Frequent alteration of MLL3 frameshift mutations in microsatellite deficient colorectal cancer.

PubWeight™: 1.19‹?› | Rank: Top 10%

🔗 View Article (PMC 3154922)

Published in PLoS One on August 11, 2011

Authors

Yoshiyuki Watanabe1, Ryan J Castoro, Hyun Soo Kim, Brittany North, Ritsuko Oikawa, Tetsuya Hiraishi, Saira S Ahmed, Woonbok Chung, Mee-Yon Cho, Minoru Toyota, Fumio Itoh, Marcos R H Estecio, Lanlan Shen, Jaroslav Jelinek, Jean-Pierre J Issa

Author Affiliations

1: Department of Leukemia, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, United States of America. ponponta@marianna-u.ac.jp

Articles citing this

Frequent mutation of the PI3K pathway in head and neck cancer defines predictive biomarkers. Cancer Discov (2013) 2.29

Mutation of epigenetic regulators TET2 and MLL3 in patients with HTLV-I-induced acute adult T-cell leukemia. Mol Cancer (2016) 1.43

The MLL3/MLL4 branches of the COMPASS family function as major histone H3K4 monomethylases at enhancers. Mol Cell Biol (2013) 1.35

Enhancer malfunction in cancer. Mol Cell (2014) 1.19

Novel recurrently mutated genes and a prognostic mutation signature in colorectal cancer. Gut (2014) 1.18

Global identification of MLL2-targeted loci reveals MLL2's role in diverse signaling pathways. Proc Natl Acad Sci U S A (2012) 1.14

Histone methyltransferase MLL3 contributes to genome-scale circadian transcription. Proc Natl Acad Sci U S A (2013) 1.11

KMT2D maintains neoplastic cell proliferation and global histone H3 lysine 4 monomethylation. Oncotarget (2013) 1.06

The mutational landscape of chromatin regulatory factors across 4,623 tumor samples. Genome Biol (2013) 1.03

WRAD: enabler of the SET1-family of H3K4 methyltransferases. Brief Funct Genomics (2012) 1.01

Driver mutations of cancer epigenomes. Protein Cell (2014) 0.98

Histone methylase MLL1 has critical roles in tumor growth and angiogenesis and its knockdown suppresses tumor growth in vivo. Oncogene (2012) 0.96

Exome sequencing identifies frequent mutation of MLL2 in non-small cell lung carcinoma from Chinese patients. Sci Rep (2014) 0.95

Evaluation of magnifying colonoscopy in the diagnosis of serrated polyps. World J Gastroenterol (2012) 0.94

Establishment and characterization of a highly tumourigenic and cancer stem cell enriched pancreatic cancer cell line as a well defined model system. PLoS One (2012) 0.89

Examining the impact of gene variants on histone lysine methylation. Biochim Biophys Acta (2014) 0.88

Histone lysine-specific methyltransferases and demethylases in carcinogenesis: new targets for cancer therapy and prevention. Curr Cancer Drug Targets (2013) 0.87

The good, the bad and the ugly: epigenetic mechanisms in glioblastoma. Mol Aspects Med (2012) 0.84

A global profile of gene promoter methylation in treatment-naïve urothelial cancer. Epigenetics (2014) 0.80

Interaction between MLL3 genetic polymorphisms, smoking, and alcohol drinking in laryngeal cancer: a case-control study. Cancer Med (2016) 0.78

DNA methylation at hepatitis B viral integrants is associated with methylation at flanking human genomic sequences. Genome Res (2015) 0.77

Enhancer deregulation in cancer and other diseases. Bioessays (2016) 0.76

Alteration of histone H3K4 methylation in glomerular podocytes associated with proteinuria in patients with membranous nephropathy. BMC Nephrol (2016) 0.75

Case-control study of candidate gene methylation and adenomatous polyp formation. Int J Colorectal Dis (2016) 0.75

The miR-200 family is increased in dysplastic lesions in ulcerative colitis patients. PLoS One (2017) 0.75

