Published in Annu Rev Genet on January 01, 1985
Millions of years of evolution preserved: a comprehensive catalog of the processed pseudogenes in the human genome. Genome Res (2003) 5.49
Gene structure prediction and alternative splicing analysis using genomically aligned ESTs. Genome Res (2001) 5.38
A genome-wide survey of human pseudogenes. Genome Res (2003) 4.34
Pseudogenes in the ENCODE regions: consensus annotation, analysis of transcription, and evolution. Genome Res (2007) 3.82
A cell that dies during wild-type C. elegans development can function as a neuron in a ced-3 mutant. Cell (1987) 3.05
Molecular fossils in the human genome: identification and analysis of the pseudogenes in chromosomes 21 and 22. Genome Res (2002) 2.89
Identification and analysis of over 2000 ribosomal protein pseudogenes in the human genome. Genome Res (2002) 2.88
Structure and chromosomal localization of the functional intronless human JUN protooncogene. Proc Natl Acad Sci U S A (1988) 2.51
Genetic variation among world populations: inferences from 100 Alu insertion polymorphisms. Genome Res (2003) 2.47
LINE-1 elements in structural variation and disease. Annu Rev Genomics Hum Genet (2011) 2.42
Nature and structure of human genes that generate retropseudogenes. Genome Res (2000) 2.21
Whole-genome screening indicates a possible burst of formation of processed pseudogenes and Alu repeats by particular L1 subfamilies in ancestral primates. Genome Biol (2003) 2.19
mRNA retroposition in human cells: processed pseudogene formation. EMBO J (1995) 2.15
A systematic analysis of LINE-1 endonuclease-dependent retrotranspositional events causing human genetic disease. Hum Genet (2005) 2.10
Comparative genomics search for losses of long-established genes on the human lineage. PLoS Comput Biol (2007) 2.07
A question of size: the eukaryotic proteome and the problems in defining it. Nucleic Acids Res (2002) 2.07
Detection and Quantitation of Circulating Human Irisin by Tandem Mass Spectrometry. Cell Metab (2015) 1.93
Sequence-dependent gene conversion: can duplicated genes diverge fast enough to escape conversion? Genetics (1987) 1.91
Comprehensive analysis of pseudogenes in prokaryotes: widespread gene decay and failure of putative horizontally transferred genes. Genome Biol (2004) 1.88
Digging for dead genes: an analysis of the characteristics of the pseudogene population in the Caenorhabditis elegans genome. Nucleic Acids Res (2001) 1.85
The testis-specific phosphoglycerate kinase gene pgk-2 is a recruited retroposon. Mol Cell Biol (1987) 1.67
Human Oct3 gene family: cDNA sequences, alternative splicing, gene organization, chromosomal location, and expression at low levels in adult tissues. Nucleic Acids Res (1992) 1.65
A comparative analysis of insertional effects in genetically engineered plants: considerations for pre-market assessments. Transgenic Res (2014) 1.57
Processed pseudogenes of human endogenous retroviruses generated by LINEs: their integration, stability, and distribution. Genome Res (2002) 1.54
Retroviral vector system for the study of cDNA gene formation. Mol Cell Biol (1988) 1.50
Identification of pseudogenes in the Drosophila melanogaster genome. Nucleic Acids Res (2003) 1.48
Microsatellite spreading in the human genome: evolutionary mechanisms and structural implications. Proc Natl Acad Sci U S A (1996) 1.45
Comprehensive analysis of amino acid and nucleotide composition in eukaryotic genomes, comparing genes and pseudogenes. Nucleic Acids Res (2002) 1.40
HOPPSIGEN: a database of human and mouse processed pseudogenes. Nucleic Acids Res (2005) 1.38
Genome-wide survey for biologically functional pseudogenes. PLoS Comput Biol (2006) 1.38
