normal rat hepatocytes. J Cell Biol (1980) 1.84
Fibronectin localization in the rat glomerulus. J Cell Biol (1980) 1.80
Concomitant loss of cell surface fibronectin and laminin from transformed rat kidney cells. J Cell Biol (1981) 1.78
Fibronectin molecule visualized in electron microscopy: a long, thin, flexible strand. J Cell Biol (1981) 1.77
Fibronectin-mediated uptake of gelatin-coated latex particles by peritoneal macrophages. J Cell Biol (1980) 1.77
Fibronectin is not present in the focal adhesions formed between normal cultured fibroblasts and their substrata. Proc Natl Acad Sci U S A (1980) 1.76
Cell attachment on replicas of SDS polyacrylamide gels reveals two adhesive plasma proteins. J Cell Biol (1982) 1.75
Fibronectin has a dual role in locomotion and anchorage of primary chick fibroblasts and can promote entry into the division cycle. J Cell Biol (1982) 1.74
Expression of transformation-associated protease(s) that degrade fibronectin at cell contact sites. J Cell Biol (1984) 1.71
Partial characterization of newly synthesized proteoglycans isolated from the glomerular basement membrane. J Cell Biol (1981) 1.66
Cellular tumorigenicity in nude mice. Test of associations among loss of cell-surface fibronectin, anchorage independence, and tumor-forming ability. J Cell Biol (1979) 1.63
Metalloproteinases from rabbit bone culture medium degrade types IV and V collagens, laminin and fibronectin. Biochem J (1981) 1.62
Cross-linking of fibronectin to collagen by blood coagulation Factor XIIIa. J Clin Invest (1979) 1.62
Functional domain structure of fibronectin. Proc Natl Acad Sci U S A (1980) 1.59
Biological properties of "partial" transformation mutants of Rous sarcoma virus and characterization of their pp60src kinase. J Virol (1981) 1.58
Fibronectin and C4-binding protein are selectively bound by aggregated amyloid P component. J Exp Med (1981) 1.53
Isolation and characterization of a collagen-binding glycoprotein from chondrocyte membranes. EMBO J (1983) 1.53
Studies on cell adhesion and recognition. I. Extent and specificity of cell adhesion triggered by carbohydrate-reactive proteins (glycosidases and lectins) and by fibronectin. J Cell Biol (1981) 1.52
Attachment of Treponema pallidum to fibronectin, laminin, collagen IV, and collagen I, and blockage of attachment by immune rabbit IgG. Br J Vener Dis (1984) 1.51
Production of laminin and fibronectin by Schwannoma cells: cell-protein interactions in vitro and protein localization in peripheral nerve in vivo. J Cell Biol (1983) 1.44
Processing and lysosomal localization of a glycoprotein whose secretion is transformation stimulated. J Cell Biol (1985) 1.41
Manipulation of cell-cell and cell-substratum interactions in mouse mammary tumor epithelial cells using broad spectrum antisera. J Cell Biol (1981) 1.41
The distribution of fibronectin in the pannus in rheumatoid arthritis. Br J Exp Pathol (1981) 1.41
Role of salivary protease activity in adherence of gram-negative bacilli to mammalian buccal epithelial cells in vivo. J Clin Invest (1981) 1.40
Biosynthesis and maturation of lactase-phlorizin hydrolase in the human small intestinal epithelial cells. Biochem J (1987) 1.39
Identification and quantitation of platelet-associated fibronectin antigen. J Clin Invest (1979) 1.38
Significance of fibronectin in rheumatoid arthritis and osteoarthrosis. Ann Rheum Dis (1981) 1.35
Localization of fibronectin within the renal glomerulus and its production by cultured glomerular cells. Am J Pathol (1979) 1.35
Characterization of human serum spreading factor with monoclonal antibody. Proc Natl Acad Sci U S A (1983) 1.33
Identification and isolation of a collagen-binding fragment of the adhesive glycoprotein fibronectin. Proc Natl Acad Sci U S A (1979) 1.32
Fibronectin in human bronchopulmonary lavage fluid. Elevation in patients with interstitial lung disease. J Clin Invest (1982) 1.31
Phagocytosis of gelatin-latex particles by a murine macrophage line is dependent on fibronectin and heparin. J Cell Biol (1981) 1.30