Targeting histone methylation for colorectal cancer. Therap Adv Gastroenterol (2016) 0.75

Regulation of tumour related genes by dynamic epigenetic alteration at enhancer regions in gastric epithelial cells infected by Epstein-Barr virus. Sci Rep (2017) 0.75

Articles cited by this

The consensus coding sequences of human breast and colorectal cancers. Science (2006) 60.02

Inactivation of the type II TGF-beta receptor in colon cancer cells with microsatellite instability. Science (1995) 13.15

Processed pseudogenes: characteristics and evolution. Annu Rev Genet (1985) 4.40

Aging and DNA methylation in colorectal mucosa and cancer. Cancer Res (1998) 4.39

Vertebrate pseudogenes. FEBS Lett (2000) 3.93

A tumor suppressive coactivator complex of p53 containing ASC-2 and histone H3-lysine-4 methyltransferase MLL3 or its paralogue MLL4. Proc Natl Acad Sci U S A (2009) 2.06

Switch from monoallelic to biallelic human IGF2 promoter methylation during aging and carcinogenesis. Proc Natl Acad Sci U S A (1996) 1.99

Novel somatic and germline mutations in cancer candidate genes in glioblastoma, melanoma, and pancreatic carcinoma. Cancer Res (2007) 1.98

The leukemia-associated-protein (LAP) domain, a cysteine-rich motif, is present in a wide range of proteins, including MLL, AF10, and MLLT6 proteins. Proc Natl Acad Sci U S A (1995) 1.58

MLL3, a new human member of the TRX/MLL gene family, maps to 7q36, a chromosome region frequently deleted in myeloid leukaemia. Gene (2002) 1.36

Molecular cytogenetic characterization of a critical region in bands 7q35-q36 commonly deleted in malignant myeloid disorders. Blood (1998) 1.36

A testis-specific gene, TPTE, encodes a putative transmembrane tyrosine phosphatase and maps to the pericentromeric region of human chromosomes 21 and 13, and to chromosomes 15, 22, and Y. Hum Genet (1999) 1.28

DNA amplification method tolerant to sample degradation. Genome Res (2004) 1.28

P14 methylation in human colon cancer is associated with microsatellite instability and wild-type p53. Gastroenterology (2003) 1.27

PRDM5 identified as a target of epigenetic silencing in colorectal and gastric cancer. Clin Cancer Res (2007) 1.21

Sensitive and specific detection of early gastric cancer with DNA methylation analysis of gastric washes. Gastroenterology (2009) 1.10

Absence of MLL3 mutations in colorectal carcinomas of Korean patients. APMIS (2007) 0.93

Spectral karyotype analysis of colon cancer cell lines of the tumor suppressor and mutator pathway. Cytogenet Genome Res (2002) 0.92

The novel human endogenous retrovirus-related gene, psiTPTE22-HERV, is silenced by DNA methylation in cancers. Int J Cancer (2010) 0.84

Articles by these authors

Decitabine improves patient outcomes in myelodysplastic syndromes: results of a phase III randomized study. Cancer (2006) 8.57

Results of a randomized study of 3 schedules of low-dose decitabine in higher-risk myelodysplastic syndrome and chronic myelomonocytic leukemia. Blood (2006) 8.38

A simple method for estimating global DNA methylation using bisulfite PCR of repetitive DNA elements. Nucleic Acids Res (2004) 7.92

Epigenetic inactivation of SFRP genes allows constitutive WNT signaling in colorectal cancer. Nat Genet (2004) 7.78

MGMT promoter methylation and field defect in sporadic colorectal cancer. J Natl Cancer Inst (2005) 5.22

Genome-wide profiling of DNA methylation reveals a class of normally methylated CpG island promoters. PLoS Genet (2007) 5.16

Gene silencing in cancer by histone H3 lysine 27 trimethylation independent of promoter DNA methylation. Nat Genet (2008) 5.08

