Published in Cell on February 01, 1977
Method for detection of specific RNAs in agarose gels by transfer to diazobenzyloxymethyl-paper and hybridization with DNA probes. Proc Natl Acad Sci U S A (1977) 40.24
Spliced segments at the 5' terminus of adenovirus 2 late mRNA. Proc Natl Acad Sci U S A (1977) 14.34
Nucleotide sequence of a mutant eukaryotic gene: the yeast tyrosine-inserting ochre suppressor SUP4-o. Proc Natl Acad Sci U S A (1977) 10.64
Filter replicas and permanent collections of recombinant DNA plasmids. Nucleic Acids Res (1979) 8.00
The intervening sequence of a mouse beta-globin gene is transcribed within the 15S beta-globin mRNA precursor. Proc Natl Acad Sci U S A (1978) 6.20
The rat serum albumin gene: analysis of cloned sequences. Proc Natl Acad Sci U S A (1979) 5.17
DNA-RNA hybrid duplexes containing oligo(dA:rU) sequences are exceptionally unstable and may facilitate termination of transcription. Nucleic Acids Res (1980) 4.37
Intervening sequence of DNA identified in the structural portion of a mouse beta-globin gene. Proc Natl Acad Sci U S A (1978) 4.02
Multiple related immunoglobulin variable-region genes identified by cloning and sequence analysis. Proc Natl Acad Sci U S A (1978) 3.88
Has the endosymbiont hypothesis been proven? Microbiol Rev (1982) 3.86
Translation of Drosophila melanogaster sequences in Escherichia coli. Proc Natl Acad Sci U S A (1977) 3.76
Nucleotide sequence of the initiation site for ribosomal RNA transcription in Drosophila melanogaster: comparison of genes with and without insertions. Proc Natl Acad Sci U S A (1981) 3.21
Variable and constant parts of the immunoglobulin light chain gene of a mouse myeloma cell are 1250 nontranslated bases apart. Proc Natl Acad Sci U S A (1977) 2.93
Molecular cloning of integrated simian sarcoma virus: genome organization of infectious DNA clones. Proc Natl Acad Sci U S A (1981) 2.74
Loop structures in hybrids of early RNA and the separated strands of adenovirus DNA. Proc Natl Acad Sci U S A (1977) 2.60
Gaps and duplicated sequences in the leaders of SV40 16S RNA. Nucleic Acids Res (1978) 2.60
The use of R-looping for structural gene identification and mRNA purification. Nucleic Acids Res (1979) 2.36
Absence of cytosine methylation at C-C-G-G and G-C-G-C sites in the rDNA coding regions and intervening sequences of Drosophila and the rDNA of other insects. Nucleic Acids Res (1979) 2.10
The 10 kb Drosophila virilis 28S rDNA intervening sequence is flanked by a direct repeat of 14 base pairs of coding sequence. Nucleic Acids Res (1980) 2.05
Comparison of cloned mouse alpha- and beta-globin genes: conservation of intervening sequence locations and extragenic homology. Proc Natl Acad Sci U S A (1978) 2.03
Variable region genes for the immunoglobulin framework are assembled from small segments of DNA--a hypothesis. Proc Natl Acad Sci U S A (1978) 1.92
Cloning immunoglobulin gamma 2b chain gene of mouse: characterization and partial sequence determination. Proc Natl Acad Sci U S A (1979) 1.80
Sequence arrangement of the 16S and 26S rRNA genes in the pathogenic haemoflagellate Leishmania donovani. Nucleic Acids Res (1978) 1.75
Fine structure of ribosomal RNA. IV. Extraordinary evolutionary conservation in sequences that flank introns in rDNA. Nucleic Acids Res (1980) 1.71
Characterisation of bacterial clones containing DNA sequences derived from Xenopus laevis vitellogenin mRNA. Nucleic Acids Res (1979) 1.57
Turnover of R1 (type I) and R2 (type II) retrotransposable elements in the ribosomal DNA of Drosophila melanogaster. Genetics (1992) 1.55
The rare transcripts of interrupted rRNA genes in Drosophila melanogaster are processed or degraded during synthesis. EMBO J (1984) 1.53
Localization of transcribed regions on extrachromosomal ribosomal RNA genes of Tetrahymena thermophila by R-loop mapping. Proc Natl Acad Sci U S A (1979) 1.45
Structure and developmental expression of the chick alpha-actin gene. Nucleic Acids Res (1980) 1.43
The ovalbumin gene: structural sequences in native chicken DNA are not contiguous. Proc Natl Acad Sci U S A (1978) 1.42