Generation of processed pseudogenes in murine cells. EMBO J (1993) 1.37
The isolation and characterization of a novel cDNA demonstrating an altered mRNA level in nontumorigenic Wilms' microcell hybrid cells. Nucleic Acids Res (1991) 1.37
The human ABC transporter pseudogene family: Evidence for transcription and gene-pseudogene interference. BMC Genomics (2008) 1.31
A complex gene superfamily encodes actin in petunia. EMBO J (1987) 1.31
Complex alternative RNA processing generates an unexpected diversity of poly(A) polymerase isoforms. Mol Cell Biol (1996) 1.30
Involvement of cDNA in homologous recombination between Ty elements in Saccharomyces cerevisiae. Mol Cell Biol (1992) 1.27
A strategy to detect and isolate an intron-containing gene in the presence of multiple processed pseudogenes. Proc Natl Acad Sci U S A (1989) 1.27
Human members of the eukaryotic protein kinase family. Genome Biol (2002) 1.25
Genes, pseudogenes, and Alu sequence organization across human chromosomes 21 and 22. Proc Natl Acad Sci U S A (2002) 1.23
Molecular cloning of ILP-2, a novel member of the inhibitor of apoptosis protein family. Mol Cell Biol (2001) 1.23
Iterative gene prediction and pseudogene removal improves genome annotation. Genome Res (2006) 1.20
Retrotransposition of gene transcripts leads to structural variation in mammalian genomes. Genome Biol (2013) 1.20
Frequent alteration of MLL3 frameshift mutations in microsatellite deficient colorectal cancer. PLoS One (2011) 1.19
Evolutionary and expression signatures of pseudogenes in Arabidopsis and rice. Plant Physiol (2009) 1.18
Pseudogene-mediated posttranscriptional silencing of HMGA1 can result in insulin resistance and type 2 diabetes. Nat Commun (2010) 1.17
Genomic rearrangements in BRCA1 and BRCA2: A literature review. Genet Mol Biol (2009) 1.14
Spliceosomal introns as tools for genomic and evolutionary analysis. Nucleic Acids Res (2008) 1.12
Human thrombomodulin gene is intron depleted: nucleic acid sequences of the cDNA and gene predict protein structure and suggest sites of regulatory control. Proc Natl Acad Sci U S A (1987) 1.11
Personal receptor repertoires: olfaction as a model. BMC Genomics (2012) 1.10
Molecular cloning and structural analysis of mouse gene and pseudogenes for proliferating cell nuclear antigen. Nucleic Acids Res (1991) 1.08
EEN encodes for a member of a new family of proteins containing an Src homology 3 domain and is the third gene located on chromosome 19p13 that fuses to MLL in human leukemia. Proc Natl Acad Sci U S A (1997) 1.08
Small RNAs originated from pseudogenes: cis- or trans-acting? PLoS Comput Biol (2009) 1.05
Distribution of short paired duplications in mammalian genomes. Proc Natl Acad Sci U S A (2004) 1.05
Many lncRNAs, 5'UTRs, and pseudogenes are translated and some are likely to express functional proteins. Elife (2015) 1.04
Roles of the four DNA polymerases of the crenarchaeon Sulfolobus solfataricus and accessory proteins in DNA replication. J Biol Chem (2011) 1.04
Pseudogene-derived small interference RNAs regulate gene expression in African Trypanosoma brucei. Proc Natl Acad Sci U S A (2011) 1.04
The vertebrate makorin ubiquitin ligase gene family has been shaped by large-scale duplication and retroposition from an ancestral gonad-specific, maternal-effect gene. BMC Genomics (2010) 1.03
Noncoding RNA in oncogenesis: a new era of identifying key players. Int J Mol Sci (2013) 1.03
Is esterase-P encoded by a cryptic pseudogene in Drosophila melanogaster? Genetics (1996) 1.02
HMGA1 pseudogenes as candidate proto-oncogenic competitive endogenous RNAs. Oncotarget (2014) 1.02
