Published in Science on September 03, 1982
ATP-binding site of adenylate kinase: mechanistic implications of its homology with ras-encoded p21, F1-ATPase, and other nucleotide-binding proteins. Proc Natl Acad Sci U S A (1986) 5.55
GTP-binding domain: three consensus sequence elements with distinct spacing. Proc Natl Acad Sci U S A (1987) 5.16
Nucleotide sequence of Abelson murine leukemia virus genome: structural similarity of its transforming gene product to other onc gene products with tyrosine-specific kinase activity. Proc Natl Acad Sci U S A (1983) 4.32
A novel GTP-binding protein, Sar1p, is involved in transport from the endoplasmic reticulum to the Golgi apparatus. J Cell Biol (1989) 4.29
Harvey murine sarcoma virus p21 ras protein: biological and biochemical significance of the cysteine nearest the carboxy terminus. EMBO J (1984) 4.28
Surface presentation of Shigella flexneri invasion plasmid antigens requires the products of the spa locus. J Bacteriol (1992) 3.91
Analysis of the transforming potential of the human H-ras gene by random mutagenesis. Proc Natl Acad Sci U S A (1984) 3.64
Oncogenic H-ras stimulates tumor angiogenesis by two distinct pathways. Proc Natl Acad Sci U S A (1997) 2.88
Mutational analysis of a ras catalytic domain. Mol Cell Biol (1986) 2.76
Nucleotide sequence to the v-myc oncogene of avian retrovirus MC29. Proc Natl Acad Sci U S A (1983) 2.66
Ha-ras proteins exhibit GTPase activity: point mutations that activate Ha-ras gene products result in decreased GTPase activity. Proc Natl Acad Sci U S A (1985) 2.58
Flat revertants isolated from Kirsten sarcoma virus-transformed cells are resistant to the action of specific oncogenes. Proc Natl Acad Sci U S A (1983) 2.44
Involvement of ras in sexual differentiation but not in growth control in fission yeast. EMBO J (1986) 2.31
The ras-related ypt protein is an ubiquitous eukaryotic protein: isolation and sequence analysis of mouse cDNA clones highly homologous to the yeast YPT1 gene. EMBO J (1987) 2.14
Transforming genes of human hematopoietic tumors: frequent detection of ras-related oncogenes whose activation appears to be independent of tumor phenotype. Proc Natl Acad Sci U S A (1983) 2.04
Posttranslational processing of p21 ras proteins involves palmitylation of the C-terminal tetrapeptide containing cysteine-186. J Virol (1985) 2.03
Direct identification of palmitic acid as the lipid attached to p21ras. Mol Cell Biol (1986) 2.02
Identification of a novel human Rho protein with unusual properties: GTPase deficiency and in vivo farnesylation. Mol Cell Biol (1996) 1.98
Expression of normal and transforming H-ras genes in Escherichia coli and purification of their encoded p21 proteins. Proc Natl Acad Sci U S A (1984) 1.94
Homologies in the primary structure of GTP-binding proteins: the nucleotide-binding site of EF-Tu and p21. EMBO J (1984) 1.88
Brain-specific genes have identifier sequences in their introns. Proc Natl Acad Sci U S A (1984) 1.71
Mutations of the ras gene product p21 that abolish guanine nucleotide binding. Proc Natl Acad Sci U S A (1986) 1.71
Glucocorticoid regulation of transcription at an amplified, episomal promoter. Mol Cell Biol (1983) 1.66
Mechanism of activation of an N-ras gene in the human fibrosarcoma cell line HT1080. EMBO J (1984) 1.56
Photoaffinity labeling with GTP of viral p21 ras protein expressed in Escherichia coli. J Virol (1984) 1.54
Efficient generation of antibodies to oncoproteins by using synthetic peptide antigens. Proc Natl Acad Sci U S A (1985) 1.51
Antibody to phosphatidylinositol 4,5-bisphosphate inhibits oncogene-induced mitogenesis. Proc Natl Acad Sci U S A (1988) 1.48
Activating mutations of the c-Ha-ras protooncogene in chemically induced hepatomas of the male B6C3 F1 mouse. Proc Natl Acad Sci U S A (1986) 1.47
Biochemical properties of a highly purified v-rasH p21 protein overproduced in Escherichia coli and inhibition of its activities by a monoclonal antibody. Mol Cell Biol (1985) 1.42
Synergism of v-myc and v-Ha-ras in the in vitro neoplastic progression of murine lymphoid cells. Mol Cell Biol (1986) 1.42
Regional chromosomal localization of N-ras, K-ras-1, K-ras-2 and myb oncogenes in human cells. Nucleic Acids Res (1983) 1.41