Fibronectin binds to the C1q component of complement. Proc Natl Acad Sci U S A (1982) 1.30
Fibronectin promotes rat Schwann cell growth and motility. J Cell Biol (1982) 1.29
Direct association of fibronectin and actin molecules in vitro. J Cell Biol (1980) 1.28
Heparin enhances the rate of binding of fibronectin to collagen. Biochem J (1980) 1.27
Interaction of Legionella micdadei with human monocytes. Infect Immun (1984) 1.26
The nature of the microfibrillar glycoproteins of elastic fibres. A biosynthetic study. Biochem J (1981) 1.25
Decrease of tyrosine-O-sulfate-containing proteins found in rat fibroblasts infected with Rous sarcoma virus or Fujinami sarcoma virus. Proc Natl Acad Sci U S A (1984) 1.25
Studies on cell adhesion and recognition. II. The kinetics of cell adhesion and cell spreading on surfaces coated with carbohydrate-reactive proteins (glycosidases and lectins) and fibronectin. J Cell Biol (1981) 1.22
Appearance of fibronectin during the differentiation of cartilage, bone, and bone marrow. J Cell Biol (1981) 1.22
Adhesion of cells to polystyrene surfaces. J Cell Biol (1983) 1.21
Identification of an adhesion factor for chondrocytes. Proc Natl Acad Sci U S A (1980) 1.21
Interactions of fibronectin with Treponema pallidum. Genitourin Med (1985) 1.19
Human glomerular visceral epithelial cells synthesize a basal lamina collagen in vitro. Proc Natl Acad Sci U S A (1979) 1.19
Fibronectin promotes epithelial migration of cultured rabbit cornea in situ. J Cell Biol (1983) 1.18
Vascular endothelial cells maintained in the absence of fibroblast growth factor undergo structural and functional alterations that are incompatible with their in vivo differentiated properties. J Cell Biol (1979) 1.16
Role of carbohydrate in biological function of the adhesive glycoprotein fibronectin. Proc Natl Acad Sci U S A (1979) 1.15
Some determinants of the locomotory behaviour of phagocytes and lymphocytes in vitro. Clin Exp Immunol (1982) 1.13
Distribution of fibronectin in normal and diseased human kidneys. J Clin Pathol (1980) 1.12
Distribution of a major connective tissue protein, fibronectin, in normal and neoplastic human nervous tissue. Acta Neuropathol (1980) 1.11
Incorporation of l-[3H]fucose and d-[3H]glucosamine into cell-surface-associated glycoconjugates in epidermis of cultured pig skin slices. Biochem J (1980) 1.08
Immunolocalization of entactin, a sulfated basement membrane component, in rodent tissues, and comparison with GP-2 (laminin). Am J Pathol (1981) 1.06
Immunochemical characterization of human plasma fibronectin. Biochem J (1980) 1.06
Synthesis and localization of fibronectin during collagenous matrix-mesenchymal cell interaction and differentiation of cartilage and bone in vivo. Proc Natl Acad Sci U S A (1980) 1.06
Point mutations within the betaG-betaH loop of foot-and-mouth disease virus O1K affect virus attachment to target cells. J Virol (1997) 1.06
A unique cell-surface protein phenotype distinguishes human small-cell from non-small-cell lung cancer. Proc Natl Acad Sci U S A (1982) 1.05
Fibronectin and immune complexes in rheumatic diseases. Ann Rheum Dis (1987) 1.03
Extracellular matrix formation by chondrocytes in monolayer culture. J Cell Biol (1981) 1.03
A collagen-binding protein on the surface of ejaculated rabbit spermatozoa. J Cell Biol (1980) 1.03
Growth and differentiation of embryonal carcinoma cell line F9 in defined media. Proc Natl Acad Sci U S A (1980) 1.02
Subtilisin and cyanogen bromide cleavage products of fibronectin that retain gelatin-binding activity. Proc Natl Acad Sci U S A (1979) 1.02
Antigenic differences between alveolar and peritoneal macrophages of the rat. Lack of population-specific determinants. Immunology (1979) 1.01
Adhesion of human platelets to immobilized trimeric collagen. J Cell Biol (1982) 1.00