Sequences homologous to ribosomal insertions occur in the Drosophila genome outside the nucleolus organizer. Proc Natl Acad Sci U S A (1977) 1.40
Unique sequence arrangement of ribosomal genes in the palindromic rDNA molecule of Physarum polycephalum. Nucleic Acids Res (1979) 1.40
Duplicated rDNA sequences of variable lengths flanking the short type I insertions in the rDNA of Drosophila melanogaster. Nucleic Acids Res (1981) 1.40
Nucleotide sequence of the ribosomal RNA gene of Physarum polycephalum: intron 2 and its flanking regions of the 26S rRNA gene. Nucleic Acids Res (1981) 1.35
The molecular through ecological genetics of abnormal abdomen. IV. Components of genetic variation in a natural population of Drosophila mercatorum. Genetics (1992) 1.34
rRNA processing: removal of only nineteen bases at the gap between 28S alpha and 28S beta rRNAs in Sciara coprophila. Nucleic Acids Res (1985) 1.23
Characterization of cloned ribosomal DNA from Drosophila hydei. Nucleic Acids Res (1980) 1.15
An electron microscopic method for localization of ribosomal proteins during transcription of ribosomal DNA: a method for studying protein assembly. Proc Natl Acad Sci U S A (1981) 1.13
Fine structure of ribosomal RNA. II. Distribution of methylated sequences within Xenopus laevis rRNA. Nucleic Acids Res (1979) 1.13
Application of the avidin-biotin method of gene enrichment to the isolation of long double-stranded DNA containing specific gene sequences. Nucleic Acids Res (1977) 1.12
Coding region deletions associated with the major form of rDNA interruption in Drosophila. Nucleic Acids Res (1981) 1.11
Variable and constant regions are separated in the 10-kbase transcription unit coding for immunoglobulin kappa light chains. Proc Natl Acad Sci U S A (1978) 1.10
Structural organization of a 17 KB segment of the alpha 2 collagen gene: evaluation by R loop mapping. Nucleic Acids Res (1980) 1.08
Processing of ribosomal precursor RNAs in Physarum polycephalum. Nucleic Acids Res (1980) 1.05
The effect of mei-41 on rDNA redundancy in Drosophila melanogaster. Genetics (1983) 1.05
Polyoma infected cells contain at least three spliced late RNAs. Nucleic Acids Res (1978) 1.04
Cloned segment of Drosophila melanogaster rDNA containing new types of sequence insertion. Proc Natl Acad Sci U S A (1977) 1.03
Structural analysis of the three vitellogenin genes in Drosophila melanogaster. Nucleic Acids Res (1981) 1.02
Structural organization of the two main rDNA size classes of Ascaris lumbricoides. Nucleic Acids Res (1984) 0.98
RNA-DNA differences are generated in human cells within seconds after RNA exits polymerase II. Cell Rep (2014) 0.97
Two distinct intervening sequences in different ribosomal DNA repeat units of Sciara coprophila. Nucleic Acids Res (1981) 0.97
Out of balance: R-loops in human disease. PLoS Genet (2014) 0.97
In vitro splicing of the ribosomal RNA precursor in isolated nucleoli from Tetrahymena. Nucleic Acids Res (1980) 0.96
Site specific insertion of a type I rDNA element into a unique sequence in the Drosophila melanogaster genome. Nucleic Acids Res (1984) 0.92
Differential elimination of rDNA genes in bobbed mutants of Drosophila melanogaster. Mol Cell Biol (1986) 0.89
Repair-defect mutations inhibit rDNA magnification in Drosophila and discriminate between meiotic and premeiotic magnification. Proc Natl Acad Sci U S A (1985) 0.89
Sequence arrangement of the rRNA genes of the dipteran Sarcophaga bullata. Nucleic Acids Res (1981) 0.86
A new family of tandem repetitive early histone genes in the sea urchin Lytechinus pictus: evidence for concerted evolution within tandem arrays. Nucleic Acids Res (1984) 0.86
Type I-like intervening sequences are found in the rDNA of the nematode Ascaris lumbricoides. Nucleic Acids Res (1987) 0.84
Chromosomal position effects reveal different cis-acting requirements for rDNA transcription and sex chromosome pairing in Drosophila melanogaster. Genetics (2000) 0.84
Comparison of late mRNA splicing among class B and class C adenoviruses. J Virol (1979) 0.84
Electron microscope study of duck globin mRNA precursor crosslinked in situ. Proc Natl Acad Sci U S A (1980) 0.83
Genetic organization of the ribosomal transcription units of the yeast Saccharomyces carlsbergensis. Nucleic Acids Res (1978) 0.82