Characterization of SRp46, a novel human SR splicing factor encoded by a PR264/SC35 retropseudogene. Mol Cell Biol (1998) 1.01
Retrotransposition as a source of new promoters. Mol Biol Evol (2008) 1.00
Genomic fossils as a snapshot of the human transcriptome. Proc Natl Acad Sci U S A (2006) 0.99
Evolutionary origin of regulatory regions of retrogenes in Drosophila. BMC Genomics (2008) 0.99
Embryonic expression of the human 40-kD keratin: evidence from a processed pseudogene sequence. Am J Hum Genet (1988) 0.98
cDNA genes formed after infection with retroviral vector particles lack the hallmarks of natural processed pseudogenes. Mol Cell Biol (1990) 0.97
The Influence of LINE-1 and SINE Retrotransposons on Mammalian Genomes. Microbiol Spectr (2015) 0.96
TARGeT: a web-based pipeline for retrieving and characterizing gene and transposable element families from genomic sequences. Nucleic Acids Res (2009) 0.95
A novel mobile element inserted in the alpha spectrin gene: spectrin dayton. A truncated alpha spectrin associated with hereditary elliptocytosis. J Clin Invest (1994) 0.95
Gene decay in archaea. Archaea (2007) 0.95
Presence of a retroviral encapsidation sequence in nonretroviral RNA increases the efficiency of formation of cDNA genes. J Virol (1990) 0.95
DNA polymorphism in the beta-Esterase gene cluster of Drosophila melanogaster. Genetics (2003) 0.95
A cluster of cuticle protein genes of Drosophila melanogaster at 65A: sequence, structure and evolution. Genetics (1997) 0.94
GC content evolution of the human and mouse genomes: insights from the study of processed pseudogenes in regions of different recombination rates. J Mol Evol (2006) 0.93
Germ cell-specific expression of a gene encoding eukaryotic translation elongation factor 1 alpha (eEF-1 alpha) and generation of eEF-1 alpha retropseudogenes in Xenopus laevis. Proc Natl Acad Sci U S A (1991) 0.93
Processed pseudogenes, processed genes, and spontaneous mutations in the Arabidopsis genome. J Mol Evol (2006) 0.91
Retrogenes in rice (Oryza sativa L. ssp. japonica) exhibit correlated expression with their source genes. Genome Biol Evol (2011) 0.90
Retroposed copies of the HMG genes: a window to genome dynamics. Genome Res (2003) 0.90
Origin and evolution of processed pseudogenes that stabilize functional Makorin1 mRNAs in mice, primates and other mammals. Genetics (2006) 0.90
Diversification of genes encoding granule-bound starch synthase in monocots and dicots is marked by multiple genome-wide duplication events. PLoS One (2012) 0.90
Promoter analysis of the rabbit POU5F1 gene and its expression in preimplantation stage embryos. BMC Mol Biol (2009) 0.90
Systematic identification of pseudogenes through whole genome expression evidence profiling. Nucleic Acids Res (2006) 0.90
Evolutionary implications of the human aldolase-A, -B, -C, and -pseudogene chromosome locations. Am J Hum Genet (1987) 0.87
Origin and fate of pseudogenes in Hemiascomycetes: a comparative analysis. BMC Genomics (2010) 0.87
Detecting transcription of ribosomal protein pseudogenes in diverse human tissues from RNA-seq data. BMC Genomics (2012) 0.86
PseudoGeneQuest - service for identification of different pseudogene types in the human genome. BMC Bioinformatics (2008) 0.86
A copy number variation in human NCF1 and its pseudogenes. BMC Genet (2010) 0.86
Expression of the woodchuck N-myc2 retroposon in brain and in liver tumors is driven by a cryptic N-myc promoter. Mol Cell Biol (1992) 0.85
Identifying causal regulatory SNPs in ChIP-seq enhancers. Nucleic Acids Res (2014) 0.85
GeneScissors: a comprehensive approach to detecting and correcting spurious transcriptome inference owing to RNA-seq reads misalignment. Bioinformatics (2013) 0.85