Appearance in confluent vascular endothelial cell monolayers of a specific cell surface protein (CSP-60) not detected in actively growing endothelial cells or in cell types growing in multiple layers. Proc Natl Acad Sci U S A (1979) 0.99
Altered cell spreading in cytochalasin B: a possible role for intermediate filaments. Mol Cell Biol (1983) 0.99
Use of immobilized lactoperoxidase to label L cell proteins involved in adhesion to polystyrene. J Cell Biol (1980) 0.98
Inhibition of fusion of embryonic muscle cells in culture by tunicamycin is prevented by leupeptin. J Cell Biol (1981) 0.97
Taking cell-matrix adhesions to the third dimension. Science (2001) 15.21
Transmembrane crosstalk between the extracellular matrix--cytoskeleton crosstalk. Nat Rev Mol Cell Biol (2001) 10.74
Fibronectins: multifunctional modular glycoproteins. J Cell Biol (1982) 8.05
Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems. Proc Natl Acad Sci U S A (1999) 7.88
Cell surface interactions with extracellular materials. Annu Rev Biochem (1983) 6.76
Integrin function: molecular hierarchies of cytoskeletal and signaling molecules. J Cell Biol (1995) 6.74
Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN. Science (1998) 6.62
Synergistic roles for receptor occupancy and aggregation in integrin transmembrane function. Science (1995) 6.45
Ultrastructure and function of growth cones and axons of cultured nerve cells. J Cell Biol (1971) 5.90
Microfilaments and cell locomotion. J Cell Biol (1971) 4.89
Molecular diversity of cell-matrix adhesions. J Cell Sci (1999) 4.33
Axon growth: roles of microfilaments and microtubules. Proc Natl Acad Sci U S A (1970) 4.33
Cell surface protein partially restores morphology, adhesiveness, and contact inhibition of movement to transformed fibroblasts. Proc Natl Acad Sci U S A (1976) 4.32
Integrins can collaborate with growth factors for phosphorylation of receptor tyrosine kinases and MAP kinase activation: roles of integrin aggregation and occupancy of receptors. J Cell Biol (1996) 4.21
Dynamics and segregation of cell-matrix adhesions in cultured fibroblasts. Nat Cell Biol (2000) 3.99
Levels of translatable mRNAs for cell surface protein, collagen precursors, and two membrane proteins are altered in Rous sarcoma virus-transformed chick embryo fibroblasts. Proc Natl Acad Sci U S A (1977) 3.80
Analysis of fibronectin receptor function with monoclonal antibodies: roles in cell adhesion, migration, matrix assembly, and cytoskeletal organization. J Cell Biol (1989) 3.77
Development of cell surface linkage complexes in cultured fibroblasts. J Cell Biol (1985) 3.59
The zinc-finger protein slug causes desmosome dissociation, an initial and necessary step for growth factor-induced epithelial-mesenchymal transition. J Cell Biol (1997) 3.52
Isolation of a major cell surface glycoprotein from fibroblasts. Proc Natl Acad Sci U S A (1974) 3.30
Dualistic nature of adhesive protein function: fibronectin and its biologically active peptide fragments can autoinhibit fibronectin function. J Cell Biol (1984) 3.18
Integrin dynamics and matrix assembly: tensin-dependent translocation of alpha(5)beta(1) integrins promotes early fibronectin fibrillogenesis. J Cell Biol (2000) 3.13
Role of carbohydrates in protein secretion and turnover: effects of tunicamycin on the major cell surface glycoprotein of chick embryo fibroblasts. Cell (1978) 3.12
The major cell surface glycoprotein of chick embryo fibroblasts is an agglutinin. Proc Natl Acad Sci U S A (1975) 3.06
The short amino acid sequence Pro-His-Ser-Arg-Asn in human fibronectin enhances cell-adhesive function. J Biol Chem (1994) 3.06
Microfilament bundles and cell shape are related to adhesiveness to substratum and are dissociable from growth control in cultured fibroblasts. Cell (1977) 2.99
A synthetic peptide from fibronectin inhibits experimental metastasis of murine melanoma cells. Science (1986) 2.91
Fibroblast cellular and plasma fibronectins are similar but not identical. J Cell Biol (1979) 2.70