Studies on transcription termination and splicing of the rRNA precursor in vivo in the presence of proflavine. Nucleic Acids Res (1984) 0.78
Regions specifying transcriptional termination and pausing in the bacteriophage SP01 terminal repeat. Nucleic Acids Res (1983) 0.78
Ribosomal DNA organization before and after magnification in Drosophila melanogaster. Genetics (2012) 0.76
Non-coding RNA gene families in the genomes of anopheline mosquitoes. BMC Genomics (2014) 0.76
The modest beginnings of one genome project. Genetics (2013) 0.75
Are there insertions in the ribosomal DNA of vertebrates? Nucleic Acids Res (1985) 0.75
Discovery of RNA splicing and genes in pieces. Proc Natl Acad Sci U S A (2016) 0.75
Preparation and isolation of covalently closed circular rDNA molecules from DNA of Xenopus laevis. Nucleic Acids Res (1978) 0.75
RNase HII saves rnhA mutant Escherichia coli from R-loop-associated chromosomal fragmentation. J Mol Biol (2017) 0.75
Colony hybridization: a method for the isolation of cloned DNAs that contain a specific gene. Proc Natl Acad Sci U S A (1975) 77.46
Construction of a genetic linkage map in man using restriction fragment length polymorphisms. Am J Hum Genet (1980) 75.25
A system for mapping DNA sequences in the chromosomes of Drosophila melanogaster. Cell (1974) 27.33
Comprehensive human genetic maps: individual and sex-specific variation in recombination. Am J Hum Genet (1998) 19.35
Characterization of six cloned DNAs from Drosophila melanogaster, including one that contains the genes for rRNA. Cell (1975) 15.07
Expression of recessive alleles by chromosomal mechanisms in retinoblastoma. Nature (1983) 11.57
Chromosomal walking and jumping to isolate DNA from the Ace and rosy loci and the bithorax complex in Drosophila melanogaster. J Mol Biol (1983) 9.78
Construction of human linkage maps: likelihood calculations for multilocus linkage analysis. Genet Epidemiol (1986) 8.95
Molecular genetics of human color vision: the genes encoding blue, green, and red pigments. Science (1986) 8.23
Molecular Genetics of the Bithorax Complex in Drosophila melanogaster. Science (1983) 7.94
Repetitive sequences in isolated Thomas circles from Drosophila melanogaster. Cold Spring Harb Symp Quant Biol (1974) 6.72
A novel arrangement of tandemly repeated genes at a major heat shock site in D. melanogaster. Cell (1978) 6.44
Hybridization of RNA to double-stranded DNA: formation of R-loops. Proc Natl Acad Sci U S A (1976) 6.30
Repeated gene families in Drosophila melanogaster. Cold Spring Harb Symp Quant Biol (1978) 5.85
A highly polymorphic locus in human DNA revealed by cosmid-derived probes. Proc Natl Acad Sci U S A (1985) 5.81
The organization of the histone genes in Drosophila melanogaster: functional and evolutionary implications. Cold Spring Harb Symp Quant Biol (1978) 5.60
The units of DNA replication in Drosophila melanogaster chromosomes. Cold Spring Harb Symp Quant Biol (1974) 5.54
Isolation, sequence analysis, and intron-exon arrangement of the gene encoding bovine rhodopsin. Cell (1983) 5.49
The Polycomb protein shares a homologous domain with a heterochromatin-associated protein of Drosophila. Proc Natl Acad Sci U S A (1991) 5.47
Molecular genetics of inherited variation in human color vision. Science (1986) 5.28
A new high-capacity cosmid vector and its use. Gene (1980) 4.72
Segmental distribution of bithorax complex proteins during Drosophila development. Nature (1985) 4.55
On the molecular basis of high negative interference. Proc Natl Acad Sci U S A (1974) 4.25
Microarray analysis of Drosophila development during metamorphosis. Science (1999) 4.00
A novel arrangement of the 18S and 28S sequences in a repeating unit of Drosophila melanogaster rDNA. Cell (1977) 3.99
Translation of Drosophila melanogaster sequences in Escherichia coli. Proc Natl Acad Sci U S A (1977) 3.76
The Drosophila EcR gene encodes an ecdysone receptor, a new member of the steroid receptor superfamily. Cell (1991) 3.57
Letter: Potential biohazards of recombinant DNA molecules. Science (1974) 3.45