Modulation of enhancer activity by the hormone responsive regulatory element from mouse mammary tumor virus. EMBO J (1984) 1.40
Prediction of the three-dimensional structure of the transforming region of the EJ/T24 human bladder oncogene product and its normal cellular homologue. Proc Natl Acad Sci U S A (1983) 1.37
Mouse cells contain two distinct ras gene mRNA species that can be translated into a p21 onc protein. Mol Cell Biol (1982) 1.34
X-ray crystal structures of transforming p21 ras mutants suggest a transition-state stabilization mechanism for GTP hydrolysis. Proc Natl Acad Sci U S A (1992) 1.34
Harvey ras induction of metastatic potential depends upon oncogene activation and the type of recipient cell. Am J Pathol (1985) 1.28
Anti-peptide antibodies detect oncogene-related proteins in urine. Proc Natl Acad Sci U S A (1985) 1.18
GGAPs, a new family of bifunctional GTP-binding and GTPase-activating proteins. Mol Cell Biol (2003) 1.18
Transforming p21 ras protein: flexibility in the major variable region linking the catalytic and membrane-anchoring domains. EMBO J (1985) 1.16
Regulated expression of ras gene constructs in Dictyostelium transformants. Proc Natl Acad Sci U S A (1985) 1.16
Nucleotide sequence of the two rat cellular rasH genes. Mol Cell Biol (1986) 1.15
Nucleotide sequence analysis of the BALB/c murine sarcoma virus transforming gene. J Virol (1985) 1.11
Transcription of two classes of rat growth hormone gene-associated repetitive DNA: differences in activity and effects of tandem repeat structure. Nucleic Acids Res (1984) 1.11
Activated v-myc and v-ras oncogenes do not transform normal human lymphocytes. Mol Cell Biol (1986) 1.07
The Parodi-Irgens feline sarcoma virus and simian sarcoma virus have homologous oncogenes, but in different contexts of the viral genomes. J Virol (1983) 1.05
Analysis of viral and somatic activations of the cHa-ras gene. J Virol (1985) 1.04
A new member of the ras gene superfamily identified in a rat liver cell line. Nucleic Acids Res (1988) 1.01
Rapid and selective alterations in the expression of cellular genes accompany conditional transcription of Ha-v-ras in NIH 3T3 cells. Mol Cell Biol (1987) 1.00
Characterization of functional domains of p21 ras by use of chimeric genes. EMBO J (1985) 0.99
Isolation of an integrated provirus of Moloney murine leukemia virus with long terminal repeats in inverted orientation: integration utilizing two U3 sequences. J Virol (1988) 0.99
Nucleotide sequence of v-fps in the PRCII strain of avian sarcoma virus. J Virol (1984) 0.97
The human c-Ha-ras2 is a processed pseudogene inactivated by numerous base substitutions. Nucleic Acids Res (1984) 0.96
Activation of Ha-ras p21 by substitution, deletion, and insertion mutations. Mol Cell Biol (1985) 0.95
Harvey sarcoma virus genome contains no extensive sequences unrelated to those of other retroviruses except ras. J Virol (1988) 0.94
Myeloid cell transformation by ras-containing murine sarcoma viruses. Mol Cell Biol (1985) 0.93
Nucleotide sequence and characterization of the 5' flanking region of the rat Ha-ras protooncogene. Proc Natl Acad Sci U S A (1987) 0.93
Regulated expression of repetitive sequences including the identifier sequence during myotube formation in culture. EMBO J (1986) 0.91
Development and analysis of a transformation-defective mutant of Harvey murine sarcoma tk virus and its gene product. J Virol (1985) 0.90
An altered DNA sequence encompassing the ras gene of Harvey murine sarcoma virus. Nucleic Acids Res (1984) 0.89
Recombinant BALB and Harvey sarcoma viruses with normal proto-ras-coding regions transform embryo cells in culture and cause tumors in mice. J Virol (1989) 0.88
Tumor suppression involves down-regulation of interleukin 3 expression in hybrids between autocrine mastocytoma and interleukin 3-dependent parental mast cells. Proc Natl Acad Sci U S A (1989) 0.86
Stable accumulation of a rat truncated repeat transcript in Xenopus oocytes. Proc Natl Acad Sci U S A (1986) 0.85
Oncogenes and the molecular biology of cancer. J Cell Biol (1983) 0.83
Mutational mechanisms by which an inactive replication origin of bacteriophage M13 is turned on are similar to mechanisms of activation of ras proto-oncogenes. J Virol (1985) 0.83