Site-directed mutagenesis of the cell-binding domain of human fibronectin: separable, synergistic sites mediate adhesive function. Cell (1988) 2.70
Activation of CD4 cells by fibronectin and anti-CD3 antibody. A synergistic effect mediated by the VLA-5 fibronectin receptor complex. J Exp Med (1989) 2.69
Identification of an alternatively spliced site in human plasma fibronectin that mediates cell type-specific adhesion. J Cell Biol (1986) 2.63
Characterization of a 140-kD avian cell surface antigen as a fibronectin-binding molecule. J Cell Biol (1986) 2.62
Physical state of the extracellular matrix regulates the structure and molecular composition of cell-matrix adhesions. Mol Biol Cell (2000) 2.58
Identification of two distinct regions of the type III connecting segment of human plasma fibronectin that promote cell type-specific adhesion. J Biol Chem (1987) 2.52
Regulation of fibronectin receptor distribution. J Cell Biol (1992) 2.46
The interaction of plasma fibronectin with fibroblastic cells in suspension. J Biol Chem (1985) 2.44
Mechanism of the decrease in the major cell surface protein of chick embryo fibroblasts after transformation. Cell (1977) 2.42
Cyclic vomiting syndrome in adults. Neurogastroenterol Motil (2008) 2.40
Novel function for beta 1 integrins in keratinocyte cell-cell interactions. J Cell Biol (1990) 2.39
Fibronectin receptor exhibits high lateral mobility in embryonic locomoting cells but is immobile in focal contacts and fibrillar streaks in stationary cells. J Cell Biol (1988) 2.38
Single subunit chimeric integrins as mimics and inhibitors of endogenous integrin functions in receptor localization, cell spreading and migration, and matrix assembly. J Cell Biol (1994) 2.27
Carbohydrate moieties of glycoproteins. A re-evaluation of their function. Biochim Biophys Acta (1982) 2.27
Characterization of fibronectin interactions with glycosaminoglycans and identification of active proteolytic fragments. J Biol Chem (1980) 2.24
Transforming growth factor beta stimulates the expression of fibronectin and of both subunits of the human fibronectin receptor by cultured human lung fibroblasts. J Biol Chem (1988) 2.23
Shc and FAK differentially regulate cell motility and directionality modulated by PTEN. J Cell Biol (1999) 2.21
Insulin-induced receptor loss in cultured human lymphocytes is due to accelerated receptor degradation. Proc Natl Acad Sci U S A (1981) 2.18
Tumor suppressor PTEN inhibition of cell invasion, migration, and growth: differential involvement of focal adhesion kinase and p130Cas. Cancer Res (1999) 2.17
Fibronectin, integrins, and growth control. J Cell Physiol (2001) 2.14
Domain structure of the carboxyl-terminal half of human plasma fibronectin. J Biol Chem (1983) 2.09
The minimal essential sequence for a major cell type-specific adhesion site (CS1) within the alternatively spliced type III connecting segment domain of fibronectin is leucine-aspartic acid-valine. J Biol Chem (1991) 2.08
Affinity chromatographic isolation of the melanoma adhesion receptor for the IIICS region of fibronectin and its identification as the integrin alpha 4 beta 1. J Biol Chem (1990) 2.08
PTEN interactions with focal adhesion kinase and suppression of the extracellular matrix-dependent phosphatidylinositol 3-kinase/Akt cell survival pathway. J Biol Chem (1999) 2.07
Immunological characterization of a major transformation-sensitive fibroblast cell surface glycoprotein. Localization, redistribution, and role in cell shape. J Cell Biol (1978) 2.05
Full-length sequence, localization, and chromosomal mapping of ameloblastin. A novel tooth-specific gene. J Biol Chem (1996) 2.00
Direct detection of antigens in sodium dodecyl sulfate-polyacrylamide gels. Anal Biochem (1977) 1.98
Health-related quality of life among persons with irritable bowel syndrome: a systematic review. Aliment Pharmacol Ther (2002) 1.97
VLA-4 mediates CD3-dependent CD4+ T cell activation via the CS1 alternatively spliced domain of fibronectin. J Exp Med (1990) 1.95