Structure and developmental expression of hatching enzyme genes of the Japanese eel Anguilla japonica: an aspect of the evolution of fish hatching enzyme gene. Dev Genes Evol (2004) 0.84
Mammalian nonsarcomeric myosin regulatory light chains are encoded by two differentially regulated and linked genes. J Cell Biol (1990) 0.84
How evolution of genomes is reflected in exact DNA sequence match statistics. Mol Biol Evol (2014) 0.84
Cloning and sequencing of a processed pseudogene derived from a human class III alcohol dehydrogenase gene. Am J Hum Genet (1990) 0.83
Identification and analysis of ancestral hominoid transcriptome inferred from cross-species transcript and processed pseudogene comparisons. Genome Res (2008) 0.83
RCPedia: a database of retrocopied genes. Bioinformatics (2013) 0.83
Crossing the LINE Toward Genomic Instability: LINE-1 Retrotransposition in Cancer. Front Chem (2015) 0.82
Splice variant PRKC-ζ(-PrC) is a novel biomarker of human prostate cancer. Br J Cancer (2012) 0.82
Diversity through duplication: whole-genome sequencing reveals novel gene retrocopies in the human population. Bioessays (2014) 0.81
Nanog retrotransposed genes with functionally conserved open reading frames. Mamm Genome (2006) 0.81
Sequence of the gene for the constant region of the mu chain of Balb/c mouse immunoglobulin. Gene (1981) 8.45
Jak2 is essential for signaling through a variety of cytokine receptors. Cell (1998) 5.92
Caspase 8 is deleted or silenced preferentially in childhood neuroblastomas with amplification of MYCN. Nat Med (2000) 5.04
Unexpected relationships between four large deletions in the human beta-globin gene cluster. Cell (1983) 3.57
A mouse alpha-globin-related pseudogene lacking intervening sequences. Nature (1980) 2.92
Factors influencing in vivo transduction by recombinant adeno-associated viral vectors expressing the human factor IX cDNA. Blood (2001) 1.74
An array of murine leukemia virus-related elements is transmitted and expressed in a primate recipient of retroviral gene transfer. J Virol (1996) 1.38
Inducible, high-level production of infectious murine leukemia retroviral vector particles pseudotyped with vesicular stomatitis virus G envelope protein. Hum Gene Ther (1995) 1.37
Protection and in vivo selection of hematopoietic stem cells using temozolomide, O6-benzylguanine, and an alkyltransferase-expressing retroviral vector. Mol Ther (2001) 1.33
High-efficiency transduction and long-term gene expression with a murine stem cell retroviral vector encoding the green fluorescent protein in human marrow stromal cells. Hum Gene Ther (1999) 1.33
Clones from the human gene complex coding for salivary proline-rich proteins. Proc Natl Acad Sci U S A (1984) 1.19
Bone marrow-derived cells contribute to tumor neovasculature and, when modified to express an angiogenesis inhibitor, can restrict tumor growth in mice. Clin Cancer Res (2001) 1.19
Differing contribution of thiopurine methyltransferase to mercaptopurine versus thioguanine effects in human leukemic cells. Cancer Res (2001) 1.15
An improved method for generating retroviral producer clones for vectors lacking a selectable marker gene. Blood Cells Mol Dis (1998) 1.12
Characterization of a replication-competent retrovirus resulting from recombination of packaging and vector sequences. Hum Gene Ther (1994) 1.11
Sequence of a cDNA for mouse thymidylate synthase reveals striking similarity with the prokaryotic enzyme. Mol Biol Evol (1986) 1.09
RD114-pseudotyped oncoretroviral vectors. Biological and physical properties. Ann N Y Acad Sci (2001) 1.01
Processed pseudogenes. Characteristics and evolution. Biochim Biophys Acta (1984) 1.00