Genetic analysis of the rat leukemia virus: influence of viral sequences in transduction of the c-ras proto-oncogene and expression of its transforming activity. J Virol (1998) 0.81
Analysis of ras genes and linked viral sequences in rat hepatocarcinogenesis. Am J Pathol (1987) 0.80
Kirsten Ras* oncogene: significance of its discovery in human cancer research. Oncotarget (2016) 0.80
Temporal sequence and cellular origin of interleukin-2 stimulated cytokine gene expression. Br J Cancer (1993) 0.79
Oncogenicity of human N-ras oncogene and proto-oncogene introduced into retroviral vectors. J Virol (1989) 0.78
Crystallization and preliminary X-ray analysis of RabX3, a tandem GTPase from Entamoeba histolytica. Acta Crystallogr F Struct Biol Commun (2014) 0.78
An appraisal of the application of recombinant DNA techniques to chromosome defects. Biochem J (1985) 0.77
Further genetic localization of the transforming sequences of the p21 v-ras gene of Harvey murine sarcoma virus. J Virol (1984) 0.77
Development of transforming function during transduction of proto-ras into Harvey sarcoma virus. Proc Natl Acad Sci U S A (1994) 0.76
The genome of simian virus 40. Science (1978) 24.46
Bayesian coalescent inference of past population dynamics from molecular sequences. Mol Biol Evol (2005) 18.57
Simian virus 40 tandem repeated sequences as an element of the early promoter. Proc Natl Acad Sci U S A (1981) 13.67
Mechanism of activation of a human oncogene. Nature (1982) 12.09
The p21 src genes of Harvey and Kirsten sarcoma viruses originate from divergent members of a family of normal vertebrate genes. Nature (1981) 8.44
In vitro synthesis of DNA complementary to purified rabbit globin mRNA (RNA-dependent DNA polymerase-reticulocyte-hemoglobin-density gradient centrifugation-oligo(dT) primer). Proc Natl Acad Sci U S A (1972) 7.89
Nucleotide sequences of integrated Moloney sarcoma provirus long terminal repeats and their host and viral junctions. Proc Natl Acad Sci U S A (1980) 7.77
Regulation of glutamine synthetase. I. Purification and properties of glutamine synthetase from Escherichia coli. Arch Biochem Biophys (1966) 7.31
Characterization of highly immunogenic p66/p51 as the reverse transcriptase of HTLV-III/LAV. Science (1986) 6.53
Characterization of gp41 as the transmembrane protein coded by the HTLV-III/LAV envelope gene. Science (1985) 6.48
The genome of human papovavirus BKV. Cell (1979) 6.36
Standardized and simplified nomenclature for proteins common to all retroviruses. J Virol (1988) 6.31
Growth of factor-dependent hemopoietic precursor cell lines. J Exp Med (1980) 5.80
Prospect for prevention of human immunodeficiency virus infection: purified 120-kDa envelope glycoprotein induces neutralizing antibody. Proc Natl Acad Sci U S A (1986) 5.55
Analysis of two divergent rat genomic clones homologous to the transforming gene of Harvey murine sarcoma virus. Proc Natl Acad Sci U S A (1981) 5.51
Characterization of envelope and core structural gene products of HTLV-III with sera from AIDS patients. Science (1985) 5.42
Murine leukemia virus protease is encoded by the gag-pol gene and is synthesized through suppression of an amber termination codon. Proc Natl Acad Sci U S A (1985) 5.36
ras-Related gene sequences identified and isolated from Saccharomyces cerevisiae. Nature (1984) 5.32
Increasing mortality due to end-stage liver disease in patients with human immunodeficiency virus infection. Clin Infect Dis (2001) 5.27
Myristyl amino-terminal acylation of murine retrovirus proteins: an unusual post-translational proteins modification. Proc Natl Acad Sci U S A (1983) 5.12
BKV splice sequences based on analysis of preferred donor and acceptor sites. Nucleic Acids Res (1979) 4.86
Murine leukemia virus maturation: protease region required for conversion from "immature" to "mature" core form and for virus infectivity. Virology (1985) 4.65
Novel mechanism for RNA maturation: the leader sequences of simian virus 40 mRNA are not transcribed adjacent to the coding sequences. Proc Natl Acad Sci U S A (1977) 4.64
Dual evolutionary origin for the rat genetic sequences of Harvey murine sarcoma virus. J Virol (1980) 4.63