Effect of heat shock on the synthesis of low molecular weight RNAs in drosophilia: accumulation of a novel form of 5S RNA. Cell (1975) 3.41
Siah-1 mediates a novel beta-catenin degradation pathway linking p53 to the adenomatous polyposis coli protein. Mol Cell (2001) 3.34
Mechanism of DNA replication in Drosophila chromosomes: structure of replication forks and evidence for bidirectionality. Proc Natl Acad Sci U S A (1974) 3.29
Isolation and nucleotide sequence of the gene encoding human rhodopsin. Proc Natl Acad Sci U S A (1984) 3.27
The E75 ecdysone-inducible gene responsible for the 75B early puff in Drosophila encodes two new members of the steroid receptor superfamily. Genes Dev (1990) 3.01
Transcriptional activation and repression by Ultrabithorax proteins in cultured Drosophila cells. Cell (1989) 3.00
Reliability of the MS-2 system in detecting methicillin-resistant Staphylococcus aureus. J Clin Microbiol (1982) 2.88
The Drosophila 74EF early puff contains E74, a complex ecdysone-inducible gene that encodes two ets-related proteins. Cell (1990) 2.87
Molecular organization of a Drosophila puff site that responds to ecdysone. Cell (1982) 2.81
Functional dissection of Ultrabithorax proteins in D. melanogaster. Cell (1990) 2.69
An expandable gene that encodes a Drosophila glue protein is not expressed in variants lacking remote upstream sequences. Cell (1982) 2.65
Genetic mapping and diagnosis of haemophilia A achieved through a BclI polymorphism in the factor VIII gene. Nature (1985) 2.61
Effect of polymorphism in the Drosophila regulatory gene Ultrabithorax on homeotic stability. Science (1996) 2.59
Novel transcripts from the Ultrabithorax domain of the bithorax complex. Genes Dev (1987) 2.58
Structure and expression of a family of Ultrabithorax mRNAs generated by alternative splicing and polyadenylation in Drosophila. Genes Dev (1989) 2.30
Intracoronary gamma-radiation therapy after angioplasty inhibits recurrence in patients with in-stent restenosis. Circulation (2000) 2.28
Drosophila tissues with different metamorphic responses to ecdysone express different ecdysone receptor isoforms. Cell (1993) 2.17
Spatial and temporal patterns of E74 transcription during Drosophila development. Cell (1990) 2.11
Dumbbell-like bifunctional Au-Fe3O4 nanoparticles. Nano Lett (2005) 2.09
The CEPH consortium linkage map of human chromosome 1. Genomics (1991) 2.09
Regulation and products of the Ubx domain of the bithorax complex. Cold Spring Harb Symp Quant Biol (1985) 2.06
Pitch perception by cochlear implant subjects. J Acoust Soc Am (1987) 2.04
An Ultrabithorax protein binds sequences near its own and the Antennapedia P1 promoters. Cell (1988) 2.00
Evaluation of antibiotic synergy against Acinetobacter baumannii: a comparison with Etest, time-kill, and checkerboard methods. Diagn Microbiol Infect Dis (2000) 1.93
Some electrical and pharmacological properties of gap junctions between adult ventricular myocytes. Am J Physiol (1985) 1.88
Prostaglandin H synthase 2 is expressed abnormally in human colon cancer: evidence for a transcriptional effect. Proc Natl Acad Sci U S A (1996) 1.88
The position and orientation of genes in lambda and lambda dg DNA. Cold Spring Harb Symp Quant Biol (1966) 1.87
BRCA1 is associated with the centrosome during mitosis. Proc Natl Acad Sci U S A (1998) 1.81
Radio-frequency coils in implantable devices: misalignment analysis and design procedure. IEEE Trans Biomed Eng (1987) 1.81
Effectiveness of positron emission tomography for the detection of melanoma metastases. Ann Surg (1998) 1.78
Drosophila ecdysone receptor mutations reveal functional differences among receptor isoforms. Cell (1997) 1.75
Coordination of Drosophila metamorphosis by two ecdysone-induced nuclear receptors. Science (1997) 1.72
Nuclear and cytoplasmic localizations of the adenomatous polyposis coli protein. Proc Natl Acad Sci U S A (1997) 1.72
The large upstream control region of the Drosophila homeotic gene Ultrabithorax. Development (1991) 1.70
Molecular analysis of a gene in a developmentally regulated puff of Drosophila melanogaster. Proc Natl Acad Sci U S A (1980) 1.70
Gating of gap junction channels. Biophys J (1984) 1.70