Evidence for role of glycoprotein carbohydrates in membrane transport: specific inhibition by tunicamycin. Proc Natl Acad Sci U S A (1979) 1.94
Characterization of a major fibroblast cell surface glycoprotein. Biochemistry (1977) 1.92
Requirement for the synergy site for cell adhesion to fibronectin depends on the activation state of integrin alpha 5 beta 1. J Biol Chem (1995) 1.91
"Environmental justice": the central role of research in establishing a credible scientific foundation for informed decision making. Toxicol Ind Health (1994) 1.85
Tumor suppressor PTEN inhibits integrin- and growth factor-mediated mitogen-activated protein (MAP) kinase signaling pathways. J Cell Biol (1998) 1.85
Neural crest cell migration: requirements for exogenous fibronectin and high cell density. J Cell Biol (1983) 1.84
Isolation and biological characterization of active fragments of the adhesive glycoprotein fibronectin. Cell (1979) 1.83
Characterization of a membrane-associated glycoprotein complex implicated in cell adhesion to fibronectin. J Cell Biochem (1985) 1.79
Effects of transformation on fibronectin gene expression using cloned fibronectin cDNA. J Biol Chem (1981) 1.79
Transmembrane signal transduction by integrin cytoplasmic domains expressed in single-subunit chimeras. J Biol Chem (1994) 1.79
Cell adhesion and migration in the early vertebrate embryo: location and possible role of the putative fibronectin receptor complex. J Cell Biol (1986) 1.78
Inhibition of binding of fibronectin to matrix assembly sites by anti-integrin (alpha 5 beta 1) antibodies. J Cell Biol (1990) 1.75
Fibronectin and integrins in invasion and metastasis. Cancer Metastasis Rev (1995) 1.75
Cell surface receptors for extracellular matrix components. Biochim Biophys Acta (1990) 1.73
Expression of transformation-associated protease(s) that degrade fibronectin at cell contact sites. J Cell Biol (1984) 1.71
p190-B, a new member of the Rho GAP family, and Rho are induced to cluster after integrin cross-linking. J Biol Chem (1995) 1.70
Electron microscopy and structural model of human fibronectin receptor. EMBO J (1988) 1.69
Differences in domain structures between plasma and cellular fibronectins. J Biol Chem (1981) 1.66
Vinexin: a novel vinculin-binding protein with multiple SH3 domains enhances actin cytoskeletal organization. J Cell Biol (1999) 1.65
Isolation of genomic DNA clones spanning the entire fibronectin gene. Proc Natl Acad Sci U S A (1983) 1.65
Regulation of fibronectin receptor distribution by transformation, exogenous fibronectin, and synthetic peptides. J Cell Biol (1986) 1.62
Biosynthesis and glycosylation of the insulin receptor. Evidence for a single polypeptide precursor of the two major subunits. J Biol Chem (1983) 1.62
Attachment, spreading and locomotion of avian neural crest cells are mediated by multiple adhesion sites on fibronectin molecules. EMBO J (1988) 1.62
Synthetic peptides competitively inhibit both direct binding to fibroblasts and functional biological assays for the purified cell-binding domain of fibronectin. J Biol Chem (1985) 1.60
Identification of a novel integrin binding site in fibronectin. Differential utilization by beta 3 integrins. J Biol Chem (1994) 1.60
Monoclonal antibody characterization of two distant sites required for function of the central cell-binding domain of fibronectin in cell adhesion, cell migration, and matrix assembly. J Cell Biol (1991) 1.59
The synthesis, turnover, and artificial restoration of a major cell surface glycoprotein. Cell (1975) 1.58
The interaction of fibronectin fragments with fibroblastic cells. J Biol Chem (1985) 1.58
The CS5 peptide is a second site in the IIICS region of fibronectin recognized by the integrin alpha 4 beta 1. Inhibition of alpha 4 beta 1 function by RGD peptide homologues. J Biol Chem (1991) 1.54
Heterogeneity of membrane vesicles from Escherichia coli and their subfractionation with antibody to ATPase. Proc Natl Acad Sci U S A (1974) 1.54