Free DNA in the serum of cancer patients and the effect of therapy. Cancer Res (1977) 4.59
Guanine nucleotide-binding and autophosphorylating activities associated with the p21src protein of Harvey murine sarcoma virus. Nature (1980) 4.43
Localization of the src gene product of the Harvey strain of MSV to plasma membrane of transformed cells by electron microscopic immunocytochemistry. Cell (1980) 4.35
Human immunodeficiency viruses. Science (1986) 4.34
Guanine nucleotide-binding activity as an assay for src protein of rat-derived murine sarcoma viruses. Proc Natl Acad Sci U S A (1979) 4.34
Mapping the spliced and unspliced late lytic SV40 RNAs. Cell (1978) 4.25
Release factors differing in specificity for terminator codons. Proc Natl Acad Sci U S A (1968) 4.18
In vivo modification of retroviral gag gene-encoded polyproteins by myristic acid. J Virol (1983) 4.09
Biochemical and immunological analysis of human immunodeficiency virus gag gene products p17 and p24. J Virol (1988) 4.06
Amino terminal myristylation of the protein kinase p60src, a retroviral transforming protein. Science (1985) 3.97
Splicing as a requirement for biogenesis of functional 16S mRNA of simian virus 40. Proc Natl Acad Sci U S A (1979) 3.89
Group-specific antigen expression during embryogenesis of the genome of the C-type RNA tumor virus: implications for ontogenesis and oncogenesis. Proc Natl Acad Sci U S A (1970) 3.71
Thin-layer chromatography of sub-nanomole amounts of phenylthiohydantoin (PTH) amino acids on polyamide sheets. Anal Biochem (1973) 3.66
Interactions of retroviral structural proteins with single-stranded nucleic acids. J Biol Chem (1987) 3.62
Friend strain of spleen focus-forming virus is a recombinant between ecotropic murine type C virus and the env gene region of xenotropic type C virus. Proc Natl Acad Sci U S A (1977) 3.62
Dynamics of Pleistocene population extinctions in Beringian brown bears. Science (2002) 3.53
Human genome contains four genes homologous to transforming genes of Harvey and Kirsten murine sarcoma viruses. Proc Natl Acad Sci U S A (1982) 3.48
Internal Hydrocephalus Following Cerebral Thrombosis, in an Infant. Proc R Soc Med (1937) 3.45
The functional human dihydrofolate reductase gene. J Biol Chem (1984) 3.28
Inhibition of lymphocyte proliferation by a synthetic peptide homologous to retroviral envelope proteins. Science (1985) 3.27
RNA-dependent DNA polymerase activity in five RNA viruses: divalent cation requirements. Proc Natl Acad Sci U S A (1970) 3.25
Changes in bone density with lactation. JAMA (1993) 3.24
Primary structure of the low molecular weight nucleic acid-binding proteins of murine leukemia viruses. J Biol Chem (1981) 3.21
Production and characterization of monoclonal antibodies to human interleukin 2: strategy and tactics. J Immunol (1983) 3.10
Immunological and chemical analysis of P6, the carboxyl-terminal fragment of HIV P15. AIDS Res Hum Retroviruses (1987) 3.03
Chemical and immunological characterizations of equine infectious anemia virus gag-encoded proteins. J Virol (1987) 3.02
Comparison of the nucleotide sequence of the messenger RNA for the major structural protein of SV40 with the DNA sequence encoding the amino acids of the protein. Nucleic Acids Res (1977) 3.00
p21 of Kirsten murine sarcoma virus is thermolabile in a viral mutant temperature sensitive for the maintenance of transformation. J Virol (1979) 2.94
Fatty acylation of proteins. Annu Rev Cell Biol (1988) 2.92
Quantitative separation of murine leukemia virus proteins by reversed-phase high-pressure liquid chromatography reveals newly described gag and env cleavage products. J Virol (1984) 2.91
Comparative biochemical properties of p21 ras molecules coded for by viral and cellular ras genes. J Virol (1982) 2.91
Identification of a precursor in the biosynthesis of the p21 transforming protein of harvey murine sarcoma virus. J Virol (1982) 2.89
Amino- and carboxyl-terminal amino acid sequences of proteins coded by gag gene of murine leukemia virus. Proc Natl Acad Sci U S A (1978) 2.87
Proteins of the murine C-type RNA tumour viruses: isolation of a group-specific antigen by isoelectric focusing. J Gen Virol (1970) 2.80