Adenomatous polyposis coli protein contains two nuclear export signals and shuttles between the nucleus and cytoplasm. Proc Natl Acad Sci U S A (2000) 1.67
A cytological map of the human X chromosome--evidence for non-random recombination. Nucleic Acids Res (1984) 1.64
Transcriptional activation by the Antennapedia and fushi tarazu proteins in cultured Drosophila cells. Cell (1989) 1.63
Genetic consequences of transfection with heterduplex bacteriophage lambda DNA. Mol Gen Genet (1975) 1.61
Molecular mapping of genetic and chromomeric units in Drosophila melanogaster. J Mol Biol (1983) 1.58
Physical mapping of the von Recklinghausen neurofibromatosis region on chromosome 17. Am J Hum Genet (1989) 1.54
APC-mediated downregulation of beta-catenin activity involves nuclear sequestration and nuclear export. EMBO Rep (2000) 1.50
Identification of homeotic target genes in Drosophila melanogaster including nervy, a proto-oncogene homologue. Genetics (1995) 1.48
Impact of methicillin-resistant Staphylococcus aureus on the incidence of nosocomial staphylococcal infections. J Infect Dis (1983) 1.48
Image recovery from data acquired with a charge-coupled-device camera. J Opt Soc Am A (1993) 1.44
Antimicrobial cycling: the future or a fad? Ann Pharmacother (2001) 1.43
Purification of isopenicillin N synthetase. Biochem J (1984) 1.36
The chromosomal arrangement of coding sequences in a family of repeated genes. Prog Nucleic Acid Res Mol Biol (1976) 1.35
The Drosophila E74 gene is required for metamorphosis and plays a role in the polytene chromosome puffing response to ecdysone. Development (1995) 1.34
Programmed cell death in the Drosophila CNS is ecdysone-regulated and coupled with a specific ecdysone receptor isoform. Development (1993) 1.32
Genetic linkage between lipoprotein(a) phenotype and a DNA polymorphism in the plasminogen gene. Genomics (1988) 1.31
Self-promotion? Intimate connections between APC and prostaglandin H synthase-2. Cell (1996) 1.30
Molecular chaperones activate the Drosophila ecdysone receptor, an RXR heterodimer. Cell (2000) 1.29
Gap junctional conductance and permeability are linearly related. Science (1986) 1.29
Phosphorylation near nuclear localization signal regulates nuclear import of adenomatous polyposis coli protein. Proc Natl Acad Sci U S A (2000) 1.29
Burn units as a source of methicillin-resistant Staphylococcus aureus infections. JAMA (1983) 1.26
Identification of a gamma-tubulin-binding domain in BRCA1. Cancer Res (2001) 1.26
E7-transduced human breast epithelial cells show partial differentiation in three-dimensional culture. Cancer Res (1999) 1.26
Ecdysone receptor expression in the CNS correlates with stage-specific responses to ecdysteroids during Drosophila and Manduca development. Development (1994) 1.23
DHR3: a Drosophila steroid receptor homolog. Proc Natl Acad Sci U S A (1992) 1.23
Spectroscopic identification and direct imaging of interfacial magnetic spins. Phys Rev Lett (2001) 1.22
Cell density and phosphorylation control the subcellular localization of adenomatous polyposis coli protein. Mol Cell Biol (2001) 1.21
Gene orientation in bacteriophage lambda as determined from the genetic activities of heteroduplex DNA formed in vitro. J Mol Biol (1968) 1.19
In vitro pharmacodynamics of ceftazidime against Pseudomonas aeruginosa isolates from cystic fibrosis patients. Antimicrob Agents Chemother (1997) 1.18
Genetic linkage map of six polymorphic DNA markers around the gene for familial adenomatous polyposis on chromosome 5. Am J Hum Genet (1990) 1.17
The lysozyme of bacteriophage lambda. I. Purification and molecular weight. J Biol Chem (1969) 1.13
The enzymes of the galactose operon in Escherichia coli. II. The subunits of uridine diphosphogalactose 4-epimerase. J Biol Chem (1969) 1.13
A wide-band efficient inductive transdermal power and data link with coupling insensitive gain. IEEE Trans Biomed Eng (1987) 1.12
Negative autoregulation by Ultrabithorax controls the level and pattern of its expression. Development (1993) 1.11
Effect of calcium on the dissociation of the mature rat heart into individual and paired myocytes: electrical properties of cell pairs. Circ Res (1986) 1.11