Gene therapy-mediated expression by tumor cells of the angiogenesis inhibitor flk-1 results in inhibition of neuroblastoma growth in vivo. J Pediatr Surg (2001) 0.96
Jak3 selectively regulates Bax and Bcl-2 expression to promote T-cell development. Mol Cell Biol (2001) 0.92
Flanking-sequence exponential anchored-polymerase chain reaction amplification: a sensitive and highly specific method for detecting retroviral integrant-host-junction sequences. Cytotherapy (2008) 0.92
Cloning, nucleotide sequence, and expression of the flavodoxin gene from Desulfovibrio vulgaris (Hildenborough). J Biol Chem (1988) 0.91
Human ventricular/slow twitch myosin alkali light chain gene characterization, sequence, and chromosomal location. J Biol Chem (1989) 0.90
Dysregulated expression of GATA-1 following retrovirus-mediated gene transfer into murine hematopoietic stem cells increases erythropoiesis. Blood (1995) 0.90
Persistent low-level engraftment of rhesus peripheral blood progenitor cells transduced with the fanconi anemia C gene after conditioning with low-dose irradiation. Mol Ther (2001) 0.89
Molecular characterization of a beta zero-thalassemia resulting from a 1.4 kilobase deletion. Blood (1988) 0.88
Synthesis and application of cleavable photoactivable heterobifunctional reagents. Biochemistry (1981) 0.87
Human embryonic/atrial myosin alkali light chain gene: characterization, sequence, and chromosomal location. Genomics (1990) 0.85
The human transcription factor CP2 (TFCP2), a component of the human gamma-globin stage selector protein, maps to chromosome region 12q13 and is within 250 kb of the NF-E2 gene. Genomics (1995) 0.85
Purified GPI-anchored CD4DAF as a receptor for HIV-mediated gene transfer. Hum Gene Ther (1994) 0.83
Structure-activity relationships of puromycin analogues on Escherichia coli polysomes. FEBS Lett (1974) 0.82
Adenovirus-mediated expresssion of the murine ecotropic receptor facilitates transduction of human hematopoietic cells with an ecotropic retroviral vector. Gene Ther (1999) 0.82
The entire beta-globin gene cluster is deleted in a form of gamma delta beta-thalassemia. Blood (1983) 0.80
Chemical crosslinking of cell membranes. Mol Cell Biochem (1983) 0.80
Targeted integration of a recombinant globin gene adeno-associated viral vector into human chromosome 19. Ann N Y Acad Sci (1998) 0.80
Enhanced neuroblastoma transduction for an improved antitumor vaccine. J Surg Res (1999) 0.79
Neuroblastoma regression and immunity induced by transgenic expression of interleukin-12. J Pediatr Surg (1999) 0.79
Retroviral transfer of a bacterial alkyltransferase gene into murine bone marrow protects against chloroethylnitrosourea cytotoxicity. Clin Cancer Res (1995) 0.77
Autocrine expression of both endostatin and green fluorescent protein provides a synergistic antitumor effect in a murine neuroblastoma model. Cancer Gene Ther (2001) 0.77
Retroviral vector-producer cell mediated angiogenesis inhibition restricts neuroblastoma growth in vivo. Med Pediatr Oncol (2000) 0.76
Humoral response to vaccination with interleukin-2-expressing allogeneic neuroblastoma cells after primary therapy. Med Pediatr Oncol (2000) 0.76
The nucleotide sequence of the mouse embryonic beta-like y-globin messenger RNA as determined from cloned cDNA. Gene (1981) 0.76
The use of adenoviral vectors for genetic manipulation and analysis of primitive hematopoietic cells. Curr Gene Ther (2001) 0.75
The preparation of high specific activity [3H]chloramphenicol base and chloramphenicol labeled in the propanediol side chain. Anal Biochem (1976) 0.75
Vector development: a major obstacle in human gene therapy. Ann Med (1998) 0.75