Processing and expression of early SV40 mRNA: a role for RNA conformation in splicing. Cell (1979) 2.80
Heteroduplex analysis of the sequence relations between the RNAs of mink cell focus-inducing and murine leukemia viruses. J Virol (1978) 2.79
C-type virus released from cultured human rhabdomyosarcoma cells. Nat New Biol (1972) 2.78
Isolation of a lentivirus from a macaque with lymphoma: comparison with HTLV-III/LAV and other lentiviruses. J Virol (1986) 2.77
Molecular characterization of gag proteins from simian immunodeficiency virus (SIVMne). J Virol (1988) 2.76
Isolation and characterization of a novel protein (X-ORF product) from SIV and HIV-2. Science (1988) 2.76
Coexistence of intraspecies and interspecies specific antigenic determinants on the major structural polypeptide of mammalian C-type viruses. Nat New Biol (1971) 2.70
Comparison of the genomic organization of Kirsten and Harvey sarcoma viruses. J Virol (1978) 2.66
Shedding and interspecies type sero-reactivity of the envelope glycopolypeptide gp120 of the human immunodeficiency virus. J Gen Virol (1986) 2.65
A rapid enzymatic DNA sequencing technique: determination of sequence alterations in early simian virus 40 temperature sensitive and deletion mutants. Nucleic Acids Res (1980) 2.65
Characterization of the phosphorylation sites and the surrounding amino acid sequences of the p21 transforming proteins coded for by the Harvey and Kirsten strains of murine sarcoma viruses. J Biol Chem (1982) 2.59
The ras oncogene product p21 is not a regulatory component of adenylate cyclase. Nature (1985) 2.57
A micromethod for complete removal of dodecyl sulfate from proteins by ion-pair extraction. Anal Biochem (1979) 2.57
Primary structure analysis of the major internal protein p24 of human type C T-cell leukemia virus. Proc Natl Acad Sci U S A (1982) 2.57
Translational readthrough of an amber termination codon during synthesis of feline leukemia virus protease. J Virol (1985) 2.53
Structure of a large segment of the genome of simian virus 40 that does not encode known proteins. Proc Natl Acad Sci U S A (1977) 2.50
The group-specific antigen and other structural proteins of hamster and mouse C-type viruses. Virology (1971) 2.46
Functional organization of the Harvey murine sarcoma virus genome. J Virol (1980) 2.46
Purification and N-terminal amino acid sequence comparisons of structural proteins from retrovirus-D/Washington and Mason-Pfizer monkey virus. J Virol (1985) 2.43
Incidentally discovered adrenal masses. Endocr Rev (1995) 2.40
The nucleotide sequence preceding an RNA polymerase initiation site on SV40 DNA. Part 2. The sequence of the early strand transcript. Nucleic Acids Res (1974) 2.40
Nucleotide sequences of RNA transcribed in infected cells and by Escherichia coli RNA polymerase from a segment of simian virus 40 DNA. Proc Natl Acad Sci U S A (1974) 2.34
Identification of a 30S RNA with properties of a defective type C virus in murine cells. J Virol (1978) 2.34
Complete mitochondrial genomes of ancient canids suggest a European origin of domestic dogs. Science (2013) 2.31
Separation of amino acid phenylthiohydantoins by high-performance liquid chromatography on phenylalkyl support. Anal Biochem (1980) 2.30
Bovine leukemia virus protease: purification, chemical analysis, and in vitro processing of gag precursor polyproteins. J Virol (1986) 2.28
Steroid induction of mouse mammary tumor virus: effect upon synthesis and degradation of viral RNA. J Virol (1977) 2.26
Myristylation of gag-onc fusion proteins in mammalian transforming retroviruses. Virology (1984) 2.22
Evaluation of seroreactivity to human papillomavirus type 16 virus-like particles in an incident case-control study of cervical neoplasia. J Infect Dis (1995) 2.21
Hepatic radioembolization with yttrium-90 containing glass microspheres: preliminary results and clinical follow-up. J Nucl Med (1994) 2.20
Species-specific and interspecific antigenic determinants associated with the structural protein of feline C-type virus. Proc Natl Acad Sci U S A (1971) 2.20
Sequential translation of trinucleotide codons for the initiation and termination of protein synthesis. Science (1968) 2.20