Dnmt3a is essential for hematopoietic stem cell differentiation. Nat Genet (2011) 4.85

The Asian tsunami: a protective role for coastal vegetation. Science (2005) 4.31

Integrated genetic and epigenetic analysis identifies three different subclasses of colon cancer. Proc Natl Acad Sci U S A (2007) 4.16

Disruption of oxygen homeostasis underlies congenital Chuvash polycythemia. Nat Genet (2002) 4.06

Comparing the DNA hypermethylome with gene mutations in human colorectal cancer. PLoS Genet (2007) 3.39

Safety and clinical activity of the combination of 5-azacytidine, valproic acid, and all-trans retinoic acid in acute myeloid leukemia and myelodysplastic syndrome. Blood (2007) 3.27

JAK2 mutation 1849G>T is rare in acute leukemias but can be found in CMML, Philadelphia chromosome-negative CML, and megakaryocytic leukemia. Blood (2005) 3.24

Widespread and tissue specific age-related DNA methylation changes in mice. Genome Res (2010) 2.99

LINE-1 hypomethylation in cancer is highly variable and inversely correlated with microsatellite instability. PLoS One (2007) 2.99

Polycythemia vera is not initiated by JAK2V617F mutation. Exp Hematol (2007) 2.75

Critical role of histone methylation in tumor suppressor gene silencing in colorectal cancer. Mol Cell Biol (2003) 2.72

Epigenetics in cancer: what's the future? Oncology (Williston Park) (2011) 2.70

DNA methylation changes after 5-aza-2'-deoxycytidine therapy in patients with leukemia. Cancer Res (2006) 2.69

Downregulation of histone H3 lysine 9 methyltransferase G9a induces centrosome disruption and chromosome instability in cancer cells. PLoS One (2008) 2.52

Season of conception in rural gambia affects DNA methylation at putative human metastable epialleles. PLoS Genet (2010) 2.49

Integrative genomic characterization of oral squamous cell carcinoma identifies frequent somatic drivers. Cancer Discov (2013) 2.49

Upregulation of miR-196a and HOTAIR drive malignant character in gastrointestinal stromal tumors. Cancer Res (2012) 2.45

Epidermal growth factor receptor copy number alterations correlate with poor clinical outcome in patients with head and neck squamous cancer. J Clin Oncol (2007) 2.40

Human application of a metallic stent covered with a paclitaxel-incorporated membrane for malignant biliary obstruction: multicenter pilot study. Gastrointest Endosc (2007) 2.36

Epigenetic changes in colorectal cancer. Cancer Metastasis Rev (2004) 2.35

DNA methylation predicts survival and response to therapy in patients with myelodysplastic syndromes. J Clin Oncol (2009) 2.23

Chromosome 5q deletion and epigenetic suppression of the gene encoding alpha-catenin (CTNNA1) in myeloid cell transformation. Nat Med (2006) 2.23

Cancer epigenetics. CA Cancer J Clin (2010) 2.16

High-throughput methylation profiling by MCA coupled to CpG island microarray. Genome Res (2007) 2.09

Histone deacetylase inhibition elicits an evolutionarily conserved self-renewal program in embryonic stem cells. Cell Stem Cell (2009) 2.09

A novel pit pattern identifies the precursor of colorectal cancer derived from sessile serrated adenoma. Am J Gastroenterol (2012) 2.06

DNA methylation and environmental exposures in human hepatocellular carcinoma. J Natl Cancer Inst (2002) 2.04

Age-related DNA methylation changes in normal human prostate tissues. Clin Cancer Res (2007) 2.02

Association between DNA methylation and shortened survival in patients with advanced colorectal cancer treated with 5-fluorouracil based chemotherapy. Clin Cancer Res (2007) 2.02

Myelodysplastic syndromes. Hematology Am Soc Hematol Educ Program (2004) 2.01

Vascular endothelial growth factor receptor-1 activation mediates epithelial to mesenchymal transition in human pancreatic carcinoma cells. Cancer Res (2006) 1.99

Recent variceal bleeding: Doppler US hepatic vein waveform in assessment of severity of portal hypertension and vasoactive drug response. Radiology (2006) 1.95

Phase II study of low-dose decitabine in patients with chronic myelogenous leukemia resistant to imatinib mesylate. J Clin Oncol (2005) 1.93

Global DNA hypomethylation (LINE-1) in the normal colon and lifestyle characteristics and dietary and genetic factors. Cancer Epidemiol Biomarkers Prev (2009) 1.88

DNA hypermethylation contributes to incomplete synthesis of carbohydrate determinants in gastrointestinal cancer. Gastroenterology (2008) 1.83

CpG island methylation in aberrant crypt foci of the colorectum. Am J Pathol (2002) 1.83

Optimizing annealing temperature overcomes bias in bisulfite PCR methylation analysis. Biotechniques (2007) 1.78

Discrimination of polycythemias and thrombocytoses by novel, simple, accurate clonality assays and comparison with PRV-1 expression and BFU-E response to erythropoietin. Blood (2002) 1.76

Current Trends of the Incidence and Pathological Diagnosis of Gastroenteropancreatic Neuroendocrine Tumors (GEP-NETs) in Korea 2000-2009: Multicenter Study. Cancer Res Treat (2012) 1.76

CIMP, at last. Gastroenterology (2005) 1.74

Targeted p16(Ink4a) epimutation causes tumorigenesis and reduces survival in mice. J Clin Invest (2014) 1.71

Mechanisms of resistance to 5-aza-2'-deoxycytidine in human cancer cell lines. Blood (2008) 1.71

Imprinted tumor suppressor genes ARHI and PEG3 are the most frequently down-regulated in human ovarian cancers by loss of heterozygosity and promoter methylation. Cancer (2008) 1.69

Correlation between CpG methylation profiles and hormone receptor status in breast cancers. Breast Cancer Res (2007) 1.68

Mutations in the VHL gene in sporadic apparently congenital polycythemia. Blood (2002) 1.65

Aberrant DNA methylation of p57KIP2 identifies a cell-cycle regulatory pathway with prognostic impact in adult acute lymphocytic leukemia. Blood (2003) 1.65

Epigenetic-genetic interactions in the APC/WNT, RAS/RAF, and P53 pathways in colorectal carcinoma. Clin Cancer Res (2008) 1.64

Characterization of microRNAs involved in embryonic stem cell states. Stem Cells Dev (2010) 1.62

EMR for early gastric cancer in Korea: a multicenter retrospective study. Gastrointest Endosc (2007) 1.59

Decitabine--bedside to bench. Crit Rev Oncol Hematol (2006) 1.59

Smad-dependent GADD45beta expression mediates delayed activation of p38 MAP kinase by TGF-beta. EMBO J (2002) 1.59

Aberrant methylation and silencing of the BNIP3 gene in colorectal and gastric cancer. Clin Cancer Res (2005) 1.58

Epigenetic inactivation of CHFR in human tumors. Proc Natl Acad Sci U S A (2003) 1.57

Variable DNA methylation patterns associated with progression of disease in hepatocellular carcinomas. Carcinogenesis (2008) 1.57

Concordant CpG island methylation in hyperplastic polyposis. Am J Pathol (2002) 1.56

Hypomethylation of LINE-1 and Alu in well-differentiated neuroendocrine tumors (pancreatic endocrine tumors and carcinoid tumors). Mod Pathol (2007) 1.56

DNA methylation predicts recurrence from resected stage III proximal colon cancer. Cancer (2010) 1.55

Alveolar macrophages are indispensable for controlling influenza viruses in lungs of pigs. J Virol (2008) 1.53

Genome architecture marked by retrotransposons modulates predisposition to DNA methylation in cancer. Genome Res (2010) 1.53

The expression of matrix metalloproteinase matrilysin indicates the degree of inflammation in ulcerative colitis. J Gastroenterol (2003) 1.53